检索结果-南通市图书馆

Effects of urotensin-Ⅱ on cytokines in early acute liver failure in mice

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第11期21卷 3239-3244页

作者： liang-ming liu liang Zhao Dong-Yu liang Fang-Ping Yu Chang-Gen Ye Wen-Juan Tu Tong Zhu Department of Hepatology Songjiang Hospital Affiliated to the First People’s HospitalShanghai Jiaotong University

AIM:To investigate urotensin-Ⅱ(UⅡ) and its effects on tumor necrosis factor(TNF)-α and interleukin(IL)-1β in early acute liver failure(ALF).METHODS:We investigated the time-dependent alteration in UⅡ levels and its effects on TNF-αand IL-1β in liver and blood in the early stage of lipopolysaccharide/D-galactosamine-induced ***:After lipopolysaccharide/D-galactosamine challenge,UⅡ rose very rapidly and reached a maximal level 0.5 h,and the level remained significantly elevated after 2 h(P ming of ALF by triggering an inflammatory cascade and driving the early release of cytokines in mice.

关键词： Acute hepatic failure Interleukin-1β Mouse Tumor n

Effect of H_2S concentration on the corrosion behavior of pipeline steel under the coexistence of H_2S and CO_2

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2014年第4期21卷 388-394页

作者： Da-peng Li Lei Zhang Jian-wei Yang Min-xu Lu Jin-hui Ding ming-liang liu Institute of Advanced Materials and Technology University of Science and Technology Beijing Shougang Research Institute of Technology

The effect of H2S concentration on H2S/CO2 corrosion of API-X60 steel was studied by scanning electron microscopy, a weight-loss method, potentiodynamic polarization tests, and the electrochemical impedance spectroscopy technique. It is found that the cor-rosion process of the steel in an environment where H2S and CO2 coexist at different H2S concentrations is related to the morphological structure and stability of the corrosion product film. With the addition of a small amount of H2S, the size of the anode reaction region is de-creased due to constant adsorption and separation of more FeS sediment or more FeHS＋ions on the surface of the steel. Meanwhile, the dou-ble-layer capacitance is diminished with increasing anion adsorption capacity. Therefore, the corrosion process is inhibited. The general cor-rosion rate of the steel rapidly decreases after the addition of a small amount of H2S under the coexistence of H2S and CO2. With a further increase in H2S concentration, certain parts of the corrosion product film become loose and even fall off. Thus, the protection provided by the corrosion product film worsens, and the corrosion rate tends to increase.

关键词： pipeline steel hydrogen sulfide carbon dioxide corrosion corrosion rate electrochemical properties

Stannous-acetylacetonate:A new catalyst for poly(trimethylene terephthalate) synthesis

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第7期18卷 827-830页

作者： Shu Yong Jia Yu Rong Ren liang ming liu Dan Zhang Yi Zeng Gong Ying Wang Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China College of Chemistry Jilin Normal University Siping 136000 China Graduate University of Chinese Academy of Sciences Beijing 100039 China

Stannous-acetylacetonate was prepared efficiently and characterized by ^1H NMR and FT-IR. Its catalytic activity for poly（trimethylene terephthalate）（PTT） synthesis was investigated. By this catalyst, the degree of esterification of pure terephthalic acid was up to 91.7% after reaction at 260 ℃ for 2 h, while the intrinsic viscosity and content of terminal carboxyl groups of the corresponding PTT polymerized at 260 ℃, 60 Pa for 2 h was 0.8816 dL/g and 17 mol/t,respectively. Stannous-acetylacetonate was more active and promising than tetrabutyl titanate and stannous octoate for PTT synthesis.

关键词： Poly(trimethylene terephthalate) Stannous-acetylacetonate 1,3-Propanediol

Study on Power Transformers Fault Diagnosis Based on Wavelet Neural Network and D-S Evidence Theory

在线全文

学校读者我要写书评

暂无评论

高电压技术 2008年第12期34卷 2694-2700页

作者： liang liu-ming CHEN Wei-gen YUE Yan-feng WEI Chao YANG Jian-feng State Key Laboratory of Power Transmission Equipment & System Security and New Technology Chongqing University Chongqing 400044 China Luoyang Power Supply Company Luoyang 471000 China

>Transformer faults are quite complicated phenomena and can occur due to a variety of *** have been several methods for transformer fault synthetic diagnosis,but each of them has its own limitations in real fault diagnosis *** order to overcome those shortcomings in the existing methods,a new transformer fault diagnosis method based on a wavelet neural network optimized by adaptive genetic algorithm(AGA)and an improved D-S evidence theory fusion technique is proposed in this *** proposed method combines the oil chromatogram data and the off-line electrical test data of transformers to carry out fault *** on the fusion mechanism of D-S evidence theory,the comprehensive reliability of evidence is constructed by considering the evidence importance,the outputs of the neural network and the expert *** new method increases the objectivity of the basic probability assignment(BPA)and reduces the basic probability assigned for uncertain and unimportant *** case study results of using the proposed method show that it has a good performance of fault diagnosis for transformers.

关键词：小波神经网络 D-S证据理论电力变压器故障诊断适应基因算法

Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function:implication of miRNAs and microvesicles

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2024年第1期11卷 1-18页

作者： Zi-Sen Zhang Yi-Yan liu Shuang-Shuang He Dai-Qin Bao Hong-Chen Wang Jie Zhang Xiao-Yong Peng Jia-Tao Zang Yu Zhu Yue Wu Qing-Hui Li Tao Li liang-ming liu State Key Laboratory of Trauma Burns and Combined InjuryDepartment of Shock and TransfusionResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon *** hypothesized that pericytes,a group of pluripotent cells that maintain vascular integrity and tension,are protective against sepsis via regulating vascular reactivity and *** We conducted a series of in vivo experiments using wild-type(WT),platelet-derived growth factor receptor-β(PDGFR-β)-Cre+mT/mG transgenic mice and Tie2-Cre+Cx43^(flox/flox)mice to examine the relative contribution of pericytes in sepsis,either induced by cecal ligation and puncture(CLP)or lipopolysaccharide(LPS)*** a separate set of experiments with Sprague-Dawley(SD)rats,pericytes were depleted using CP-673451,a selective PDGFR-βinhibitor,at a dosage of 40 mg/(kg·d)for 7 consecutive *** pericytes,vascular endothelial cells(VECs)and vascular smooth muscle cells(VSMCs)were used for mechanistic *** effects of pericytes and pericyte-derived microvesicles(PCMVs)and candidate miRNAs on vascular reactivity and barrier function were also *** CLP and LPS induced severe injury/loss of pericytes,vascular hyporeactivity and leakage(P<0.05).Transplantation with exogenous pericytes protected vascular reactivity and barrier function via microvessel colonization(P<0.05).Cx43 knockout in either pericytes or VECs reduced pericyte colonization in microvessels(P<0.05).Additionally,PCMVs transferred miR-145 and miR-132 to VSMCs and VECs,respectively,exerting a protective effect on vascular reactivity and barrier function after sepsis(P<0.05).miR-145 primarily improved the contractile response of VSMCs by activating the sphingosine kinase 2(Sphk2)/sphingosine-1-phosphate receptor(S1PR)1/phosphorylation of myosin light chain 20 pathway,whereas miR-132 effectively improved the barrier function of VECs by activating the Sphk2/S1PR2/zonula occludens-1 and vascular endothelial-cadherin *** Pericytes are protective a

关键词： Pericyte Vascular reactivity Vascular permeability Cx43 Microvesicle

Opioid receptor antagonists increase [Ca2+]i in rat arterial smooth muscle cells in hemorrhagic shock

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第3期25卷 141-146页

作者： Li KAI,Zhong-feng WANG2,Yu-liang SHI2,3,liang-ming liu,De-yao HU Institute of Surgery,Department of Pharmacology,Third Military Medical University,Chongqing 400042 Key Laboratory of 2 Neurobiology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China Institute of Surgery Department of Pharmacology Third Military Medical University Key Laboratory of Neurobiology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

AIM: To examine the effects of opioid receptor antagonists and norepinephrine on intracellular free Ca2+ concentra- tion ([Ca2+]i) in mesenteric arterial (MA) smooth muscle cells (SMC) isolated from normal and hemorrhagic shocked rats in the vascular hyporesponse stage. METHODS: The rat model of hemorrhagic shock was made by withdrawing blood to decrease the artery mean blood pressure to 3.73-4.26 kPa and keeping at the level for 3 h. [Ca2+]i of vascular smooth muscle cells (VSMC) were detected by the laser scan confocal microscopy. RESULTS: In the hyporesponse VMSC of rats in hemorrhagic shock, selective δ-, κ-, and μ-opioid receptor antagonists (naltrindole, nor-binaltorphimine, and β-funaltrexamine, 100 nmol/L) as well as norepinephrine 5 μmol/L significantly increased [Ca2+]i by 47 %±13 %, 37 %±14 %, 33 %±10 %, and 54 %±17 %, respectively, although their effects were lower than those in the normal rat cells (the increased values were 148 %±54 %, 130 %±44 %, 63 %±17 % and 110 %±38 %, respectively); and the norepinephrine-induced increase in [Ca2+]i was further augmented by three δ-, κ-, and μ-opioid receptor antagonists (50 nmol/L, respectively) application (from 52 %±16 % to 99 %±29 %, 146 %±54 % and 137 %±47 %, respectively). CONCLUSION: The disorder of [Ca2+]i regulation induced by hemorrhagic shock was mediated by opioid receptor and α-adrenoceptor, which may be partly responsible for the vascular hyporesponse, and the opioid receptor antagonists improved the response of resistance arteries to vascu- lar stimulants in decompensatory stage of hemorrhagic shock.

关键词： hemorrhagic shock vascular smooth muscle opioid receptors calcium

Research advances in pericyte function and their roles in diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2020年第2期23卷 89-95页

作者： Zi-Sen Zhang He-Nan Zhou Shuang-Shuang He ming-Ying Xue Tao Li liang-ming liu State Key Laboratory of Trauma Bums and Combined InjuryResearch Institute of SurgeryDoping HospitalArmy Medical UniversityChongqing 400042China

Pericyte,a kind of pluripotent cell,may regulate the irigation flow and permeability of *** are similar to the smooth muscle cells,which express several kinds of contractile proteins and have *** dysfunction of pericytes is related to many microvascular diseases,including hypoxia,hypertension,diabetic retinopathy,fibrosis,inflammation,Alzheimer's disease,multiple scle-rosis,and tumor *** a long time,their existence and function have been *** distribution,structure,biomarker,related signaling pathways as well as the roles of pericytes on vascular diseases will be introduced in this review.

关键词： Pericytes Vascular diseases Microcirculation

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei Li Qianqian liang Li Xu Changsheng Ding Yu liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

Fabrication and Characterization of VO_2 Thin Films by Direct Current Facing Targets Magnetron Sputtering and Low Temperature Oxidation

在线全文

学校读者我要写书评

暂无评论

Transactions of Tianjin University 2008年第3期14卷 173-177页

作者：梁继然胡明刘志刚韩雷陈涛 School of Electronic Information Engineering Tianjin University

Low valence vanadium oxide(VO2-x) thin films were prepared on SiO2/Si substrates at room temperature by direct current facing targets reactive magnetron sputtering, and then proc- essed through rapid thermal annealing. The effects of the annealing on the structure and phase transition property of VO2 were discussed. X-ray photoelectron spectroscopy, X-ray diffraction tech- nique and Fourier transform infrared spectroscopy were employed to study the phase composition and structure of the thin films. The resistance-temperature property was measured. The results show that VO2 thin film is obtained after annealed at 320 ℃ for 3 h, its phase transition tempera- ture is 56 ℃, and the resistance changes by more than 2 orders. The vanadium oxide thin films are applicable in thermochromic smart windows, and the deposition and annealing process is compatible with micro electromechanical system process.

关键词： vanadium dioxide direct current facing targets magnetron sputtering low temperature oxidation: microstructure