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Volcanism Pacing Slumping Gravity Flow Deposits during the Late Carboniferous in the Southern Margin of the Junggar Basin,China

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地质学报:英文版 2023年第5期97卷 1422-1450页

作者： LI Shixin ZHANG Tingshan ZHANG Xi liang Zeliang JI Dongsheng Mihai Emilian POPA YONG Jinjie LUO Jinyu ZENG Jianli ZHU haihua School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China Natural Gas Geology Key Laboratory of Sichuan Province Southwest Petroleum UniversityChengdu 610500China PetroChina Xinjiang Oilfield Company KaramayXinjiang 834000China Faculty of Geology and Geophysics University of BucharestBucharest 010041Romania

Deep-water gravity depositional processes and evolution in arc systems have become topics of intense research focus in recent *** study discusses the co-evolution of volcanism and deep-water gravity flow deposits at the southern margin of the Junggar Basin,based on petrology,geochronology and geochemical *** results show that a massive collapse of unstable sediments from the slope was triggered by volcanism,resulting in the formation of slumping gravity *** occurrence of volcanic beds in the slump deposits confirm that synchronous volcanism likely affected sediment instability,triggering gravity *** Th/Yb,Ta/Yb and Th/Ta elemental ratios,U-Pb ages of detrital zircons and paleocurrent directions indicate that the North Tianshan(NTS)island arc represents the provenance of the Qianxia ***,statistical data on the pyroclastic components in the gravity flow deposits reveal an intensity index of volcanism,indicating that volcanism is strongly related to gravity flow deposits,especially in terms of the type and distribution of the deposits.A model for volcanically-triggered deep-water gravity flow deposits is established,in order to provide a more in-depth understanding of the co-evolution of volcanism and gravity flow deposits within the depositional setting of the late Paleozoic NTS oceanic subduction margin in the Junggar Basin.

关键词： volcanism trigger gravity flow deposits island arc Qianxia Formation Junggar Basin

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异丙隆原药对大鼠的致畸作用

癌变．畸变．突变 2024年第4期36卷 294-297页

作者：程秀荣王海华陈巍梁一帆谢广云中国疾病预防控制中心职业卫生与中毒控制所北京100050

目的:研究异丙隆原药对大鼠的致畸作用。方法:将受孕的雌性Wistar大鼠随机分为对照组(花生油)和低(36.9 mg/kg)、中(73.8 mg/kg)、高(369.0 mg/kg)3个异丙隆原药染毒剂量组,每组15只孕鼠。对照组和各染毒组于大鼠妊娠第6~15天灌胃给予... 详细信息

目的:研究异丙隆原药对大鼠的致畸作用。方法:将受孕的雌性Wistar大鼠随机分为对照组(花生油)和低(36.9 mg/kg)、中(73.8 mg/kg)、高(369.0 mg/kg)3个异丙隆原药染毒剂量组,每组15只孕鼠。对照组和各染毒组于大鼠妊娠第6~15天灌胃给予受试物,每天1次,连续10 d。于妊娠第20天处死各组孕鼠,观察母鼠和胎鼠的生长、发育情况。结果:与对照组比较,低、中剂量组孕鼠各项观察指标差异均无统计学意义(P>0.05)。高剂量组孕鼠于受孕第9天出现萎靡不振、背毛蓬松、体质量下降(P<0.01);着床数、活胎数减少,死胎数增多,窝均体质量降低(P<0.5);部分胎鼠出现囟门大、枕骨及胸骨骨化不全、肋骨弯曲,骨骼畸形率为27.78%,与对照组相比,差异均具有统计学意义(P<0.05)。结论:在本实验条件下,369.0 mg/kg组异丙隆原药可引起Wistar大鼠的母体毒性和胚胎发育毒性。

关键词：异丙隆原药 Wistar大鼠母体毒性胚胎发育毒性致畸作用

Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle

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Bioactive Materials 2020年第4期5卷 1053-1061页

作者： Tongren Yang Chunhui Li Xiaoxia Wang Deyao Zhao Mengjie Zhang Huiqing Cao Zicai liang haihua Xiao Xing-Jie liang Yuhua Weng Yuanyu Huang School of Life Science Advanced Research Institute of Multidisciplinary ScienceInstitute of Engineering MedicineKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing100081China Institute of Molecular Medicine Peking UniversityBeijing100871China Suzhou Ribo Life Science Co.Ltd. Jiangsu215300China Beijing National Laboratory for Molecular Science State Key Laboratory of Polymer Physical and ChemistryInstitute of ChemistryChinese Academy of ScienceBeijing100190China Chinese Academy of Sciences(CAS)Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing100190China School of Materials and the Environment Beijing Institute of TechnologyZhuhai519085China Department of Radiation Oncology The First Affiliated Hospital of Zhengzhou UniversityErqiZhengzhou450000China

mRNA is a novel class of therapeutic modality that holds great promise in vaccination,protein replacement therapy,cancer immunotherapy,immune cell engineering ***,optimization of mRNA molecules and efficient in vivo delivery are quite important but challenging for its broad *** we present an ionizable lipid nanoparticle(iLNP)based on iBL0713 lipid for in vitro and in vivo expression of desired proteins using codon-optimized *** encoding luciferase or erythropoietin(EPO)were prepared by in vitro transcription and formulated with proposed iLNP,to form iLP171/mRNA *** was revealed that both luciferase and EPO proteins were successfully expressed by human hepatocellular carcinoma cells and *** maximum amount of protein expression was found at 6 h *** expression efficiency of EPO with codon-optimized mRNA was significantly higher than that of unoptimized ***,no toxicity or immunogenicity was observed for these mRNA ***,our study provides a useful and promising platform for mRNA therapeutic development.

关键词： mRNA therapy Lipid nanoparticle mRNA delivery Erythropoietin Codon optimization

Effects of nano-pore system characteristics on CH4 adsorption capacity in anthracite

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Frontiers of Earth Science 2019年第1期13卷 75-91页

作者： Chang'an SHAN Tingshan ZHANG Xing liang Dongchu SHU Zhao ZHANG Xiangfeng WEI Kun ZHANG Xuliang FENG haihua ZHU Shengtao WANG Yue CHEN School of Earth Sciences and Engineering Xi'an Shiyou UniversityXi'an 710065China Shandong Provincial Key Laboratory of Depositional Mineralization &Sedimentary Minerals Shandong University of Science and Technology Qingdao 266590China Key Laboratory of Tectonics and Petroleum Resources (China University of Geosciences) Ministry of EducationWuhan 430074China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China Exploration and Development Department Zhejiang Oilfield CompanyCNPCHangzhou 310023China SINOPEC Exploration Company Chengdu 610014China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China Shaanxi Yanehang Petroleum International Exploration and Development Engineering Co.Ltd Xi'an 710075China

This study aims to determine the effects of nanoscale pores system characteristics on CH4 adsorption capacity in anthracite.A total of 24 coal samples from the southern Sichuan Basin,China,were examined systemically using coal maceral analysis,vitrinite reflectance tests, proximate analysis,ultimate analysis,low-temperature N2 adsorption-desorption experiments,nuclear magnetic resonance (NMR)analysis,and CH4 isotherm adsorption *** show that nano-pores are divided into four types on the basis of pore size ranges:super micropores (100 nm).Super micropores,micropores,and mesopores make up the bulk of coal porosity,providing extremely large adsorption space with large intemal surface *** leads us to the conclusion that the threshold of pore diameter between adsorption pores and seepage pores is 100 *** "ink bottle"pores have the largest CH4 adsorption capacity, followed by semi-opened pores,whereas opened pores have the smallest CH4 adsorption capacity which indicates that anthracite pores with more irregular shapes possess higher CH4 adsorption ***4 adsorption capacity increased with the increase in NMR porosity and the bound water ***,CH4 adsorption capacity is positively correlated with NMR permeability when NMR permeability is less than 8 ×10^-3 *** contrast,the two factors are negatively correlated when NMR permeability is greater than 8 × 10^-3 md.

关键词： CH4 adsorption capacity anthracite nanopore structure NMR physical properties

Influence of ginsenoside on expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in the medial septum of aged rats

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Neural Regeneration Research 2008年第5期3卷 490-493页

作者： liang Zeng haihua Zhao Yongli Lu Wenbo Dai Department of Anatomy Shenyang Medical College Shenyang 110034 Liaoning Province China Department of Anatomy China Medical University Shenyang 110001 Liaoning Province China Department of Pathology First People＇s Hospital Shenyang 110041 Liaoning Province China

BACKGROUND： It has beenshown that ginsenoside, the effective component of ginseng, can enhance expression of choline acetyl transferase, as well as brain-derived neurotrophic factor （BDNF） and its receptor tyrosine kinase B （TrkB）, in cholinergic neurons of the basal forebrain. OBJECTIVE： To qualitatively and quantitatively verify the influence of ginsenoside on expression of BDNF and its receptor, TrkB, in the medial septum of aged rats, and to provide a molecular basis for clinical application. DESIGN~ TIME AND SETTING： A contrast study, which was performed in the Department of Anatomy, China Medical University, and the Department of Anatomy, Shenyang Medical College between December 2005 and May 2007. MATERIALS： Thirty-five, healthy, female, Sprague Dawley rats were selected for this study. Ginsenoside （81% purity） was provided by Jilin Ji＇an Wantai Chinese Medicine Factory; anti-BDNF antibody, anti-TrkB antibody, and their kits were provided by Wuhan Boster Company. METHODS： A total of 35 rats were divided into three groups： young （four months old）, aging （26 months old）, and ginsenoside. Rats in the ginsenoside group were administered ginsenoside （25 mg/kg/d） between 17 months and 26 months. MAIN OUTCOME MEASURES： Immunohistochemistry and in situ hybridization were used to measure expression of BDNF and TrkB in the medial septum of aged rats, and the detected results were expressed as gray values. RESULTS：（1） Qualitative detection： using microscopy, degenerative neurons were visible in the medial septum in the aging group. However, neuronal morphology in the ginsenoside group was similar to neurons in the young group. （2） Quantitative detection： the mean gray value of BDNF-positive and TrkB-positive products in the aging group were significantly higher than in the young group （t = 3.346, 4.169, P 〈 0.01）; however, the mean gray value in the ginsenoside group was significantly lower than in the aging group （t = 2.432, 2.651, P 〈 0.01）. CONCLUSION： Ginsenoside c

关键词： BDNF TrkB ginsenoside medial septum aged rat

基于ReHo和fALFF的优势半球与非优势半球基底节区脑梗死后运动障碍的静息态脑功能成像研究

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中国中西医结合影像学杂志 2024年第1期22卷 66-71页

作者：熊丹梁育源朱盼谢海花陆琳李浩谭洁赵宁湖南中医药大学针灸推拿与康复学院湖南长沙410208 深圳大学第六附属医院康复医学科广东深圳518052 福建省厦门市湖里区江头街道社区卫生服务中心针灸科福建厦门361009

目的:采用静息态fMRI技术联合局部一致性(ReHo)和比率低频振幅(fALFF)探讨优势半球与非优势半球基底节区脑梗死后运动障碍患者的脑局部自发活动变化。方法:招募20例基底节区脑梗死后运动障碍患者,按照病灶位置分为优势半球脑梗死组11例... 详细信息

目的:采用静息态fMRI技术联合局部一致性(ReHo)和比率低频振幅(fALFF)探讨优势半球与非优势半球基底节区脑梗死后运动障碍患者的脑局部自发活动变化。方法:招募20例基底节区脑梗死后运动障碍患者,按照病灶位置分为优势半球脑梗死组11例和非优势半球脑梗死组9例;招募18例性别、年龄匹配的健康志愿者(对照组)分别行静息态fMRI,利用基于MATLAB的SPM12和DPARSF软件对数据进行分析,采用双样本t检验(体素水平P<0.01,团块水平P<0.05,GRF校正)对3组受试者的ReHo及fALFF脑图行组间两两比较,提取差异脑区的ReHo值及fALFF值。结果:与对照组相比,优势半球脑梗死组左侧三角部额下回的ReHo值显著升高(t=4.97,P<0.05),左侧扣带回白质的fALFF值显著降低(t=-7.57,P<0.05)。与对照组相比,非优势半球脑梗死组左侧额中回的ReHo值显著升高(t=6.01,P<0.05),左侧内侧和旁扣带脑回(t=-6.02,P<0.05)、右侧枕上回(t=-5.25,P<0.05)的ReHo值显著降低,右侧眶部额下回(t=5.01,P<0.05)、左侧枕中回(t=4.74,P<0.05)的fALFF值显著升高,右侧内侧和旁扣带脑回fALFF值显著降低(t=-5.58,P<0.05)。与非优势半球脑梗死组相比,优势半球脑梗死组左侧小脑的ReHo值显著升高(t=4.51,P<0.05),左侧三角部额下回(t=5.29,P<0.05)、左侧舌回(t=5.63,P<0.05)、左侧额中回(t=6.72,P<0.05)的fALFF值显著升高。结论:静息状态下,与对照组相比,优势半球与非优势半球基底节区脑梗死后双侧大脑皮质运动、感觉及认知等多个脑区神经元活动发生变化;与非优势半球脑梗死相比,优势半球脑梗死能更快地出现代偿性激活,增强神经元活动,这一发现可能有助于进一步理解不同半球间基底节区脑梗死后运动障碍患者的大脑局部神经影像学差异。

关键词：基底节区脑梗死运动功能障碍局部一致性比率低频振幅静息态功能磁共振成像

The Space Environment Monitors of Shenzhou Manned Spacecrafts

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空间科学学报 2004年第Z1期24卷 32-38页

作者： XU Ying ZHU Guangwu WANG Shijin QIN Guotai liang Jinbao SUN Yueqiang HUANG Xiuying YANG Xiaochao WANG Yue WANG Chunqin YE haihua JING Guiru Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 China

For the purpose of ensuring normal operations of Shenzhou (SZ) series of manned spacecrafts and cosmonauts' safety, Space Environment Monitors (SEM)are mounted on board SZ-2, 3, 4, 5. SEMs aim to detect the high energy particles, the low energy particles, charging potential, atmospheric desity and composition. Detection of SEMs enable us to understand better the space environment in the manned spacecraft's orbit, and to provide a good space environment services for the spacecraft and cosmonauts. In addition, by using the data from SEMs, we have achieved some scientific accomplishments, such as the energy spectra of precipitating electrons, the abnormal variety of atmospheric density and composition during geomagnetic disturbances, the electron angle distribution in the low orbit and so on.

关键词： Shenzhou manned spacecrafts Space environment Detect

基于随机森林模型的产妇出院准备度影响因素分析

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中国医药导报 2024年第23期21卷 87-91,101页

作者：王慧娟杜瑄刘晓慧樊莉梁立东杨玉静甘茹高海花宁夏医科大学护理学院宁夏银川750004 宁夏医科大学总医院产科宁夏银川750004 银川市妇幼保健院护理部宁夏银川750001 银川市妇幼保健院产科宁夏银川750001

目的探讨基于随机森林模型的产妇出院准备度的影响因素,为临床提高出院准备度提供理论依据。方法采用便利抽样法,选取2022年3月至7月于宁夏医科大学总医院和银川市妇幼保健院产科住院的418例产妇作为研究对象。采用产妇一般资料问卷、... 详细信息

目的探讨基于随机森林模型的产妇出院准备度的影响因素,为临床提高出院准备度提供理论依据。方法采用便利抽样法,选取2022年3月至7月于宁夏医科大学总医院和银川市妇幼保健院产科住院的418例产妇作为研究对象。采用产妇一般资料问卷、产妇出院准备度量表、家庭功能评定量表进行调查。采用Spearman相关分析产妇出院准备度与家庭功能的相关性,采用多元线性回归和随机森林模型分析产妇出院准备度的影响因素。结果产妇出院准备度量表总分为133.00(116.00,148.00)分,家庭功能评定量表总分为129.00(119.00,137.00)分。不同家庭人均月收入、婚龄、住院时间、孕次、产次、分娩方式、喂养方式及参加孕妇学校或课程的产妇出院准备度量表总分比较,差异有统计学意义(P<0.05)。除自身状况、疾病知识和出院后应对能力与情感反应无相关性外,产妇出院准备度量表及各维度评分与家庭功能评定量表及其余维度评分呈负相关(P<0.01)。住院时间、产次、分娩方式、喂养方式、参加孕妇学校或课程、家庭功能评定量表总分可解释出院准备度22.9%的变异。随机森林模型对各影响因素重要性排序从高到低依次为家庭功能评定量表总分、产次、喂养方式、参加孕妇学校或课程、住院时间及分娩方式。结论产妇出院准备度处于中上水平,在临床工作中应将家庭功能评估纳入出院准备教育中,制订适合家庭需要的提高出院准备度的方案。

关键词：产妇出院准备度家庭功能影响因素随机森林

Eu^(3+)∶Y_2SiO_5晶体中电磁感应透明及群速度减慢研究

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光学学报 2007年第5期27卷 946-950页

作者：梁卿昌王海华蒋占魁烟台大学光电信息科学技术学院物理系烟台264005 吉林大学物理学院长春130023

利用光与物质相互作用的密度矩阵方程及其数值解研究了Eu3+∶Y2SiO5晶体中一种Λ型的电磁感应透明(EIT)和群速度减慢(SGV),得到了探测场的透射率随着探测场的失谐与耦合场的拉比频率的变化关系。分析了自旋子能级非均匀线宽及光学跃迁... 详细信息

利用光与物质相互作用的密度矩阵方程及其数值解研究了Eu3+∶Y2SiO5晶体中一种Λ型的电磁感应透明(EIT)和群速度减慢(SGV),得到了探测场的透射率随着探测场的失谐与耦合场的拉比频率的变化关系。分析了自旋子能级非均匀线宽及光学跃迁非均匀线宽对电磁感应透明和群速度减慢的影响,这两个线宽的增加不同程度地抑制了电磁感应透明。根据浓度与非均匀线宽的关系发现中心透射率不是随着浓度的增加而单调变化,而是存在一个最佳浓度使电磁感应透明的效果更加明显。分析表明对某一耦合场强,光群速度存在一极小值。

关键词：量子光学量子相干效应电磁感应光透明群速度减慢密度矩阵方程 Eu^3+:Y2SiO5