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Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin(mTOR)pathway in calf hepatocytes

Animal Nutrition 2023年第4期15卷 88-98页

作者： Guo yan Wang Sen Lin Qin Yi Ning Zheng hui Jun Geng Lei Chen Jun Hu Yao Lu Deng College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China

Enhancing hepatic gluconeogenesis is one of the main modes of meeting the glucose requirement of dairy *** study attempted to determine whether the gluconeogenesis precursor propionate had an effect on the expression of the main genes involved in gluconeogenesis in calf hepatocytes and elucidate the associated *** hepatocytes were obtained from 5 healthy calves(1 d old;30to 40 kg)and exposed to 0-,1-,2.5-,or 5-mM sodium propionate(NaP),which is known to promote the expression of genes involved in the gluconeogenesis pathway,including fructose 1,6-bisphosphatase,phosphoenolpyruvate carboxykinase,and *** regard to the underlying mechanism,propionate promoted the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha,hepatocyte nuclear factor 4,and forkhead box O1(transcription factors that regulate the expression of hepatic gluconeogenic genes)by promoting mammalian target of rapamycin complex 1(mTORC1),but inhibiting mTORC2 activity(P<0.01).We also established a model of palmitic acid(PA)-induced hepatic injury in calf hepatocytes and found that PA could inhibit the gluconeogenic capacity of calf hepatocytes by suppressing the expression of gluconeogenic genes,inhibiting m TORC1,and promoting the activity of m TORC2(P<0.01).In contrast,NaP provided protection to calf hepatocytes by counteracting the inhibitory effect of PA on the gluconeogenic capacity of calf hepatocytes(P<0.05).Collectively,these findings indicate that NaP enhances the gluconeogenic capacity of calf hepatocytes by regulating the mTOR pathway ***,in addition to improving the glucose production potential,propionate may have therapeutic potential for the treatment of hepatic injury in dairy cows.

关键词： Propionate Gluconeogenesis Mechanistic target of rapamycin Palmitic acid

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以气电为支撑的综合能源基地储气与调峰方式

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油气与新能源 2024年第3期36卷 79-85页

作者：梁严杨义周淑慧王璇张丹迪昝光杰中国石油天然气股份有限公司规划总院北京100083 中国石油天然气销售浙江分公司杭州310051 中国石油天然气销售分公司北京100007

气电是解决风光新能源出力随机性、波动性、间歇性的关键调峰调频电源,也是支撑风光综合能源大基地、电力特高压外送通道建设的主体调节电源。清洁低碳高效的天然气将在新型能源体系中发挥不可替代的调节作用。以气电为支撑的综合能源... 详细信息

气电是解决风光新能源出力随机性、波动性、间歇性的关键调峰调频电源,也是支撑风光综合能源大基地、电力特高压外送通道建设的主体调节电源。清洁低碳高效的天然气将在新型能源体系中发挥不可替代的调节作用。以气电为支撑的综合能源基地用气特性与传统行业用气特性存在较大差异,综合能源基地用气的“冬夏双峰”季节性波动、逐日不规则波动、日内小时规则波动等特征对储气与调峰的保障要求更高。在分析地下储气库、气田灵活调峰、LNG储罐、地面高压球罐和高压管道等储气调峰方式技术经济性的基础上,结合综合能源基地用气特性探索出多系统层次、多时间尺度的储气与调峰方式,并从政策支持、示范应用及技术攻关角度提出相应建议。

关键词：天然气气电综合能源基地储气与调峰

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Effect of Fuzheng Jiedu granule on immunological function and level of immune-related cytokines in immune-suppressed mice

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Journal of Integrative Agriculture 2016年第3期15卷 650-657页

作者： YU Zhan-mei HUANG Xian-hui yan Chao-qun GAO Jin liang Zi-sen Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation College of Veterinary Medicine South China Agricultural University

Fuzheng Jiedu granule exhibits a number of health benefits and it is thought that the mechanisms involved in these effects are due to the modulation of immunity. In this article, we studied the effect of Fuzheng Jiedu granule on immunological function and the expression of immune-related cytokines in immune-suppressed mice. 72 mice were randomly divided into six groups, with 12 in each group. The control groups included an untreated group, a negative control group（Cyclophosphamide） and a positive control group（Astragalus polysaccharide）. There were three treated groups, which were given different doses of Fuzheng Jiedu granule： a low dose（100 mg kg^（–1））, a medium dose（400 mg kg^（–1）） and a high dose（600 mg kg^（–1））. With the exception of the untreated control animals, each group received an intraperitoneal injection of Cyclophosphamide（100 mg kg^（–1）） for 3 days to establish the immune-suppressed model. Mice were then treated for 19 consecutive days and, 24 h after the last treatment, blood was taken for the eyeballs and serum separation was performed. Analysis was made of the levels of related cytokines（IgA, IgG, IgM, IL-6, IFN-γ, C3, C4 and TNF-α）, the transformation of lymphocytes and the immune organ indexes. The results showed that Fuzheng Jiedu granule can improve the levels of cytokines, the rate of proliferation of lymphocytes and the immune organ indexes of immune-suppressed mice.

关键词： Fuzheng Jiedu granule immune suppression cytokines lymphocytes immune organ index

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Octopaminergic neurons function in appetitive but not aversive olfactory learning and memory in Bactrocera dorsalis

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Insect Science 2022年第6期29卷 1747-1760页

作者： Jin-Xin Yu Qian Xiang Jia-Bao Qu yan-Min hui Tao Lin Xin-Nian Zeng Jia-Li Liu Guangdong Engineering Research Center for Insect Behavior Regulation College of Plant ProtectionSouth China Agricultural UniversityGuangzhouGuangdongChina College of Life Sciences Department of Biological ScienceShangrao Normal UniversityShangraoJiangxiChina

The biogenic amine octopamine(OA,invertebrate counterpart of nora-drenaline)plays critical roles in the regulation of olfactory ***,OA has been thought to mediate appetitive but not aversive learning in honeybees,fruit flies(Drosophila),and ***,this viewpoint has recently been challenged because OA activity through aβ-adrenergic-like receptor drives both appetitive and aversive ***,we explored the roles of OA neurons in olfactory learning and memory retrieval in Bactrocera *** trained flies to associate an orange odor with a sucrose reward or to associate methyl eugenol,a male lure,with N,N-diethyl-3-methyl benzoyl amide(DEET)*** then treated flies with OA receptor antagonists before appetitive or aversive conditioning and a memory retention *** of OA receptor antagonist mianserin or epinastine into the abdomen of flies led to impaired of appetitive learning and memory retention with a sucrose reward,while aversive learning and memory reten-tion with DEET punishment remained *** results suggest that the OA signaling participates in appetitive but not aversive learning and memory retrieval in *** through OA receptors.

关键词： appetitive aversive Bactrocera dorsalis learning and memory octopamine

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三七总皂苷心肌靶向脂质体对内毒素血症心肌损伤小鼠的保护作用及机制研究

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广西医科大学学报 2024年第6期41卷 856-862页

作者：严小青陈红丽冯慧王梦瑶黄建春广西医科大学药学院南宁530021

目的:研究三七总皂苷心肌靶向脂质体(PAC-L-PNS)对内毒素血症心肌损伤小鼠的心肌保护作用,并探讨其可能的作用机制。方法:将50只雄性C57BL/6J小鼠随机分为正常组、模型组、PAC-L-PNS组、三七总皂苷普通脂质体(L-PNS)组和三七总皂苷(PNS)... 详细信息

目的:研究三七总皂苷心肌靶向脂质体(PAC-L-PNS)对内毒素血症心肌损伤小鼠的心肌保护作用,并探讨其可能的作用机制。方法:将50只雄性C57BL/6J小鼠随机分为正常组、模型组、PAC-L-PNS组、三七总皂苷普通脂质体(L-PNS)组和三七总皂苷(PNS)组,每组10只。PAC-L-PNS组、L-PNS组和PNS组分别尾静脉注射相应药物,正常组和模型组小鼠尾静脉注射等体积空白脂质体,连续给药5 d,末次给药4 h后,正常组小鼠腹腔注射生理盐水,其余各组小鼠分别腹腔注射脂多糖(LPS,10 mg/kg)建立心肌损伤模型。造模12 h后处死小鼠,采用TUNEL染色和苏木精—伊红(HE)染色分别观察各组小鼠心肌细胞凋亡及心肌组织病理变化;检测仪检测小鼠血清中肌酸激酶(CK)和乳酸脱氢酶(LDH)的活性;采用酶联免疫吸附法(ELISA)检测血清中IL-6、IL-1β、TNF-α和MCP-1的含量;采用RT-qPCR法检测小鼠心肌组织NF-κB P65、IκBα、TLR4和IRAK1mRNA的表达;此外,进行血管刺激性、溶血性试验初步评价PAC-L-PNS的安全性。结果:PAC-L-PNS几乎无溶血和血管刺激性现象,生物相容性良好。与正常组比较,模型组小鼠心肌细胞凋亡率显著升高(P<0.01),心肌组织损伤较严重。与模型组比较,PAC-L-PNS组和L-PNS组小鼠心肌凋亡细胞显著减少(P<0.01),组织病变有所改善,PNS组小鼠无显著变化。与正常组比较,模型组小鼠CK、LDH活性、IL-6、IL-1β、TNF-α和MCP-1含量、TLR4、IRAK1、NF-κB P65和IκBαmRNA表达均显著升高(P<0.01)。与模型组比较,PAC-L-PNS组小鼠CK、LDH活性、各炎症因子含量、TLR4、IRAK1、NF-κB P65、IκBαmRNA表达均显著降低(均P<0.05)。与L-PNS组和PNS组比较,PAC-L-PNS组CK活性、各炎症因子含量、TLR4、IRAK1 mRNA表达均显著下降(均P<0.05)。结论:PAC-L-PNS对LPS致内毒素血症心肌损伤具有明显的保护作用,可减轻心脏组织的病变,其机制可能与抑制炎症因子产生有关。

关键词：三七总皂苷心肌靶向脂质体心肌保护

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生铁遗传性对球墨铸铁性能的影响

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铸造设备与工艺 2024年第3期 79-84页

作者：李晓艳赵培根马宏军杨麟俞健良宁波日月重工股份有限公司浙江宁波315113 宁波明凌科技有限公司浙江宁波315700 宁波日星铸业有限公司浙江宁波315700

研究了同样的炉料配比情况下,生铁种类对球磨铸铁性能的影响。试验浇注温度为1340℃~1350℃,浇注边长250 mm的立方块,观察其显微组织,并进行性能测试。结果表明:相同生产条件下,不同生铁在占比相同的情况下,其自身组织形态对球墨铸铁的... 详细信息

研究了同样的炉料配比情况下,生铁种类对球磨铸铁性能的影响。试验浇注温度为1340℃~1350℃,浇注边长250 mm的立方块,观察其显微组织,并进行性能测试。结果表明:相同生产条件下,不同生铁在占比相同的情况下,其自身组织形态对球墨铸铁的石墨大小、球化率、组织及性能有明显的差异,其中石墨球数量与低温冲击性能的影响程度最大,A、B、C、D生铁的边缘与心部每平方毫米石墨跨度分别在10~25与20~35两区间。

关键词：球墨铸铁生铁种类显微组织组织形态石墨大小球化率

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Spatial distributions of intra-community tree species under topographically variable conditions

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Journal of Mountain Science 2023年第2期20卷 391-402页

作者： LV Ting ZHAO Rong WANG Ning-jie XIE Lei FENG Yue-yao LI Yao DING hui FANG yan-ming Co-Innovation Center for Sustainable Forestry in Southern China Key Laboratory of State Forestry and Grassland Administration on Subtropical Forest Biodiversity ConservationCollege of Biology and the EnvironmentNanjing Forestry UniversityNanjing 210037China Research Center for Nature Conservation and Biodiversity State Environmental Protection Scientific Observation and Research Station for Ecology and Environment of Wuyi MountainsState Environmental Protection Key Laboratory on BiosafetyNanjing Institute of Environmental SciencesMinistry of Ecology and EnvironmentNanjing 210037China

Growing public awareness of the importance of protecting biodiversity requires the development of forest practices that increase the complexity of stand *** the ecological processes of different forest vegetation provide insights into community coexistence *** this paper,the spatial patterns of three different communities,evergreen broadleaf forest,deciduous broadleaf forest,and mixed needleleaf and broadleaf forest at ***,China,were quantified with four structural parameters,the mingling index,the uniform angle index,the diameter dominance index and the crowdedness *** trees with a diameter at breast height of more than 5 cm were *** analyses highlighted that most trees in the three communities were extremely dense and slightly clumped,with a moderate size differentiation and high mixed *** mixed needleleaf and broadleaf forest,the distribution pattern of tree species was better than the other two ***,spatial patterns in mixed needleleaf and broadleaf forest exhibited a strong stability-effect,that is,the stand had a suitable environment for the stable survival of the *** the increasing of elevation,the degree of the mingling index and the crowdedness index increased,however,there was no influence on the uniform angle index and the diameter dominance ***,at the same elevation,four structural parameters of shady slope were larger than that of sunny *** we found the relationship between stand spatial structure and environment factors had important influence on forest *** work contributes to the knowledge of population structure,and further provide theoretical basis for the sustainable development of forest resources and protecting biodiversity of Huangshan *** future studies,it is necessary to explore the limiting factors of community spatial distribution by combining species diversity and functional traits.

关键词： Intra-community Stand spatial structure Comprehensive evaluation Topographical factor Forest vegetation

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Positron emission tomography imaging for the assessment of mild traumatic brain injury and chronic traumatic encephalopathy:recent advances in radiotracers

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Neural Regeneration Research 2022年第1期17卷 74-81页

作者： Chu-Xin Huang yan-hui Li Wei Lu Si-Hong Huang Meng-Jun Li Li-Zhi Xiao Jun Liu Department of Radiology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Neurology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina PET-CT Center the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

A chronic phase following repetitive mild traumatic brain injury can present as chronic traumatic encephalopathy in some cases,which requires a neuropathological examination to make a definitive *** emission tomography(PET)is a molecular imaging modality that has high sensitivity for detecting even very small molecular changes,and can be used to quantitatively measure a range of molecular biological processes in the brain using different radioactive *** changes have also been reported in patients with different forms of traumatic brain injury,especially mild traumatic brain injury and subsequent chronic traumatic ***,PET provides a novel approach for the further evaluation of mild traumatic brain injury at molecular *** this review,we discuss the recent advances in PET imaging with different radiotracers,including radioligands for PET imaging of glucose metabolism,tau,amyloid-beta,γ-aminobutyric acid type A receptors,and neuroinflammation,in the identification of altered neurological *** novel radiolabeled ligands are likely to have widespread clinical application,and may be helpful for the treatment of mild traumatic brain ***,PET functional imaging with different ligands can be used in the future to perform largescale and sequential studies exploring the time-dependent changes that occur in mild traumatic brain injury.

关键词： amyloid-β chronic traumatic encephalopathy flumazenil fluorodeoxyglucose mild traumatic brain injury positron emission tomography tau protein traumatic brain injury

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Quantitative evaluation of Tibet’s resource and environmental carrying capacity

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Journal of Mountain Science 2019年第7期16卷 1702-1714页

作者： WANG liang LIU hui Key Laboratory of Regional Sustainable Development Modeling Chinese Academy of SciencesBeijing 100101China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China College of Resource and Environment University of Chinese Academy of SciencesBeijing 100049China

This study identifies the carrying state and value of Tibet’s resource and environmental carrying capacity.A new theoretical framework is proposed for exploring the resource and environmental carrying capacity based on two perspectives of“growth limit”and“stability of Human-Earth relationship system”.On this basis,an ideal growth model that accords with the“short board”effect is established to predict the population *** results show that the holistic state of resource and environmental carrying capacity in Tibet is in *** 2010 to 2016,Tibet’s carrying state continued to decline,moreover,the negative forces still overwhelm the positive *** the resource reserves still have room for more population,the environmental capacity and ecological capacity have been ***,the Human-Earth relationship system is in an unstable *** scenarios that respond to different socioeconomic developments are implemented to predict the population limitation of resource and environmental carrying capacity in Tibet;thus,authors argue that Tibet should keep its population size within 4 million around *** research will provide reference for sustainable development and resources and environmental conservation in Tibet.

关键词： Population limitation Resources carrying capacity Environmental carrying capacity Short board effect Tibet

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Smart Management Information Systems(Smis):Concept,Evolution,Research Hotspots and Applications

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Data Intelligence 2023年第4期5卷 857-884页

作者： Changyong liang Xiaoxiao Wang Dongxiao Gu Pengyu Li hui Chen Zhengfei Xu School of Management Hefei University of TechnologyHefei 230009China MOE Philosophy and Social Science Laboratory for Data Science and Smart Social Governance Hefei University of Technology Hefei 230009China

Management information system(MiS),a human-computer system that deeply integrates next-generation information technology and management services,has become the nerve center of society and *** the development of next-generation information technology,Mis has gradually entered the smart ***,research on smart managementinformation systems(SMIS)is still limited,lacking systematic summarization of its conceptual definition,evolution,research hotspots,and typical ***,this paper defines the conceptual characteristics of SMIS,provides an overview of the evolution of SMIS,examines research focus areas using bibliometric methods,and elaborates on typical application practices of sMis in fields such as health care,elderly care,manufacturing,and ***,we discuss the future development directions of SMIS in four key areas:smart interaction,smart decisionmaking,efficient resource allocation,and flexible system *** discussions provide guidance and a foundation for the theoretical development and practical application of SMIS.

关键词： Smart management information system Next-generation information technology Human-computer integration Collaborative decision making Personalized knowledge services

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