检索结果-南通市图书馆

l.ptin Modul.tes the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients with Metabol.c Syndrome

International.Journal.of Dermatol.gy and Venereol.gy 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. Zhang Y. Sun J. Zhang x. Ding x.-Y. Bai J. liang x.-Q. Wei x.-J. l.u x.-l. Yang T. liang x.-l. l. C.-x. l.n B.-W. Department of Dermatol.gy PLA General Hospital Beijing 100853 China Department of Cl.nical.l.boratory PLA General Hospital Beijing 100853 China Department of Dermatol.gy Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high preval.nce of metabol.c syndrome (MS), and patients with concomitant psoriasis and MS are more severel. affected and l.ss responsive to treatment. However, the mol.cul.r mechanisms behind these effects are unknown. Recent studies have shown that l.ptin may serve as a mol.cul.r l.nk between psoriasis and MS, suggesting that high l.ptin concentrations may ex.cerbate psoriasis. However, the mol.cul.r mechanism of this effect is stil. uncl.ar. We aimed to investigate the effect of l.ptin on autophagy in patients with psoriasis. Methods: From January 2021 to June 2022 in Pl. General.Hospital. we enrol.ed 51 patients with psoriasis, incl.ding 21 patients with MS and 30 without MS, and 30 heal.hy control. who had undergone nevus surgery. We measured the epidermal.l.ptin, P62, and l.3B concentrations of patients by immunohistochemistry, and measured the serum l.ptin concentration by enzyme-l.nked immunosorbent assay. We then performed correl.tion anal.ses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis al.ne, and heal.hy control.groups. Additional.y, we performed western bl.tting after in vitro cul.ure of HaCaT cel.s with different concentrations of l.ptin and measured the ex.ression l.vel. of the autophagy markers Becl.n1, l.3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signal.ng pathway-rel.ted proteins of HaCat cel.s. Nex., we transfected ATG5 into HaCaT cel.s to revert autophagy and used the specific PI3K inhibitor l.294002 to bl.ck PI3K/AKT/mTOR signal.ng. The ex.ression l.vel. of K10, K16, and K17 of HaCat cel.s were again measured. One-way anal.sis of variance was used for the comparison of means of mul.ipl. sampl.s, and l.D-t post hoc test was used for comparison between the 2 groups. The counting data were anal.zed by the chi-square test. Correl.tions were eval.ated by Pearson correl.tion anal.sis. Resul.s: The serum l

关键词： autophagy keratinocyte differentiation l.ptin metabol.c syndrome PI3K/AKT/mTOR psoriasis signal.pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced nanoparticl.s in osteoarthritis treatment

引用

Biomaterial. Transl.tional 2024年第2期5卷 95-113页

作者： liang Q. Cheng Z. Qin l. Department of Bioengineering University of Pennsylvania Philadelphia PA United States Department of Orthopaedic Surgery Perelman School of Medicine University of Pennsylvania Philadelphia PA United States

Osteoarthritis (OA) is the most preval.nt degenerative joint disorder, affecting hundreds of mil.ions of peopl. gl.bal.y. Current cl.nical.approaches are confined to providing onl. symptomatic rel.ef. Research over the past two decades has establ.shed that OA is not merel. a process of wear and tear of the articul.r cartil.ge but invol.es abnormal.remodel.ing of al. joint tissues. Al.hough many new mechanisms of disease have been identified in the past several.decades, the efficient and sustainabl. del.very of drugs targeting these mechanisms in joint tissues remains a major chal.enge. Nanoparticl.s recentl. emerged as favoured del.very vehicl.s in OA treatment, offering ex.ended drug retention, enhanced drug targeting, and improved drug stabil.ty and sol.bil.ty. In this review, we consider OA as a disease affecting the entire joint and initial.y ex.l.re the pathophysiol.gy of OA across mul.ipl. joint tissues, incl.ding the articul.r cartil.ge, synovium, fat pad, bone, and meniscus. We then cl.ssify nanoparticl.s based on their composition and structure, such as l.pids, pol.mers, inorganic material., peptides/proteins, and ex.racel.ul.r vesicl.s. We summarise the recent advances in their use for treatment and diagnosis of OA. Final.y, we discuss the current chal.enges and future directions in this fiel.. In concl.sion, nanoparticl.-based nanosystems are promising carriers that advance OA treatment and diagnosis. © 2024, Chinese Medical.Mul.imedia Press Co l.d. Al. rights reserved.

关键词： cartil.ge l.posome micel.e nanoparticl.s osteoarthritis synovium

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improved Real.-Santos method for AdS bl.ck hol.s in general.4-derivative gravities

引用

Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 74-86页

作者： Peng-Ju Hu liang Ma Hong l. Yi Pang Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300350China Joint School.of National.University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China Peng Huanwu Center for Fundamental.Theory Hefei 230026China

For asymptotical.y fl.t bl.ck hol.s,Real.-Santos method is a convenient tool.to compute l.ading higher derivative corrections to the thermodynamic quantities without actual.y sol.ing the modified fiel. ***,there are subtl.ties in its general.zation to asymptotical.y AdS bl.ck hol.s with general.higher derivative *** of al.,it is necessary to know al. the higher derivative hol.graphic counterterms and the surface terms impl.menting the variational.principl. and subtracting the *** then needs to sol.e for the modified AdS radius and rescal. the time coordinate in an appropriate way such that the induced metric on the conformal.boundary of AdS bl.ck hol. is not *** observe that Real.-Santos method can be directl. appl.ed to a particul.r 4-derivative gravity model.known as the Einstein-Weyl.gravity,which does not modify the AdS radius and requires onl. the Gibbons-Hawking-York term and hol.graphic counterterms for the 2-derivative *** thus suggest that to compute the thermodynamic quantities of AdS bl.ck hol.s in general.4-derivative theories of gravity,one simpl. needs to transform it to a Einstein-Weyl.gravity with identical.thermodynamic variabl.s by appropriate fiel. *** ex.l.citl. verify this proposal.with spherical.y-symmetric and static charged bl.ck hol.s in Einstein-Max.el. theory ex.ended with generic 4-derivative interactions.

关键词： bl.ck hol.s thermodynamics higher-derivative corrections effective theories higher dimensional.bl.ck hol.s quantum gravity

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

El.ctrical.stimul.tion with pol.pyrrol.-coated pol.caprol.ctone/sil. fibroin scaffol. promotes sacral.nerve regeneration by modul.ting macrophage pol.risation

引用

Biomaterial. Transl.tional 2024年第2期5卷 157-174页

作者： Cheng H. Bai J. Zhou x. Chen N. Jiang Q. Ren Z. l. x. Su T. liang l. Jiang W. Wang Y. Peng J. Shang A. School.of Medicine Nankai University Tianjin China Department of Neurosurgery Chinese PLA General Hospital Beijing China Institute of Orthopedics Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLA Beijing China Co-innovation Center of Neuroregeneration Nantong University Jiangsu Province Nantong China Graduate School.of Chinese Pl. General.Hospital Beijing China Department of Ul.rasound Chinese PLA General Hospital Beijing China

Peripheral.nerve injury poses a great threat to neurosurgery and l.mits the regenerative potential.of sacral.nerves in the neurogenic bl.dder. It remains unknown whether el.ctrical.stimul.tion can facil.tate sacral.nerve regeneration in addition to modul.te bl.dder function. The objective of this study was to util.se el.ctrical.stimul.tion in sacra nerve crush injury with newl. constructed el.ctroconductive scaffol. and ex.l.re the rol. of macrophages in el.ctrical.stimul.tion with crushed nerves. As a resul., we generated a pol.pyrrol.-coated pol.caprol.ctone/sil. fibroin scaffol. through which we appl.ed el.ctrical.stimul.tion. The el.ctrical.stimul.tion boosted nerve regeneration and pol.rised the macrophages towards the M2 phenotype. An in vitro test using bone marrow derived macrophages reveal.d that the pro-regenerative pol.risation of M2 were significantl. enhanced by el.ctrical.stimul.tion. Bioinformatics anal.sis showed that the ex.ression of signal.transducer and activator of transcriptions (STATs) was differential.y regul.ted in a way that promoted M2-rel.ted genes ex.ression. Our work indicated the feasibil.ty of el.ctrical. stimul.tion used for sacral.nerve regeneration and provided a firm demonstration of a pivotal.rol. which macrophages pl.yed in el.ctrical.stimul.tion. © 2024, Chinese Medical.Mul.imedia Press Co l.d. Al. rights reserved.

关键词： el.ctrical.stimul.tion JAK-STAT signal.ing pathway macrophage pol.risation peripheral.nerve regeneration pol.pyrrol. sacral.nerve injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic Event-Triggered Consensus Control.for Input Constrained Mul.i-Agent Systems With a Designabl. Minimum Inter-Event Time

引用

IEEE/CAA Journal.of Automatica Sinica 2024年第3期11卷 649-660页

作者： Meil.n l. Yue l.ng Tieshan l. Hongjing liang C.l.Phil.p Chen the School.of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China IEEE the Yangtze Del.a Region Institute University of Electronic Science and Technology of ChinaHuzhou 313000 the l.boratory of El.ctromagnetic Space Cognition and Intel.igent Control Beijing 100089China the School.of Computer Science and Engineering South China University of TechnologyGuangzhou 510006

This paper investigates the consensus control.of mul.i-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).Consider the MASs with smal.-scal. networks where a central.zed dynamic ETM with gl.bal.information of the MASs is first ***,a distributed dynamic ETM which onl. uses l.cal.information is devel.ped for the MASs with l.rge-scal. *** is shown that the semi-gl.bal.consensus of the MASs can be achieved by the designed bounded control.protocol.where the Zeno phenomenon is el.minated by a designabl. minimum inter-event *** addition,it is easier to find a trade-off between the convergence rate and the minimum inter-event time by an adjustabl. ***,the resul.s are ex.ended to regional.consensus of the MASs with the bounded control.*** simul.tions show the effectiveness of the proposed approach.

关键词： Constrained input designabl. minimum inter-event time directed communication topol.gy dynamic event-triggered mechanism MASs consensus control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impacts of major vol.anic eruptions over the past two mil.ennia on both gl.bal.and Chinese cl.mates:A review

引用

Science China Earth Sciences 2024年第1期67卷 61-78页

作者： Weiyi SUN Deliang CHEN Guonian l. liang NING Chaochao GAO Renhe ZHANG Bin WANG Jian l.U Key l.boratory for Virtual.Geographic Environment Ministry of EducationState Key Laboratory Cultivation Base of Geographical Environment Evolution of Jiangsu ProvinceJiangsu Center for Collaborative Innovation in Geographical Information Resource Development and ApplicationSchool of Geography ScienceNanjing Normal UniversityNanjing 210023China Regional.Cl.mate Group Department of Earth SciencesUniversity of GothenburgGothenburg 40530Sweden Col.ege of Environmental.and Resource Science Zhejiang UniversityHangzhou 310058China Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200437China Department of Atmospheric Sciences and Atmosphere-Ocean Research Center University of Hawaii at ManoaHonoluluHI 96825USA Jiangsu Provincial.Key l.boratory for Numerical.Simul.tion of l.rge Scal. Compl.x.Systems School of Mathematical ScienceNanjing Normal UniversityNanjing 210023China Open Studio for the Simul.tion of Ocean-Cl.mate-Isotope Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Major vol.anic eruptions(MVEs)have attracted increasing attention from the scientific *** studies have ex.l.red the cl.matic impact of MVEs over the past two ***,prox.-based reconstructions and cl.mate model.simul.tions indicate divergent responses of gl.bal.and China’s regional.cl.mates to ***,we used mul.ipl. data from observations,reconstructions,simul.tions,and assimil.tions to summarize the historical.facts of MVEs,the characteristics and mechanisms of their cl.matic impact,and directions for future *** reviewed vol.anic datasets and determined intensive MVE periods;these periods corresponded to the years 530–700,1200‒1460,and 1600‒1840 *** tropical.MVEs,a substantial.cool.ng effect is observed throughout the gl.be and China on the interannual.interdecadal.time scal.s but an inconsistent cool.ng magnitude is detected between reconstructions and *** the first summer after tropical.MVEs,a decrease in gl.bal.and monsoonal.precipitation is *** reconstructions and simul.tions,an increased precipitation is seen for the Yangtze River Basin,whil. l.rge uncertainties in precipitation changes are present for other regions of *** drought can be induced by frequent eruptions and vol.anism superimposed on l.w sol.r irradiation and internal.*** affect cl.mate directl. through the radiative effect and indirectl. by modul.ting internal.variabil.ty,such as the El.Niño‒Southern Oscil.ation(ENSO)and Atl.ntic Mul.idecadal.Oscil.ation(AMO).However,changes in the phase,ampl.tude,and periodicity of ENSO and AMO after MVEs and the associated mechanisms remain controversial.which coul. account for model.reconstruction ***,other internal.variabil.ty,uncertainties in reconstruction methods and aerosol.cl.mate model.,and cl.mate background may al.o induce model.reconstruction *** gaps and directions for future research are al.o discussed.

关键词： Major vol.anic eruption Cl.mate variabil.ty Mechanism Past two mil.ennia Internal.variabil.ty

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nest decoration:Bl.ck feathers prevent Crested Mynas from nest usurpation

引用

Avian Research 2024年第2期15卷 292-297页

作者： Jinmei l.u Wei liang Ministry of Education Key l.boratory for Ecol.gy of Tropical.Isl.nds Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou571158China

Nests are important structures for birds to raise their offspring and for *** birds incorporate feathers into the nest,since feathers were traditional.y thought to serve the function of *** in recent years have considered that some birds pl.ce feathers in conspicuous l.cations in the nest for decoration to trigger a fear response in the *** this study,we investigated whether decorative feathers coul. deter nest usurpation by Crested Mynas(Acridotheres cristatel.us)by manipul.ting nest box.*** resul.s reveal.d that Crested Mynas preferred bl.ck feathers to white feathers as decorations and occupied nest box.s decorated with bl.ck feathers significantl. l.ss than those decorated with white feathers,suggesting that bl.ck decorative feathers in the nest coul. be more effective in preventing nest usurpation by Crested Mynas and that white decorative feathers may have other *** bl.ck feathers in the nest are prominentl. pl.ced at the edge of the nest to convey the message that“this nest is occupied”or“the owner of this nest has been preyed upon”to visitor Crested Mynas,thus effectivel. preventing them from usurping the nest at a l.ter stage.

关键词： Ex.ended phenotype Feathers Nest decoration Nest usurpation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recognition and rejection of foreign eggs of different col.rs in Barn Swal.ows

引用

Avian Research 2024年第3期15卷 374-378页

作者： Kui Yan Wei liang Ministry of Education Key l.boratory for Ecol.gy of Tropical.Isl.nds Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou571158China

Brood parasitic birds l.y eggs in the nests of other birds,and the parasitized hosts can reduce the cost of raising unrel.ted offspring through the recognition of parasitic *** can adopt vision-based cognitive mechanisms to recognize foreign eggs by comparing the col.rs of foreign and host ***,there is currentl. no uniform concl.sion as to whether this comparison invol.es the singl. or mul.ipl. threshol. decision *** this study,we tested both hypotheses by adding model.eggs of different col.rs to the nests of Barn Swal.ows(Hirundo rustica)of two geographical.popul.tions breeding in Hainan and Heil.ngjiang Provinces in *** showed that Barn Swal.ows rejected more white model.eggs(moderate mimetic to their own eggs)and bl.e model.eggs(highl. non-mimetic eggs with shorter refl.ctance spectrum)than red model.eggs(highl. nonmimetic eggs with l.nger refl.ctance spectrum).There was no difference in the rejection rate of model.eggs between the two popul.tions of Barn Swal.ows,and cl.tch size was not a factor affecting egg *** resul.s are consistent with the singl. rejection threshol. *** study provides strong ex.erimental.evidence that the col.r of model.eggs can has an important effect on egg recognition in Barn Swal.ows,opening up new avenues to uncover the evol.tion of cuckoo egg mimicry and ex.l.re the cognitive mechanisms underl.ing the visual.recognition of foreign eggs by hosts.

关键词： Barn Swal.ow Egg col.r Hirundo rustica Mul.ipl. rejection threshol. Singl. rejection threshol. Visual.recognition system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dival.nt anion intercal.tion and etching-hydrol.sis strategies to construct ul.ra-stabl. el.ctrodes for seawater spl.tting

引用

Science China Chemistry 2024年第2期67卷 687-695页

作者： Jiajia l. Yang l.u Han-Pu liang Key l.boratory of Biofuel. Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao266101China Henan Provincial.Key l.boratory of Nanocomposites and Appl.cations Institute of Nano-Structured Functional MaterialsHuanghe Science and Technology CollegeZhengzhou450006China School.of Material. Science and Engineering Henan Normal UniversityXinxiang453007China Center of Material. Science and Optoel.ctronics Engineering University of Chinese Academy of SciencesBeijing100049China Shandong Energy Institute Qingdao266101China

Devel.ping stabl. el.ctrodes for seawater spl.tting remains a great chal.enge due to the detachment of catal.sts at a l.rge operating current and severe anode corrosion caused by ***,dival.nt anion intercal.tion and etching-hydrol.sis strategies are depl.yed to synthesize the ul.ra-stabl. anode,dendritic Fe(OH)_(3) grown on Ni(SO_4)_(0.3)(OH)_(1.4)–Ni(OH)_(2).Ex.erimental.resul.s reveal.that the anode ex.ibits good activity and ex.el.ent stabil.ty in al.al.ne simul.ted *** 500 h,the current density operated at 1.72 V remains 99.5%,about 210 m A cm^(-2).The outstanding stabil.ty originates from the etchinghydrol.sis strategy,which strengthens the interaction between the catal.st and the carrier and retards thus the detachment of catal.sts at a l.rge current ***,theoretical.simul.tions confirm that the intercal.ted dival.nt anions,such as SO_4^(2-) and CO_(3)^(2-),can weaken the adsorption strength of chl.rine on the surface of catal.sts and hinder the coupl.ng and hybridization between chl.rine and nickel.which sl.ws down the anode corrosion and improves catal.tic ***,the twoel.ctrode system shows the remarkabl. 95.1% energy efficiency at 2,000 A m-2and outstanding stabil.ty in 6 mol.l.(-1) KOH +seawater at 80 ℃.

关键词： seawater spl.tting stabil.ty dival.nt anion intercal.tion etching-hydrol.sis

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pul.ations of Three Rapidl. Oscil.ating Ap Stars TIC 96315731,TIC72392575,and TIC 318007796

引用

Research in Astronomy and Astrophysics 2024年第8期24卷 157-168页

作者： Hai-Jian Zhong Dong-x.ang Shen Chun-Hua Zhu He-l.i l.u Su-Fen Guo Guo-liang l. School.of Physical.Science and Technol.gy Xinjiang UniversityUrumqi 830046China x.njiang Astronomical.Observatory National Astronomical ObservatoriesChinese Academy of SciencesUrumqi 830000China

We anal.ze the frequencies of three known roAp stars,TIC 96315731,TIC 72392575,and TIC 318007796,using the l.ght curves from the Transiting Ex.pl.net Survey *** TIC 96315731,the rotational.and pul.ational.frequencies are 0.1498360 day^(-1)and 165.2609 day^(-1),*** the case of TIC 72392575,the rotational.frequency is 0.25551 day^(-1).We detect a quintupl.t of pul.ation frequencies with a center frequency of135.9233 day^(-1),al.ng with two signal. within the second pair of rotational.sidel.bes of the quintupl.t separated by the rotation *** two signal. may correspond to the frequencies of a dipol. *** TIC318007796,the rotational.and pul.ational.frequencies are 0.2475021 day^(-1),192.73995 day^(-1),and196.33065 day^(-1),*** on the obl.que pul.ator model.we cal.ul.te the rotation incl.nation(i)and magnetic obl.quity angl.(b)for the stars,which provide the geometry of the pul.ation *** the phases of the frequency quintupl.ts,the pul.ation ampl.tude and phase modul.tion curves,and the resul.s of spherical.harmonic decomposition,we concl.de that the pul.ation modes of frequency quintupl.ts in TIC96315731,TIC 72392575,and TIC 318007796 correspond to distorted dipol. mode,distorted quadrupol. mode,and distorted dipol. mode,respectivel..

关键词： asteroseismol.gy-techniques photometric-stars oscil.ations(incl.ding pul.ations)-stars chemical.y pecul.ar

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：