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Dynamic soil-tunnel interaction in layered half-space for incident P-and SV-waves

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Earthquake Science 2015年第4期28卷 275-284页

作者： Jia Fu Jianwen liang Lin Qin Department of Civil Engineering Tianjin University Tianjin Key Laboratory of Civil Engineering Structures & New Materials

The dynamic soil-tunnel interaction is studied by the model of a rigid tunnel embedded in layered half-space, which is simplified as a single soil layer on elastic bedrock to the excitation of P- and SV-waves. The indirect boundary element method is used, combined with the Green＇ s function of distributed loads acting on inclined lines. It is shown that the dynamic characteristics of soil-tunnel interaction in layered half-space are different much from that in homoge- neous half-space, and that the mechanism of soil-tunnel interaction is also different much from that of soil-founda- tion-superstructure interaction. For oblique incidence, the tunnel response for in-plane incident SV-waves is com- pletely different from that for incident SH-waves, while the tunnel response for vertically incident SV-wave is very similar to that of vertically incident SH-wave.

关键词： Underground tunnel Layered half-space P-wave and SV-wave Indirect boundary element method Soil-tunnel interaction ~ Site dynamic characteristics

Hypoxia Inhibits Proliferation of Human Dermal Lymphatic Endothelial Cells via Downregulation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 Expression

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Current Medical Science 2021年第6期41卷 1192-1197页

作者： Qi XIE Tong-yao SHANG Shuo FENG Ru-cai ZHAN Jing liang Meng-ge FAN liang ZHANG Ju LIU Department of Oncology the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalShandong Key Laboratory of Rheumatic Disease and Translational MedicineShandong Lung Cancer InstituteJinan 250014China Department of Blood Transfusion the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250014China Institutue of Microvascular Medicine Medical Research Centerthe First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250014China Graduate School Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250014China Department of Neurosurgery the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250014China Shandong Provincial Key Laboratory of Animal Resistance Biology Institute of Biomedical SciencesCollege of Life SciencesShandong Normal UniversityJinan 250014China

Objective:Lymphatic endothelial cell(LEC)proliferation is essential for *** induces lymphangiogenesis,but it directly inhibits LEC proliferation and the underlying mechanisms have not been fully *** aim of this study was to investigate the role of carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1)in hypoxia-repressed LEC ***:Human dermal lymphatic endothelial cells(HDLECs)were cultured under normoxic or hypoxic conditions,and cell proliferation was determined using MTT or CCK-8 ***1 expression was silenced by siRNA *** of mitogen-activated protein kinases(MAPKs)was examined by Western blotting and blocked by specific ***:Under hypoxia,HDLECs proliferation was suppressed and CEACAM1 expression was *** of CEACAM1 in normoxia inhibited HDLECs proliferation and did not further decrease proliferation in HDLECs in response to hypoxia,suggesting that CEACAM1 may mediate hypoxia-induced inhibition of HDLECs *** addition,silence of CEACAM1 increased phosphorylation of MAPK molecules:extracellular signal-regulated kinase(ERK),p38 MAPK and Jun N-terminal kinase(JNK)in ***,only inhibition of the JNK pathway rescued the reduction of HDLEC proliferation induced by CEACAM1 ***:Our results suggested that hypoxia downregulates CEACAM1 expression by activation of the JNK pathway,leading to inhibition of HDLEC *** findings may help to understand the mechanisms of LEC-specific response to hypoxia and develop novel therapies for pathological lymphangiogenesis.

关键词： lymphatic endothelial cell hypoxia proliferation carcinoembryonic antigen-related cell adhesion molecule 1 Jun N-terminal kinase pathway

Effect of complication grade on survival following curative gastrectomy for carcinoma

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World Journal of Gastroenterology 2014年第25期20卷 8244-8252页

作者： Nan Jiang Jing-Yu Deng Xue-Wei Ding Li Zhang Hong-Gen Liu Yue-Xiang liang Han liang Department of Gastric Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of Cancer Key Laboratory of Cancer Prevention and Therapy

AIM: To elucidate the potential impact of the grade of complications on long-term survival of gastric cancer patients after curative surgery.

关键词： Gastric cancer Complication grade Gastrectomy Overall survival Prognosis

ADAMTS3 and FLT4 gene mutations result in congenital lymphangiectasia in newborns:A case report

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World Journal of Clinical Cases 2023年第21期11卷 5179-5186页

作者： Zhu-Wei liang Wan-Li Gao Department of Obstetrics and Gynecology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Congenital lymphangiectasia is a rare disease characterized by dilated interstitial lymphatic vessels and cystic expansion of the lymphatic *** lymphangiectasia can affect various organ systems;however,it frequently occurs in the lungs accompanied with unexplained pleural ***,it might not be diagnosed during prenatal examination owing to the absence of pronounced ***,after birth the newborn rapidly develops respiratory distress that quickly *** variations in proteins controlling the development of lymphatic vessels contribute to the pathophysiology of this *** report a rare case of heterozygous mutation of ADAMTS3 and FLT4 genes,which have not been reported *** SUMMARY We analysed the case of a neonate who had presented with only pleural effusion at a late gestational age and eventually died due to its inability to establish spontaneous breathing after *** autopsy revealed lymphangiectasia of the organ ***,whole exome sequencing revealed heterozygous mutations of the lymphangiogenesis-controlling genes,ADAMTS3 and FLT4,and Sanger verification revealed similar lesions in the mother with no *** Considering the presented case,obstetricians should observe unexplained foetal pleural effusion,and perform pathology analysis and whole exome sequencing for a conclusive diagnosis and prompt treatment.

关键词： Congenital lymphangiectasia ADAMTS3 FLT4 Gene mutations Foetal pleural effusion Case report

Amplification of in-plane seismic ground motion by group cavities in layered half-space (Ⅰ)

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Earthquake Science 2012年第4期25卷 275-285页

作者： Jianwen liang Ji Zhang Zhenning Ba Department of Civil Engineering Tianjin University Tianjin Key Laboratory of Civil Engineering Structures and New Materials

Amplification of in-plane seismic ground motion by underground group cavities in layered half-space is studied both in frequency domain and time domain by using indirect boundary element method （IBEM）, and the effect of cavity interval and spectrum of incident waves on the amplification are studied by numerical examples. It is shown that there may be large interaction between cavities, and group cavities with certain intervals may have significant amplification to seismic ground motion. The amplification of PGA （peak ground acceleration） and its PRS （peak response spectrum） can be increased up to 45.2% and 84.4%, for an example site in Tianjin, under the excitation of Taft wave and E1 Centro wave; and group cavities may also affect the spectra of the seismic ground motion. It is suggested that the effect of underground group cavities on design seismic ground motion should be considered.

关键词： underground group cavity amplification in-plane seismic ground motion time domain frequency domain indirect boundary element method (IBEM)

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Integration Technology of Micro-LED for Next-Generation Display

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Research 2023年第2期2023卷 389-413页

作者： Dingbo Chen Yu-Chang Chen Guang Zeng David WeiZhang Hong-liang Lu State Key Laboratory of ASIC and System Shanghai lnstitute of Inteligent Electronics&SystemsSchoolof MicroelectronicsFudan UniversityShanghai 200433China Jia Shan Fudan Institute jaxingZhejang Province 314100China Key Laboratory of Specialty Fiber Optics and Optical Access Networks Shanghai Institute Communication and Data ScienceShanghai UniversityShanghai 200444China

Inorganic micro light-emitting diodes(micro-LEDs)based on II-V compound semiconductors have been widely studied for self-emissive *** chips to applications,integration technology plays an indispensable role in micro-L... 详细信息

关键词： LED diodes LEDs

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

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Frontiers of Medicine 2008年第3期2卷 216-228页

作者： Xufeng ZHANG liang YU Yi LU Department of Hepatobiliary Surgery The First Affiliated Hospital of Medical CollegeXi’an Jiaotong UniversityXi’an 710061China

Wnt/β-catenin signaling pathway has been identified as a key cellular pathway in embryogenesis and disease,including *** recent years,more and more interacting components have been observed and their exact functions approached,thus ensuring the most complicated understanding of this pathway in normal organism development and *** hepatocellular carcinoma(HCC),with a deeply understanding of this pathway,more and more genes which contribute to aber-rant activation of Wnt/β-catenin signaling pathway has recently been identified and their exact roles in HCC *** this review,we will focus on a mostly updated understanding of this pathway and its observed role in HCC by emphasizing the gene defects identified to pro-mote tumorigenesis and development.

关键词： Wnt protein β-catenin hepatocellular carcin-oma tumorigenesis

Transcriptional regulation of VEGF expression by estrogen-related receptor γ

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Acta Pharmaceutica Sinica B 2013年第6期3卷 373-380页

作者： Jichao liang Fengmei Han Yong Chen Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine Hubei UniversityWuhan 430062China

Vascular endothelial growth factor(VEGF)is associated with endothelial cell proliferation,migration and ***-related receptorγ(ERRγ)plays important regulatory roles in fatty acid oxidation,mitochondrial biogenesis and ***,ERRγ has been shown to be involved in angiogenesis;however,the mechanism of ERRγ-mediated angiogenesis is poorly *** the results show that ERRγactivates VEGF gene transcription via two putative estrogen-related receptor binding elements(ERREs)mapped to the promoter *** immunoprecipitation assays confirmed that ERRγ binds to the identified ***-mediated overexpression of ERRγ increased the expression of VEGF gene and induced an increase in VEGF secretion in C2C12 *** contrast,the secretion of VEGF was significantly decreased in the presence of the ERRγ inverse agonist ***,treatment of human umbilical vein endothelial cells(HUVECs)with the conditioned medium from ERRγ-overexpressing C2C12 myotubes significantly increased proliferation,migration and tube *** data indicate that VEGF functions as a downstream target gene of ERRγ and mediates the effects of ERRγ on endothelial cells proliferation,migration and *** physiological function of ERRγ might provide a novel target for treatment of ischemic diseases.

关键词： Estrogen-related receptorγ VEGF Promoter Transcription Migration

Response of underground pipeline through fault fracture zone to random ground motion

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Earthquake Science 2011年第4期24卷 351-363页

作者： Dai Wang Zhuobin Wei Jianwen liang Postdoctoral Station of Naval Architecture and Ocean Engineering Naval University of Engineeringi Wuhan 30033 China Department of Logistics Command and Engineering Naval University of Engineering Tianjin 300450 China Department of Civil Engineering Tianjin University Tianjin 300072 China

It is assumed that a pipeline is laid through a vertical fault fracture zone, and is excited by seismic ground motion modelled as stationary stochastic process. For horizontal incidence of waves, the cross-PSD （Power Spectral Density） function is developed using wave propagation theory, while for vertical incidence of waves the cross-PSD function is composed by auto-PSD model, coherence model and site response model. As the seismic input, the eross-PSD function is used to calculate the the axial and lateral seismic responses of underground pipeline through the fracture zone. The results show that the incident directions of seismic waves, width and soil property of the fracture zone have great influence on underground pipeline. It is suggested that the flexible joints with appropriate stiffness should be added into the pipeline near the interfaces between the fracture zone and the surrounded media.

关键词： fault fracture zone flexible joint underground pipeline seismic excitation