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The role of primary cilia in mechanical transmission of osteocyte based on a 3D finite element model

Medicine in Novel Technology and Devices 2024年第1期21卷 31-38页

作者： Zhuang Han Dong Ding Yu-bo Fan Xin-tong Wu Xiao Yang lian-wen sun Key Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The primary cilium,as a mechanical receptor of osteocytes,participates in the regulation of osteocyte ***,how the length of osteocyte primary cilia changes with fluid shear stress(FSS)are unclear,and how the mechanical transmission within osteocytes altered by primary cilia is not well understood ***,the ciliary length changes of osteocyte under 15dyn/cm2 of FSS were experimentally detected,and then 3D finite element models of osteocyte primary cilia containing the basal body and axoneme were *** results showed that(1)The ciliary length of the CON group,FSS 1h,and FSS 6h were 3.71±1.34μm,3.79±1.04μm,and 1.24±0.73μm respectively,indicating the different durations of FSS might lead to the adaptive changes of cilium *** calculations showed(2)when the ciliary length became shorter with the ciliary angle stayed the same,the deformation and stress of the cell membrane and membrane skeleton was ***,the deformation and stress of the cilia membrane,basal body,the rotation angles of basal body were decreased,and those of cytoplasm,cytoskeleton,actin cortex and nucleus were also decreased;(3)With the decrease of the ciliary angle,the deformation and stress of the cilia membrane,basal body,as well as the rotation angles of basal body were *** of the cytoplasm,cytoskeleton,actin cortex,and nucleus were also increased except the cell membrane and membrane *** calculation results suggested the length and angle of the primary cilia,the deformation and stress of intracellular structures in osteocyte were altered with ciliary basal body,indicated the connection between the basal body and cytoskeleton may be a key factor that affected the mechanical transport in osteocytes across the cell *** finally promoted the adaptive change of ciliary length under FSS.

关键词： Primary cilia Osteocyte model Finite element analysis Mechanotransduction

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The study on the mechanical characteristics of articular cartilage in simulated microgravity

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Acta Mechanica Sinica 2012年第5期28卷 1488-1493页

作者： Hai-Jun Niu Qing Wang Yue-Xiang Wang Ang Li lian-wen sun Yan Yan Fan Fan De-Yu Li Yu-Bo Fan Key Laboratory of the Ministry of Education for Biomechanics and Mechanobiology State Key Laboratory of Software Development EnvironmentSchool of Biological Science and Medical EngineeringBeihang University School of Biomedical Engineering Southern Medical University Department of Ultrasound People Liberation Army General Hospital

The microgravity environment of a long-term space flight may induce acute changes in an astronaut＇s musculo-skeletal systems. This study explores the effects of simulated microgravity on the mechanical characteristics of articular cartilage. Six rats underwent tail suspension for 14 days and six additional rats were kept under normal earth gravity as controls. Swelling strains were measured using high-frequency ultrasound in all cartilage samples subject to osmotic loading. Site-specific swelling strain data were used in a triphasic theoretical model of cartilage swelling to determine the uniaxial modulus of the cartilage solid matrix. No severe surface irregularities were found in the cartilage samples obtained from the control or tail-suspended groups. For the tail-suspended group, the thickness of the cartilage at a specified site, as determined by ultrasound echo, showed a minor decrease. The uniaxial modulus of articular cartilage at the specified site decreased significantly, from （6.31 ± 3.37） MPa to （5.05 ± 2.98）MPa （p 〈 0.05）. The histology- stained image of a cartilage sample also showed a reduced number of chondrocytes and decreased degree of matrix staining. These results demonstrated that the 14 d simulated microgravity induced significant effects on the mechanical characteristics of articular cartilage. This study is the first attempt to explore the effects of simulated microgravity on the mechanical characteristics of articular cartilage using an osmotic loading method and a triphasic model. The conclusions may provide reference information for manned space flights and a better understanding of the effects of microgravity on the skeletal system.

关键词： Simulated microgravity Articular cartilage.Triphasic theory High-frequency ultrasound Uniaxialmodulus

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On the global smooth solutions of 3D incompressible Hall-MHD equations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 319-327页

作者： YUE Gao-cheng sun wen-da School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The present paper is devoted to the well-posedness issue for the 3D incompressible Hall-MHD system obtained from kinetic models. Our analysis strongly relies on the use of the Fourier analysis. We establish the global existence of smooth solutions for a class of large initial data, this result implies the initial velocity and magnetic field can be arbitrarily large.

关键词： 3D Hall-MHD well-posedness Fourier analysis

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Neural Dynamics for Cooperative Motion Control of Omnidirectional Mobile Manipulators in the Presence of Noises: A Distributed Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1605-1620页

作者： Yufeng lian Xingtian Xiao Jiliang Zhang Long Jin Junzhi Yu Zhongbo sun the Department of Control Engineering Changchun University of TechnologyChangchun 130012China IEEE the College of Information Science and Engineering Northeastern UniversityShenyang 110819 the National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China the School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China the State Key Laboratory for Turbulence and Complex Systems Department of Advanced Manufacturing and RoboticsCollege of EngineeringPeking UniversityBeijing 100871China

This paper presents a distributed scheme with limited communications, aiming to achieve cooperative motion control for multiple omnidirectional mobile manipulators(MOMMs).The proposed scheme extends the existing single-agent motion control to cater to scenarios involving the cooperative operation of MOMMs. Specifically, squeeze-free cooperative load transportation is achieved for the end-effectors of MOMMs by incorporating cooperative repetitive motion planning(CRMP), while guiding each individual to desired poses. Then, the distributed scheme is formulated as a time-varying quadratic programming(QP) and solved online utilizing a noise-tolerant zeroing neural network(NTZNN). Theoretical analysis shows that the NTZNN model converges globally to the optimal solution of QP in the presence of noise. Finally, the effectiveness of the control design is demonstrated by numerical simulations and physical platform experiments.

关键词： Cooperative motion control noise-tolerant zeroing neural network(NTZNN) omnidirectional mobile manipulator(OMM) repetitive motion planning

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Flow behavior of a coupled model between horizontal well and fractal reservoir

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Energy Geoscience 2024年第4期5卷 267-277页

作者： Peiqing lian Jianfang sun Jincai Zhang Zhihui Fan Sinopec Petroleum Exploration and Production Research Institute Beijing100083China Sinopec Tech Houston HoustonTX77056USA

Many research findings have proven that the system of porous medium reservoirs exhibits different heterogeneous structures at various scales,demonstrating some form of self-similarity with fractal *** this paper,fractal theory is incorporated into the reservoir to investigate coupled flow between reservoir and horizontal *** examining the pore structure of highly heterogeneous reservoirs,the fractal dimension can be *** methods are utilized to solve the Green function of a point source in a reservoir with fractal *** Green's function and the principle of spatial superposition,a finite flow model for a horizontal well coupled with a fractal reservoir is developed to calculate the flow rate and flow profile of the horizontal *** model also accounts for the impact of wellbore friction and is solved numerically.A specific example is used for calculation to analyze the influence of fractal parameters on the production and flow rate of the horizontal *** considering the fractal characteristics of oil reservoirs,the flow rate of the horizontal well is lower than that in Euclidean *** the fractal dimension increases,the connectivity of pores in the reservoir improves,making it easier to drive the fluid into the wellbore,and the flow distribution along the wellbore becomes more ***,as the anomalous diffusion index increases,the connectivity between pores deteriorates,thus the distribution of flow rate along the wellbore becomes more uneven.

关键词： Fractal dimension Reservoir Horizontal well Anomalous diffusion index

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Rhodium-Catalyzed N-Arylation Addition of Arylboronic Acids to Ketimines

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Chinese Journal of Chemistry 2024年第18期42卷 2243-2248页

作者： Xue-Wei Qian Xing-wen sun Department of Chemistry Fudan University220 Handan RoadShanghai 200433China

Herein,we report rhodium catalyzed N-arylation via addition of arylboronic acids to electron-deficientα-iminoesters which can be prepared in high efficiency by using easily accessible B-carbonyl *** reaction is highly regiospecific to achieve the N-aryl addition efficiently with up to 99%yield under mild *** corresponding product can be further efficiently converted into indoles andaseries of other important building blocks.

关键词： Rhodium catalyzed N-Arylation addition Amines Umpolung Indole C-C coupling

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Simulation Study on Constraining Gravitational Wave Propagation Speed by Gravitational Wave and Gamma-ray Burst Joint Observation on Binary Neutron Star Mergers

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Research in Astronomy and Astrophysics 2024年第8期24卷 42-51页

作者： Jin-Hui Rao Shu-Xu Yi lian Tao Qing-wen Tang Department of Physics School of Physics and Materials ScienceNanchang UniversityNanchang 330031China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Theories of modified gravity suggest that the propagation speed of gravitational waves(GW)v_gmay deviate from the speed of light c.A constraint can be placed on the difference between c and v_gwith a simple method that uses the arrival time delay between GW and electromagnetic wave simultaneously emitted from a burst *** simulated the joint observation of GW and short gamma-ray burst signals from binary neutron star merger events in different observation campaigns,involving advanced LIGO(aLIGO)in design sensitivity and Einstein Telescope(ET)joint-detected with Fermi/*** a result,the relative precision of constraint on v_gcan reach~10~(-17)(aLIGO)and~10^(-18)(ET),which are one and two orders of magnitude better than that from GW170817,*** continue to obtain the bound of graviton mass m_g≤7.1(3.2)×10~(-20)eV with aLIGO(ET).Applying the Standard-Model Extension test framework,the constraint on v_gallows us to study the Lorentz violation in the nondispersive,nonbirefringent limit of the gravitational *** obtain the constraints of the dimensionless isotropic coefficients S_(00)^(4)at mass dimension d=4,which are-1×10^(-15)

关键词： gravitational waves-(stars)gamma-ray burst general-stars neutron

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Applications of single-cell RNA sequencing in spermatogenesis and molecular evolution

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Zoological Research 2024年第3期45卷 575-585页

作者： wen-Bo Chen Meng-Fei Zhang Fan Yang Jin-lian Hua College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China

Spermatogenic cell heterogeneity is determined by the complex process of spermatogenesis ***,effectively revealing the regulatory mechanisms underlying mammalian spermatogenic cell development and differentiation via traditional methods is *** in technology have led to the emergence of many single-cell transcriptome sequencing protocols,which have partially addressed these *** this review,we detail the principles of 10x Genomics technology and summarize the methods for downstream analysis of single-cell transcriptome sequencing ***,we explore the role of single-cell transcriptome sequencing in revealing the heterogeneity of testicular ecological niche cells,delineating the establishment and disruption of testicular immune homeostasis during human spermatogenesis,investigating abnormal spermatogenesis in humans,and,ultimately,elucidating the molecular evolution of mammalian spermatogenesis.

关键词： Single-cell RNA sequencing(scRNA-seq) Spermatogenesis Molecular evolution Sertoli cell

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Effect of nourishing Yin and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 95-102页

作者： sun Yanyan XUE Yuanyuan sun wen WANG Yonghong YU Jian Department of Traditional Chinese Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatrics Zibo Central HospitalZibo 255000China

OBJECTIVE:To elucidate the mechanism of the nourishing Yin and purging fire Chinese herbal mixture(NYPF)in delaying light-induced premature puberty in ***:Twenty-one days old female SpragueDawley rats were randomly assigned to normal group(N),long light exposure group(L),NYPF and normal saline group(NS).Rats in the L,NYPF and NS groups were exposed to 16 h:350 lux light/8 h:dark,while rats in the N group were exposed to 12 h:50 lux light/12 h:*** and normal saline was administered to the rats in the NYPF group or NS group,respectively,from day *** rats in every group were sacrificed at 9 *** day 28(P28),on the day when rat's vulva opened in the L group(L-VO),on the day when the first estrous interphase occurred in rats of L group(L-E1),and on the day when the second estrous interphase occurred in rats of L group(L-E2),***:On day 34,all rats in the L group,80%of rats in the NS group,40%of rats in the N group,and 20%of rats in the NYPF group showed complete opening of the *** P28,m RNA level of hypothalamic kisspeptin(Kiss-1)in the L group was significantly higher than that in the N group(P<0.05).The rats in the L and NS groups had significantly lower hypothalamic argininephenylalanine-amide(RFamide)-related peptide 3(RFRP-3)m RNA levels than those in the N group(P<0.05),whereas RFRP-3 m RNA level was significantly higher in the NYPF group than that in the L group(P<0.05).At L-VO,the ovarian index of the L and NS groups was significantly higher than that of the N group(P<0.05)and estradiol(E2)level of the NYPF group was significantly lower than that of the N and NS groups(P<0.05);hypothalamic Kiss-1 m RNA level in the L and NS groups was significantly higher than that in the N and NYPF groups(P<0.05),whereas hypothalamic RFRP-3 m RNA level in the L,NYPF,and NS groups was significantly lower than that in the N group(P<0.05).At L-E1,E2 level of the L and NS groups was significantly higher than that of the N group(P<0.01),wher

关键词： light puberty precocious kisspeptins RFRP-3 melatonin Nourishing Yin and Purging Fire

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Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： Chao-Yue sun wen Li Hai-Qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

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