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Long-term tadalafil once daily in Chinese men with erectile dysfunction:a 2-year final analysis of a post-marketing,multicenter,randomized,open-label trial

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Asian Journal of Andrology 2024年第3期26卷 282-287页

作者： Hui Jiang lian-Ming zhao Su Yan Ji-Hong Liu zhao-Hui Zhu Jin-Dan Luo Yu-Tian Dai Fu-Biao Li Hao-cheng Lin Zhi-Chao Zhang Department of Urology Peking University First HospitalBeijing 100000China Department of Urology Peking University Third HospitalBeijing 100191China Department of Urology Peking Union Medical College HospitalBeijing 100730China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Urology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Departmentof Andrology Nanjing Drum Tower HospitalNanjing 210008China Department of Andrology The First Hospital of Jilin UniversityChangchun 130021China Andrology Center Department of UrologyPeking University First HospitalBeijing 100034China

The long-term safety and effectiveness of once-daily tadalafil is crucial,but limited data are available in Chinese patients witherectile dysfunction(ED).In this post-marketing,multicenter,randomized,open-label trial with 2-year follow-up,635 ED caseswere randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months,of whom 580 continued once-daily tadalafil 5 mg for21 ***-emergent adverse events in the 12-month and 24-month period were similar,with the most common beingviral upper respiratory tract infection,upper respiratory tract infection,and *** improvement from baseline inthe International Index of Erectile Function-Erectile Function(IIEF-EF)score was detected at month 12(least squares mean[LSM]change:7.9,95%confidence interval[CI]:7.5–8.4,P<0.001)and was maintained to month 24(LSM change:8.6,95%CI:8.1–9.0,P<0.001).The proportions of patients regaining normal erectile function(IIEF-EF score≥26)were 43.7%and 48.0%at months 12 and 24,*** Assessment Questionnaire results showed improved erection function in 97.5%ofpatients and improved ability to engage in sexual activity in 95.9%of patients at month 12;these values were 96.1%and 95.0%at month 24,*** quality of sexual life score based on the Sexual Life Quality Questionnaire(SLQQ)was increased by52.2%at month 12 and by 55.3%at month 24(both P<0.001).The treatment satisfaction score determined by SLQQ(mean±standard deviation)was 62.4±21.0 at month 12 versus 65.9±20.2 at month ***-year daily application of tadalafil 5mg in Chinese men with ED showed a favorable safety profile and durable improvement in sexual performance and satisfaction.

关键词： clinical trial erectile dysfunction long-term safety once-daily dosing tadalafil

Identification of reservoir types in deep carbonates based on mixedkernel machine learning using geophysical logging data

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Petroleum Science 2024年第3期21卷 1632-1648页

作者： Jin-Xiong Shi Xiang-Yuan zhao lian-Bo Zeng Yun-zhao Zhang Zheng-Ping Zhu Shao-Qun Dong Key Laboratory of Exploration Technologies for Oil and Gas Resources of the Ministry of Education Yangtze UniversityWuhan4310HubeiChina School of Geosciences Yangtze UniversityWuhan430100HubeiChina College of Geosciences China University of Petroleum(Beijing)Beijing102249China Petroleum Exploration and Production Research Institute of SINOPEC Beijing100083China School of Earth Sciences and Engineering Xi'an Shiyou UniversityXi'an 710065ShaanxiChina

Identification of reservoir types in deep carbonates has always been a great challenge due to complex logging responses caused by the heterogeneous scale and distribution of storage *** cross-plot analysis and empirical formula methods for identifying reservoir types using geophysical logging data have high uncertainty and low efficiency,which cannot accurately reflect the nonlinear relationship between reservoir types and logging ***,the kernel Fisher discriminant analysis(KFD),a kernel-based machine learning technique,attracts attention in many fields because of its strong nonlinear processing ***,the overall performance of KFD model may be limited as a single kernel function cannot simultaneously extrapolate and interpolate well,especially for highly complex data *** address this issue,in this study,a mixed kernel Fisher discriminant analysis(MKFD)model was established and applied to identify reservoir types of the deep Sinian carbonates in central Sichuan Basin,*** MKFD model was trained and tested with 453 datasets from 7 coring wells,utilizing GR,CAL,DEN,AC,CNL and RT logs as input *** particle swarm optimization(PSO)was adopted for hyper-parameter optimization of MKFD *** evaluate the model performance,prediction results of MKFD were compared with those of basic-kernel based KFD,RF and SVM ***,the built MKFD model was applied in a blind well test,and a variable importance analysis was *** comparison and blind test results demonstrated that MKFD outperformed traditional KFD,RF and SVM in the identification of reservoir types,which provided higher accuracy and stronger *** MKFD can therefore be a reliable method for identifying reservoir types of deep carbonates.

关键词： Reservoir type identification Geophysical logging data Kernel Fisher discriminantanalysis Mixedkernel function Deep carbonates

Evolution of inner wall wrinkle defects in the sinking zone of a thick-walled steel tube during radial forging

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Advances in Manufacturing 2024年第2期12卷 396-408页

作者： Yu-zhao Yang cheng Xu Li-Xia Fan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094People’s Republic of China

An axial wrinkle defect was observed in the inner wall of the sinking zone of a thick-wall steel tube processed by cold radial *** can evolve into *** present study focuses on the evolution of wrinkles and the effects of process parameters on them using a three-dimensional radial forging process finite element model,radial forging experiments,and surface morphology *** results indicated that the vertical section angle of the hammer die and the size of the tube blank significantly affect the evolution of *** height-to-width ratioλwas introduced to describe the morphology of *** had an approximately linear relationship with the radius reduction in the sinking *** was a linear correlation between the growth slope ofλand the axial to circumferential strain ratio|εr/εθ|,which can predict theλunder few process *** the 30SiMn2MoVA steel,at the junction of the forging and sinking zones,the threshold ofλof the wrinkle that can evolve into a fissure is approximately 1.123.

关键词： Radial forging Inner wall Wrinkle defects Evolution Sinking zone

Defects in the grain interiors of 3 mol%yttria-stabilized tetragonal zirconia polycrystal ceramics with 0.25 wt%alumina

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Journal of Advanced Ceramics 2024年第4期13卷 469-477页

作者： Yan Xiong lian Luo Yao cheng Zhi Liu Qi Liu Weimin Wang Wei Ji School of Materials&Chemical Engineering Hubei Province Key Laboratory of Green Materials for Light IndustryHubei University of TechnologyWuhan 430068China Fujian Institute of Research on the Structure of Mater Chinese Academy of SciencesFuzhou 350002China Jiangxi Provincial Engineering Research Center for Multifunction Zirconia Materials Jiangxi Size Materials Co.Ltd.Jiujiang 332500China State Key Laboratory of Advance Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

The presence of high-density defects is rarely observed in bulk 3 mol%yttria-stabilized tetragonal zirconia polycrystal(3Y-TZP)ceramics obtained through conventional pressureless *** the present work,fine-grained dense 147 nm 3Y-TZP ceramics were prepared by pressureless sintering of commercial 0.25 wt%alumina-doped zirconia powders at 1300℃.A novel discovery was reported in which large amounts of defects were present in the grain interiors of the *** phenomenon was further examined using three types of powder samples,and the reasons for defect formation were investigated by microstructural characterization using high-resolution transmission electron microscopy(HRTEM)analysis and Rietveld *** results confirmed the essential dependence of the defect formation on the alumina *** authors attributed the defect formation to the significant difference in ionic radii of the solvent and solute during the dissolution of alumina into the zirconia *** sintering kinetics were proposed to be enhanced by the presence of substantial defects,which consequently favored the low-temperature sintering of the alumina-doped zirconia ceramics.

关键词： 3 mol%yttria-stabilized tetragonal zirconia polycrystal(3Y-TzP)ceramics alumina addition microstructure defect

Femtosecond laser-induced periodic surface structures on hard and brittle materials

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Science China(Technological Sciences) 2024年第1期67卷 19-36页

作者： zhao GuoXu WANG Gong LI YunFei WANG Lei lian YuDong YU Yu zhao Hui WANG YuLei LU ZhiWei Center for Advanced Laser Technology Hebei University of TechnologyTianjin 300401China Hebei Key Laboratory of Advanced Laser Technology and Equipment Tianjin 300401China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China School of Information and Electrical Engineering Hebei University of EngineeringHandan 056038China

Hard and brittle materials have high hardness,excellent optical stability,chemical stability,and high thermal ***,they have huge application potential in various fields,such as optical components,substrate materials,and quantum information,especially under harsh conditions,such as high temperatures and high *** laser direct writing technology has greatly promoted the development of femtosecond laser-induced periodic surface structure(Fs-LIPSS or LIPSS by a femtosecond laser)applications of hard and brittle materials due to its high precision,controllability,and three-dimensional processing *** far,LIPSSs have been widely used in material surface treatment,optoelectronic devices,and ***,a consensus has not been reached regarding the formation mechanism of LIPSSs on hard and brittle *** this paper,three widely accepted LIPSS formation mechanisms are introduced,and the characteristics and applications of LIPSSs on diamonds,silicon,silicon carbide,and fused silica surfaces in recent years are *** addition,the application prospects and challenges of LIPSSs on hard and brittle materials by a femtosecond laser are discussed.

关键词： laser-induced periodic surface structures hard and brittle materials femtosecond laser

Analysis of destructive effect of Zn on carbon brick and way of Zn into carbon brick

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Journal of Iron and Steel Research(International) 2024年第6期31卷 1344-1354页

作者： Peng-bo Liu Shu-sen cheng Yu-qing Xue Xiao-man cheng zhao Liu University of Science and Technology Beijing Beijing 100083China Ministry of Ironmaking Shangdong Taishan Steel Group Co.Ltd.Taian 271000ShandongChina

The service life of a blast furnace depends largely on the degree of damage to the carbon brick in the *** brick and ramming material in the hearth of a 1780 m3 blast furnace after shutdown were sampled and *** was found that the substances in the cracks of the carbon brick near and above the taphole were ZnO and Zn_(2)SiO_(4),whereas the substances in the cracks of the carbon brick below the taphole were *** reaction of Zn with CO,SiO_(2),and Fes generates ZnO,Zn_(2)SiO_(4),and ZnS,resulting in volume expansion,which is an important reason for the cracking of carbon ***,several obvious Zn vapor flow channels were found in the ramming material,through which Zn vapor could enter the carbon brick,causing damage to the carbon *** the compactness of the ramming material is beneficial to preventing Zn vapor from entering the carbon brick through the voids in the ramming material,reducing the destructive effect of Zn on the carbon brick and further extending the service life of the blast furnace.

关键词： Zn Blast furnace Carbon brick Ramming material Crack

Numerical analysis of coupled sloshing and motion of a cylindrical FPSO in regular waves

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Journal of Hydrodynamics 2024年第3期36卷 457-465页

作者： Wei-wen zhao Xiao-long Yang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Offshore Oil Engineering Co.Ltd. Tianjin300461China

In this paper,the coupled sloshing and motion characteristics of a cylindrical floating production storage offloading(CFPSO)are numerically investigated by means of computational fluid dynamics(CFD)*** simulations are performed using an in-house CFD solver naoe-FOAM-SJTU which is developed based on *** active wave generating-absorbing boundary condition(GABC)is utilized for wave generation and *** stabilized k-omega SST turbulence model are used to avoid excessive eddy viscosity near the free *** with and without partially filled liquid tanks in regular waves with different wave periods are simulated and vertical planar motions such as surge,heave and pitch response amplitude operators(RAOs)are *** due to liquid sloshing and wave loads are extracted and *** free surface motions inside liquid tanks in one wave period presented to explain the motion characteristics.

关键词： Coupled analysis liquid sloshing wave motion cylindrical floating production storage offloading(CFPSO)

Al-modified yolk-shell silica particle-supported NiMo catalysts for ultradeep hydrodesulfurization of dibenzothiophene and 4,6-dimethyldibenzothiophene:Efficient accessibility of active sites and suitable acidity

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Petroleum Science 2024年第1期21卷 654-666页

作者： Ke Yu Wei-Min Kong Zhen zhao Ai-Jun Duan lian Kong Xi-Long Wang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034LiaoningChina

Yolk-shell SiO2 particles(YP)with center-radial meso-channels were fabricated through a simple and effective ***-containing YP-supported NiMo catalysts with different Al amounts(NiMo/AYP-x,x=Si/Al molar proportion)were prepared and dibenzothiophene(DBT)and 4,6-dimethyl-dibenzothiophene(4,6-DMDBT)were employed as the probes to evaluate the hydrodesulfurization(HDS)catalytic *** as-prepared AYP-x carriers and corresponding catalysts were characterized by some advanced characterizations to obtain deeper correlations between physicochemical properties and the HDS *** average pore sizes of series AYP-x supports are above 6.0 nm,which favors the mass transfer of organic *** cavity between the yolk and the shell is beneficial for the enrichment of S-containing compounds and the accessibility between reactants and active *** embedded into the silica framework could facilitate the formation of Lewis(L)and Brønsted(B)acid sites and adjust the metal-support interaction(MSI).Among all the as-synthesized catalysts,NiMo/AYP-20 catalyst shows the highest HDS *** improved HDS activity of NiMo/AYP-20 catalyst is attributed to the perfect combination of excellent structural properties of the yolk-shell mesoporous silica,enhanced acidity,moderate MSI,and good accessibility/dispersion of active components.

关键词： Al-containing yolk-shell silica particles Accessibility Acidity Metal-support interaction Hydrodesulfurization

Nuclearity and Finite-Representability in the System of Completely Integral Mapping Spaces

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1197-1214页

作者： Zhe DONG Ji cheng TAO Ya Fei zhao Department of Mathematics Zhejiang UniversityHangzhou 310027P.R.China Department of Mathematics China Jiliang UniversityHangzhou 310018P.R.China Department of Mathematics Zhejiang International Studies UniversityHangzhou 310023P.R.China

In this paper,we investigate local properties in the system of completely integral mapping *** introduce notions of injectivity,local reflexivity,exactness,nuclearity,finite-represent ability and WEP in the system of completely integral mapping *** we obtain that any finite-dimensional operator space is injective in the system of completely integral mapping *** we prove that C is the unique nuclear operator space and the unique exact operator space in this *** also show that C is the unique operator space which is finitely representable in{T_(n)}n∈Nin this *** corollaries,Kirchberg’s conjecture and QWEP conjecture in the system of completely integral mapping spaces are false.

关键词： Completely integral mapping space injectivity exactness nuclearity finite-representability WEP