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Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation

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Chinese Journal of Natural Medicines 2022年第4期20卷 258-269页

作者： LI Xue-Ming YUAN Ding-Yi liu ya-hui ZHU Lei QIN Hong-Kun yaNG Yu-Bing LI yan yaN Fang WANG ya-Jing Department of physiology School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Pharmaceutical Analysis School of pharmacologyChina Pharmaceutical UniversityNanjing 210009China Department of Chronic Communicable Disease Jiangsu Provincial Center for Disease Prevention and ControlNanjing 210009China

Colorectal cancer(CRC)is the third most lethal cancer and leading cause of cancer mortality worldwide.A key driver of CRC development is colon inflammatory responses especially in patients with inflammatory bowl disease(IBD).It has been proved that Panax notoginseng saponins(PNS)have anti-inflammatory,anti-oxidant and anti-tumor *** chemopreventive and immunomodulatory functions of PNS on colitis-associated colorectal cancer(CAC)have not been *** present study was designed to study the potential protective effects of PNS on AOM/DSS-induced CAC mice to explore the possible mechanism of PNS against *** study showed that PNS significantly alleviated colitis severity and prevented the occurrence of *** assays revealed that PNS relieved immunosuppression of Treg cells in the CAC microenvironment by inhibiting the expression of IDO 1 mediated directly by signal transducer and activator of transcription 1(STAT1)rather than phosphorylated ***,Rhl,one of the PNS metabolites,exhibited the best inhibitory effect on IDO1 enzyme *** study showed that PNS exerted significant chemopreventive function and immunomodulatory properties on *** could reduce macrophages accumulation and Treg cells differentiation to reshape the immune microenvironment of *** findings provided a promising approach for CAC intervention.

关键词： Panax notoginseng saponins Colitis-associated colorectal cancer Chemoprevention Treg cells IDO1

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α-Hederin inhibits growth of lung cancer A549 cells in vitro and in vivo by decreasing c-Myc and HIF-1α dependent glycolysis

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中国药理学与毒理学杂志 2019年第9期33卷 682-683页

作者： FANG Cong CHEN Lan-ying LUO Ying-ying CUI ya-ru ZHANG Ni liu Peng ZHOU Meng-jing XIE Yong-yan liu ya-hui National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China College of Traditional Chinese Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China

OBJECTIVEα-Hederin is an effective component of the traditional Chinese medicine Pulsatilla chinensis,which has been reported to exert many pharmacological ***,the effect ofα-hederin on metabolism is still *** study aimed to illuminate the role ofα-hederin in glucose metabolism in lung cancer cells and investigate the molecular mechanism ofα-*** CCK8 and colony formation assays were employed to assess the anti-proliferative effects induced byα-*** uptake,ATP generation,and reduced lactate production were measured using kits,and an A549 tumor xenograft mouse model of lung cancer was used to assess the in vivo antitumor effect ofα-hederin(5,10 mg·kg^-1).Glycolytic-related key enzymes were detected by Western blotting and immunohisto⁃chemical *** Cell proliferation was significantly inhibited byα-hederin in a dose-dependent manner and thatα-hederin inhibited glucose uptake and ATP generation and reduced lactate ***,α-hederin remarkably inhibited hexokinase 2(HK2),glucose transporters 1(GLUT1),pyruvate kinase M2(PKM2),lactate dehydro⁃genase A(LDHA),monocarboxylate transporter(MCT4),c-Myc,and hypoxia inducible factor-1α(HIF-1α)protein expres⁃*** inhibitors,we proved thatα-hederin inhibits glycolysis by inhibiting glycolytic ***,a tumor xenograft mouse model of lung cancer further confirmed thatα-hederin inhibits lung cancer growth via inhibiting glycolysis in ***α-Hederin inhibits the growth of non-small cell lung cancer A549 cells by inhibiting *** mechanism of glycolysis inhibition includesα-hederin inhibiting the expression of the glycolytic regulatory factors HIF-1α and c-Myc.

关键词： α-hederin lung cancer glycolysis c-Myc hypoxia inducible factor-1α

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Mining Heat Stress Associated Genes in Tomato Fruit (Solanum lycopersicum L.) Through RNA-seq

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Journal of Northeast Agricultural University(English Edition) 2021年第4期28卷 12-24页

作者： Zhang Ying-ying liu ya-hui Zhang hui Zhu Wei-min Shanghai Key Laboratory of Protected Horticulture Technology The Protected Horticulture InstituteShanghai Academy of Agricultural SciencesShanghai 201403China

Tomato(Solanum lycopersicum L.)is a thermophilic vegetable crop,but sensitive to high temperature stress,especially under the greenhouse *** to global climate changes,heat stress has now become a great threat to tomato production and fruit *** studies have been conducted to determine the functions of genes in tomato responsive to abiotic and biotic stresses,but transcriptomic information on heat stress responses of tomato fruit is still *** investigate heat stress associated genes in tomato fruit,a cDNA library was constructed using fruit harvested from tomato cv.P19-9 plants grown under 42℃for 0,1,2 and4 h and the expression profiles of heat stress responsive genes in tomato fruit were analyzed through RNA-seq.A total of 632224558 clean high quality paired-end reads were obtained and then mapped to reference genome for RNA-seq *** quality control analysis,alignment analysis and transcript assembly,a total of 55457 RNA transcripts were obtained with functional ***,6869 differentially expressed genes(DEGs)were identified with a significant response to one or more of the three heat stress treatment *** on GO enrichment analysis,22 genes potentially involved in tomato thermo-tolerance were selected and validated for their expressions through *** expression profile of tomato fruit genes obtained in this study could shed light on the mechanism and gene editing breeding projects for tomato *** findings could also benefit improvement of harvest and storage of tomato in greenhouse.

关键词： tomato fruit heat stress transcriptomic analysis gene expression profiling

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Preliminary molecular basis of Danggui-buxue-tang on Qi deficiency and blood stasis syndrome

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沈阳药科大学学报 2008年第S1期25卷 110-111页

作者： liu ya,LI Xiao-hui(Institute of Materia Medica,College of Pharmacy,Third Military Medical University,Chongqing 400038,China)

Objective To study the molecular biology mechanism of Danggui-buxue-tang on tonifying Qi and controlling blood circulation through modulation the immune functional *** Rats were randomly divided into control group,model group,and Danggui-buxue-tang *** of Dang-guibuxue-tang on mRNA expressions of IL-1β,TNF-α,HSP-70,NF-κB,p38MAPK and JNK in blood cells of rats with Qi deficiency and blood stasis were measured with real-time fluorescent quantitative-PCR at 5th,14th and 28th *** that in artery wall were determined at the 28th ***-κB/p65 and p-c-jun protein expressions in rat artery wall were detected by western blotting as *** In model group,TNF-α,IL-1β,NF-κB,HSP-70,p38MAPK and JNK mRNA expression in blood cell increased significantly compared with control *** with model group,mRNA expression of IL-1βand JNK decreased significantly;TNF-α decreased at 5th,14th day;HSP-70,p38MAPK decreased at 14th,28th day;NF-κB decreased at 28th *** model group,TNF-α,IL-1β,NF-κB,p38MAPK and JNK mRNA expression in artery increased compared with control group,excluded HSP-70,and that in Danggui-buxue-tang group decreased *** model group,NF-κB/p65 and p-c-jun protein expression in artery increased compared with control group,and that in Danggui-buxue-tang group decreased *** The effects of Dang-guibuxue-tang on Qi deficiency and blood stasis syndrome was brought from the regulating of cytokine network at multi-link and multi-target,NF-κB,p38MAPK and JNK signal transduction pathways *** which the immune system and whole body reached to a functional balance status.

关键词： qi deficiency and blood stasis dang-guibuxue-tang cytokine network immunity signal transduction pathway

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澜沧江景洪水电站下引航道口门区通航水流条件试验

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重庆建筑大学学报 2006年第5期28卷 55-58,62页

作者：刘亚辉李鑫重庆交通大学西南水运工程科学研究所重庆400016 国电重庆恒泰发电有限公司重庆400050

基于物理模型试验,研究分析了景洪水电站不同泄流方式对升船机下引航道口门区的通航水流条件的影响,针对原设计所存在的问题,提出了下引航道外引墙采取透空布置的优化工程措施,较好地改善了引航道口门区的通航水流条件。

关键词：水电站枢纽下引航道口门区通航条件透空式导航墙

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马若瑟《汉语札记》中的语法化、词汇化意识——以“以”的研究为例

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汉语学习 2015年第1期 93-100页

作者：刘亚辉浙江财经大学人文学院浙江杭州310018

马若瑟所著《汉语札记》对"以"字的研究体现出明显的语法化和词汇化意识。马若瑟不仅依据是否做句子基本成分来划分实词和虚词,还点明了隐喻这条语法化路径,并举出一些虚化例证,在衔接中国传统实词虚化思想与现代语法化思想方面具有重... 详细信息

马若瑟所著《汉语札记》对"以"字的研究体现出明显的语法化和词汇化意识。马若瑟不仅依据是否做句子基本成分来划分实词和虚词,还点明了隐喻这条语法化路径,并举出一些虚化例证,在衔接中国传统实词虚化思想与现代语法化思想方面具有重要的里程碑式的意义。其对"所以""以为"等的研究呈现出由分开的两个词到一个凝固词语转化的过程,表现出超前的词汇化意识,这在汉语语言学史和欧洲汉学史上都具有重要的意义和价值。

关键词：马若瑟《汉语札记》隐喻语法化词汇化

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基于激光测距巷道顶底板移近量传感器的设计与应用

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煤炭工程 2016年第8期48卷 71-73页

作者：刘亚辉中煤科工集团重庆研究院有限公司重庆400039

根据矿压分析工艺要求,以及现有顶底板移近量传感器的不足,提出一种基于激光测距原理的巷道顶底板移近量传感器,利用电池为激光测距模块供电,克服了传感器功耗大的缺点,实现了煤矿井下传感器的大量分布式布置。试验及现场应用表明,该传... 详细信息

根据矿压分析工艺要求,以及现有顶底板移近量传感器的不足,提出一种基于激光测距原理的巷道顶底板移近量传感器,利用电池为激光测距模块供电,克服了传感器功耗大的缺点,实现了煤矿井下传感器的大量分布式布置。试验及现场应用表明,该传感器测量精度高,传输速度快,环境适应性强,能够准确、及时的反映巷道顶底板移近量的变化,为顶板动态监测及分析提供了可靠数据基础。

关键词：顶底板移近量激光测距锂-亚硫酰氯相位测距法

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本安设备用电源模块的设计及实现

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煤炭技术 2021年第7期40卷 181-184页

作者：刘亚辉中煤科工集团重庆研究院重庆400039

针对无线类本安用电设备的功耗存在脉冲型变化的特点,提出一种基于内部集成MOS管的降压管理芯片TPS54540的电源电路设计,通过增加本安处理电路、电流限制电路、大电容储能电路等实现本安化的高负载效应电源模块。实验表明该电源模块具... 详细信息

针对无线类本安用电设备的功耗存在脉冲型变化的特点,提出一种基于内部集成MOS管的降压管理芯片TPS54540的电源电路设计,通过增加本安处理电路、电流限制电路、大电容储能电路等实现本安化的高负载效应电源模块。实验表明该电源模块具有负载调整率高、抗干扰能力强、冲击电流小等特点,可为瞬时脉冲型负载提供可靠的电源输出,且完全满足本安技术要求。

关键词：负载调整率无线发射本安电源阻塞二极管电压限制

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