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STUDY ON THE ANGLE OF REPOSE OF NONUNIFORM SEDIMENT

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Journal of Hydrodynamics 2009年第5期21卷 685-691页

作者： YANG Feng-guang liu xing-nian YANG Ke-jun CAO Shu-you State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu 610065China

A conception of exposure degree is used in this article to account for the hiding and exposure mechanism of nonuniform sediment transport. The force arms of particles on the bed slope are assumed to be a function of the exposure degree, which is stochastically related to the size and gradation of bed materials. Based on this conception, the formula for the angle of repose of nonuniform sediment is developed. The angle of repose of nonuniform sediment is experimentally investigated in rotation drum at the rolling motion of sediment particles. The nonuniform sediment is gotten from the mixture of two kinds of uniform sediment with different weight ratios and two experimental plans that one for changing the weight ratio of two kinds of uniform sediment from 1：9 to 9：1 and the other changing the uniform sediment size and weight ratio are used. The effect of the rotation speed and the filling degree on the angle of repose is investigated, too. Finally, the formula has been tested against a wide range of laboratory data, the prediction by the newly proposed formulas is very good.

关键词： the angle of repose nonuniform sediment rotation drum exposure degree

An OpenFlow-based performance-oriented multipath forwarding scheme in datacenters

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Frontiers of Information Technology & Electronic Engineering 2016年第7期17卷 647-660页

作者： Bo liu Ming CHEN Bo XU Hui HU Chao HU Qing-yun ZUO Chang-you xing College of Command Information Systems PLA University of Science and TechnologyNanjing 210007China PLA Academy of National Defense Information Wuhan 430020China

Although dense interconnection datacenter networks(DCNs)(e.g.,Fat Tree) provide multiple paths and high bisection bandwidth for each server pair,the widely used single-path Transmission Control Protocol(TCP)and equal-cost multipath(ECMP) transport protocols cannot achieve high resource utilization due to poor resource excavation and *** this paper,we present LESSOR,a performance-oriented multipath forwarding scheme to improve DCNs' resource *** adopting an Open Flow-based centralized control mechanism,LESSOR computes near-optimal transmission path and bandwidth provision for each flow according to the global network view while maintaining nearly real-time network view with the performance-oriented flow observing *** and comprehensive simulations show that LESSOR can efficiently improve the network throughput,which is higher than ECMP by 4.9%–38.3% under different *** also provides 2%–27.7% improvement of throughput compared with ***,LESSOR decreases the average flow completion time significantly.

关键词： Datacenter network Traffic engineering Open Flow Multipath transmission

不同传染性法氏囊病病毒株感染对CCL19-CCR7轴系表达量的影响

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中国兽医杂志 2022年第11期58卷 27-32页

作者：王秋霞张新楚富茗王明明王芳卢浪魏小兵余燕张艳红马金友姜金庆欧长波刘兴友河南科技学院动物科技学院河南新乡453003 新乡学院生命科学与基础医学学院河南新乡453003

为了解不同毒株传染性法氏囊病病毒(IBDV)对CC类趋化因子配体CCL19及其受体CCR7基因表达量的影响,探明趋化因子在IBDV致病中的作用,本试验分别用经典毒株CJ801和本地分离毒株HN-1对SPF鸡进行攻毒,攻毒成功后取法氏囊提取总RNA,反转录后... 详细信息

为了解不同毒株传染性法氏囊病病毒(IBDV)对CC类趋化因子配体CCL19及其受体CCR7基因表达量的影响,探明趋化因子在IBDV致病中的作用,本试验分别用经典毒株CJ801和本地分离毒株HN-1对SPF鸡进行攻毒,攻毒成功后取法氏囊提取总RNA,反转录后荧光定量分析,检测CCL19-CCR7轴系基因mRNA表达水平的差异。结果显示,经典毒株CJ801攻毒后,趋化因子CCL19及其受体CCR7基因mRNA表达量均于1d时达峰值,3d时显著下降低;而本地分离毒株HN-1攻毒后,趋化因子CCL19及其受体CCR7基因mRNA表达量于1d、3d和5d逐步上升。结果表明,在IBDV经典毒株CJ801和本地分离毒株HN-1感染过程中,CCL19及其受体CCR7基因表达量差异显著,其对T细胞迁移和IBDV复制的影响机制有待进一步探索。

关键词：趋化因子趋化因子受体 CCL19 CCR7 表达量

Needs and challenges of optical atmospheric monitoring on the background of carbon neutrality in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 49-62页

作者： Wenqing liu Chengzhi xing Anhui Institute of Optics and Fine Mechanics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 23001China

The achievement of the targets of coordinated control of PM2.5 and O3 and the carbon peaking and carbon neutrality depend on the development of pollution and greenhouse gas monitoring *** monitoring technology,based on its technical characteristics of high scalability,high sensitivity and wide-targets detection,has obvious advantages in pollution/greenhouse gases monitoring and has become an important direction in the development of environmental monitoring *** present,a system of environmental optical monitoring technology with differential optical absorption spectroscopy(DOAS),cavity ring-down spectroscopy(CRDS),light detection and ranging(LIDAR),laser heterodyne spectroscopy(LHS),tunable diode laser absorption spectroscopy(TDLAS),fourier transform infrared spectroscopy(FTIR)and fluorescence assay by gas expansion(FAGE)as the main body has been ***,with the promotion of“reduction of pollution and carbon emissions”strategy,there have been significant changes in the sources of pollution/greenhouse gases,emission components and emission concentrations,which have put forward new and higher requirements for the development of monitoring *** the future,we should pay more attention to the development of new optical monitoring techniques and the construction of stereoscopic monitoring system,the interdisciplinarity(among mathematics,physics,chemistry and biology,etc.),and the monitoring of greenhouse gases and research on atmospheric chemistry.

关键词： Pollution Greenhouse gas Optical atmospheric monitoring Needs and challenges

Advances in understanding the molecular mechanism of pancreatic cancer metastasis

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 361-370页

作者： Yong-xing Du Zi-Wen liu Lei you Wen-Ming Wu Yu-Pei Zhao Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND： Pancreatic cancer（PC） is usually diagnosed at the late-stage and therefore, has widespread metastasis and a very high mortality rate. The mechanisms underlying PC metastasis are not well understood. Recent advances in genomic sequencing have identified groups of gene mutations that affect PC metastasis, but studies elucidating their roles are lacking. The present review was to investigate the molecular mechanisms of PC *** SOURCES： Relevant articles on PC metastasis were searched in MEDLINE via Pub Med prior to April 2015. The search was limited in English ***： PC metastatic cascades are multi-factorial events including both intrinsic and extrinsic elements. This review highlights the most important genetic alterations and other mechanisms that account for PC invasion and metastasis, with particular regard to epithelial-mesenchymal transition, inflammation, stress response, and circulating tumor ***： Analyses of relevant gene functions and signaling pathways are needed to establish the gene regulatory network and to define the pivotal modulators. Another promising area of study is the genotyping and phenotyping of circulating tumor cells, which could lead to a new era of personalized therapy by identifying specific markers and targets.

关键词： pancreatic cancer metastasis molecular mechanism targeted therapy

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病毒利用UPP逃避抗病毒反应的研究进展

生命科学 2008年第4期20卷 638-640页

作者：赵朴贾贝贝王宪文刘兴友郑玉姝河南科技学院动物科学学院新乡453003

泛素-蛋白酶体途径是溶酶体外蛋白降解的主要系统,在许多细胞功能中发挥蘑要作用。越来越多的证据表明病毒参与泛素-蛋白酶体途径,干扰IFN信号通路和免疫受体表达、凋亡抑制及介导病毒潜伏。深入理解病毒利用泛素-蛋白酶体途径逃避宿主... 详细信息

泛素-蛋白酶体途径是溶酶体外蛋白降解的主要系统,在许多细胞功能中发挥蘑要作用。越来越多的证据表明病毒参与泛素-蛋白酶体途径,干扰IFN信号通路和免疫受体表达、凋亡抑制及介导病毒潜伏。深入理解病毒利用泛素-蛋白酶体途径逃避宿主抗病毒反应的策略,有助于揭示病毒的致病机理和鉴定抗病毒药物新靶标。

关键词：病毒泛素-蛋白酶体途径逃避抗病毒反应

CRISPR/dCas9-mediated imaging of endogenous genomic loci in living Bombyx mori cells

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Insect Science 2020年第6期27卷 1360-1364页

作者： Wei-Qing xing San-Yuan Ma Yuan-Yuan liu Qing-you Xia Biological Science Research Center Southwest UniversityChongqingChina Chongqing Engineering and Technology Research Center for Novel Silk Materials Southwest UniversityChongqingChina Chongqing Key Laboratory of Sericulture Southwest UniversityChongqingChina Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Dear Editor,Visualization of specific endogenous genomic loci is crucial to understand the molecular basis underlying the spatiotemporal regulation of gene *** genetic loci were previously visualized primarily via flu... 详细信息

关键词： endogenous expression. al.

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豆状囊尾蚴的超微结构观察

畜牧兽医学报 2012年第4期43卷 653-658页

作者：潘耀谦刘兴友赵振升陈金山张慧蓉朱广蕊夏银可银梅唐海蓉河南科技学院动物科学学院新乡453003 河南科技大学动物科技学院洛阳453007

本研究旨在观察豆状囊尾蚴在不同状态下的超微结构。从肉联厂屠宰检验采取豆状囊尾蚴,直接剪破囊泡从中取出豆状囊尾蚴;或用含10%胆汁生理盐水培养囊尾蚴,待其从囊泡中翻出后,用扫描电镜观察和记录。位于囊泡内的头节,从其顶端观察,顶... 详细信息

本研究旨在观察豆状囊尾蚴在不同状态下的超微结构。从肉联厂屠宰检验采取豆状囊尾蚴,直接剪破囊泡从中取出豆状囊尾蚴;或用含10%胆汁生理盐水培养囊尾蚴,待其从囊泡中翻出后,用扫描电镜观察和记录。位于囊泡内的头节,从其顶端观察,顶突呈伞状,皮肌柱连接小钩覆盖于头节的前端。从侧面观察,一排有鹿角样的小钩附着于顶突。4个吸盘呈洞穴状位于顶突之后分布在头节的四周。原始颈节较宽,体节较细,表面均有许多皱褶。培养后的豆状囊尾蚴可明显区分为头节、颈节、体节和囊泡区,顶突上的皮肌柱收缩,鹿角样的小钩向周围伸展,吸盘也发生环形和纵形收缩,颈节的环状收缩和体节的纵行收缩均明显可辨。豆状囊尾蚴处于不同状态时,其超微结构明显不同。

关键词：豆状囊尾蚴超微结构顶突吸盘扫描电镜

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猪囊尾蚴凋亡蛋白酶抑制剂基因的克隆与表达

中国兽医科学 2016年第11期46卷 1365-1369页

作者：王秋霞苏文强关俊勇郭爱疆骆学农李辉欧长波余燕姜金庆马金友刘兴友王松张艳红才学鹏中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室甘肃省动物寄生虫病重点实验室甘肃兰州730046 河南科技学院动物科技学院河南新乡453003

为了探究凋亡蛋白酶抑制剂基因在猪囊尾蚴生活过程中的作用,利用RT-PCR技术克隆了猪囊尾蚴凋亡蛋白酶抑制剂基因,并将其克隆至原核表达载体p ET-30a中,转化大肠杆菌BL21(D E3),经IPTG诱导后,用SDS-PAGE进行初步分析,在53 ku处出现明显... 详细信息

为了探究凋亡蛋白酶抑制剂基因在猪囊尾蚴生活过程中的作用,利用RT-PCR技术克隆了猪囊尾蚴凋亡蛋白酶抑制剂基因,并将其克隆至原核表达载体p ET-30a中,转化大肠杆菌BL21(D E3),经IPTG诱导后,用SDS-PAGE进行初步分析,在53 ku处出现明显的蛋白条带,与预期结果一致。W estern-blot结果表明,重组融合蛋白能够与抗H is特异性抗体发生反应。凋亡蛋白酶抑制剂基因的成功表达为后续对其功能进行研究奠定了基础。

关键词：猪囊尾蚴凋亡蛋白酶抑制剂基因克隆表达