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SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas

Biomedical and Environmental Sciences 2022年第3期35卷 194-205页

作者： PAN dong DU Ya Rong LI Rong SHEN Ai Hua liu xiao dong LI Chuan Yuan HU Bu Rong Department of Radiological Health and Radiation Medicine School of Public Health and ManagementWenzhou Medical UniversityWenzhou 325035ZhejiangChina Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences&Key laboratory of Space Radiobiology of Gansu province Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000GansuChina Department of Dermatology Duke University Medical CenterDurhamNC27710USA

Objective SET8 is a member of the SET domain-containing family and the only known lysine methyltransferase(KMT)that monomethylates lysine 20 of histone H4(H4 K20 me1).SET8 has been implicated in many essential cellular processes,including cell cycle regulation,DNA replication,DNA damage response,and carcinogenesis.There is no conclusive evidence,however,regarding the effect of SET8 on radiotherapy.In the current study we determined the efficacy of SET8 inhibition on radiotherapy of tumors and the underlying mechanism.Methods First,we explored the radiotherapy benefit of the SET8 expression signature by analyzing clinical data.Then,we measured a series of biological endpoints,including the xenograft tumor growth in mice and apoptosis,frequency of micronuclei,and foci of 53 BP1 andγ-H2 AX in cells to detect the SET8 effects on radiosensitivity.RNA sequencing and subsequent experiments were exploited to verify the mechanism underlying the SET8 effects on radiotherapy.Results Low expression of SET8 predicted a better benefit to radiotherapy in lung adenocarcinoma(LUAD)and invasive breast carcinoma(BRCA)patients.Furthermore,genetic deletion of SET8 significantly enhanced radiation treatment efficacy in a murine tumor model,and A549 and MCF7 cells;SET8 overexpression decreased the radiosensitivity.SET8 inhibition induced more apoptosis,the frequency of micronuclei,and blocked the kinetics process of DNA damage repair as 53 BP1 andγ-H2 AX foci remained in cells.Moreover,RNF8 was positively correlated with the SET8 impact on DNA damage repair.Conclusion Our results demonstrated that SET8 inhibition enhanced radiosensitivity by suppressing DNA damage repair,thus suggesting that SET8 potentiated radiotherapy of carcinomas.As new inhibitors of SET8 are synthesized and tested in preclinical and clinical settings,combining SET8 inhibitors with radiation warrants consideration for precise radiotherapy.

关键词： SET8 Histone methylation DNA repair Radiotherapy Carcinoma

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超表面透镜偏振可切换的多通道功能复用

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红外与毫米波学报 2024年第3期43卷 369-374页

作者：刘小东朱亦鸣上海尼博电子科技有限公司上海201615 上海理工大学光电信息与计算机工程学院上海200093

超表面概念的提出为研究平面化和超薄的光学元器件提供了一种全新的设计思路。传统的几何相位型的超表面透镜受制于偏振锁定的限制,阻碍了其实现多功能的复用。文章提出了一种通过几何相位实现超表面透镜偏振解耦的方法。进一步,利用该... 详细信息

超表面概念的提出为研究平面化和超薄的光学元器件提供了一种全新的设计思路。传统的几何相位型的超表面透镜受制于偏振锁定的限制,阻碍了其实现多功能的复用。文章提出了一种通过几何相位实现超表面透镜偏振解耦的方法。进一步,利用该方法作者实现了超表面聚焦透镜在纵向以及纵向和横向实现多通道功能(如聚焦光斑和聚焦涡旋)的复用和偏振可切换特性。相关研究为实现多功能可集成的平面化器件提供了新的研究思路。

关键词：超表面超透镜聚焦涡旋

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乾隆时期督抚题调制度谫论

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东北师大学报（哲学社会科学版） 2024年第3期 92-99页

作者：刘晓东何涛华南师范大学历史文化学院广东广州510637 东北师范大学历史文化学院吉林长春130024

乾隆时期,清廷构建了较为完备的督抚题调制度,乾隆帝一方面出于地方治理的现实需求,在构建稳定制度体系的同时也给予督抚一定合理的运作空间,在一定程度上赋予了题调制度较大的弹性空间。另一方面,督抚题调权力的行使,也被置于吏部核查... 详细信息

乾隆时期,清廷构建了较为完备的督抚题调制度,乾隆帝一方面出于地方治理的现实需求,在构建稳定制度体系的同时也给予督抚一定合理的运作空间,在一定程度上赋予了题调制度较大的弹性空间。另一方面,督抚题调权力的行使,也被置于吏部核查的制度之下,呈现出皇帝、督抚、吏部三者之间权力交织、相互博弈的政治格局。随着督抚用人环境日渐紧张,乾隆初期构建的相对有序的督抚题调制度也日渐被破坏,“率请捐复”“私下调署”之风愈演愈烈,成为清代后期地方督抚势力上升的一个重要诱因。

关键词：乾隆督抚题调制度捐复

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慢性阻塞性肺疾病临床新型三联治疗药物研究现况与进展

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中国新药与临床杂志 2024年第2期43卷 127-132页

作者：胡涵硕王卓刘晓东中国医科大学附属盛京医院药学部辽宁沈阳110004 中国医科大学药学院第二临床药学教研室辽宁沈阳110001

目前指南建议,对于在接受吸入性糖皮质激素(ICS)+长效肾上腺素β2受体激动药(LABA)或LABA+长效抗胆碱药(LAMA)双联治疗后仍出现急性加重的慢性阻塞性肺疾病(COPD)患者[血嗜酸性粒细胞计数(EOS)≥100个细胞·μL^(-1)],推荐使用ICS+LABA+... 详细信息

目前指南建议,对于在接受吸入性糖皮质激素(ICS)+长效肾上腺素β2受体激动药(LABA)或LABA+长效抗胆碱药(LAMA)双联治疗后仍出现急性加重的慢性阻塞性肺疾病(COPD)患者[血嗜酸性粒细胞计数(EOS)≥100个细胞·μL^(-1)],推荐使用ICS+LABA+LAMA三联疗法。多项研究结果显示,三联疗法可有效减少中重度COPD患者的急性加重次数,改善肺功能和生活质量,且安全性良好。在EOS≥300个细胞·μL^(-1)的患者中,三联疗法对急性加重风险的保护作用更加明显。与多吸入器三联疗法相比,单吸入器三联疗法在改善COPD患者第1秒用力呼气容积方面有显著优势,但两者在控制中重度急性加重率、降低圣乔治呼吸问卷得分、减少不良事件方面无显著差异,不同三联疗法治疗COPD的疗效和安全性值得进一步研究。

关键词：肺疾病,慢性阻塞性药物疗法,联合糖皮质激素类肾上腺素能β-2受体激动剂胆碱能拮抗剂

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Studies on the Mechanism of Methyl Methacrylate Polymerization Initiated　by　Volatile　and　Nonvolatile　Products　of　Methyl　Methacrylate　Plasma

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Chemical Research in Chinese Universities 1995年第3期11卷 250-255页

作者： liu, xiao-dong Li, Jing Ma, Yu-gang Shen, Jia-cong NORMAN BETHUNE UNIV MED SCI BASIC MED COLLCHANGCHUN 130023PEOPLES R CHINA JILIN UNIV KEY LAB MOLEC SPECTRA & STRUCTCHANGCHUN 130023PEOPLES R CHINA

he volatile (VPP) and nonvolatile (NVPP) products of methyl methacrylate(MMA) reaction in plasma chamber were used as initiators of MMA polymeriza-tion. From the structure analyses of the two initiators, the measurement of poly-merization kinetics, and the determination of the molecular weight of resultantpolymers , we found tliat MMA polymerization initiated by NVPP is a typical radical mechanism of polymerization which undergoes a process of continuous initiationand bifunction termination , while VPP-initiated polymerization suggested a mech-anism of living radical process fpolymerization with instantaneous initiation , chain-transfer to monomer , without termination).

关键词： Plasma initiated polymerzation Methyl methacrylate Kinetics

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太子参及提取物对动物免疫调节作用研究进展

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动物医学进展 2024年第5期45卷 97-102页

作者：张森欧婧豆晓霞刘晓东付本懂黔东南民族职业技术学院贵州凯里556000 吉林大学动物医学学院吉林长春130062

太子参是一味传统中药,具有生津润肺、益气健脾的功效。现代研究表明其富含微量元素、氨基酸、糖类、苷类、环肽类、脂肪酸类、油脂类、挥发油类、甾醇类等多种活性成分,能有效提高动物免疫力。论文综述了近年来太子参及其提取物对动物... 详细信息

太子参是一味传统中药,具有生津润肺、益气健脾的功效。现代研究表明其富含微量元素、氨基酸、糖类、苷类、环肽类、脂肪酸类、油脂类、挥发油类、甾醇类等多种活性成分,能有效提高动物免疫力。论文综述了近年来太子参及其提取物对动物免疫器官、免疫细胞、免疫分子以及肠道免疫作用的研究成果,为太子参的进一步研究、开发和利用提供参考。

关键词：太子参太子参提取物免疫

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Trimeric Hydrogen Bond in Geometrically Frustrated Hydroxyl Cobalt Halogenides

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Chinese Physics Letters 2011年第1期28卷 197-200页

作者： liu xiao-dong Hagihala Masato ZHENG Xu-Guang TAO Wan-Jun MENG dong-dong ZHANG Sen-Lin GUO Qi-Xin Department of Physics Graduate School of Science and Engineering Saga University Saga 840-8502 Japan Department of Physics College of Science Tianjin Polytechnic University Tianjin 300160 Department of Physics Faculty of Science and' Engineering Saga University Saga 840-8502 Japan Synchrotron Light Application Center & Department of Electrical and Electronic Engineering Saga University Saga 840-8502 Japan

The mid-infrared absorption spectra of geometrically frustrated hydroxyl cobalt halogenides Co2 （OH）3 CI and Co2 （OH）3Br are measured by FTIR spectrometers, and the stretching vibrational modes of hydroxyl groups are found to be 3549 cm-1 and 3524 cm-1 respectively. Through finding their true terminal O II group stretching vibration frequencies, we obtain 107cm-1 and 99cm-1 red shift caused by the corresponding O-H...Cl and 0 H...Br hydrogen bonds. Rarely reported trimeric hydrogen bonds （Co3≡O H）3….C1/Br are pointed out to demonstrate the relative weakness of this kind of hydrogen bond which may have a critical effect on the lattice symmetry and magnetic structures.

关键词： Condensed matter: electrical, magnetic and optical Condensed matter: structural, mechanical & thermal

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Preliminary studies on methane flux from the ornithogenic soils on Xi-sha atoll, South China Sea

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Journal of Environmental Sciences 2005年第5期17卷 789-793页

作者： ZHU Ren-bin SUN Li-guang ZHAO San-ping XIE Zhou-qing liu xiao-dong YIN Xue-bin Institute of Polar Environment University of Science and Technology of China Hefei 230026 China

Methane flux from the ornithogenic soils was preliminarily measured by closed chamber method on Xi-sha atoll, South China Sea during March 10 to April 11, 2003 for the first time. The CH4 flux ranged from - 226.7 μg/（m^2 ·h） to 226.3 μg/（m^· h） at the observation sites on dong Island. High atmospheric CH4 consumption was observed from the ornithogenic soils on sunny days. CH4 uptake rates showed the highest value after the midday and they had a strong positive correlation with soil temperatures. Under the same weather conditions, the CH4 fluxes were also observed from the intact and disturbed soils on Yongxing Island. Results showed that the intact soils with natural vegetation also showed high atmospheric CH4 consumption and the average flux was - 141.8 μg/（ m^2· h）. However, disturbed soils via anthropogenic reclamation showed CH4 emissions and the average flux was 441 .7 μg/（ m^2· h）. Therefore land use changes may have an important effect on the CH4 fluxes from the tropical ornithogenic soils. In addition, different observation sites show a high spatial variation in CH4 fluxes. The wetland in salt marsh showed the CH4 emission on dong Island, and the dry soil sites all showed high atmospheric CH4 consumption, suggesting that CH4 fluxes were predominantly controlled by soil water regime. The effects of soil chemical properties on CH4 fluxes were also analyzed and discussed in this paper.

关键词： methane flux South China Sea ornithogenic soil Xi-sha atoll

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明代阴山地区政治变动与移民农业开发

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内蒙古大学学报（哲学社会科学版） 2024年第2期56卷 5-11页

作者：刘晓东北京师范大学历史学院北京100875

明代是阴山地区农业发展的重要阶段。明初在阴山地区实行军事卫所制,设卫兴屯,成为明代内地民人进入阴山地区的重要端始。明中叶,山陕边民、边镇军卒与白莲教徒等内地民人不断进入阴山地区丰州滩等地进行农业垦殖,促进了阴山地区的农业... 详细信息

明代是阴山地区农业发展的重要阶段。明初在阴山地区实行军事卫所制,设卫兴屯,成为明代内地民人进入阴山地区的重要端始。明中叶,山陕边民、边镇军卒与白莲教徒等内地民人不断进入阴山地区丰州滩等地进行农业垦殖,促进了阴山地区的农业发展。隆庆和议后,阴山地区农业生产规模进一步扩大。明代阴山地区政治变动所导致的人口迁移是农业开发的重要动力,因政治形势变化驱动的移民涌入进一步推动了阴山地区的农业生产发展,外来人口迁移规模扩大与阴山地区农业开发进程深化相互作用,为阴山地区的农业生产发展奠定基础。

关键词：阴山地区人口迁移农业开发明代

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Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of Liquorice extract in rats

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Chinese Journal of Natural Medicines 2015年第7期13卷 540-549页

作者： ZHAO Wei-Man JIANG Shu-Wen CHEN Yang ZHONG Ze-Yu WANG Zhong-Jian ZHANG Mian LI Ying XU Ping liu Li liu xiao-dong State Key Laboratory of Natural Medicines Department of Complex Prescription of TCMChina Pharmaceutical University

The present study was designed to investigate the effects of Laminaria japonica(Laminaria) on pharmacokinetics of glycyrrhetinic acid(GA) following oral administration of Liquorice extract in rats.Following oral administrations of single-dose and multi-dose Liquorice extract and Liquorice-Laminaria extract,respectively,plasma samples were obtained at various times and the concentrations of GA,liquiritigenin,and isoliquiritigenin were measured by LC-MS.The effects of Laminaria extract on pharmacokinetics of GA were also investigated,following single-dose and multidose of glycyrrhizic acid(GL).The effects of Laminaria extract on intestinal absorption of GA and GL were studied using the in situ single-pass intestinal perfusion model.The metabolism of GL to GA in the contents of small and large intestines was also studied.The results showed Liquorice-Laminaria extract markedly increased the plasma concentration of GA,accompanied by a shorter Tmax.Similar alteration was observed following multidose administration.However,pharmacokinetics of neither liquiritigenin nor isoliquiritigenin was affected by Laminaria.Similarly,Laminaria markedly increased concentration and decreased Tmax of GA following oral GL were observed.The data from the intestinal perfusion model showed that Laminaria markedly increased GL absorption in duodenum and jejunum,but did not affect the intestinal absorption of GA.It was found that Laminaria enhanced the metabolism of GL to GA in large intestine.In conclusion,Laminaria increased plasma exposures of GA following oral administration of liquorice or GL,which partly resulted from increased intestinal absorption of GL and metabolism of GL to GA in large intestine.

关键词： Pharmacokinetics Liquorice Laminaria japonica Glycyrrhizic acid Glycyrrhetinic acid In situ single-pass intestinal perfusion Intestinal contents

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