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Process Modeling of Ferrofluids Flow for Magnetic Targeting Drug Delivery

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Chinese Journal of Mechanical Engineering 2009年第3期22卷 440-445页

作者： liu Handan WANG shigang XU Wei School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200240 China

Among the proposed techniques for delivering drugs to specific sites within the human body, magnetic targeting drug delivery surpasses due to its non-invasive character and its high targeting efficiency. Although there have been some analyses theoretically for magnetic drug targeting, very few researchers have addressed the hydrodynamic models of magnetic fluids in the blood vessel of human body. This paper presents a mathematical model to describe the hydrodynamics of ferrofluids as drug carriers flowing in a blood vessel under the applied magnetic field. A 3D flow field of magnetic particles in a blood vessel model is numerically simulated in order to further understand clinical application of magnetic targeting drug delivery. Simulation results show that magnetic nanoparticles can be enriched in a target region depending on the applied magnetic field intensity. Magnetic resonance imaging confirms the enrichment of ferrofluids in a desired body tissue of Sprague-Dawley rats. The simulation results coincide with those animal experiments. Results of the analysis provide the important information and can suggest strategies for improving delivery in favor of the clinical application.

关键词： Magnetic targeting drug delivery ferrofluids magnetic nano-particels process modeling hydrodynamics computational fluid dynamics(CFD) numerical simulation Magnetic resonance imaging

Effect of electrolysis voltage on electrochemical reduction of titanium oxide to titanium in molten calcium chloride

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Rare Metals 2007年第6期26卷 547-551页

作者： liu Meifeng LU shigang KAN Surong LI Guoxun General Research Institute for Non-ferrous Metals Beijing 100088 China

The electrochemical reduction of solid TiO2 directly to solid metal is a promising alternative to the current Kroll process. The present work is aimed at studying the effect of electrolysis voltage on the rate of electrochemical reduction. The products of electrochemical reduction of TiO2 and Ti2O were examined using the scanning electron microscopy （SEM） and X-ray diffraction （XRD） techniques. The results show that Ti2O was reduced to low valent titanium oxide at 1.5 -1.7 V, which was the result of ionization of oxygen. TiO2 and Ti20 were reduced to titanium metal at 2.1-3.1 V, which was the co-action of ionization of oxygen and calciothermic reduction. The oxygen content decreased rapidly with voltage increasing from 2.1 to 2.6 V, while it changed little from 2.6 to 3.1 V. The optimized cell voltage was 2.6-3.1 V.

关键词： electrochemical reduction electrolysis voltage molten salt titanium TiO2

MEASUREMENT OF ANGULAR VIBRATION AMPLITUDE BY ACTIVELY BLURRED IMAGES

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Chinese Journal of Mechanical Engineering 2007年第1期20卷 77-81页

作者： GUAN Baiqing WANG shigang liu Chong LI Qian School of Mechanical Engineenng Shanghai Jiaotong University Shanghai 200030 China

A novel motion-blur-based method for measuring the angular amplitude of a high-frequency rotational vibration is schemed. The proposed approach combines the active vision concept and the mechanism of motion-from-blur, generates motion blur on the image plane actively by extending exposure time, and utilizes the motion blur information in polar images to estimate the angular amplitude of a high-frequency rotational vibration. This method obtains the analytical results of the angular vibration amplitude from the geometric moments of a motion blurred polar image and an unblurred image for reference. Experimental results are provided to validate the presented scheme.

关键词： Vibration measurement Rotational vibration Active vision Motion blur Geometric moment

Early life history traits of chub mackerel Scomber japonicus in the Oyashio water revealed by otolith microstructure

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Journal of Oceanology and Limnology 2023年第6期41卷 2444-2450页

作者： Xiaolu LI Chi ZHANG Yongjun TIAN Longshan LIN shigang liu Research Centre for Deep Sea and Polar Fisheries and Key Laboratory of MaricultureMinisty of EducationOcean University of ChinaQingdao 266100China Frontiers Science Center for Deep Ocean Multispheres and Earth System(FDOMES) Ocean University of ChinaQingdao 266100China Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361000China

Information on survival and growth during the early life stage is essential to understand the mechanism of interannual variations in fish *** mackerel Scomber japonicus is a commercially important pelagic fish widely distributed in the northwestern *** catch showed large fluctuations with changes in distribution and migration under climate change and strong *** determined the hatch dates and growth rates of young-of-the-year of chub mackerel through otolith microstructure using samples collected in the Oyashio water in autumn *** show that the ages of young chub mackerel ranged between 120 and 180 d,and the estimated hatch date lasted from midJanuary to late May with a peak from mid-March to *** otolith daily increment width during the early life stages(from hatching to 25 d)showed an increasing *** mackerel grows slowly in the first 10 d,and then grows faster during the 10thto *** groups with dissimilar growth histories and migration routes were identified using unsupervised random forest clustering analysis,but all eventually converge on the same nursery *** faster growth of young-of-the-year chub mackerel leads to better recruitment due to the hypothesis of growth-dependent *** chub mackerels hatched in March and April,the spawning period is longer and earlier,which could lead to strong year *** findings on population composition and life history traits of young-of-the-year of chub mackerel provide valuable information on its recruitment processes during the period of stock recovery.

关键词： Scomber japonicus otolith microstructure growth history unsupervised random forest clustering recruitment

Otolith Shape Analysis as a Tool to Identify Two Pacific Saury(Cololabis saira) Groups from a Mixed Stock in the High-Seas Fishing Ground

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Journal of Ocean University of China 2021年第2期20卷 402-408页

作者： LI Wenjia ZHANG Chi TIAN Yongjun liu Yang liu shigang TIAN Hao CAO Chang College of Fisheries Ocean University of ChinaQingdao 266003China Frontiers Science Center for Deep Ocean Multispheres and Earth System(FDOMES) Ocean University of ChinaQingdao 266100China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and TechnologyQingdao 266237China Marine Biology and Ecology Third Institute of OceanographyMinistry of Natural ResourcesXiamen 361005China

The Pacific saury Cololabis saira is a commercially important pelagic species with wide distribution in the North Pacific Ocean. Previous studies identified two geographical groups by comparing the radius of otolith annual rings(ROA) of the fish collected during the pre-fishing season. Moreover, understanding the group composition in the mixed catch from the fishing ground is essential for sustainable exploitation of this species. Using samples collected during the fishing season(July–November) from 2016 to 2018, the potential of applying otolith shape analysis as a tool to identify these two mixed groups was tested in this research. Two otolith morphotypes that belong to the eastern group and western group were identified by K-means cluster analysis using Fourier coefficients and ROA. The high classification success of random forest further confirmed the effectiveness of otolith shape analysis. The western group accounted for the majority of catch in July and August at 160?E. With the passing of sampling time and fishing fleets moving westward, the proportion of eastern group gradually increased and finally reached more than 60% of the whole catch in November at 150°E. This result suggests that the eastern and western groups are well mixed during spawning migration. In addition, the temporal and spatial dynamics of their catch composition provide information for their migration route. This study is helpful for improving fisheries management and understanding the short-term stock fluctuation of Pacific saury.

关键词： Pacific saury otolith shape analysis geographical group radius of otolith annual ring

A new sensitivity model with blank space for layout optimization

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Journal of Semiconductors 2017年第6期38卷 102-108页

作者： Junping Wang Yao Wu shigang liu Runsen Xing School of Communication Engineering Xidian University Xi'an 710071 China School of Microelectronics Xidian University Xi'an 710071 China

As the technology scales advancing into the nanometer region,the concept of yield has become an increasingly important design *** reduce the yield loss caused by local defects,layout optimization can play a critical *** this paper,we propose a new open sensitivity-based model with consideration of the blank space around the net,and study the corresponding net *** proposed new model not only has a high practicability in the selection of nets to be optimized but also solves the issue of the increase in short critical area brought during the open optimization,which means to reduce the open critical area with no new short critical area produced,and thereby this model can ensure the decrease of total critical area and finally achieves an integrative *** with the models available,the experimental results show that our sensitivity model not only consumes less time with concise algorithm but also can deal with irregular layout,which is out of the scope of other *** the end of this paper,the effectiveness of the new model is verified by the experiment on the randomly selected five metal layers from the synthesized OpenSparc circuit layout.

关键词： blank space critical area missing material defect layout optimization

WIDELY LINEAR RLS CONSTANT MODULUS ALGORITHM FOR COMPLEX-VALUED NONCIRCULAR SIGNALS

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Journal of Electronics(China) 2014年第5期31卷 416-426页

作者： Zhang Ting Wang Bin liu shigang National Digital Switching System Engineering and Technological R&D Center

Based on the constant modulus criterion, a new Widely Linear(WL) blind equalizer and a novel widely linear recursive least square constant modulus algorithm are proposed to improve the blind equalization performance for complex-valued noncircular signals. The new algorithm takes advantage of the WL filtering theory by taking full use of second-order statistical information of the complex-valued noncircular signals. Therefore, the weight vector contains the complete second-order information of the real and imaginary parts to decrease the residual inter-symbol interference effectively. Theoretical analysis and simulation results show that the proposed scheme can significantly improve the equalization performance for complex-valued noncircular signals compared with traditional blind equalization algorithms.

关键词： Complex-valued noncircular signals Blind equalization Widely Linear(WL) filtering Constant modulus

Attacks and defences on intelligent connected vehicles:a survey

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Digital Communications and Networks 2020年第4期6卷 399-421页

作者： Mahdi Dibaei Xi Zheng Kun Jiang Robert Abbas shigang liu Yuexin Zhang Yang Xiang Shui Yu Department of Computing Macquarie UniversitySydneyNSWAustralia China State Key Lab of Automotive Safety and Energy Tsinghua UniversityBeijingChina School of Engineering Macquarie UniversitySydneyNSWAustralia School of Software and Electrical Engineering Swinburne University of TechnologyHawthornVICAustralia School of Software University of Technology SydneyAustralia

Intelligent vehicles are advancing at a fast speed with the improvement of automation and connectivity,which opens up new possibilities for different cyber-attacks,including in-vehicle attacks(e.g.,hijacking attacks)and vehicle-to-everything communicationattacks(e.g.,data theft).These problems are becoming increasingly serious with the development of 4G LTE and 5G communication *** many efforts are made to improve the resilience to cyber attacks,there are still many unsolved *** paper first identifies some major security attacks on intelligent connected ***,we investigate and summarize the available defences against these attacks and classify them into four categories:cryptography,network security,software vulnerability detection,and malware *** challenges and future directions for preventing attacks on intelligent vehicle systems have been discussed as well.

关键词： Intelligent vehicles Vehicular networks Software vulnerabilities Deep learning 3GPP Software defined security

水生甲壳动物硬组织生长带计数鉴龄法研究进展

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渔业研究 2025年第1期47卷 120-128页

作者：彭源王芮张然刘世刚妙星李渊林龙山福建农林大学海洋学院福建福州350002 自然资源部第三海洋研究所福建厦门361005

【背景】甲壳动物是渔业和水产养殖业中一类具有重要商业价值的生物资源。近些年来,由于某些传统渔业的衰退和人类对高蛋白食物需求的增长,甲壳动物如蟹、龙虾、虾、磷虾等资源被大量开发。因此,亟需发展甲壳动物的资源评估和管理工作,... 详细信息

【背景】甲壳动物是渔业和水产养殖业中一类具有重要商业价值的生物资源。近些年来,由于某些传统渔业的衰退和人类对高蛋白食物需求的增长,甲壳动物如蟹、龙虾、虾、磷虾等资源被大量开发。因此,亟需发展甲壳动物的资源评估和管理工作,以维持其资源的可持续发展,但甲壳动物年龄鉴定的困难阻碍了这项工作的开展。目前,鉴定甲壳动物年龄的方法有许多种,主要包括饲养法、标记重捕法、体长频次法、脂褐素分析法、放射性同位素法以及硬组织生长带计数法等,其中硬组织生长带计数法被广泛应用,备受关注。【进展】基于以上背景,本文首先介绍了甲壳动物的生物学特性和硬组织结构,阐述利用硬组织生长带计数法鉴定水生甲壳动物年龄的主要实验过程,与以往水生甲壳动物年龄鉴定方法进行对比,分析该方法的优点和缺点,并对利用硬组织生长带分析水生甲壳动物年龄与生长的研究进展进行回顾,对该方法未来需要进一步解决的问题和发展方向作出展望。【展望】在未来水生甲壳动物年龄鉴定的工作中,需进一步了解生长带沉积机制,准确掌握硬组织生长带的计数,深入分析所获得的实验数据,并开展相关的验证实验等。【意义】本文可为水生甲壳动物的年龄鉴定工作提供一个系统的参考。

关键词：年龄鉴定甲壳动物生长带眼柄胃磨