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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： qi liu Jianye Xie Runxue Zhou Jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

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Association between age at diagnosis of diabetes and ocular disease:Insights from a recent article

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World Journal of Diabetes 2025年第1期16卷 211-216页

作者： Shi-qi liu Dong Wang Cheng-Chun Tang Department of Cardiology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

In this article,we discuss Ye et al's recent article on the association between age at diabetes diagnosis and subsequent risk of age-related ocular *** study,which utilized United Kingdom Biobank data,highlighted a strong link between early diabetes onset and major eye conditions,such as cataracts,glaucoma,agerelated macular degeneration,and vision loss,independent of glycemic control and disease *** finding challenges the previous belief that diabetic eye disease primarily correlates with *** lifestyles evolve and the age of diabetes diagnosis decreases,understanding this relationship may reveal the complex pathogenesis underlying diabetes-related *** editorial summarizes potential mechanisms connecting the age of diabetes onset with four types of ocular diseases,emphasizing the significance of early diagnosis.

关键词： Diabetes Age at diagnosis Cataract Glaucoma Age-related macular disease Vision acuity

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一种新型压配式腰椎椎间融合器的机械性能

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中国组织工程研究 2025年第21期29卷 4492-4498页

作者：李世文于长水刘启王智博刘禹良祁全哈尔滨医科大学附属第一医院黑龙江省哈尔滨市150000

背景:行经皮微创椎间孔腰椎椎间融合置入椎间融合器时,由于入路操作范围狭窄,有牵拉神经根损伤或置入融合器位置不良等风险,为了解决以上问题作者课题组发明了一种新型机械结构可变形压配式cage(Press-fit cage,YP-cage)。目的:对新型... 详细信息

背景:行经皮微创椎间孔腰椎椎间融合置入椎间融合器时,由于入路操作范围狭窄,有牵拉神经根损伤或置入融合器位置不良等风险,为了解决以上问题作者课题组发明了一种新型机械结构可变形压配式cage(Press-fit cage,YP-cage)。目的:对新型腰椎融合器YP-cage的机械强度特性进行初步评估。方法:对不同尺寸9,11,13 mm高度的新型YP-cage(n=9)和聚醚醚酮-cage(n=9)进行了静态轴向压缩实验和静态轴向扭转实验,分别采集力-位移曲线计算屈服位移及载荷、极限载荷位移及刚度,屈服角位移及扭矩、极限载荷角位移扭矩及刚度,并进行对比分析。结果与结论:(1)在静态轴向压缩测试中,YP-cage在3组测试中(9,11,13 mm),其刚度、屈服载荷、极限位移和载荷极限方面均优于聚醚醚酮-cage(P <0.01),但YP-cage的屈服位移小于聚醚醚酮-cage(P <0.05);(2)在静态扭转测试中,除了9 mm组的YP-cage和聚醚醚酮-cage在极限扭转角度上差异无显著性意义,YP-cage在屈服扭矩、屈服扭转角度及极限扭矩均小于聚醚醚酮-cage(P <0.01),而YP-cage扭转刚度在9 mm组和11 mm组大于聚醚醚酮-ccage(P <0.01);(3)结果表明新型压配式机械结构椎间融合器相较于聚醚醚酮材质cage具有更高的抗压强度,但抗扭强度不如聚醚醚酮-cage。

关键词：椎间融合装置经孔椎体间融合术脊柱融合机械性能物理性质

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Joint timing synchronization and frequency offset acquisition algorithm for MIMO OFDM systems

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Journal of Systems Engineering and Electronics 2009年第3期20卷 470-478页

作者： liu qi Hu Bo Dept. of Electronic Engineering Fudan Univ. Shanghai 200433 P. R. China

For multiple-input multiple-output （MIMO） orthogonal frequency division multiplexing （OFDM） systems, a joint timing synchronization and frequency offset acquisition algorithm based on fractional Fourier transform （FRFT） is proposed. The linear frequency modulation signals superimposed on the data signals are used as the training signals. By performing FRFT on the received signals and searching the peak value of the FRFT results, the receiver can realize timing synchronization and frequency offset acquisition simultaneously. Compared with the existing methods, the proposed algorithm can provide better timing synchronization performance and larger frequency offset acquisition range even under multi-path channels with low signal to noise ratio. Theoretical analysis and simulation results prove this point.

关键词： multiple-input multiple-output orthogonal frequency division multiplexing timing synchronization frequency offset acquisition fractional Fourier transform.

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Modeling bubble column reactor with the volume of fluid approach:Comparison of surface tension models

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Chinese Journal of Chemical Engineering 2019年第11期27卷 2659-2665页

作者： qi liu Zhenghong Luo Department of Chemical Engineering College of Chemistry and Chemical EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

This work aims at comparing surface tension models in VOF(Volume of Fluid) modeling and investigating the effects of gas distributor and gas velocity. Hydrodynamics of a continuous chain of bubbles inside a bubble column reactor was simulated. The grid independence study was first conducted and a grid size of 1.0 mm was adopted in order to minimize the computing time without compromising the accuracy of the results. The predictions were validated by comparing the experimental studies reported in the literature. It was found that all surface tension models can describe the bubble rise and bubble plume in a column with slight deviations.

关键词： Bubble column reactor Computational fluid dynamics Volume of fluid method Surface tension models Gas distributor

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A Dual-spline Approach to Load Error Repair in a HEMS Sensor Network

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Computers, Materials & Continua 2018年第11期57卷 179-194页

作者： Xiaodong liu qi liu School of Computing Edinburgh Napier University10 Colinton RoadEdinburgh EH105DTUK

In a home energy management system(HEMS),appliances are becoming diversified and intelligent,so that certain simple maintenance work can be completed by appliances *** the measurement,collection and transmission of electricity load data in a HEMS sensor network,however,problems can be caused on the data due to faulty sensing processes and/or lost links,*** order to ensure the quality of retrieved load data,different solutions have been presented,but suffered from low recognition rates and high *** this paper,a validation and repair method is presented to detect potential failures and errors in a domestic energy management system,which can then recover determined load errors and losses.A Kernel Extreme Learning Machine(K-ELM)based model has been employed with a Radial Basis Function(RBF)and optimised parameters for verification and recognition;whilst a Dual-spline method is presented to repair missing load *** to the experiment results,the method outperforms the traditional B-spline and Cubic-spline methods and can effectively deal with unexpected data losses and errors under variant loss rates in a practical home environment.

关键词： Electric load data analysis home energy management quality assurance and control

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A time-over-threshold technique for PMT signals processing

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Nuclear Science and Techniques 2007年第3期18卷 164-171页

作者： liu Xuzong liu Shubin AN qi Fast Electronics Lab Modern Physics Department University of Science and Technology of China Hefei 230026 China

A novel front-end circuit designed for PMT signals processing considering the solution of "Time Walk" correction is discussed in this paper. We are trying to apply the TOT (Time over Threshold) technique to our research. Different from traditional ways, where amplitude is measured, time width is measured for slew correction here, which takes the advantage of TDC. Expensive fast ADCs are abandoned and the whole time measurement electronics design becomes more effective and economical. Test boards have been developed and a convenient method is introduced to evaluate our TOT technique. Results have shown that a 10ps slew correction resolution is achieved throughout the amplitude range from -108mV to -2000mV for negative signals of both 5 ns leading and trailing edge with 10 ns 50%-50% pulse width.

关键词：光电倍增管脉冲时间测量回转修正

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Jointly Recommending Library Books and Predicting Academic Performance： A Mutual Reinforcement Perspective

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Journal of Computer Science & Technology 2018年第4期33卷 654-667页

作者： De-Fu Lian qi liu School of Computer Science and Engineering University of Electronic Science and Technology of China Chengdu 611731 China School of Computer Science and Technology University of Science and Technology of China Hefei 230022 China

The prediction of academic performance is one of the most important tasks in educational data mining, and has been widely studied in massive open online courses （MOOCs） and intelligent tutoring systems. Academic performance can be affected by factors like personality, skills, social environment, and the use of library books. However, it is still less investigated about how the use of library books can affect the academic performance of college students and even leverage book-loan history for predicting academic performance. To this end, we propose a supervised content-aware matrix factorization for mutual reinforcement of academic performance prediction and library book recommendation. This model not only addresses the sparsity challenge by explainable dimension reduction techniques, but also quantifies the importance of library books in predicting academic performance. Finally, we evaluate the proposed model on three consecutive years of book-loan history and cumulative grade point average of 13 047 undergraduate students in one university. The results show that the proposed model outperforms the competing baselines on both tasks, and that academic performance not only is predictable from the book-loan history but also improves the recommendation of library books for students.

关键词： book-borrowing record educational data mining matrix factorization multi-task learning student performance prediction transfer learning

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Stress-state dependence of dynamic strain aging:Thermal hardening and blue brittleness

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 854-866页

作者： Wen-qi liu Jun-he Lian Advanced Manufacturing and Materials Department of Mechanical EngineeringAalto UniversityPuumiehenkuja 302150 EspooFinland Impact and Crashworthiness Lab Department of Mechanical EngineeringMassachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139-4307USA

This study aims to discover the stress-state dependence of the dynamic strain aging(DSA)effect on the deformation and fracture behavior of high-strength dual-phase(DP)steel at different deformation temperatures(25-400°C)and reveal the damage mechanisms under these various *** achieve different stress states,predesigned specimens with different geometric features were *** electron microscopy was applied to analyze the fracture modes(e.g.,dimple or shear mode)and underlying damage mechanism of the investigated *** is present in this DP steel,showing the Portevin-Le Chatelier(PLC)effect with serrated flow behavior,thermal hardening,and blue brittleness *** show that the stress state contributes distinctly to the DSA effect in terms of the magnitude of thermal hardening and the pattern of blue *** low stress triaxiality or Lode angle parameter promotes DSA-induced blue ***,the damage mechanisms also show dependence on the stress states in conjunction with the DSA effect.

关键词： dynamic strain aging effect Portevin-Le Chatelier effect damage mechanism dimple fracture shear fracture dual-phase steel

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Difference analysis in terahertz wave propagation in thermochemical nonequilibrium plasma sheath under different hypersonic vehicle shapes

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Chinese Journal of Aeronautics 2023年第10期36卷 137-151页

作者： Wenchong OUYANG qi liu Zhengwei WU School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Joint Laboratory of Plasma Application Technology Institute of Advanced TechnologyUniversity of Science and Technology of ChinaHefei 230031China CAS Key Laboratory of Geospace Environment University of Science and Technology of ChinaHefei 230026China

Research on terahertz communication under different vehicles has important guiding significance for the design of future hypersonic vehicle and Radio Frequency(RF)*** this paper,a joint simulation model of plasma flow under thermochemical nonequilibrium state and terahertz transmission is developed to investigate the differences in terahertz wave transmission characteristics under different vehicle shapes and the related *** comparing the plasma sheath characteristics and terahertz transmission among HIFIRE-5b(Hypersonic International Flight Research Experimentation-5b),RAM C(Radio Attenuation Measurement C)and ARD(Atmospheric Reentry Demonstrator)vehicles,it is found that the sheath thickness and electron density of ARD vehicles is significantly larger than that of HIFIRE-5b and RAM C vehicles,resulting in greater terahertz wave *** absorption plays a major role in the terahertz attenuation of vehicles,and the contribution of reflection effects is only observed in the ARD vehicle due to its larger plasma sheath thickness and spatial structure *** on the above comparison results,a shape design scheme of reducing the vehicle head and tail for mitigating RF blackout is proposed,and the scheme is proved by further analyzing the effects of different vehicle heads and tails on the terahertz *** the decrease of the head radius and tail width of hypersonic vehicle,the wave attenuation at the same terahertz frequency decreases,and the contribution of reflection effect to wave attenuation gradually ***,the shape design scheme of reducing the vehicle head and tail can effectively alleviate the RF blackout problem,which provides an important reference value for future hypersonic vehicle design.

关键词： Hypersonic vehicles Plasma flow Plasma sheaths Shape optimization Terahertz waves Wave propagation

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