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Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo

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Light(Science & Applications) 2024年第9期13卷 1878-1887页

作者： Yang Lu Xu Zhao Dongmei Yan Yingqian mi Peng Sun Xu Yan Xiaomin liu Geyu Lu State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University130012 ChangchunChina Department of Immunology College of Basic Medical SciencesJilin University130021 ChangchunChina

Chiral assemblies have become one of the most active research areas due to their versatility,playing an increasingly important role in bio-detection,imaging and *** this work,chiral UCNPs/CuxOS@ZIF nanoprobes are prepared by encapsulating upconversion nanoparticles(UCNPs)and CuxOS nanoparticles(NPs)into zeolitic imidazolate framework-8(ZIF-8).The novel excited-state energy distribution-modulated upconversion nanostructure(NaYbF4@-NaYF4:Yb,Er)is selected as the fluorescence source and energy donor for highly efficient fluorescence resonance energy transfer(FRET).CuxOS NP is employed as chiral source and energy acceptor to quench upconversion luminescence(UCL)and provide circular dichroism(CD)*** the natural adsorption and sorting advantages of ZIF-8,the designed nanoprobe can isolate the influence of other common disruptors,thus achieve ultra-sensitive and highly selective UCL/CD dual-mode quantification of H2S in aqueous solution and in living ***,the nanoprobe is also capable of in vivo intra-tumoral H2S *** work highlights the multifunctional properties of chiral nanocomposites in sensing and opens a new vision and idea for the preparation and application of chiral nanomaterials in biomedical and biological analysis.

关键词： chiral sulfide donor

Latest assessment methods for mitochondrial homeostasis in cognitive diseases

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Neural Regeneration Research 2024年第4期19卷 754-768页

作者： Wei You Yue Li Kaixi liu Xinning mi Yitong Li Xiangyang Guo Zhengqian Li Department of Anesthesiology Peking University Third Hospital Peking University Third Clinical Medical College Beijing Center of Quality Control and Improvement on Clinical Anesthesia Anesthesia and Perioperative Medicine Branch of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

mitochondria play an essential role in neural function,such as supporting normal energy metabolism,regulating reactive oxygen species,buffering physiological calcium loads,and maintaining the balance of morphology,subcellular distribution,and overall health through mitochondrial *** the recent technological advances in the assessment of mitochondrial structure and functions,mitochondrial dysfunction has been regarded as the early and key pathophysiological mechanism of cognitive disorders such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,mild cognitive impairment,and postoperative cognitive *** review will focus on the recent advances in mitochondrial medicine and research methodology in the field of cognitive sciences,from the perspectives of energy metabolism,oxidative stress,calcium homeostasis,and mitochondrial dynamics(including fission-fusion,transport,and mitophagy).

关键词： cognitive disorders mitochondrial dysfunction mitochondrial energy metabolism mitochondrial dynamics mitochondrial transport mitophagy mitochondrial biogenesis oxidative stress calcium homeostasis

A novel Tb^(3+) and Eu^(3+) co-doped dual-emitting phosphate K_(3)SrBi(P_(2)O_(7))_(2) phosphor for application in FIR thermometers

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Journal of Rare Earths 2024年第3期42卷 455-463,I0001页

作者： Baochen Wang Shifeng Sun Zeqi Li Zongwang Li Weiwei Lin Chao Zeng Yan-gai liu Ruiyu mi School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhu241000China State-Province Joint Engineering Laboratory of Zeolite Membrane Materials Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationInstitute of Advanced MaterialsCollege of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China Beijing Key Laboratory of Materials Utilization of Nonmetallic minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of GeosciencesBeijing100083China

Rare earth co-doped phosphor for fluorescence intensity ratio(FIR) thermometer has gained increasing attention in recent years. Herein, the novel Tb^(3+)and Eu^(3+)co-doped K_(3)SrBi(P_(2)O_(7))_(2)(KSBP) phosphate phosphors were reported. The crystal structure of the title phosphor was determined using Rietveld refinement and proved to have a three-dimensional structure. The time-resolved spectroscopy reveals that there is almost no energy transfer between Tb^(3+)and Eu^(3+). More importantly, Tb^(3+)and Eu^(3+)emissions show different thermal quenching behaviors, which claims the potential of this material for application in optical thermometer. The FIR of the typical KSBP:0.02Tb^(3+),0.04Eu^(3+)sample demonstrates a polynomial relationship as a function of temperature and the absolute and relative sensitivity are0.025 K^(-1) and 0.59%/K, respectively. In general, our study reports a novel and potential KSBP:Tb^(3+),Eu^(3+)phosphate phosphor that is promising for use in high-sensitive FIR thermometers.

关键词： Phosphor Thermometer Fluorescence intensity ratio Thermal stability Rare earths

Gut microbiota-derived short-chain fatty acids and depression:deep insight into biological mechanisms and potential

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General Psychiatry 2024年第1期37卷 17-32页

作者： Junzhe Cheng Hongkun Hu Yumeng Ju Jin liu mi Wang Bangshan liu Yan Zhang Department of Psychiatry National Clinical Research Center for Mental DisordersSecond Xiangya Hospital of Central South UniversityChangshaHunanChina Clinical Medicine Eight-Year Program Xiangya School of MedicineCentral South UniversityChangshaHunanChina Mental Health Institute of Central South University China National Technology Institute on Mental DisordersHunan Key Laboratory of Psychiatry and Mental HealthHunan Medical Center for Mental HealthChangshaHunanChina Department of Mental Health Center Xiangya Hospital of Central South UniversityChangshaHunanChina

The gut microbiota is a complex and dynamic ecosystem known as the second brain'.Composing the microbiota-gut-brain axis,the gut microbiota and its metabolites regulate the central nervous system through neural,endocrine and immune pathways to ensure the normal functioning of the organism,tuning individuals'health and disease ***-chain fatty acids(SCFAs),the main bioactive metabolites of the gut microbiota,are involved in several neuropsychiatric disorders,including *** have essential effects on each component of the microbiota-gut-brain axis in *** the present review,the roles of major SCFAs(acetate,propionate and butyrate)in the pathophysiology of depression are summarised with respect to chronic cerebral hypoperfusion,neuroinflammation,host epigenome and neuroendocrine *** remarks on the biological mechanisms related to gut microbiota will hopefully address the clinical value of microbiota-related treatments for depression.

关键词： alterations inflammation perfusion

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气候变化情景下中国金荞麦适生区变化分析

中国农业气象 2024年第8期45卷 835-848页

作者：张保得谢准马玉珊赵艳丽韦春冕符莹莹刘米徐福荣云南中医药大学昆明650500

基于MaxEnt生态位模型和ArcGIS技术,以中国金荞麦为研究对象,结合全国137条金荞麦有效分布点和32项环境因子进行适生区分析,筛选金荞麦适宜生长的关键环境因子,并预测末次盛冰期(The last glacial maximum,LGM)、全新世中期(The mid hol... 详细信息

基于MaxEnt生态位模型和ArcGIS技术,以中国金荞麦为研究对象,结合全国137条金荞麦有效分布点和32项环境因子进行适生区分析,筛选金荞麦适宜生长的关键环境因子,并预测末次盛冰期(The last glacial maximum,LGM)、全新世中期(The mid holocene,MH)、当前(Current)和未来时期(2041-2060年,2050s;2061-2080年,2070s)3种不同温室气体排放情景金荞麦适宜区域的地理空间格局变化及质心迁移。结果表明:评价MaxEnt模型的指标训练和测试数据的AUC为0.928±0.005和0.916±0.027,模型模拟精度较高。制约金荞麦生态适宜分布的9个环境因子及阈值为年平均降水量(915~1899mm)、最冷月最低温度(-2.4~6.9℃)、温度季节变化系数(3031~6319)、海拔(61~357.2m,1540~3408m)、昼夜温差月均值(7.5~10.9℃)、7月平均风速(0.6~1.9m·s^(−1))、最暖季度平均降水量(506.8~1060.9mm)、4月平均风速(0.5~2.3m·s^(−1))和降水量季节变化方差(45.4~84.9)。从末次盛冰期到未来时期,金荞麦适生区呈逐渐增加趋势,尤以未来温室气体中高排放情景下扩张幅度较大,最大扩张面积达到45.93×10^(4)km^(2),扩张区域主要集中在横断山脉附近和秦岭-淮河一带。气候变化情景下金荞麦适生区质心呈高纬度、高海拔迁移趋势。

关键词：金荞麦 MaxEnt模型气候变化适生区变化

艾灸神阙穴对原发性痛经模型大鼠的作用及其机理

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中医药导报 2024年第5期30卷 24-28,70页

作者：邝敏何清湖胡宗仁刘密沈敬国黄文静王久源湖南中医药大学湖南长沙410208 湖南医药学院湖南怀化418000 广州百家灸生物科技有限公司广东广州510000

目的:探究艾灸神阙穴对原发性痛经模型大鼠的作用及其机制。方法:通过阴道涂片实验确定大鼠动情周期后使用苯甲酸雌二醇联合缩宫素制备原发性痛经大鼠模型。通过观测原发性痛经大鼠体质量、脏器指数、扭体潜伏期和扭体分数变化,检测各... 详细信息

目的:探究艾灸神阙穴对原发性痛经模型大鼠的作用及其机制。方法:通过阴道涂片实验确定大鼠动情周期后使用苯甲酸雌二醇联合缩宫素制备原发性痛经大鼠模型。通过观测原发性痛经大鼠体质量、脏器指数、扭体潜伏期和扭体分数变化,检测各组大鼠血清性激素、前列腺素和疼痛因子等各项指标水平,比较艾灸治疗原发性痛经大鼠药效差异,其艾灸种类包括有烟艾灸与无烟艾灸。结果:在大鼠一般情况和行为学测试观察中,模型组比空白组扭体反应显著增加(P<0.01),表明造模成功;而与模型组比较,两个艾灸组大鼠体质量减轻相对缓慢,扭体潜伏期显著增加,扭体反应显著减少(P<0.05),其中有烟艾灸组和无烟艾灸组、阳性药物组大鼠扭体抑制率分别为54.89%、37.21%、68.82%。与模型组比较,两个艾灸组大鼠血清中雌二醇、缩宫素、前列腺素F_(2α)、白介素-6浓度均显著降低(P<0.05),前列腺素E_(2)和β-内啡肽水平显著升高(P<0.05)。结论:艾灸大鼠神阙穴能够有效缓解原发性痛经,调节机体性激素、前列腺素和疼痛相关因子可能是其潜在的作用机制。

关键词：原发性痛经艾灸神阙穴大鼠机制研究

Noncovalent cross-linked engineering hydrogel with low hysteresis and high sensitivity for flexible self-powered electronics

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Journal of Energy Chemistry 2024年第7期94卷 136-147页

作者： Hang Yuan Shaowei Han Jia Wei Songwei Li Peipei Yang Hao-Yang mi Chuntai liu Changyu Shen National Engineering Research Center for Advanced Polymer Processing Technology Key Laboratory of Materials Processing and Mold(Ministry of Education)Zhengzhou UniversityZhengzhou450002HenanChina Yunnan TobaccoQuality Inspection&Supervision Station Kunming 650106YunnanChina

In this study,the hydrogel network was reinforced by covalent-like hydrogen bonding,and the strong binding ability of boron-nitrogen coordination served as the main driving *** them,acrylamide(AM)and 3-acrylamidophenylboronic acid(AAPBA)were the main body,and the numerous hydroxyl groups in the trehalose(Treh)molecule and other polymer groups formed strong hydrogen bonding interactions to improve the mechanical properties of the PAM/PAAPBA/Treh(PAAT)hydrogel and ensured the simplicity of the synthesis *** hydrogel possessed high strain at break(1239%),stress(64.7 kPa),low hysteresis(100%to 500%strain,corresponding to dissipation energy from 1.37 to 7.80 kJ/m^(3)),and outstanding cycling stability(retained more than 90%of maximum stress after 200 ten-sile cycles).By integrating carbon nanotubes(CNTs)into PAAT hydrogel(PAATC),the PAATC hydrogel with excellent strain response performance was successfully *** PAATC conductive hydro-gel exhibited high sensitivity(gauge factor(GF)=10.58 and sensitivity(S)=0.304 kPa^(-1)),wide strain response range(0.5%-1000%),fast response time(450 ms),and short recovery time(350 ms),excellent fatigue resistance,and strain response ***,the PAATC-based triboelectric nanogener-ator(TENG)displayed outstanding energy harvesting performance,which shows its potential for appli-cation in self-powered electronic devices.

关键词： Low hysteresis Covalent-like hydrogen bonding Boron-nitrogen coordination Hydrogel sensor Triboelectric nanogenerator

Classification of tight sandstone reservoirs based on NMR logging

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Applied Geophysics 2019年第4期16卷 549-558,562页

作者： Li Chang-Xi liu mi Guo Bin-Cheng Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China Petroleum Exploration and Production Research Institute SINOPECBeijing 100083China.

The traditional reservoir classification methods based on conventional well logging are inefficient for determining the properties,such as the porosity,shale volume,J function,and flow zone index,of the tight sandstone reservoirs because of their complex pore structure and large ***,the method that is commonly used to characterize the reservoir pore structure is dependent on the nuclear magnetic resonance(NMR)transverse relaxation time(T2)distribution,which is closely related to the pore size ***,the pore structure parameters(displacement pressure,maximum pore-throat radius,and median pore-throat radius)can be determined and applied to reservoir classification based on the empirical linear or power function obtained from the NMR T2 distributions and the mercury intrusion capillary pressure ***,the effective generalization of these empirical functions is difficult because they differ according to the region and are limited by the representative samples of different regions.A lognormal distribution is commonly used to describe the pore size and particle size distributions of the rock and quantitatively characterize the reservoir pore structure based on the volume,mean radius,and standard deviation of the small and large *** this study,we obtain six parameters(the volume,mean radius,and standard deviation of the small and large pores)that represent the characteristics of pore distribution and rock heterogeneity,calculate the total porosity via NMR logging,and classify the reservoirs via cluster analysis by adopting a bimodal lognormal distribution to fit the NMR T2 ***,based on the data obtained from the core tests and the NMR logs,the proposed method,which is readily applicable,can effectively classify the tight sandstone reservoirs.

关键词： nuclear magnetic resonance(NMR) tight sandstone pore structure lognormal distribution cluster analysis reservoir classification

Exploration of IRES Elements within the ORF of the Coxsackievirus B3 Genome

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Biomedical and Environmental Sciences 2022年第4期35卷 322-333页

作者： SONG Qin Qin LUO Xiao Nuan SHI Bing Tian liu mi SONG Juan XIA Dong XIA Zhi Qiang WANG Wen Jun YAO Hai Lan HAN Jun State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Molecular Immunology Laboratory Capital Institute of PediatricsBeijing 100020China

Objective This study aimed to identify internal ribosome entry sites(IRESs)in the open reading frame(ORF)of the Coxsackievirus B3(CVB3)*** The sequences of P1,P2,or P3 of the CVB3 genome or the truncated sequences from each antithymocyte globulin(ATG)to the end of the P1,P2,or P3 gene were inserted into the *** transfection,possible IRES-dependent green fluorescent protein(GFP)-fused proteins were detected by anti-GFP western *** sequences of possible IRESs were inserted into specific Fluc/Rluc bicistronic vectors,in which the potential IRESs were determined according to the Fluc/Rluc activity *** of Fluc and Rluc mRNA of the bicistronic vector was detected by *** After transfection of full length or truncated sequences of the P1,P2,or P3 plasmids,six GFPfused protein bands in P1,six bands in P2 and nine bands in P3 were detected through western *** IRESs in VP2(1461–1646 nt)and VP1(2784–2983 nt)of P1;one IRES in 2C(4119–4564 nt)of P2;and two IRESs in 3C(5634–5834 nt)and 3D(6870–7087 nt)of P3 were identified according to Fluc/Rluc activity *** cryptic promoter was also excluded by *** Five IRESs are present in the CVB3 coding region.

关键词： CVB3 ORF P1 P2 P3 IRESs