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Association between Serum Alkaline Phosphatase and Carotid Atherosclerosis in a Chinese Population: A Community-based Cross-sectional Study

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Biomedical and Environmental Sciences 2019年第6期32卷 446-453页

作者： YE Yi Cong liu hua min ZHOU Yong ZENG Yong Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing Anzhen Hospital Capital Medical University Beijing 100029 China School of public health Taishan Medical University Tai'an 271016 Shandong China Sanbo Brain Institute Sanbo Brain Hospital Capital Medical University Beijing 100029 China

Objective This study aimed to investigate the relationship between alkaline phosphatase(ALP) and common carotid intima media thickness(IMT), carotid plaque, and extracranial carotid artery stenosis(ECAS). Methods A total of 3,237 participants aged ≥ 40 years were recruited from Jidong community in 2013-2014. Participants were divided into five quintile groups based on their serum ALP levels. Carotid atherosclerosis was assessed using ultrasound. Abnormal IMT, carotid plaque, and ECAS were defined as IMT > 0.9 mm, IMT > 1.5 mm, and ≥ 50% stenosis in at least one extracranial carotid artery, respectively. Results Common carotid IMT values and the prevalence of carotid plaque increased across serum ALP quintiles. Higher ALP quintiles were correlated with an increased risk of abnormal IMT [fourth quintile: odds ratio(OR) 1.78, 95% confidence interval(CI) 1.13-2.82, P = 0.0135;fifth quintile: OR = 1.82, 95% CI: 1.15-2.87, P = 0.0110] and ECAS compared to the lowest quintile(fifth quintile: OR = 1.47, 95% CI: 1.09-1.97, P = 0.0106). The association between ALP and prevalence of carotid plaque became insignificant after adjustment for confounders. Conclusion Serum ALP levels were independently associated with abnormal common carotid IMT and ECAS. These conclusions need to be further corroborated in future prospective cohort studies.

关键词： Alkaline phosphatase Atherosclerosis Intima media thickness Carotid plaque Extracranial carotid artery stenosis

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Effect of Body Mass Index on the Associations between Parity and Metabolic Syndrome and its Components among Northern Chinese Women

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Biomedical and Environmental Sciences 2020年第1期33卷 11-18页

作者： YAO Yan liu hua min WANG Xian Wei FENG Xia GAO Li Jian LI Dong ZHOU Yong Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesTai'an 271016ShandongChina Eye Hospital Wenzhou Medical UniversityWenzhou 325027ZhejiangChina Center for Coronary Heart Disease Department of CardiologyCardiovascular Institute&Fuwai HospitalNational Center for Heart DiseaseBeijing 100037China

Objectives The aims of this study were to assess the associations between parity and metabolic syndrome(Met S)and its components and to evaluate the effects of body mass index(BMI)on these *** A total of 5,674 women were enrolled from Jidong and Kailuan communities(Tangshan,Hebei)in Northern *** participants completed standardized questionnaires,physical examination,and biochemical *** regression analysis was used to test the *** Compared with women with parity of one,nulliparous women had decreased odds ratios(ORs);those with parity of two had odds of abdominal obesity[OR=1.45,95%confidence interval(CI)1.17–1.81,P<0.001],high blood pressure(OR=1.26,95%CI:1.03–1.54,P=0.025),elevated fasting glucose levels(OR=1.36,95%CI:1.03–1.79,P=0.029),and Met S(OR=1.39,95%CI:1.13–1.73,P=0.002);and those with parity of three or more had increased odds of elevated triglyceride levels(OR=1.42,95%CI:1.04–1.94,P=0.027)and Met S(OR=1.50,95%CI:1.10–2.05,P=0.011)after complete adjustment for ***,BMI and age subgroups partially modified the associations between parity and Met S and its *** Parity is positively associated with Met S and select components in *** is an important modifier involved in the associations between parity and MetS.

关键词： Parity Metabolic syndrome BMI Risk factor Association

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Association between Parity, Carotid Plaques, and Intima Media Thickness in Northern Chinese Women

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Biomedical and Environmental Sciences 2021年第5期34卷 416-420页

作者： YAO Yan liu hua min FENG Xia LI Dong ZHOU Yong ZHANG Zhi Hui Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesTai'an 271016ShandongChina Clinical Research Institute Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Cardiology the Third Xiangya Hospital of Central South UniversityChangsha 410013HunanChina

Pregnancy is always associated with several important physiological changes in women,including sex hormone levels,glycolipid metabolism,and oxidative *** changes may have short-term and long-term effects on their cardiovascular *** is the number of times a woman has given *** studies have investigated the association between parity and risk of cardiovascular diseases in *** studies have shown a fairly low incidence of cardiovascular endpoints for parous women[1].Therefore,it would be meaningful to assess the relationship between parity and other surrogate markers.

关键词： parity meaningful oxidative

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Protocol of Jidong Women Health Cohort Study: Rationale, Design, and Baseline Characteristics

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Biomedical and Environmental Sciences 2019年第2期32卷 144-152页

作者： QIU Meng Si WANG Xian Wei YAO Yan GE Si Qi liu hua min DAI Ying Chun ZHOU Yong Department of Epidemiology School of Public Health Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research) Sanbo Brain Institute Sanbo Brain Hospital Capital Medical University Department of Cardiology Beijing Anzhen Hospital Capital Medical University Department of Neuroepidemiology Beijing Neurosurgical Institute Capital Medical University School of Public Health Taishan Medical University

Objective The Jidong Women Health Cohort Study is a prospective cohort study on female-specific characteristics and risks of chronic diseases in Chinese women and focuses on the potential association between menopause and risks of cardiovascular disease(CVD). Methods The study includes 4,179 female participants with an age of older than 18 years from Caofeidian district, Tangshan city, northern China. Baseline information on female-specific characteristics and potential cardiovascular risk factors was collected and all the participants underwent a physical examination with blood samples collected in 2013. To establish a better risk assessment tool of female CVD, updated information from questionnaire investigation, physical examinations and occurrence of outcome events will be collected through a longitudinal follow-up annually up to the year 2024. Results At baseline, Mean age of the participants was 42.3 ± 12.8 years. Reproduction occurred in 2,948 participants(70.5%), menopausal transition in 173(4.3%), and postmenopause in 1,058(25.3%). The incidence of arterial hypertension, dyslipidemia, and diabetes showed significant difference across different groups stratified by Stage of Reproductive Aging Workshop(STRAW) system(P < 0.05). Conclusion The Jidong Women Health Cohort Study will contribute to the scientific evidence on association between female-specific characteristics and cardiovascular risks, and will also be helpful to provide a new path for early detection and prevention of CVD.

关键词： Cardiovascular disease Menopause Women Protocol Chinese population-based

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Association between Metabolic Syndrome and Carotid Atherosclerosis: A Cross-sectional Study in Northern China

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Biomedical and Environmental Sciences 2019年第12期32卷 914-921页

作者： ZHOU Ping An ZHANG Chen huan CHEN Yan Ru LI Dong SONG Dai Yu liu hua min ZHOU ming Yue SONG Guo Shun CHEN Sheng Yun Department of Ultrasound Yan'an University Affiliated HospitalYan'an 716000ShanxiChina Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesMedical College of Soochow UniversitySuzhou 215123JiangsuChina School of public health Shandong First Medical University&Shandong Academy of Medical SciencesTai'an 271016ShandongChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Staff Hospital of Chinese National Petroleum Jidong Oilfield IncTangshan 063200HebeiChina Stroke center Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China

Objective Increased carotid artery intima-media thickness(CIMT)and carotid plaque as manifestations of carotid atherosclerosis have been used as markers of cardiovascular disease(CVD).The components of metabolic syndrome(Met S)are linked to CVD,but the association between Met S and CVD is *** A total of 8,933 Chinese adults aged 40 years or older from 2010 to 2014 were selected from the Jidong and Kailuan *** S was defined by the International Diabetes Federation *** and carotid plaque were measured using color Doppler *** regression models were used to assess the association of Met S with carotid plaque and *** Met S was found among 3,461(3,461/8,933)*** odds ratio and 95%confidence internal(CI)for carotid plaques in participants with Met S was 1.16(1.03-1.30).The risk of carotid plaques increased with the number of Met S *** average CIMT was higher in participants with Met S(β=0.020,95%CI,0.014-0.027)and in participants with more Met S *** Individuals with Met S are at an increased risk for carotid atherosclerosis compared to those without MetS.

关键词： Metabolic syndrome Components Carotid atherosclerosis Intima-media thickness

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Concurrence of Bartter syndrome and minimal change nephrotic syndrome

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Chinese Medical Journal 2009年第15期122卷 1834-1838页

作者： SHEN Hui-jun DAI Yu-wen MAO Jian-hua liu Ai-min Department of Nephrology Children's Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China

Nephrotic syndrome （NS） is a common disease in children with a group of symptoms including heavy proteinuria （≥50 mg/kg per 24 hours）, hypoalbuminaemia, hypercholesterolaemia and edema. Bartter syndrome （BS） is a clinically and genetically heterogenous kidney disease characterized by hypokalemia, hypochloremic metabolic alkalosis, obvious increase of rennin, angiotesin II, and normal blood pressure. Cases of Banter syndrome were frequently reported in recent years, but the Bartter syndrome accompanied by nephrotic syndrome as the first symptom has not been previously reported. Although BS is not classically associated with proteinuria, there have been a few reported cases of concomitant focal segmental glomerulosclerosis （FSGS） with BS.1-6 Recently, Hanevold et al5 and Sardani et al7 respectively described an African American child with BS and proteinuria whose renal biopsy revealed findings consistent with Clq nephropathy （ClqN）, as well as the expected hyperplasia of the juxtaglomerular apparatus （JGA） which is characteristic of BS. It was previously reported that BS was first diagnosed, and then gradually proteinuria followed, but the simultaneous presence of BS and NS is unusual. We herein present a boy with BS and NS whose renal biopsy revealed findings consistent with glomeruli minimal change disease and BS.

关键词： Bartter syndrome nephrotic syndrome, children

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基于信息熵的多传感器数据分类方法

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控制与决策 2006年第4期21卷 410-414,420页

作者：刘敏华萧德云清华大学自动化系北京100084

在回顾数据分类和信息熵的基础上,提出了基于信息熵的多传感器数据分类方法.该方法根据传感器数据自熵和互熵的关系实现冲突、冗余和补充的数据分类,建立多传感器数据分类结构并进行分类融合.实例分析说明了这种数据分类方法的合理性和... 详细信息

在回顾数据分类和信息熵的基础上,提出了基于信息熵的多传感器数据分类方法.该方法根据传感器数据自熵和互熵的关系实现冲突、冗余和补充的数据分类,建立多传感器数据分类结构并进行分类融合.实例分析说明了这种数据分类方法的合理性和分类融合的有效性.

关键词：信忠熵多传感器融合多传感器数据分类

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基于证据理论的多传感器加权融合

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数据采集与处理 2005年第4期20卷 407-410页

作者：刘敏华萧德云清华大学自动化系北京100084

多传感器数据融合多基于证据理论进行加权,但识别框架确定和基本可信度分配是关键。本文简述了证据理论并分析了总均方误差最小意义下加权融合的缺点,在引入抽象传感器的基础上,根据M函数的区间覆盖次数进行基本可信度分配,确定对历史... 详细信息

多传感器数据融合多基于证据理论进行加权,但识别框架确定和基本可信度分配是关键。本文简述了证据理论并分析了总均方误差最小意义下加权融合的缺点,在引入抽象传感器的基础上,根据M函数的区间覆盖次数进行基本可信度分配,确定对历史数据和各个传感器的支持度,然后进行加权融合。仿真表明,这种基于证据理论的多传感器加权融合方法只需要很少的先验信息,但具有较好的融合效果和鲁棒性。

关键词：多传感器融合证据理论抽象传感器先验信息

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基于趋势分析和SDG模型的故障诊断

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控制理论与应用 2006年第2期23卷 306-310页

作者：刘敏华萧德云清华大学自动化系北京100084

基于趋势分析的故障诊断受数据影响较大,基于定向符号图(signed d irected graph)模型的故障诊断难于建模和推理,而两者结合以提高故障诊断效果的方法还未被考虑.本文将趋势分析的趋势信息和SDG模型的节点信息进行了比较,阐明了两者信... 详细信息

基于趋势分析的故障诊断受数据影响较大,基于定向符号图(signed d irected graph)模型的故障诊断难于建模和推理,而两者结合以提高故障诊断效果的方法还未被考虑.本文将趋势分析的趋势信息和SDG模型的节点信息进行了比较,阐明了两者信息互补的特点,然后利用趋势分析建立SDG模型,并利用SDG模型改进基于趋势分析的故障诊断,建立了数据驱动方法和基于模型方法相结合的故障诊断方法.CSTR(continuous stirred-tankreactor)实例分析表明,基于趋势分析和SDG模型的故障诊断方法提高了诊断的准确性和精确性.

关键词：故障诊断定向符号图趋势分析

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丙三醇溶液液滴形成过程的数值模拟

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北京工业大学学报 2008年第1期34卷 14-19页

作者：刘赵淼刘华敏金艳梅北京工业大学机械工程与应用电子技术学院北京100022

为了更为精确地研究液滴的形成和下落过程,对不同质量分数丙三醇溶液液滴的形成进行了数值模拟,得到的水滴形成过程与实验结果非常吻合、对不同的溶液液滴的长度、形成时间以及体积进行模拟和比较发现,质量分数对液滴形成有明显影响.结... 详细信息

为了更为精确地研究液滴的形成和下落过程,对不同质量分数丙三醇溶液液滴的形成进行了数值模拟,得到的水滴形成过程与实验结果非常吻合、对不同的溶液液滴的长度、形成时间以及体积进行模拟和比较发现,质量分数对液滴形成有明显影响.结果表明,数值模拟在研究液滴形成和下落问题上具有很好的适用性.

关键词：液滴数值模拟丙三醇体积分数法

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