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Studies on fluorenscence resonance energy transfer between CdS nanoparticles and DOCAI dyes

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Chinese Chemical Letters 2007年第3期18卷 369-372页

作者： Lun Wang Yan liu hong Qi chen A Ni Liang Fa Gong Xu College of Chemistry and Materials Science Anhui Key Laboratory of Functional Molecular Solids Anhui Normal University Wuhu 241000 China

The water-soluble CdS nanoparticles were synthesized in aqueous solution. A novel fluorescence resonance energy transfer （FP, ET） system with CdS nanoparticles as energy donors and 3,3＇-diethyl-oxadicarbocyanine io... 详细信息

关键词： FRET CdS nanoparficles DOCAI

The Effect of 2,5-hexanedione on Myelin Protein Zero Expression,and Its Mitigation Using Ginkgo Biloba Extract

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Biomedical and Environmental Sciences 2011年第4期24卷 374-382页

作者： ZHAO Lei liu QingJun chen hong DUAN HuaWei BIN Ping liu Qing NIU Yong DAI YuFei ZHENG YuXin National Institute for Occupational Health and Poison Control and Key laboratory of Chemical Safety and Health Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To investigate the role of myelin protein zero （P 0） in 2,5-hexanedione （2,5-HD）-induced peripheral nerve injury,and the protective effect of Ginkgo biloba extract （Egb761） on 2,5-HD-induced toxic peripheral *** After 4 weeks of treatment with 2,5-HD at different doses （50,100,200,400 mg/kg） in rats,changes in the levels of P 0 in rat sciatic nerves was investigated,and the effect of Egb761 on 2,5-HD-induced toxic peripheral neuropathy was *** The blood-nerve barrier （BNB） permeability of the sciatic nerve increased,and the expression of P 0 mRNA and P 0 protein decreased in a dose-dependent manner after treatment with 2,5-HD for 4 *** with Egb761 protected against BNB interruption,and inhibited P 0 mRNA and protein reduction during 2,5-HD *** with Egb761 significantly reduced loss of body weight （P0.01） and mitigated gait abnormalities （2.85±0.22） induced by 400 mg/kg 2,5-HD （P0.01）.It also reduced the signs of neurotoxicity induced by 2,*** 2,5-HD inhibited the expression of P 0 in a dose-dependent manner,and this may be an important mechanism by which toxic peripheral neuropathy is induced by 2,***761 has a protective effect against 2,5-HD-induced peripheral neurotoxicity in rats.

关键词： Myelin protein zero 2 5-hexanedione Ginkgo biloba extract

Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinyl Group

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Chemical Research in Chinese Universities 2010年第4期26卷 558-562页

作者： YAO Peng XUE Hao liu Qian liu hong-tao chen Ming-jia GONG Ping Key Lab of New Drugs Design and Discovery of Liaoning Province School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P R. China.

A series of 2-amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinyl substituted diaryl urea derivatives was designed and synthesized. Their in vitro cytotoxicities against two cancer cell lines（Bel-7402 and A549） were evaluated by standard MTT assay. Six of tested compounds 6, 8, 10, 17, 21 and 22 exhibited more potent cytotoxicity superior to sorafenib. The structure activity relationship（SAR） study indicates that 2-amino-5,6,7,8-tetrahydropyrido- [4,3-d]pyrimidinyl group was an option for cytotoxic potency.

关键词： Diaryl urea 2-Amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Cytotoxicity

Bending-Rays Imaging Based on Genetic Algorithm

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 585-588页

作者： Foundation item: liu Huai lin, liu hong, chen Shu zhen College of Electronic Information, Wuhan University, Wuhan 430072, China College of Electronic Information Wuhan University Wuhan China

Basic principle of bending rays imaging is discussed briefly and an improved genetic algorithm is presented to settle the converse computation of bending rays imaging. Compared with other algorithms, this one improv... 详细信息

关键词： genetic algorithm bending rays incomplete projection travel time

Administration of imatinib in the first 90 days after allogeneic hematopoietic cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

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Chinese Medical Journal 2011年第2期124卷 246-252页

作者： chen Huan liu Kai-yan XU Lan-ping liu Dai-hong chen Yu-hong SHI hong-xia HAN Wei ZHAN Xiao-hui WANG Yu ZHAO Ting HUANG Xiao-jun Peking University Institute of Hematology Peking University People's Hospital Beijing 100044 China

Background Relapse happens frequently after allogeneic hematopoietic cell transplantation （alIo-HCT） in the patients with Philadelphia chromosome-positive acute lymphoblastic leukemia （Ph^＋ ALL）. Detection of the minimal residual disease （MRD） before and after alIo-HCT is associated with higher relapse rate. Early administration of imatinib after alIo-HCT may prevent recurrent Ph^＋ ALL. The aim of this study was to evaluate the safety and efficacy of imatinib in preventing hematological relapse when imatinib was administrated in the first 90 days after alIo-HCT. Methods Patients with Ph^＋ ALL that underwent alIo-HCT were enrolled in a prospective study. A TaqMan-based real-time quantitative polymerase chain reaction （RQ-PCR） technique was used to detect the MRD （bcr-abl transcript levels）. Imatinib therapy was initiated prior to 90 days after alIo-HCT if the patient＇s absolute neutrophil count （ANC） was above 1.0×10^9/L （without granulocyte colony-stimulating factor （G-CSF） administration） and the platelet count was greater than 50.0×10^9/L, or if the bcr-abl transcript levels were elevated in two consecutive tests, or if the bcr-abl transcript levels were 〉10.2 after the initial engraftment. The initial daily dose of imatinib was 400 mg/d for adults and 260 mg/m^2 for children （younger than 17 years）. Imatinib was administered for at least I month and the bcr-abl TaqMan results were negative for 3 consecutive tests, or complete molecular remission （CR^mol） was sustained for at least 3 months. Results From May 2005 to October 2008, 29 patients were enrolled in this study, of whom, 19 patients were male and 10 were female. The median age of the enrolled patients was 33 years （range 6-50 years）. Imatinib therapy was started at a median time of 60 days （range 20-122 days） post HCT （only one patient started Imatinib therapy at 122nd day after HCT）. Twenty-five adult patients could tolerate a dose of 300-400 mg/d of imatinib, and three children tolerated a dose of 260 mg

关键词： Philadelphia chromosome acute lymphoblastic leukemia allogeneic hematopoietic cell transplantation minimal residual disease

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补燃循环发动机关机过程仿真研究

推进技术 2016年第12期37卷 2219-2225页

作者：陈宏玉刘红军陈建华洪流液体火箭发动机技术国防科技重点实验室陕西西安710100

以补燃循环液氧煤油发动机系统为研究对象,对其关机特性进行了研究。在分析发动机系统工作原理的基础上,应用模块化建模的思想,建立了该系统中各主要部件的数学模型;采用新的面向对象仿真语言Modelica和MWorks平台,开发了可扩展的发动... 详细信息

以补燃循环液氧煤油发动机系统为研究对象,对其关机特性进行了研究。在分析发动机系统工作原理的基础上,应用模块化建模的思想,建立了该系统中各主要部件的数学模型;采用新的面向对象仿真语言Modelica和MWorks平台,开发了可扩展的发动机仿真模型库;在此基础上,利用模型库搭建了液氧煤油补燃循环发动机关机过程仿真模型,并对发动机关机过程进行了仿真计算,计算结果表明与试车数据基本相符,其中稳态相对误差小于5%,动态相对误差小于15%,初步验证了所建仿真模型的正确性;进一步分析了吹除气体压力、阀后腔道容积、关机工况等因素对发动机关机过程的影响。

关键词：液体火箭发动机补燃循环关机过程数值仿真

单相H桥逆变器单极性正弦脉宽调制下的分岔及混沌行为研究

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物理学报 2013年第21期62卷 36-42页

作者：刘洪臣杨爽哈尔滨工业大学电气工程及自动化学院哈尔滨150001

本文研究了单相H桥逆变器在单极性正弦脉宽调制下的分岔和混沌行为,建立了系统在比例控制下的一阶离散映射模型,采用分岔图、折叠图和Lyapunov指数谱分析了比例系数k对系统性能的影响,通过Matlab/Simulink仿真得到了不同比例系数下的时... 详细信息

本文研究了单相H桥逆变器在单极性正弦脉宽调制下的分岔和混沌行为,建立了系统在比例控制下的一阶离散映射模型,采用分岔图、折叠图和Lyapunov指数谱分析了比例系数k对系统性能的影响,通过Matlab/Simulink仿真得到了不同比例系数下的时域波形图,验证了理论分析的正确性.最后运用分岔图研究了输入电压E、负载电阻R和电感L等外部参数变化时变换器中存在的非线性行为.本文将单相H桥逆变器的混沌研究从双极性正弦脉宽调制转向单极性正弦脉宽调制,使之更具实用性,研究结果对于正确设计和调试单相H桥逆变器具有重要的指导意义和应用价值.

关键词：单相H桥逆变器单极性调制离散迭代映射分岔和混沌

Effect of Genetic Connectedness on the Selection Results of Breeding Pigs

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Agricultural Sciences in China 2005年第11期4卷 872-876页

作者： ZHANG Hao LI Jia-qi WANG Chong liu Xiao-hong chen Yao-sheng Department of Animal Genetics and Breeding College of Animal Science South China Agricultural University Guangzhou 510642 P.R.China

Two pig populations were simulated with Monte Carlo method; each consisted of 5 boars and 50 sows per generation. Genetic connectedness between herds was established by randomly selecting 1 or 2 boars from one population to mate sows of the other population. Breeding pigs were selected within populations according to animal model BLUP. The benefits of genetic connectedness between herds were examined. The results showed that, the average coefficients of inbreeding decreased, while the cumulative selection responses of populations increased, and the higher response occurred randomly in the two populations at generation 5 with the increase of the genetic connectedness between herds. Selection response was affected by genetic connectedness and trait heritability, the lower heritability and higher connectedness, the better selection results. When the number of exchanged litters between populations per generation was 6 litters, the selection results reached a reflection point; if the number of exchanged litters between populations increased further from this point, neither the increase of the cumulative selection responses nor the decrease of coefficients of inbreeding was significant.

关键词： Pigs Genetic connectedness Cumulative selection response Coefficient of inbreeding

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting liu Shiqi Huang Xiangliang chen Shen liu Junshan Zhou hongdong Zhao Ye hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization