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Genetic Structure and Diversity of Parental Cultivars Involved in China Mainland Sugarcane Breeding Programs as Inferred from DNA Microsatellites

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Journal of Integrative Agriculture 2012年第11期11卷 1794-1803页

作者： QI Yong-wen PAN Yong-bao LAO Fang-ye ZHANG Chui-ming FAN Li-na HE Hui-yi liu Ruin WANG Qin-nan liu Shao-mou liu fu-ye LI Qi-wei DENG Hai-hua Guangdong Key Laboratory of Sugarcane Improvement and Biorefinery Guangzhou Sugarcane Industry Research Institute Guangzhou 510316 P.R.China USDA-ARS Mid-South Area Sugarcane Research Laboratory Houma 70360 USA

To understand genetic structure and diversity of parental cultivars involved in China Mainland sugarcane breeding programs, 92 elite parents and 4 wild relatives were genotyped with 18 microsatellite DNA markers. The genetic similarity （GS） values among the cultivars ranged from 0.346 to 0.960 with an average of 0.533. Among the introduced cultivars, India accessions had the closest genetic distance to China Mainland accessions （0.447）, while Australia accessions have the furthest distance （0.503）. A comparison of allelic diversity among geographical origins showed that there were 22 China Mainland specific alleles, of which 28% were derived from native S. spontaneaum germplasm in China. Model-based genetic structure, clustering, and principal components analyses consistently revealed there were five groups within the 96 accessions. Groups 1, 2, 4, and 5 consisted of all cultivars and group 3 only contained wild germplasm. Group 2 was characterized as the Introduction group with 46 cultivars predominantly introduced from Australia, Taiwan of China, India, and USA. Groups 1, 4, and 5 consisted of cultivars mostly originated from China Mainland, defined as the Complex group, Yacheng lines group, and F134/CP72-1210 group, respectively, upon their pedigree. By understanding the genetic relationships among the parental cultivars, breeders can gain a rational basis for expanding the gene pool and select the best parental accessions for crossing.

关键词： genetic diversity microsatellite DNA marker population structure sugarcane

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考虑地域差异的配电网空间负荷聚类及一体化预测方法

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电力系统自动化 2017年第3期41卷 70-75,82页

作者：刘思傅旭华叶承晋黄民翔浙江大学电气工程学院浙江省杭州市310027 国网浙江省电力公司经济技术研究院浙江省杭州市310008

针对基于智能算法的负荷密度指标法对样本依赖性强且在各地实际应用困难的不足,提出一种考虑地域差异的配电网空间负荷聚类及一体化预测方法。该方法首先通过大量调研得到分布在不同地区、分属不同类型的负荷样本及所处地区信息;然后利... 详细信息

针对基于智能算法的负荷密度指标法对样本依赖性强且在各地实际应用困难的不足,提出一种考虑地域差异的配电网空间负荷聚类及一体化预测方法。该方法首先通过大量调研得到分布在不同地区、分属不同类型的负荷样本及所处地区信息;然后利用基于日负荷曲线的负荷分类校验及精选方法对所有调研样本进行分类精选;再根据区域分类、负荷分类对精选样本构成的全样本空间进行两级划分,得到分层级子样本空间;最后根据待测地块的属性信息对子样本空间进行匹配,选取与其最相似的子样本空间作为训练样本,构建支持向量机模型预测各地块的负荷密度,进而得到电力负荷的空间分布。工程实例分析表明了该方法的实用性和有效性。

关键词：空间负荷预测负荷密度指标法地域差异聚类分析支持向量机

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南水北调中线总干渠豫北“96·8”洪水调查分析

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人民长江 2000年第5期31卷 12-13页

作者：刘富叶丁永杰唐纯喜河南省水利勘测设计院河南郑州450008

根据南水北调中线总干渠初步设计工程水文计算要求 ,进行了南水北调中线总干渠交叉河流的洪水调查、分析研究工作。“96·8”洪水调查主要是针对豫北地区与总干渠交叉的 2 5条河流进行的 ,外业调查范围一般选在总干渠与河流交叉断面上下... 详细信息

根据南水北调中线总干渠初步设计工程水文计算要求 ,进行了南水北调中线总干渠交叉河流的洪水调查、分析研究工作。“96·8”洪水调查主要是针对豫北地区与总干渠交叉的 2 5条河流进行的 ,外业调查范围一般选在总干渠与河流交叉断面上下游 1～ 2km的河段上 ,主要摸清“96·8”洪水发生日期、洪痕位置、洪水过流情况以及上下游水利工程及卡口工程情况、洪水淹没范围等 ,重点对洪痕高程进行测量。着重介绍调查洪水洪峰流量计算。

关键词：洪痕测量洪峰流量南水北调中线工程洪水调查

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Array-based Nano-amplification Technique Was Applied in Detection of Hepatitis E Virus

Array-based Nano-amplification Technique Was Applied in Dete...

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2006年度学术研讨会

作者： Hui-Hui liu, Xuan Cao, Yong Yang, Ming-Gui liu and ye-fu Wang College of Life Sciences, Wuhan University, Wuhan, 430072, P. R. China

A rapid method for the detection of Hepatitis E Virus (HEV) was developed by utilizing nano-gold labeled oligonucleotide probes, silver stain enhancement and the microarray technique. The 5’-end -NH2 modified oligonucleotide probes were immobilized on the surface of the chip base as the capture probe. The detection probe was made of the 3’-end -SH modified oligonucleotide probe and nano-gold colloid. The optimal concentrations of these two probes were determined. To test the detection sensitivity and specificity of this technique, a conservative fragment of the virus RNA was amplified by the RT-PCR/ PCR one step amplification. The cDNA was hybridized with the capture probes and the detection probes on microarray. The detection signal was amplified by silver stain enhancement and could be identified by naked eyes. 100 fM of amplicon could be detected out on the microarray. As the results, preparation of nano-gold was improved and faster. Development time also was shortened to 2 min. Thus, considering high efficiency, low cost, good specificity and high sensitivity, this technique is alternative for the detection of HEV.

关键词： HEV Microarray Nano-gold Sensitivity Visual detection

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Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan ye Hongzhang Cheng Xiaoming liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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中文新异组合概念的解释及影响因素

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心理学报 2004年第3期36卷 265-273页

作者：刘烨傅小兰孙宇浩中国科学院心理研究所北京100101

通过分析 6 0 0名中国大学生对 32个概念组成的 16 0个新异组合概念的解释 ,考察了中文名词 -名词组合概念的解释策略及影响因素。结果表明 :⑴关系解释和属性解释是两种主要的解释策略 ;⑵第一个子概念具有显著属性的组合概念得到更多... 详细信息

通过分析 6 0 0名中国大学生对 32个概念组成的 16 0个新异组合概念的解释 ,考察了中文名词 -名词组合概念的解释策略及影响因素。结果表明 :⑴关系解释和属性解释是两种主要的解释策略 ;⑵第一个子概念具有显著属性的组合概念得到更多的属性解释 ;⑶子概念之间相似性的高低不影响属性解释出现的比率 ,但影响关系解释出现的比率 ;⑷生物组合概念比人造物组合概念得到更多的属性解释。其中的新发现既不支持关系竞争理论 ,也不支持双重加工理论 ,引出了有待研究的新问题。

关键词：组合概念概念组合子概念属性解释关系解释

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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu Shan ye Xiangyi liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

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微波消融在结直肠癌肝转移中的应用

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中国医学创新 2017年第14期14卷 134-138页

作者：刘宇刘也夫大连医科大学辽宁大连116044 辽宁省肿瘤医院

结直肠恶性肿瘤作为全球最为常见的癌症一,其发病率逐年递增且死亡人数居高不下。因此,如何减少结直肠恶性肿瘤的患病人数及提高患者的生存率成为目前急需解决的问题之一。相关数据显示,25%的初次确诊患者已经发现同时性肝脏转移灶,另外... 详细信息

结直肠恶性肿瘤作为全球最为常见的癌症一,其发病率逐年递增且死亡人数居高不下。因此,如何减少结直肠恶性肿瘤的患病人数及提高患者的生存率成为目前急需解决的问题之一。相关数据显示,25%的初次确诊患者已经发现同时性肝脏转移灶,另外75%的患者在后续的治疗过程中约有20%发现肝转移灶。国际上公认的根治结直肠恶性肿瘤肝脏转移(colorectal liver metastases,CRLM)灶金标准为开腹手术,然而仅有20%左右的患者适合行肝转移灶切除。目前,热消融治疗在临床上的应用逐年增加,得到了结直肠癌肝转移患者的认可。本文对近年来结直肠恶性肿瘤肝脏转移患者微波消融治疗的研究现状进行系统综述。

关键词：结直肠癌肝转移微波消融

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Development Strategy of Sugarcane Industry in Guangdong Province

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Asian Agricultural Research 2012年第10期4卷 17-22,27页

作者： CHEN Yue-gui WU Jian-tao YANG Jun-xian LI Qi-wei XIE Jing PAN Fang-yin WU Wen-long liu fu-ye DENG Hai-hua QI Yong-wen Guangzhou Sugarcane Industry Research Institute/Guangdong Key Laboratory of Sugarcane Improvement & Biorefinery

Guangdong Province is one of the main producing areas of sugarcane in China, and one of China's three regions with dominant advantage in sugarcane, having good basis and conditions for developing sugarcane industry. In this research, using the SWOT-AHP method, we set 20 assessment indicators (such as the regions with dominant advantage in sugarcane, huge demand for domestic sugar, increased production costs and backward system of sugarcane), to analyze the development strategy of sugarcane industry in Guangdong Province, from strengths, weaknesses, opportunities and challenges of sugarcane industrial development in Guangdong Province. The results show that in order to promote the development of sugarcane industry in Guangdong Province, it is necessary to adopt the SO development strategy (relying on its own strengths and using favorable external environment), to achieve the rapid development.

关键词： Guangdong Province Sugarcane industry Development

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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting liu Shiqi Huang Xiangliang Chen Shen liu Junshan Zhou Hongdong Zhao ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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