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Meibomian glands segmentation in infrared images with limited annotation

International Journal of Ophthalmology(English edition) 2024年第3期17卷 401-407页

作者： Jia-Wen lin ling-Jie lin Feng Lu Tai-Chen Lai Jing Zou lin-ling Guo Zhi-Ming lin Li Li College of Computer and Data Science Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Shengli Clinical Medical College of Fujian Medical University Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial Hospital South BranchFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

●AIM:To investigate a pioneering framework for the segmentation of meibomian glands(MGs),using limited annotations to reduce the workload on ophthalmologists and enhance the efficiency of clinical diagnosis.●METHODS:Totally 203 infrared meibomian images from 138 patients with dry eye disease,accompanied by corresponding annotations,were gathered for the study.A rectified scribble-supervised gland segmentation(RSSGS)model,incorporating temporal ensemble prediction,uncertainty estimation,and a transformation equivariance constraint,was introduced to address constraints imposed by limited supervision information inherent in scribble *** viability and efficacy of the proposed model were assessed based on accuracy,intersection over union(IoU),and dice coefficient.●RESULTS:Using manual labels as the gold standard,RSSGS demonstrated outcomes with an accuracy of 93.54%,a dice coefficient of 78.02%,and an IoU of 64.18%.Notably,these performance metrics exceed the current weakly supervised state-of-the-art methods by 0.76%,2.06%,and 2.69%,***,despite achieving a substantial 80%reduction in annotation costs,it only lags behind fully annotated methods by 0.72%,1.51%,and 2.04%.●CONCLUSION:An innovative automatic segmentation model is developed for MGs in infrared eyelid images,using scribble annotation for *** model maintains an exceptionally high level of segmentation accuracy while substantially reducing training *** holds substantial utility for calculating clinical parameters,thereby greatly enhancing the diagnostic efficiency of ophthalmologists in evaluating meibomian gland dysfunction.

关键词： infrared meibomian glands images meibomian gland dysfunction meibomian glands segmentation weak supervision scribbled annotation

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Serum monoterpene levels, glucose homeostasis, lipid profiles, and metabolic syndrome in adults: NHANES, 2013–2014

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Emerging Contaminants 2024年第2期10卷 33-39页

作者： Wei-Jie Wang Yu-ling lin Chikang Wang Chien-Yu lin Division of Nephrology Department of Internal MedicineTaoyuan General HospitalMinistry of Health and WelfareTaoyuan330TaiwanChina Department of Biomedical Engineering Chung Yuan Christian UniversityTaoyuan300TaiwanChina Department of Nephrology Hsinchu Cathay General HospitalHsinchu300TaiwanChina Department of Healthcare Management Yuanpei University of Medical TechnologyHsinchu300TaiwanChina Department of Environmental Engineering and Health Yuanpei University of Medical TechnologyHsinchu300TaiwanChina Department of Internal Medicine En Chu Kong HospitalNew Taipei City237TaiwanChina School of Medicine Fu Jen Catholic UniversityNew Taipei City242TaiwanChina

Monoterpenes are organic compounds which have been studied for their medicinal ***,the association between monoterpene exposure and metabolic parameters in humans is *** investigated the connection between three specific monoterpenes(α-pinene,β-pinene,and limonene),glucose homeostasis biomarkers,lipid profiles,and metabolic syndrome(MS)in 1627 adults from the National Health and Nutrition Examination Survey(NHANES)2013–*** found serum levels ofα-pinene andβ-pinene were positively associated with fasting glucose,total cholesterol,triglyceride,and apolipoprotein *** addition,increased levels of limonene andΣmonoterpene(sum of three monoterpene chemicals)were linked to higher insulin,β-cell function,total cholesterol,low density lipoprotein cholesterol(LDL-C),triglycerides,and apolipoprotein *** with all three monoterpenes above the 50th percentile had notably higher values for total cholesterol and triglycerides compared to those with all three monoterpenes below the 50th percentile(P for trendlinked to an increased risk of high-density lipoprotein cholesterol(HDL-C)insufficiency and *** concentrations ofβ-pinene were associated with a higher prevalence of ***,increased levels of limonene andΣmonoterpene were connected to a higher risk of MS,larger waist circumference,low HDL-C,hypertriglyceridemia,and higher blood pressure according to MS *** conclusion,serum monoterpenes levels were linked to glucose regulation,lipid profiles,and indicators of *** studies are necessary to clarify the potential causal relationships.

关键词： Glucose homeostasis Lipid profiles Monoterpenes National health and nutrition examination survey(NHANES)

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Paradoxical herniation associated with hyperbaric oxygen therapy after decompressive craniectomy: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1793-1798页

作者： Zhong-Xing Ye Xin-Xin Fu Yang-Zong Wu ling lin Liang-Qi Xie Yu-ling Hu Yi Zhou Zhu-Gui You Hai lin Department of Neurosurgery The Second People's Hospital of Fujian Province(The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine)Fuzhou 350001Fujian ProvinceChina Department of Neurosurgery The Second Hospital of LongyanLongyan 364000Fujian ProvinceChina Department of Neurosurgery Zhangping City HospitalLongyan 364400Fujian ProvinceChina

BACKGROUND Whether hyperbaric oxygen therapy(HBOT)can cause paradoxical herniation is still *** SUMMARY A 65-year-old patient who was comatose due to brain trauma underwent decompressive craniotomy and gradually regained consciousness after *** was administered 22 d after surgery due to speech *** herniation appeared on the second day after treatment,and the patient’s condition worsened after receiving mannitol treatment at the rehabilitation *** timely skull repair,the paradoxical herniation was resolved,and the patient regained consciousness and had a good recovery as observed at the follow-up *** Paradoxical herniation is rare and may be caused by ***,the underlying mechanism is unknown,and the understanding of this phenomenon is *** use of mannitol may worsen this *** skull repair can treat paradoxical herniation and prevent serious complications.

关键词： Decompressive craniectomy Hyperbaric oxygen therapy Mannitol Paradoxical herniation Case report

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Manufacturing task data chain-driven production logistics trajectory analysis and optimization decision making method

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Advances in Manufacturing 2024年第1期12卷 185-206页

作者： lin ling Zhe-Ming Song Xi Zhang Peng-Zhou Cao Xiao-Qiao Wang Cong-Hu Liu Ming-Zhou Liu School of Mechanical Engineering Hefei University of TechnologyHefei230009People’s Republic of China Guobo Electronics Co.Ltd. Nanjing211111People’s Republic of China School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou234000AnhuiPeople’s Republic of China Sino-US Global Logistics Institute Shanghai Jiao Tong UniversityShanghai200030People’s Republic of China

Production logistics(PL)is considered as a critical factor that affects the efficiency and cost of production operations in discrete manufacturing *** effectively utilize manufacturing big data to improve PL efficiency and promote job shop floor economic benefits,this study proposes a PL trajectory analysis and optimization decision making method driven by a manufacturing task data chain(MTDC).First,the manufacturing task chain(MTC)is defined to characterize the discrete production process of a *** handle manufacturing big data,the MTC data paradigm is designed,and the MTDC is ***,the logistics trajectory model is presented,where the various types of logistics trajectories are extracted using the MTC as the search engine for the *** on this,a logistics efficiency evaluation indicator system is proposed to support the optimization decision making for the ***,a case study is applied to verify the proposed method,and the method determines the PL optimization decisions for PL efficiency without changing the layout and workshop equipment,which can assist managers in implementing the optimization decisions.

关键词： Production logistics(PL) Logistics trajectory analysis Logistics optimization Data driven Manufacturing task data chain(MTDC)

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Retrospective analysis of patients with hepatocellular carcinoma complicated with human immunodeficiency virus infection after hepatectomy

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3851-3864页

作者： Jia-Jie Lu Shuai Yan lin Chen lin-ling Ju Wei-Hua Cai Jin-Zhu Wu Department of Hepatobiliary Surgery Nantong Third People's HospitalMedical School of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Medical School Nantong UniversityNantong 226300Jiangsu ProvinceChina Institute of Liver Disease Nantong Third People’s HospitalAffiliated Nantong Hospital 3 of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Hepatobiliary Surgery Affiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the third leading cause of cancer death worldwide,with a 5-year relative survival rate of approximately 18%.The similarity between incidence and mortality(830000 deaths per year)underscores the bleak prognosis associated with the *** is the fourth most common malignancy and the second leading cause of cancer death in *** patients with HCC have a history of chronic liver disease such as chronic hepatitis B virus(HBV)or hepatitis C virus(HCV)infection,alcoholism or alcoholic steatohepatitis,nonalcoholic fatty liver disease,or nonalcoholic *** diagnosis and effective treatment are the keys to improving the prognosis of patients with *** the total number of human immunodeficiency virus(HIV)-infected patients is declining globally the incidence of HCC is increasing in HIVinfected patients,especially those who are coinfected with HBV or *** a result,people infected with HIV still face unique challenges in terms of their risk of developing *** To investigate the survival prognosis and clinical efficacy of surgical resection in patients with HCC complicated with HIV *** The clinical data of 56 patients with HCC complicated with HIV admitted to the Third Affiliated Hospital of Nantong University from January 2013 to December 2023 were retrospectively *** these,27 patients underwent hepatectomy(operation group)and 29 patients received conservative treatment(nonoperation group).All patients signed informed consents in line with the provisions of medical *** general data,clinicopathological features and prognoses for the patients in the two groups were analyzed and the risk factors related to the prognoses of the patients in the operation group were *** The median disease-free survival(DFS)and overall survival(OS)of HIV-HCC patients in the surgical group were 13 months and 17 months,respectively,and the median OS of patients in the nonsurgic

关键词： Hepatocellular carcinoma Human Immunodeficiency virus Liver resection Retrospective analysis Prognosis

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A microfluidic biosensor for multiplex immunoassay of foodborne pathogens agitated by programmed audio signals

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Chinese Chemical Letters 2024年第10期35卷 370-374页

作者： Gaowa Xing Yuting Shang Xiaorui Wang Zengnan Wu Qiang Zhang Jiebing Ai Qiaosheng Pu ling lin Key Laboratory of Ecology-Toxicological Efects and Control for Emerging Contaminants of Fujian Province College of Environmental&Biological EngineeringPutian UniversityPutian351100China Xining Urban Vocational&Technical College Xining 810000China Department of Bioengineering Beijing Technology and Business UniversityBeijing 100048China Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and InstrumentationTsinghua UniversityBejing 100084China College of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou 730000China

Foods are often contaminated by multiple foodborne pathogens,which threatens human *** this work,we developed a microfluidic biosensor for multiplex immunoassay of foodborne bacteria with agitation driven by programmed audio *** agitation,powered by the vibration of a speaker cone during music playing,accelerated the mass transport in the incubation process to form bacterial complexes within 10 *** reagents of the two target bacteria(Escherichia coli O157:H7 and Salmonella typhimurium)were preloaded into the corresponding fore-vacuum storage chamber on the chip,and released to participate in the subsequent immune analysis process by piercing the *** the detection processes were integrated into a single microfluidic chip and controlled by a smartphone through *** selected conditions,wide linear ranges and low limits of detection(LODs<2CFU/m L)were obtained,and real food samples were successfully determined within 30 *** biosensing method can be extended to wide-ranging applications by loading different recognizing reagents.

关键词： Multiplex immunoassay Microfluidic biosensor Audio signals Foodborne bacteria Smartphone

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Effects of intensive psychological intervention on treatment compliance,psychological status,and quality of life of patients with epilepsy

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World Journal of Psychiatry 2024年第5期14卷 670-677页

作者： Su-Hua Zhang Jie-Hua Wang Hong-Yu Liu Yue-Xia Zhang Ya-ling lin Bi-Yu Wu Department of Neurology Quanzhou First HospitalQuanzhou 362000Fujian ProvinceChina Department of Nursing Quanzhou First HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Epilepsy is a nervous system disease characterized by recurrent attacks,a long disease course,and an unfavorable *** is associated with an enduring therapeutic process,and finding a cure has been *** with epilepsy are predisposed to adverse moods,such as resistance,anxiety,nervousness,and anxiety,which compromise treatment compliance and overall *** To explored the influence of intensive psychological intervention on treatment compliance,psychological status,and quality of life(QOL)of patients with *** The clinical data of 105 patients with epilepsy admitted between December 2019 and July 2023 were retrospectively analyzed,including those of 50 patients who underwent routine intervention(control group)and 55 who underwent intensive psychological intervention(research group).Treatment compliance,psychological status based on the Self-Rating Anxiety Scale(SAS)and Depression Scale Self-Rating Depression Scale(SDS)scores,hope level assessed using the Herth Hope Scale(HHS),psychological resilience evaluated using the Psychological Resilience Scale,and QOL determined using the QOL in Epilepsy-31 Inventory(QOLIE-31)were comparatively *** Treatment compliance in the research group was 85.5%,which is significantly better than the 68.0%of the control *** notable intergroup differences in preinterventional SAS and SDS scores were identified(P>0.05);however,after the intervention,the SAS and SDS scores decreased significantly in the two groups,especially in the research group(P0.05).After 6 months of intervention,the research group showed evidently higher HHS,CD-RISC,tenacity,optimism,strength,and QOLIE-31 scores(P<0.05).CONCLUSION Intensive psychological intervention enhances treatment compliance,psychological status,and QOL of patients with epilepsy.

关键词： Intensive psychological intervention Epilepsy Treatment compliance Psychological status Quality of life

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论康德对教育科学的贡献——以科学知识积累演进的基本逻辑为分析框架

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教育学报 2024年第3期20卷 30-43页

作者：林凌浙江师范大学教育学院浙江金华321004

在“哲学的世纪”向“科学的世纪”行进之际,康德在哥尼斯堡大学的教育学讲座中提出要将教育技艺发展为科学或判断性的教育学。然而,围绕《康德论教育》存在诸多争议。以这些争议为起点,以科学知识积累演进的基本逻辑为分析框架,重新理... 详细信息

在“哲学的世纪”向“科学的世纪”行进之际,康德在哥尼斯堡大学的教育学讲座中提出要将教育技艺发展为科学或判断性的教育学。然而,围绕《康德论教育》存在诸多争议。以这些争议为起点,以科学知识积累演进的基本逻辑为分析框架,重新理解康德对教育科学发展的思想贡献,可以发现:首先,康德为教育科学置入一种先验哲学的、前提理论的理性批判考察方式,并向教育学同时提出了理论、经验研究和实验的要求。其次,康德基于教育理念—[实践的]实验—教育技艺的关系模式来阐释教育科学知识,该模式摧毁了教育学知识发展的实践循环模式,也超越了缺乏先天原则的诠释学循环模式和近代自然科学模式。最后,康德在教育科学领域引发了先验自由是否为教育行动留下余地的争议,进而为教育学的独立性或自身逻辑的出场埋下伏笔。

关键词：康德教育科学作为科学的教育学判断性的技艺实践的实验经验研究

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异域故事的中国之旅:鹿乳奉亲故事考

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民族文学研究 2024年第4期42卷 52-62页

作者：林玲上海大学文学院

郯子鹿乳奉亲故事源于印度民间的苦行者故事,起初被佛教征引,创编为睒子本生故事,三世纪后传入中国。魏晋时期众僧为传播佛教义理,有意在宣讲中强化睒子的孝行。唐宋时期是睒子佛子与孝子身份的更迭阶段,睒子本生故事的佛教色彩逐渐消解... 详细信息

郯子鹿乳奉亲故事源于印度民间的苦行者故事,起初被佛教征引,创编为睒子本生故事,三世纪后传入中国。魏晋时期众僧为传播佛教义理,有意在宣讲中强化睒子的孝行。唐宋时期是睒子佛子与孝子身份的更迭阶段,睒子本生故事的佛教色彩逐渐消解,孝道伦理日益增强。元明以后,睒子随着二十四孝故事的普及进入童蒙教育体系,州子剡子逐渐演变为周朝剡子,后形讹作周郯子。后世在解读时又演绎出郯国国君郯子说,完成了异域故事的本土化过程。

关键词：鹿乳奉亲睒子剡子郯子孝子故事

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Knock-in of exogenous sequences based on CRISPR/Cas9 targeting autosomal genes and sex chromosomes in the diamondback moth,Plutella xylostella

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Journal of Integrative Agriculture 2024年第9期23卷 3089-3103页

作者： Shanyu Li Guifang lin Haoqi Wen Haiyan Lu Anyuan Yin Chanqin Zheng Feifei Li Qingxuan Qiao Lu Jiao ling lin Yi Yan Xiujuan Xiang Huang Liao Huiting Feng Yussuf Mohamed Salum Minsheng You Wei Chen Weiyi He State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops/Ministerial and Provincial Joint Innovation Centre for Safety Production of Cross-Strait Crops/International Joint Research Laboratory of Ecological Pest Control Ministry of EducationInstitute of Applied EcologyFujian Agriculture and Forestry UniversityFuzhou 350002China Ganzhou Key Laboratory of Greenhouse Vegetable Gannan Normal UniversityGanzhou 341000China

Genetic pest control strategies based on precise sex separation and only releasing sterile males can be accomplished by site-specific genome *** the current study,we showed that the mutation of single-allele Pxfl(2)d can significantly impair the normal mating behavior and testis development in male adults of the notorious cruciferous insect pest Plutella xylostella,in addition to its known functions in the ovarian development in female adults and egg *** CRISPR/Cas9-based knock-in experiments revealed that site-specific integration of an exogenous green fluorescent protein(GFP)gene into autosomal Pxfl(2)d for labelling mutants could be ***,this gene is not a suitable target for GFP insertion to establish a genetically stable knock-in strain because of the severe decline in reproductive *** further screened for the W-chromosome-linked and Z-chromosome-linked regions to test the knock-in efficiency mediated by CRISPR/*** results verified that both types of chromosomes can be targeted for the site-specific insertion of exogenous *** ultimately obtained a homozygous knock-in strain with the integration of both Cas9 and cyan fluorescent protein(CFP)expression cassettes on a Z-linked region in ***,which can also be used for early sex *** injecting the sgRNA targeting Pxfl(2)d alone into the eggs laid by female adults of the Z-Cas9-CFP strain,the gene editing efficiency reached 29.73%,confirming the success of expressing a functional Cas9 *** together,we demonstrated the feasibility of the knock-in of an exogenous gene to different genomic regions in ***,while the establishment of a heritable strain required the positioning of appropriate *** study provides an important working basis and technical support for further developing genetic strategies for insect pest control.

关键词： cruciferous specialist fl(2)d CRISPR/Cas9 knock-in sex chromosome

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