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Transmissive metasurface for multi-channel and full-polarization modulation of electromagnetic wavefronts

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Photonics Research 2023年第2期11卷 245-251页

作者： linda shao ZHENFEI LI JIALIN FENG JIN ZHANG HONGYU SHI XUDONG BAI WEIREN ZHU Department of Electronic Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Information and Communications Engineering Xi’an Jiaotong UniversityXi’an 710049China School of Microelectronics Northwestern Polytechnical UniversityTaicang 215400China

Metasurfaces have great potential for flexible manipulation of electromagnetic wave polarizations and ***, we propose a general method for achieving independent wavefront manipulation in a single polarizationmultiplexing transmissive metasurface. As a proof of concept, we design a transmission-type anisotropic metasurface for independent wavefront manipulation in full-polarization channels. An x-polarized wave transmitted through such a metasurface could be converted into four outgoing beams with delicately designed polarization states that converge to specific positions for holographic imaging. The measured results are in good agreements with simulated ones, verifying the independent wavefront manipulations with arbitrary polarization *** with the existing traditional meta-devices with single-polarization modulation, we achieve polarization-multiplexed metasurfaces with mixed polarization and phase control, which can greatly improve the functional richness of the system.

关键词： surface. proof holographic

An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP^(+)mononuclear cells and PDGF-BB secretion

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Bone Research 2021年第4期9卷 582-592页

作者： Gehua Zhen Yang Dan Ruomei Wang Ce Dou Qiaoyue Guo Melissa Zarr linda N.Liu Lieping Chen Ruoxian Deng Yusheng Li Zengwu shao Xu Cao Department of Orthopedic Surgery Institute of Cell EngineeringJohns Hopkins University School of MedicineBaltimoreMDUSA Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina NextCure Inc.BeltsvilleMDUSA Department of Immunobiology Yale University School of MedicineNew HavenCTUSA Department of Biomedical Engineering Johns Hopkins University School of MedicineBaltimoreMDUSA

Osteoporosis(OP)is a common age-related disease characterized by a deterioration of bone mass and structure that predisposes patients to fragility *** therapies that promote anabolic bone formation in OP patients and OP-induced fracture are *** investigated whether a neutralizing antibody against Siglec-15 can simultaneously inhibit bone resorption and stimulate bone *** found that the multinucleation of osteoclasts was inhibited in SIGLEC-15 conditional knockout mice and mice undergoing Siglec-15 neutralizing antibody *** secretion of platelet-derived growth factor-BB(PDGF-BB),the number of tartrate-resistant acid phosphatase-positive(TRAP+)mononuclear cells,and bone formation were significantly increased in the SIGLEC-15 conditional knockout mice and antibody-treated *** anabolic effect of the Siglec-15 neutralizing antibody on bone formation was blunted in mice with Pdgfb deleted in TRAP-1"*** findings showed that the anabolic effect of the Siglec-15 neutralizing antibody was mediated by elevating PDGF-BB production of TRAP4 mononuclear *** test the therapeutic potential of the Siglec-15 neutralizing antibody,we injected the antibody in an ovariectomy-induced osteoporotic mouse model,which mimics postmenopausal osteoporosis in women,and in two fracture healing models because fracture is the most serious health consequence of *** Siglec-15 neutralizing antibody effectively reduced bone resorption and stimulated bone formation in estrogen deficiency-induced *** note,the Siglec-15 neutralizing antibody promoted intramembranous and endochondral ossification at the damaged area of cortical bone in fracture healing mouse ***,the Siglec-15 neutralizing antibody shows significant translational potential as a novel therapy for OP and bone fracture.

关键词： healing inhibited fracture

Insulin-3基因敲除鼠生殖系统LGR8蛋白的表达

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西安交通大学学报（医学版） 2012年第2期33卷 172-175页

作者：王毅张少华刘娟 BAKER linda 西安交通大学医学院第一附属医院内分泌科 Department of Urology UT Southwestern Medical Center at DallasDallasTexasUSA 75235

目的 Insulin-3(Insl3)和其唯一配体富含亮氨酸的G蛋白受体[LGR8(aka RXFP2)]系统在睾丸下降过程中起重要作用。本研究拟利用Insl3基因敲除鼠探讨Insl3与LGR8相互关系及其在生殖系统的表达情况。方法使用免疫共沉淀、Western blot及免... 详细信息

目的 Insulin-3(Insl3)和其唯一配体富含亮氨酸的G蛋白受体[LGR8(aka RXFP2)]系统在睾丸下降过程中起重要作用。本研究拟利用Insl3基因敲除鼠探讨Insl3与LGR8相互关系及其在生殖系统的表达情况。方法使用免疫共沉淀、Western blot及免疫组化法检测雄性野生型小鼠和Insl3基因敲除雄性小鼠各生殖器官LGR8蛋白的表达并比较分析。结果 LGR8蛋白在野生型小鼠睾丸、睾丸引带、附睾及输精管等多个雄性生殖器官均有表达。其表达程度在不同生殖器官不同,野生型小鼠睾丸LGR8的表达强于Insl3基因敲除鼠(P<0.05)。结论 LGR8蛋白在多个雄性生殖器官均有表达,Insl3-LGR8系统可能在男性多种生殖发育疾病中起作用。

关键词：胰岛素样因子3 富含亮氨酸的G蛋白受体睾丸下降隐睾症男性生殖发育疾病

Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis

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Stroke & Vascular Neurology 2022年第1期7卷 77-85页

作者： linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu Hong Kong Chinese Medicine Clinical Study Centre School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Department of Medicine and Therapeutics and Hong Kong Institute of Integrative Medicine Prince of Wales HospitalFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonOntarioCanada Clinical Laboratory Shanghai Traditional Chinese Medicine Integrated Institute of Vascular AbnomaliesShanghaiChina Institute of Medical Research Northwestern Polytechnical UniversityXi'anShanxiChina Evidence Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina School of Chinese medicine Hong Kong Baptist UniversityHong Kong SARChina Brain Center Guangdong Procincial Hospital of Traditional Chinese MedicineGuangdong University of Chinese MedicineGuangzhouChina The Nethersole School of Nuring Faculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Department of Medicine Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SARChina Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong SARChina Hong Kong Association for Integration of Chinese-Western Medicine Limited Hong Kong SARChina

Background Stroke is a major cause of death or long-term disability *** patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal ***,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke *** The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM *** The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were ***,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were *** included outcomes were dependency,motor function,depression and swallowing *** analysis was performed,and publication bias was assessed using funnel *** of review 58 studies and 6339 patients were included in the *** analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy *** superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also *** Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy ***,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn ***,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined.

关键词： acupuncture routine alone

Molecular identification of bloom-forming species Phaeocystis globosa (Pryninesiophyta) and its dispersal based on rDNA ITS sequence analysis

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Acta Oceanologica Sinica 2003年第2期22卷 243-254页

作者： ChenYueqin shaoPeng WangNing ZhouHui QuLianghu lindaK.Medlin KeyLaboratoryofGeneEngineeringofEducationMinistry BiotechnologyReserachCenterZhongshanUniversityGuangzhou510275China AlfredWegenerInstituteforPolarandMarineResearch Postfach120161Columbusstrasse27525BremerhavenGermany

The colony-forming Phaeocystis species are causative agents of dense bloom occurrences incoastal waters worldwide. It is difficult to separate them because of the different morphologies associated with their colonial stages. In this study we applied molecular approaches to analyze the genetic variation of Phaeocystis globosa and Phaeocystis pouchetii from several geographic regions, and to assist in tracing the dispersal of bloom-forming Phaeocystis species in coastal waters of China. The sequences of the internal transcribed spacers (ITS1 and ITS2) of rDNA and the 5. 8S ribosomal RNA gene of Phaeocystis strains were determined. Sequence comparison shows that *** was the most divergent to P. pouchetii, exhibiting sequence divergence higher than 0.08. However, lower genetic divergences existed between strains of P. globosa. The sequence comparison of the Phaeocystis rDNA ITS clearly shows that the species isolated from the southeast coast of China is identified as P. globosa rather than P. cf. pouchetii or other species. Furthermore, the significance of rDNA variation in distinct global populations of P. globosa suggested it might have had sufficient time to accumulate detectable mutations at the rDNA locus, supporting the hypothesis of ancient dispersal of P .globosa to many areas, meaning that P. globosa blooms in the coastal waters of China are endemic rather than a newly introduced species or a foreign source. Finally, based on the high divergent region of rDNA ITS, a pair of species-specific primers for P. globosa were designed, they could be useful to detect the presence of this species in mixed plankton assemblages or flagellate stages that are recognized with diffculties by means of conventional microscopy.

关键词： Genetic variation Phaeocystis globosa Phaeocystis pouchetii population dispersal rDNA ITS

Peroxisome and pexophagy in neurological diseases

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Fundamental Research 2024年第6期4卷 1389-1397页

作者： Weilin Xu Jun Yan Anwen shao Cameron Lenahan Liansheng Gao Haijian Wu Jingwei Zheng Jianmin Zhang John H.Zhang Department of Neurosurgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases Hangzhou 310009China Department of Neurosurgery Affiliated Tumor Hospital of Guangxi Medical UniversityGuangxi 537406China Burrell College of Osteopathic Medicine New Mexico State UniversityLas CrucesNM 88001USA Department of Physiology&Pharmacology Loma linda University Loma LindaCA 92350USA Department of Neurosurgery Loma linda University Loma LindaCA 92350USA

Peroxisomes and pexophagy have gained increasing attention in their role within the central nervous system(CNS)in recent *** this review,we comprehensively discussed the physiological and pathological mech-anisms of peroxisomes and pexophagy in neurological *** communicate with mitochondria,endoplasmic reticulum,and lipid *** types,sizes,and shapes vary in different regions of the ***,peroxisomes play an important role in oxidative homeostasis,lipid synthesis,and degradation in the CNS,whereas its dysfunction causes various neurological ***,selective removal of dysfunctional or superfluous peroxisomes(pexophagy)provides neuroprotective effects,which indicate a promising therapeu-tic ***,pexophagy largely remains unexplored in neurological *** studies are needed to explore the pexophagy’s crosstalk mechanisms in neurological pathology.

关键词： Peroxisome Pexophagy Autophagy Neurological diseases Neuroprotection

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丰饶醇美创意中国

大美术 2006年第2期 116-121,155页

作者： linda

马清运、邵帆、叶庭浒、周佚与邱志杰,五位涉及包括家具、建筑乃至多媒体艺术等不同领域在内的中国设计师,因其设计作品的巧妙心思,个性色彩而得到了国际专业设计杂志《Wallpaper*》,以及彰显内在奢华的芝华士18年苏格兰威士忌的共同赏... 详细信息

马清运、邵帆、叶庭浒、周佚与邱志杰,五位涉及包括家具、建筑乃至多媒体艺术等不同领域在内的中国设计师,因其设计作品的巧妙心思,个性色彩而得到了国际专业设计杂志《Wallpaper*》,以及彰显内在奢华的芝华士18年苏格兰威士忌的共同赏识与推崇。衡山路41号顶楼公寓、昔日绿树林荫的法租界繁荣景象尽显眼底。

关键词：多媒体艺术邱志杰衡山路中国设计师马清运叶庭个性色彩法租界华士纯手工制作

猪linda病毒实时荧光定量PCR检测方法的建立

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中国兽医科学 2023年第11期53卷 1384-1389页

作者：于浩洋史喜菊冯春燕王彩霞刘晓飞仇松寅吴绍强林祥梅中国检验检疫科学研究院动物检验检疫研究所北京100176 中国海关科学技术研究中心北京100026 三亚中国检科院生物安全中心海南三亚572000

为建立猪linda病毒(LV)的实时荧光定量PCR检测方法,本研究基于LV的Erns基因序列,设计并合成了实时荧光定量PCR引物和探针,经过优化退火温度、引物和探针的比例,建立了一种灵敏度高、特异性好且操作简便的LV实时荧光定量PCR检测方法。该... 详细信息

为建立猪linda病毒(LV)的实时荧光定量PCR检测方法,本研究基于LV的Erns基因序列,设计并合成了实时荧光定量PCR引物和探针,经过优化退火温度、引物和探针的比例,建立了一种灵敏度高、特异性好且操作简便的LV实时荧光定量PCR检测方法。该方法具有良好的线性、稳定性及准确性,最低检出限为1×10^(1)copies/μL,批内和批间变异系数均小于2%,且该方法检测非洲猪瘟病毒、猪瘟病毒、猪伪狂犬病病毒、高致病性猪繁殖与呼吸综合征病毒、猪圆环病毒2型时呈阴性。通过对不同模拟样品的检测结果进行比较分析,发现该方法能够检测到1×10^(1)copies/μL模拟DNA样品、1×10^(1)TU/mL模拟RNA样品。本研究建立的实时荧光定量PCR方法可用于LV的快速检测,为口岸检测、预防与控制由LV引起的进境仔猪先天性震颤提供了技术支持。

关键词：猪linda病毒检测方法瘟病毒属实时荧光定量PCR

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我国医院护理人力资源配置与需求的研究

中国实用护理杂志 2011年第31期27卷 1-5页

作者：许莹尤黎明刘可刘华平李小妹李小寒何国平尚少梅胡雁蒋晓莲颜君郑晶朱晓雯中山大学孙逸仙纪念医院广州510089 中山大学护理学院北京协和医学院护理学院西安交通大学护理学院中国医科大学护理学院中南大学护理学院北京大学护理学院复旦大学护理学院四川大学护理学院

目的了解我国医院护理人力资源的配置与教育现状及医院对护理人力资源的需求情况。方法采用问卷调查法对我国内地181所三级、二级医院及9774名护士进行调查。结果三级、二级医院的平均医护比分别为1：1．39和l：1．31，均低于卫生部编... 详细信息

目的了解我国医院护理人力资源的配置与教育现状及医院对护理人力资源的需求情况。方法采用问卷调查法对我国内地181所三级、二级医院及9774名护士进行调查。结果三级、二级医院的平均医护比分别为1：1．39和l：1．31，均低于卫生部编制标准。164所占97．6％医院的医护比和105所占61．8％医院的护士人数占卫生技术人员总数的比例不达标。6050人占62．3％的护士的起始学历是中专。2003年至2007年医院招聘中专生的构成比下降而大专／高职生、本科生的构成比均上升。合同制已成为医院聘用护士的主要形式，从2003年占新人职护士的60％上升到2007年的78％，有的地区已超过90％。2009年至2013年医院对中专生和大专／高职生的需求量及构成比均呈下降趋势，而对本科生和硕士生的需求呈上升趋势。结论我国医院护理人员配置不足，起始学历偏低，新入职护士聘用形式主要为合同制。我国医院对护理人员的需求总量增加，其中对中专生的需求量呈减少的趋势，大专／高职生是需求的主体但需求量呈先增加后减少的趋势，对本科生及研究生的需求量呈增加的趋势。建议合理配置护理人员数量，重视合同制护士的就业环境与职业前景，改善我国护理专业起始教育的层次结构。

关键词：护理人力资源教育需求