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Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia

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Neural Regeneration Research 2018年第8期13卷 1384-1389页

作者： Xiao-Qiao Zhang li li Jiang-Tao Huo Min Cheng lin-hong li Department of General Medicine & Neurology Taihe Hospital Hubei University of Medicine Department of Pharmacy Taihe Hospital Hubei University of Medicine

Repetitive transcranial magnetic stimulation （rTMS） is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive function after vascular dementia remains unknown, In this study, a rat model for vascular dementia was established by the two-vessel occlusion method. Two days after injury, 30 pulses of rTMS were ad- ministered to each cerebral hemisphere at a frequency of 0.5 Hz and a magnetic field intensity of 1,33 T. The Morris water maze test was used to evaluate learning and memory function. The Karnovsky-Roots method was performed to determine the density of cholinergic neurons in the hippocampal CA1 region. Immunohistochemical staining was used to determine the number of brain-derived neurotroph- ic factor （BDNF）-immunoreactive cells in the hippocampal CA1 region, rTMS treatment for 30 days significantly improved learning and memory function, increased acetylcholinesterase and choline acetyltransferase activity, increased the density of cholinergic neurons, and increased the number of BDNF-immunoreactive cells. These results indicate that rTMS can ameliorate learning and memory deficiencies in rats with vascular dementia, The mechanism through which this occurs might be related to the promotion of BDNF expression and subsequent restoration of cholinergic system activity in hippocampal CA 1 region.

关键词： nerve regeneration cholinergic system neurotrophic factor hippocampal CA1 region learning and memory function repetitivetranscranial magnetic stimulation vascular dementia neural regeneration

Fabrication of 2D ZnO Nanosheet Thin Film by a Simple Two-Step Approach

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稀有金属材料与工程 2006年第A03期35卷 642-643页

作者： Ning Wang hong lin Jianbao li Xiaozhan Yang Jun Yang Chunfu lin State Key Lab of New Ceramics ＆ Fine Processing Department of Materials Science ＆ Engineering Tsinghua University Beijing 100084 China

In this paper,2D single-crystalline ZnO nanosheets thin film was fabricated successfully on silicon wafer by a simple two-step ***,SEM and TEM were used to characterize the phase structures and morphologies of ZnO nan... 详细信息

关键词： ZnO nanosheets crystal growth thin film

Faithful Teleportation of an Unknown Atomic-Entangled State Without Bell-State Measurement

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Communications in Theoretical Physics 2008年第3期49卷 621-624页

作者： lin Xiu li hong-Cai YANG Rong-Can HUANG Zhi-Ping School of Physics and OptoElectronics Technology Fujian Normal University Fuzhou 350007 China

An alternative scheme is proposed for teleportation of an unknown atomic-entangled state. The scheme is based on the resonant interaction of a two-mode cavity field with a A-type three-level atom. In contrast with the previously proposed scheme of [Commun. Theor. Phys. 47 （2007） 253], the present scheme is ascendant, since the fidelity is 1.0 in principle similarly without the Bell-state measurement. The scheme may be generalized to not only the teleportation of the cavity-mode-entangled-state but also the teleportation of the multi-atomic entangled states included in generalized GHZ states. And the scheme is experimentally feasible based on the current cavity QED technique.

关键词： teleportation A-type atom two-mode cavity field Bell-state measurement

Hydrological Processes of Storm Runoff from Catchments of Different Land Uses

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Wuhan University Journal of Natural Sciences 2007年第2期12卷 317-321页

作者： hong lin li Minggang SONG Yuansheng State Key Laboratory of Water Resources and Hydropower Engineering Science/School of Water Resources and Hydropower Wuhan University Wuhan 430072 Hubei China

In this paper, a novel and efficient study on the hydrological processes of storm runoff from catchments of different land uses is conducted. The motivation is to precisely simulate the hydrological processes of storm runoff in the agricultural catchments with different patterns of land uses, i.e., forest, paddy, and upland, respectively. As it is discussed in this paper, different land use leads to different characteristics of storm runoff. In order to understand the changes in the hydrological processes of storm runoff from catchments of different land uses, the effects of rainfall intensity, initial soil moisture deficit, evapotranspiration rate, percolation rate, and retention capacity on hydrological processes of the catchments are taken into consideration. According to the principle of water balance, a general model to connect the separate hydrological processes is developed; then, the individual hydrological process is studied in detail： Firstly, the daily evaporation is calculated according to the relation between the actual evapotranspiration and the potential evapotranspiration rate; Secondly, the retention of storm runoff is plotted against the total rainfall, and the maximum storage is calculated; Thirdly, the percolation rate is calculated for each catchment.

关键词： storm runoff hydrological process catchments different land use

Potential Hazards in Smoke-Flavored Fish

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Journal of Ocean University of China 2008年第3期7卷 294-298页

作者： lin hong JIANG Jie li Donghua Seafood Safety Lab College of Food Science and Engineering Ocean University of China Qingdao 266003 P. R. China

Smoking is widely used in fish processing for the color and flavor. Smoke flavorings have evolved as a successful alternative to traditional smoking. The hazards of the fish products treated by liquid-smoking process are discussed in this review. The smoke flavoring is one important ingredient in the smoke-flavored fish. This paper gives the definition of smoke flavorings and the hazard of polycyclic aromatic hydrocarbons （PAHs） residue in the smoke flavorings on the market. It gives also an assessment of chemical hazards such as carcinogenic PAHs, especially Benzo-[α]pyrene, as well as biological hazards such as listeria monocytogenes, Clostridium botulinum, histamine and parasites in smoke-flavored fish. The limitations in regulations or standards are discussed. Smoke flavored fish have lower content of PAHs as compared with the traditional smoking techniques if the PAHs residue in smoke flavorings is controlled by regulations or standards.

关键词： smoke-flavored fish hazards smoke flavoring PAHs

EFFECTS OF TRANSCRANIAL MAGNETIC STIMULATION ON MOTOR CORTICAL EXCITABIliTY AND NEUROFUNCTION AFTER CEREBRAL ISCHEMIA-REPERFUSION INJURY IN RATS

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Chinese Medical Sciences Journal 2005年第4期20卷 226-230,页

作者： hong-lin Feng li Yan Yu-zhou Guan li-ying Cui Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To clarify the effects of repetitive transcranial magnetic stimulation (rTMS) on rat motor cortical excitabi- lity and neurofunction after cerebral ischemia-reperfusion injury. Methods After determined awake resting motor threshold (MT) and motor evoked potentials (MEPs) of right hindlimbs, 20 Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) reperfusion injury, then rTMS were applied to rTMS group (n = 10) at different time, while control group (n = 10) received no stimulation. A week later, MT and MEPs were evaluated again, as well as neurological deficits and infarct volume. The effects of rTMS and MCAO reperfusion injury on these parameters were analyzed. Results After MCAO reperfusion, both MT level and neurological deficit scores increased, distinct focal infarction formed, and latency of MEP elongated. Compared with the control group, the increased extent of MT and neurological scores of rats receiving rTMS were significantly lower (P linear correlation between postinjury MT and infarct volume (r = 0.64, P litate neurofunction recovery after cerebral ischemia-reperfusion. Postinjury MT could provide prognostic information after MCAO reperfusion injury.

关键词： repetitive transcranial magnetic stimulation cerebral ischemia-reperfusion.injury motor threshold motor evoked potential

The discovery of new scaffold of plant activators：From salicylic acid to benzotriazole

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Chinese Chemical Letters 2017年第4期28卷 919-926页

作者： Kang Chang Jian-Qin Chen Yan-Xia Shi Mei-Jian Sun Peng-Fei li Zhen-Jiang Zhao Wei-Ping Zhu hong-lin li Yu-Fang Xu Bao-Ju li Xu-hong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology Shanghai 200237 China State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China Institute of Vegetables and Flowers Chinese Academy of AgricuRural Science Beijing 100081 China

Started from salicylic acid（SA） and related commercialized plant activators,based on molecular threedimensional shape and pharmacophore similarity comparison（SHAFTS）,a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and *** bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo,but no activity in *** the introduction of proper groups at the1＇-position and 5＇-position was beneficial to the ***,they had the potential to be exploited as novel plant activators.

关键词： Plant activator Systemic acquired resistance Salicylic acid Benzotriazole Virtual screening

Design,synthesis and evaluation of PPAR gamma binding activity of 2-thioxo-4-thiazolidinone derivatives

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Chinese Chemical Letters 2015年第1期26卷 63-68页

作者： li Zhou Ye Zhong Meng-Zhu Xue Dong Kuang Xian-Wen Cao Zhen-Jiang Zhao hong-lin li Yu-Fang Xu Rui Wang Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and Technology

We designed and synthesized a series of 2-thioxo-4-thiazolidinone derivatives and evaluated them on peroxisome proliferator activated receptor γ（PPARγ） binding *** the biological assays,compounds 18 and 38 were highlighted with K_i values of 12.15 nmol/Land 14.46 nmol/L,*** structure-activity relationship（SAR） was analyzed to screen privileged structural ***,molecular fitting of these compounds onto the approved drug Rosightazone in the PPARγligand binding domain was performed to elucidate the SAR and explore potential receptor-ligand *** results demonstrate that the 2-thioxo-4-thiazolidinones can be considered as new promising molecular probes with excellent binding activities to PPARγ.

关键词： 2-Thioxo-4-thiazolidinone Peroxisome proliferator activated receptorγ Binding activities SAR Molecular docking

SOME RESULTS OF UPPER ATMOSPHERIC COMPOSITION MEASUREMENTS BY A MASS-SPECTROMETER ON BOARD "SZ-2":CHANGE OF COMPOSITIONS DURING SOLAR AND GEOMAGNETIC DISTURBANCES

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空间科学学报 2002年第Z1期22卷 42-48页

作者： QIN Guotai QIU Shiyan HE Aiqing ZHU Yiqiang SUN lilin lin Xianwen li hong XU Xuepei Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 P.R. China Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 P.R. China Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 P.R. China Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 P.R. China Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 P.R. China Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 P.R. China Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 P.R. China Center for Space Science and Applied Research The Chinese Academy of Sciences Beijing 100080 P.R. China

Upper atmosphere composition data were obtained for the last half year with a quadruple mass spectrometer on board spacecraft "SZ-2" launched on 10 Jan uary 2001. Based on the analysis of these data, the variations of atmospheric compositions in solar and geomagnetic quiet conditions are reported first, then a detailed discussion on the atmospheric composition variations under the so lar and geomagnetic disturbed conditions is given. The results show that near the altitude of 400 km the variations of main atmospheric compositions corre sponding to solar disturbances are more remarkable in the sunlit area than in the shade area. On the contrary, in geomagnetic disturbance events the corre sponding variations are more obvious in the shade area, an evident increase of N2 density at relatively higher latitudes was observed.

关键词： Solar activity, Geomagnetic activity, Atmospheric composition