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Open Journal of Applied Sciences 2025年第1期15卷 329-351页

作者： lin yu School of Foreign Languages Henan University Kaifeng China

This study examines the “V + Dào” construction as a state change event through the lens of the Event Integration Hypothesis. It focuses on how these constructions represent state changes, exploring distinctions between “change” and “stasis”. Using a corpus-based approach, the analysis covers the semantic and syntactic features of “V + Dào” constructions and their event integration patterns. The findings highlight the distribution of agency, animacy, and support relations in state change events, emphasizing the complex interaction of internal and external event integrations and their correlation with the conceptual primitives of change and transition. This study offers insights into the lexicalization and grammaticalization processes of the “V + Dào” construction, and potentially the broader verb-complement constructions in Mandarin.

关键词： “V + Dào” Construction State Change Event Event Integration Semantic Properties Syntactic Properties

Nd@C3N4-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines

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Chinese Chemical Letters 2025年第2期36卷 412-416页

作者： Hong-Tao Ji yu-Han Lu Yan-Ting Liu yu-lin Huang Jiang-Feng Tian Feng Liu Yan-Yan Zeng Hai-Yan Yang Yong-Hong Zhang Wei-Min He Department of Ophthalmology The Affiliated Nanhua Hospital Hengyang Medical School University of South China School of Chemistry and Chemical Engineering University of South China Department of Lung Cancer and Gastroenterology Hunan Cancer Hospital The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University

The first example of Nd@C3N4-photoredox/chlorine dual catalyzed alkylation with unactivated alkanes as the alkyl sources has been developed,which allows for the synthesis of various 4-alkylated cyclic sulfonyl *** this process,chlorine functions as both a redox and hydrogen atom transfer *** synergism of the reversible Nd2+/Nd3+and Clˉ/Cl˙redox pairs significantly enhances overall photocatalytic *** in vitro anticancer activity of 4-alkylated products was evaluated by using the CCK8assay against both human choroidal melanoma （MUM-2B） and lung cancer （A549） *** 3da showed approximately triple the potency of 5-fluorouracil.

关键词： Chlorine Dual catalysis Hydrogen atom transfer Redox catalyst Semiconductor

Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer‑like social memory loss

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Military Medical Research 2025年第1期12卷 48-71页

作者： Hui-Yang Lei Gui-lin Pi Ting He Rui Xiong Jing-Ru Lv Jia-Le Liu Dong-Qin Wu Meng-Zhu Li Kun Shi Shi-Hong Li Na-Na yu Yang Gao Hui-ling yu lin-yu Wei Xin Wang Qiu-Zhi Zhou Pei-lin Zou Jia-Yang Zhou Ying-Zhou Liu Nai-Ting Shen Jie Yang Dan Ke Qun Wang Gong-Ping Liu Xi-Fei Yang Jian-Zhi Wang Ying Yang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Traditional Chinese Medicine the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Key Laboratory of Modern Toxicology of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055GuangdongChina Co‑Innovation Center of Neuroregeneration Nantong UniversityNantong 226000JiangsuChina

Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease(AD),which is closely related to tau pathology and hippocampal *** to the heterogeneity of brain neurons,the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain ***,further investigation is ***:We investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis,social behavioural tests,hippocampal electrophysiology,immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and ***,we utilized optogenetics and administered ursolic acid(UA)via oral gavage to examine the effects of these agents on social memory in ***:The results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1(vCA1)under both physiological conditions and AD-like tau *** tau progressively accumulated,vCA1,especially its excitatory and parvalbumin(PV)neurons,were fully filled with mislocated and phosphorylated tau(p-Tau).This finding was not observed for dorsal hippocampal CA1(dCA1).The overexpression of human tau(hTau)in excitatory and PV neurons mimicked AD-like tau accumulation,significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within *** excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social ***,1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB(TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social ***:This study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau

关键词： Alzheimer’s disease Tau protein Ventral hippocampus Social memory Ursolic acid Transcription factor EB(TFEB)

Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study

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World Journal of Gastroenterology 2025年第2期31卷 102-112页

作者： Thanaboon Chaemsupaphan Aviv Pudipeddi Hui-yu lin Sudarshan Paramsothy Viraj C Kariyawasam Melissa Kermeen Rupert W Leong Department of Gastroenterology and Liver Services Concord Repatriation General HospitalSydney 2139New South WalesAustralia Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Faculty of Medicine and Health University of SydneySydney 2139New South WalesAustralia Department of Gastroenterology Tan Tock Seng HospitalSingapore 308433Singapore Faculty of Medicine and Health Sciences Macquarie UniversitySydney 2139New South WalesAustralia Department of Gastroenterology and Hepatology Blacktown HospitalSydney 2148New South WalesAustralia Blacktown Clinical School Western Sydney UniversitySydney 2148New South WalesAustralia

BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory condition requiring continuous treatment and *** is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thiopurines on vedolizumab trough concentrations is *** To investigate the exposure-response relationship of vedolizumab and the impact of thiopurine withdrawal in UC patients who have achieved sustained clinical and endoscopic remission during maintenance *** This is a post-hoc analysis of prospective randomized clinical trial(VIEWS)involving UC patients across 8 centers in Australia from 2018 to *** in clinical and endoscopic remission were randomized to continue or withdraw thiopurine while receiving *** evaluated vedolizumab serum trough concentrations,presence of anti-vedolizumab antibodies,and clinical outcomes over 48 weeks to assess exposure-response asso-ciation and impact of thiopurine *** There were 62 UC participants with mean age of 43.4 years and 42%were *** participants received vedolizumab as maintenance therapy with 67.7%withdrew *** serum trough concentrations remained stable over 48 weeks regardless of thiopurine use,with no anti-vedolizumab antibodies ***-tients with clinical remission had higher trough concentrations at week *** quartile analysis,a threshold of>11.3μg/mL was associated with sustained clinical remission,showing a sensitivity of 82.4%,specificity of 60.0%,and an area of receiver operating characteristic of 0.71(95%CI:0.49-0.93).Patients discontinuing thiopurine required higher vedolizumab concentrations for achieving *** A positive exposure-response relationship between vedolizumab trough concentrations and UC outcomes suggests that monitoring drug levels may be *** thiopurine did not influence vedolizumab levels,its with-drawal may necessitate higher vedolizumab trough concentrations to maintain remi

关键词： Pharmacokinetic Vedolizumab Thiopurine Ulcerative colitis Trough concentration Antibody Inflammatory bowel diseases

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婴儿泌尿系感染合并高钾血症的临床诊治进展

中国实用儿科杂志 2025年第1期40卷 41-45页

作者：康郁林上海市儿童医院/上海交通大学医学院附属儿童医院肾脏风湿免疫科上海200062

高钾血症是婴儿泌尿系感染(UTI)少见但严重的并发症,其病因包括继发性假性醛固酮减少症(PHA)、药物(如磺胺甲口恶唑)等。其中,继发性PHA是UTI最易被忽视的一类并发症,多见于6月龄以下的UTI或(和)泌尿系畸形患儿,男多于女,临床表现为非... 详细信息

高钾血症是婴儿泌尿系感染(UTI)少见但严重的并发症,其病因包括继发性假性醛固酮减少症(PHA)、药物(如磺胺甲口恶唑)等。其中,继发性PHA是UTI最易被忽视的一类并发症,多见于6月龄以下的UTI或(和)泌尿系畸形患儿,男多于女,临床表现为非特异性,包括喂养困难、饮水量下降、呕吐、腹泻和生长发育迟缓等,少数患儿甚至出现血容量不足、抽搐发作,甚至心脏骤停。实验室检查可见高钾血症、低钠血症、代谢性酸中毒、尿钾排泄减少、尿钠排泄增多、高醛固酮和高肾素活性等。在临床中,应与各类先天性、获得性醛固酮减少症(如先天性肾上腺皮质增生症)等疾病进行鉴别。继发于UTI或(和)泌尿系畸形的PHA患儿,若能早期识别,积极给予补钠、抗感染或外科手术等治疗措施,临床预后较好。

关键词：高钾血症低钠血症泌尿系感染假性醛固酮减少症

Insights on Peripheral Blood Biomarkers for Parkinson’s Disease

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生物化学与生物物理进展 2025年第1期52卷 72-87页

作者：刘经凯 LI yu-Meng LIU Jing-Kai CHEN Zi-Xuan DENG yu-lin Beijing Key Laboratory for the Separation and Analysis of Biomedical Components School of Medical TechnologyBeijing Institute of TechnologyBeijing 100081China

Parkinson’s disease(PD)is a common neurodegenerative disorder with profound impact on patients’quality of life and long-term health,and early detection and intervention are particularly *** recent years,the search for precise and reliable biomarkers has become one of the key strategies to effectively address the clinical challenges of *** this paper,we systematically evaluated potential biomarkers,including proteins,metabolites,epigenetic markers,and exosomes,in the peripheral blood of PD *** markers are one of the main directions of biomarker research in *** particular,α‑synuclein and its phosphorylated form play a key role in the pathological process of *** has been shown that aggregation ofα-synuclein may be associated with pathologic protein deposition in PD and may be a potential marker for early diagnosis of *** terms of metabolites,uric acid,as a metabolite,plays an important role in oxidative stress and neuroprotection in *** has been found that changes in uric acid levels may be associated with the onset and progression of PD,showing its potential as an early diagnostic *** markers,such as DNA methylation modifications and miRNAs,have also attracted much attention in Parkinson’s disease *** in these markers may affect the expression of PD-related genes and have an important impact on the onset and progression of the disease,providing new research perspectives for the early diagnosis of *** addition,exosomes,as a potential biomarker carrier for PD,are able to carry a variety of biomolecules involved in intercellular communication and pathological *** have shown that exosomes may play an important role in the pathogenesis of PD,and their detection in blood may provide a new breakthrough for early *** has been shown that exosomes may play an important role in the pathogenesis of PD,and their detection in blood may provide new breakthroughs in early *** summary,through

关键词： Parkinson’s disease peripheral blood biomarkers early diagnosis

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PBAT全生物降解地膜降解特征

环境科学 2025年第1期46卷 551-559页

作者：金安妮余奋霞王玉林杜特贺婧宁夏大学生态环境学院银川750021 宁夏大学省部共建煤炭高效利用与绿色化工国家重点实验室银川750021 平罗县农业机械化综合服务中心平罗753400 西北退化生态系统恢复与重建教育部重点实验室银川750021 省部共建西北土地退化与生态恢复国家重点实验室培育基地银川750021

全生物降解地膜代替传统塑料地膜是解决“白色污染”的重要研究方向,但其是否能够真正实现生物降解仍是众多学者研究的焦点.以聚己二酸/对苯二甲酸丁二醇酯(PBAT)全生物降解地膜和普通聚乙烯地膜(PE)为研究对象,以不覆膜(CK)为对照,在... 详细信息

全生物降解地膜代替传统塑料地膜是解决“白色污染”的重要研究方向,但其是否能够真正实现生物降解仍是众多学者研究的焦点.以聚己二酸/对苯二甲酸丁二醇酯(PBAT)全生物降解地膜和普通聚乙烯地膜(PE)为研究对象,以不覆膜(CK)为对照,在宁夏回族自治区平罗县开展田间试验和室内试验,观察地膜表观开裂程度、地膜面积损失以及失重率等宏观特征,结合扫描电镜(SEM)、傅里叶红外光谱(FTIR)、热重分析(TG)和CO_(2)释放量等微观特征,综合探究PBAT在银北灌区的降解特征,为其大面积推广提供数据支撑.结果表明,宏观上,PBAT地膜覆盖60 d已经开始破裂,PBAT处理110 d后地膜面积损失率为27.92%,质量损失率(失重率)达到19.04%,均远大于PE地膜.微观上,综合SEM、FTIR图谱以及热重分析,在包埋110 d后,PE地膜无明显变化,而PBAT表面结构发生很大变化,层状结构更加明显,酯基结构发生改变,热稳定性变差.室内模拟试验发现,培养90 d后,PBAT地膜的矿化率为18.30%,接近树叶的矿化率,而PE地膜几乎无矿化.

关键词：聚己二酸/对苯二甲酸丁二醇酯(PBAT) 宏观微观 CO_(2) 降解特征地膜

Combination therapy strategy based on selective internal radiation therapy as conversion therapy for inoperable giant hepatocellular carcinoma: A case report

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 410-417页

作者： Hao, Ming-Zhi lin, Hai-Lan Hu, yu-Bin Chen, Qi-Zhong Chen, Zhang-Xian Qiu, lin-Bin lin, Duan-yu Zhang, Hui Zheng, De-Chun Fang, Zhu-Ting Liu, Jing-Feng Department of Tumor Interventional Radiology Clinical Ocology School of Fujian Medical University Fujian Cancer Hospital Fujian Province Fuzhou 350014 China Department of Oncology and Vascular Interventional Radiology Clinical Oncology School of Fujian Medical University Fujian Province Fuzhou 350014 China Department of Nuclear Medicine Clinical Oncology School of Fujian Medical University Fujian Province Fuzhou 350014 China Department of Hepatopancreatobiliary Surgical Oncology Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital Fujian Province Fuzhou 350014 China Department of Radiology Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital Fujian Province Fuzhou 350014 China Department of Oncology and Vascular Interventional Radiology Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital Fujian Province Fuzhou 350014 China Department of Hepatobiliary Surgery Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital Fujian Province Fuzhou 350014 China

BACKGROUND Hepatocellular carcinoma (HCC) has become a growing health concern globally. Microvascular invasion and high tumor burden are key factors limiting the curative effect of selective internal radiation therapy (SIRT). CASE SUMMARY This case study reports a 49-year-old woman who was diagnosed with China Liver Cancer Staging (CNLC) IIIa HCC and > 15 cm tumor diameter. Initially, due to insufficient future liver remnant and vascular invasion, the tumor was unresectable;however, radical hepatectomy was performed after successful conversion therapy with SIRT using yttrium-90 (90Y) resin microspheres followed by hepatic arterial infusion chemotherapy (HAIC) with tyrosine kinase inhibitor (TKI) and anti-programmed death-1 (PD-1) antibody. SIRT using 90Y resin microspheres was given by the right hepatic artery and chemoembolization was simultaneously performed in the tumor’s feeding vessels from the right diaphragmatic artery. HAIC was followed every three weeks with lenvatinib and tislelizumab. At 4 months post-SIRT, the tumor was downstaged to CNLC Ib and the patient successfully underwent hepatectomy. The histopathological examination of the resected specimen showed extensive necrosis. CONCLUSION This case study provides evidence for an integrated treatment strategy combining SIRT and HAIC with TKI and anti-PD-1 antibodies for patients with large HCC and microvascular invasion. Further confirmatory trials are required in the future. © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

关键词： Case report Conversion therapy Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Selective internal radiation therapy Yttrium-90 resin microspheres

形成性评价在口腔医学理论教学中的实践与反思

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黑龙江高教研究 2025年第1期43卷 60-65页

作者：郭若兰林思宇林江首都医科大学附属北京同仁医院北京100730

目的:利用形成性评价对学生的教学评价进行改进,对口腔医学理论的教学方法进行修正,以期望提升临床教学的效果。方法:实验对象为某医科大学临床医学专业学生(包括五年制和5+3一体化两种学制),通过是否参与形成性评价教学分为对照组和实... 详细信息

目的:利用形成性评价对学生的教学评价进行改进,对口腔医学理论的教学方法进行修正,以期望提升临床教学的效果。方法:实验对象为某医科大学临床医学专业学生(包括五年制和5+3一体化两种学制),通过是否参与形成性评价教学分为对照组和实验组。对照组采用传统教学模式,主要利用教师课堂授课;实验组利用形成性评价改进教学模式,不断对学生的学习情况进行反馈和改进,最终通过期末考试定量评价对比学生的学习效果。结果:在两种学制中,实验组学生均比同学制对照组学生期末成绩有所提高,且差异具有统计学意义(P<0.05)。结论:通过形成性评价改进教学模式,能促进学生自主学习,提高学生综合学习的能力,提升学习效果。

关键词：形成性评价口腔医学教学方法

智能汽车时代下的生态驾驶模式创新与发展趋势研究

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内燃机与配件 2025年第1期 133-135页

作者：林煜福建船政交通职业学院汽车学院福建福州350007

随着中国经济的快速发展,汽车数量快速增加,为了有效保证人们的行车安全,使各类交通事故的发生概率得到降低,需要确保驾驶员掌握相关的驾驶技能,增强驾驶员的安全意识,以此来进一步保证汽车的安全驾驶。生态驾驶是符合当前各国落实的节... 详细信息

随着中国经济的快速发展,汽车数量快速增加,为了有效保证人们的行车安全,使各类交通事故的发生概率得到降低,需要确保驾驶员掌握相关的驾驶技能,增强驾驶员的安全意识,以此来进一步保证汽车的安全驾驶。生态驾驶是符合当前各国落实的节能减排要求的,既能够降低能耗,也可以减少碳排放。通过将生态驾驶与智能网联汽车驾驶技术进行融合,推动二者实现更好地发展,以此满足时代发展要求。基于此,本文针对智能汽车时代下的生态驾驶模式创新与发展趋势进行重点分析。

关键词：智能汽车生态驾驶模式创新与发展