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Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming Li Jianfeng Li Guoliang Chen tao lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu Liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

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Metastable seed-crystals: epitaxial growth of branched-array organic heterostructure nanowires

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Science China Chemistry 2025年

作者： Jin Feng Zhen-Yu Geng Ting-Yao Song Ying-Xin Ma Chuan-Zeng Wang Wei Zhang Hong-tao lin Jin Zhou Shu-Ping Zhuo Shu-Hai Chen Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of Technology Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University College of Chemistry and Chemical Engineering Hunan Normal University

Tunable light–matter interactions are exhibited by organic low-dimensional crystals, making these crystals a promising platform for organic photonics. However, the precise synthesis of organic low-dimensional crystals remains challenging due to the stochastic nature of molecular nucleation processes. Herein, the directed nucleation process is driven by the introduction of metastable seed-crystals as the trunk, which ultimately leads to branched-array organic heterostructures. The successful formation of organic heterostructures with high-density branched arrays is attributed to the highest attachment energy (Eatt（023）=-104.25 kcal mol-1) of the exposed （023） crystal plane during the seed-crystal growth route. Significantly, these as-prepared heterostructures inherently have an ultralow lattice mismatch ratio η of 0.7%between trunk and branch, which contributes to the multi-channel photon transportation. Therefore, this work provides valuable insights into a versatile synthetic strategy for accessing low-dimensional heterostructures for integrated optoelectronics.

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《诗经》“风”义原始与《风》诗文体

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广西师范大学学报（哲学社会科学版） 2025年第1期61卷 137-146页

作者：林训涛深圳大学人文学院广东深圳518060

《诗经》分为风、雅、颂,体现了清晰的文体分类意识。从《毛诗大序》对“风”的定义和阐释出发,考察“风”的字形字义及其所具有的早期社会的文化意蕴,可认为“风”的本义是以容器(食器)又兼礼器的盘(槃)为基础而产生的具有两性关系及... 详细信息

《诗经》分为风、雅、颂,体现了清晰的文体分类意识。从《毛诗大序》对“风”的定义和阐释出发,考察“风”的字形字义及其所具有的早期社会的文化意蕴,可认为“风”的本义是以容器(食器)又兼礼器的盘(槃)为基础而产生的具有两性关系及生殖方面文化意蕴的地方音乐。历代关于“风”义的说法诸如讽刺、风教、声调都是在本义基础上的引申义。“风”的本义对《诗经》中《风》诗文体的形成具有明显的作用:其一,通过“采诗”,“风”从“两性关系和生殖”的意义转变为“风教”的教化意义,进而形成《风》诗文体;其二,“风”的本义决定了《风》诗相较于《雅》《颂》在内容、功用及辞章结构上明显的文体区别。

关键词：《诗经》风本义风教文体

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Development of a new continuous process for the production of 3,5-dimethylpiperidine

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Chinese Journal of Chemical Engineering 2022年第1期35卷 374-383页

作者： tao lin Xiaoxun Ma School of Chemical Engineering Northwest UniversityXi’an 710069China Kaili Catalyst&New Materials Co. Ltd.Xi’an 710201China Chemical Engineering Research Center of the Ministry of Education(MOE)for Advanced Use Technology of Shanbei Energy Xi’an 710069China Shaanxi Research Center of Engineering Technology for Clean Coal Conversion Xi’an 710069China Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi Xi’an 710069China International Scientific and Technological Cooperation Base of the Ministry of Science and Technology(MOST)for Clean Utilization of Hydrocarbon Resources Xi’an 710069China

This paper developed a new clean continuous process for the hydrogenation of 3,5-dimethylpyridine(DPY)to 3,5-dimethylpiperidine(DPI)without solvent.A series of Ru/C catalysts were prepared by impregnation method,which were characterized by the BET,ICP,CO chemisorptions,XRD,SEM,EDS,TEM and *** effect of active species,loading,catalyst support,reaction temperature and pressure on the catalytic performance was *** influence of internal and external diffusion in the trickle-bed reactor(TBR)was basically eliminated by adjusting the particle size and dosage of the Ru/C *** reaction performance of the hydrogenation of DPY to DPI in the TBR and kettle reactor(KR)was compared,and the superiority of the TBR process was *** results show that this new continuous process developed in this study is an efficient way to realize the hydrogenation of DPY to DPI,and has a good industrial application prospect.

关键词： Trickle-bed reactor(TBR) Kettle reactor(KR) Hydrogenation 3,5-Dimethylpyridine(DPY) 3,5-Dimethylpiperidine(DPI)

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Development of an in-situ H_(2)reduction and moderate oxidation method for 3,5-dimethylpyridine hydrogenation in trickle bed reactor

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Frontiers of Chemical Science and Engineering 2022年第12期16卷 1807-1817页

作者： tao lin Xiaoxun Ma School of Chemical Engineering Northwest UniversityXi’an 710069China Kaili Catalyst&New Materials Co. Ltd.Xi’an 710201China Shaanxi Key Laboratory of Catalytic Materials and Technology Xi’an 710201China Chemical Engineering Research Center of the Ministry of Education(MOE)for Advanced Use Technology of Shanbei Energy Xi’an 710069China Shaanxi Research Center of Engineering Technology for Clean Coal Conversion Xi’an 710069China Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi Xi’an 710069China International Scientific and Technological Cooperation Base of the Ministry of Science and Technology(MOST)for Clean Utilization of Hydrocarbon Resources Xi’an 710069China

The Ru/C catalyst prepared by impregnation method was used for hydrogenation of 3,5-dimethylpyridine in a trickle bed *** the same reduction conditions(300°C in H_(2)),the catalytic activity of the non-in-situ reduced Ru/C-n catalyst was higher than that of the in-situ reduced Ru/C-y ***,an in-situ H_(2)reduction and moderate oxidation method was developed to increase the catalyst ***,the influence of oxidation temperature on the developed method was *** catalysts were characterized by Brunauer–Emmett–Teller method,hydrogen temperature programmed reduction H_(2)-TPR,hydrogen temperature-programmed dispersion(H_(2)-TPD),X-ray diffraction,energy dispersive spectroscopy,X-ray photoelectron spectroscopy,Raman spectroscopy,O2 chemisorption and oxygen temperature-programmed dispersion(O2-TPD)*** results showed that there existed an optimal Ru/RuO_(x)ratio for the catalyst,and the highest 3,5-dimethylpyridine conversion was obtained for the Ru/C-i1 catalyst prepared by in-situ H_(2)reduction and moderate oxidation(oxidized at 100°C).Excessive oxidation(200°C)resulted in a significant decrease in the Ru/RuO_(x)ratio of the in-situ H_(2)reduction and moderate oxidized Ru/C-i2 catalyst,the interaction between RuO_(x)species and the support changed,and the hard-to-reduce RuO_(x)species was formed,leading to a significant decrease in catalyst *** developed in-situ H_(2)reduction and moderate oxidation method eliminated the step of the non-in-situ reduction of catalyst outside the trickle bed reactor.

关键词： Ru C catalyst in-situ H_(2)reduction and moderate oxidation in-situ reduction non-in-situ reduction hydrogenation of 3,5-dimethylpyridine

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INTERIOR PENALTY BIlinEAR IFE DISCONTINUOUS GALERKIN METHODS FOR ELLIPTIC EQUATIONS WITH DISCONTINUOUS COEFFICIENT

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Journal of Systems Science & Complexity 2010年第3期23卷 467-483页

作者： Xiaoming HE tao lin Yanping lin Department of Mathematics Virginia Teeh Blacksburg VA 24061 USA Department of Applied Mathematics Hong Kong Polytechnic University Hung Horn Hong Kong China Department of Mathematical and Statistics Science University of Alberta Edmonton AB T6G 2G1 Canada.

This paper applies bilinear immersed finite elements （IFEs） in the interior penalty discontinuous Galerkin （DG） methods for solving a second order elliptic equation with discontinuous coefficient. A discontinuous bihnear IFE space is constructed and applied to both the symmetric and nonsymmetric interior penalty DG formulations. The new methods can solve an interface problem on a Cartesian mesh independent of the interface with local refinement at any locations needed even if the interface has a nontrivial geometry. Numerical examples are provided to show features of these methods.

关键词： Adaptive mesh discontinuous Calerkin immersed interface interface problems penalty.

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Parallel processing architecture of H.264 adaptive deblocking filters

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第8期10卷 1160-1168页

作者： Hu WEI tao lin Zheng-hui lin Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

In H.264,computational complexity and memory access of deblocking filters are variable,dependent on video *** paper proposes a VLSI architecture of deblocking filters with adaptive dynamic power,which avoids redundant computations and memory accesses by precluding the blocks that can be *** vertical and horizontal edges are simulta-neously processed in an advanced scan order to speed up the *** a result,dynamic power of the proposed architecture can be reduced adaptively(up to about 89%) for different videos,and the off-chip memory access is improved when compared to previous ***,the processing capability of the proposed architecture is in particular appropriate for real-time deblocking of high-definition television(HDTV,1920×1080 pixels/frame,60 frames/s video signals) video operation at 62 *** the proposed architecture,power can be reduced by up to about 89% and processing time by from 25% to 81% compared with previous designs.

关键词： Deblocking filter Adaptive dynamic power Parallel processing Pipeline H.264

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Macroblock-level decoding and deblocking method and its pipeline implementation in H.264 decoder SOC design

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 36-41页

作者： WANG Shu-hui lin tao lin Zheng-hui Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200030 China

This paper presents a macroblock-level (MB-level) decoding and deblocking method for supporting the flexible macroblock ordering (FMO) and arbitrary slice ordering (ASO) bit streams in H.264 decoder and its SOC/ASIC implementation. By searching the slice containing the current macroblock in the bit stream and switching slices correctly, MBs can be decoded in the raster scan order, while the decoding process can immediately begin as long as the slice containing the current MB is available. This architectural modification enables the MB-level decoding and deblocking 3-stage pipeline, and saves about 20% of SDRAM bandwidth. Implementation results showed that the design achieves real-time decoding of 1080HD (1920×1088@30 fps) at a system clock of 166 MHz.

关键词： Flexible macroblock ordering (FMO) Arbitrary slice ordering (ASO) System-on-chip (SOC) Raster scan order Pipeline

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Enhanced removal of organic matter and typical disinfection byproduct precursors in combined iron–carbon micro electrolysis-UBAF process for drinking water pre-treatment

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Journal of Environmental Sciences 2019年第4期31卷 315-327页

作者： Yinghan Chen tao lin Wei Chen Ministry of Education Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Hohai University College of Environment Hohai University

The organic matter and two types of disinfection byproduct(DBP) precursors in micropolluted source water were removed using an iron–carbon micro-electrolysis(ICME)combined with up-flow biological aerated filter(UBAF) process. Two pilot-scale experiments(ICME-UBAF and UBAF alone) were used to investigate the effect of the ICME system on the removal of organic matter and DBP precursors. The results showed that ICME pretreatment removed 15.6% of dissolved organic matter(DOM)and significantly improved the removal rate in the subsequent UBAF process. The ICME system removed 31% of trichloromethane(TCM) precursors and 20% of dichloroacetonitrile(DCAN) precursors. The results of measurements of the molecular weight distribution and hydrophilic fractions of DOM and DBP precursors showed that ICME pretreatment played a key role in breaking large-molecular-weight organic matter into low-molecular-weight components, and the hydrophobic fraction into hydrophilic compounds, which was favorable for subsequent biodegradation by ***-dimensional fluorescence spectroscopy(3D-EEM) further indicated that the ICME system improved the removal of TCM and DCAN precursors. The biomass analysis indicated the presence of a larger and more diverse microbial community in the ICME-UBAF system than for the UBAF alone. The high-throughput sequencing results revealed that domination of the genera Sphingomonas, Brevundimonas and Sphingorhabdus contributed to the better removal of organic matter and two types of DBP precursors. Also, Nitrosomonas and Pseudomonas were beneficial for ammonia removal.

关键词： Drinking water pre-treatment Micro-electrolysis Up-flow biological aerated filter Organic matter Disinfection by-product precursors

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Particle properties in granular activated carbon filter during drinking water treatment

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Journal of Environmental Sciences 2010年第5期22卷 681-688页

作者： tao lin Wei Chen Leilei Wang Key Laboratory of lntegrated Regulation and Resource Development on Shallow Lakes Ministry of Education Hohai University Nanjing 210098 China College of Environment Hohai University Nanjing 210098 China

The elemental composition and bacteria attached in particles were investigated during granular activated carbon （GAC） *** experimental results showed that trapped influent particles could form new,larger particles on GAC *** sloughing of individuals off GAC surface caused an increase in effluent particles in the size range from 5 to 25 μ*** selectivity for element removal in GAC filters caused an increasing proportion of metallic elements in the effluent *** distribution of molar ratio indicated a complicated composition for large particles,involving organic and inorganic *** organic proportion accounted for 40% of total carbon attached to the *** with dissolved carbon,there was potential for the formation of trihalomethanes by organic carbon attached to particles,especially for those with size larger than 10 μ*** pure carbon energy spectrum was found only in the GAC effluent and the size distribution of carbon fines was mainly above 10 μ*** larger carbon fines provided more space for bacterial colonization and stronger protection for attached bacteria against *** residual attached bacteria after chorine disinfection was increased to 10 2-10 3 CFU/mL within 24 hours at 25°C.

关键词： drinking water treatment GAC filters bacterial attachment to carbon

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