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Sintilimab(anti-PD-1.antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2765-2773页

作者： Yan gao Haixia He Xueping li liling Zhang Wei Xu Ru feng Wenyu li Yin Xiao Xinxiu liu Yu Chen Xiaoxiao wang Bing Bai Huijing Wu Qingqing Cai Zhiming li Jibin li Suxia lin Yanxia He liqin Ping Cheng Huang Jiaying Mao Xiujin Chen Baitian zhao Huiqiang Huang State Key Laboratory of Oncology in South china&Collaborative Innovation Center of Cancer Medicine Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina department of Hematology Sun Yat-sen University Cancer CenterGuangzhouChina Cancer Center Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingChina department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina department of Lymphoma Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina department of pathology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina department of Medical Oncology Hubei Cancer CenterWuhanChina department of C{1.ical Research Sun Yat-sen University Cancer CenterGuanzhouChina department of Pathology Sun Yat-sen University Cancer CenterGuangzhouChina

Anti-PD-1.antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be *** phase 1./2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1.antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with *** objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21.days cycles up to 1. *** dose-limiting events were observed,RP2D of chidamide was 30 mg twice a ***-nine patients were enrolled in phase *** the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,*** most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(1..5%),immune-related AEs were reported in 1.(47.3%)*** biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic ***3 mutation shows an unfavorable *** outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first *** is a promising therapeutic option for this population.

关键词： killer lymphoma doses

Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang Zheng-De Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng liu Gen Lu Ji-Kui Deng Guang-Hua liu Xiao-Chuan wang Jian-She wang Lu-zhao feng Wei liu Yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang liu li-Wei gao li-Juan Xiong Yan Bai li-Kai lin Zhuang Wei feng-Xia Xue Tian-You wang Dong-Chi zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong Zheng-Yan zhao Xing-wang li Yong-Hong Yang Kun-ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China department of Respiratory Shenzhen Children's HospitalShenzhen 518038China department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China department of C{1.ical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 201.(COVID-1.)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

Blocking the PD-1.signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2

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Science china {1.fe Sciences 2024年

作者： Wenjie li Wenyi Mei Hewei Jiang Jie wang Xiaoli li lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi feng Zhang Lei Ma Jian Zhang Yufeng gao Aris Paschalidis Honghuang lin Fangfang liu Kangdong liu Mingliang Ye Zhenjiang zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao lili Zhu Honglin li Innovation Center for AI and Drug Discovery East China Normal University Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&Technology Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine (Ministry of Education)Shanghai Jiao Tong University lingang Laboratory Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan University CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences department of Cardiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China department of Infectious Diseases The First Affiliated Hospital of Anhui Medical University department of Medicine University of Massachusetts Chan Medical School department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou University

Targeting the PD-1.PD-L1.axis with small-molecular inhibitors is a promising approach for immunotherapy. Here, we identify a natural pentacyclic triterpenoid, Pygenic Acid A(PA), as a PD-1.signa{1.g inhibitor. PA exerts anti-tumor activity in hPD-1.knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the PD-1.signa{1.g transduction. Furthermore, we identify SHP-2 as the direct molecular target of PA for inhibiting the PD-1.signa{1.g transduction. Subsequently, mechanistic studies suggest that PA binds to a new druggable site in the phosphorylated PD-1.ITSM recognition site of SHP-2, inhibiting the recruitment of SHP-2 by PD-1. Taken together, our findings demonstrate that PA has a potential application in cancer immunotherapy and occupying the phosphorylated ITSM recognition site of SHP-2 may serve as an alternative strategy to develop PD-1.signa{1.g inhibitors. In addition, our success in target recognition provides a paradigm of target identification and confirmation for natural products.

关键词：

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied {1. department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing normal {1. Beijing Brown university ProvidenceRI Budker Institute of Nuclear physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china {1. university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering {1. MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Ji{1.ang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china {1. of Geosciences Beijing china {1. of Geosciences WuhanHubei china {1. of Mining and Technology XuzhouJiangsu china West {1. university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu {1. DalianLiaoning Dalian {1. of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china {1. Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by{1.,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×1.^(34)cm^(-2)s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1. ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,201.)and the Conceptual Design Report(CDR,201.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

The first four cases of successful NeoChord procedure in Chinese mainland

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World Journal of Emergency Medicine 2019年第3期10卷 133-137页

作者： li-han {1. zhao-xia Pu Min-jian Kong Ju-bo Jiang Kai-da Ren feng gao Xin-ping lin Lei Yu Wei He Min Yan Xian-bao liu Jian-an {1. Cardiovascular department the Second Affiliated HospitalZhejiang University School of Medicine

BACKGROUND:Transapical off-pump NeoChord procedure is a novel minimally invasive surgical repair of degenerative mitral regurgitation(MR).Here,we report the first four cases of NeoChord procedure in patients with mitral valve prolapse in Chinese ***:Four patients,aged 86,84,80 and 60 years,with severe MR due to posterior middle scallop prolapse(P2),underwent transapical off-pump artifi cial chordae implantation on April 9 and 1.,*** procedure was performed by left mini-thoracotomy under general anaesthesia and guided by 2D and 3D dimensional transoesophageal echocardiography(TEE).RESULTS:Mitral valve repair via NeoChord procedure was successfully performed with implantation of 3 artifi cial chordae in the fi rst patient and 3,2,and 3 artifi cial chordae in the following patients,*** TEE and pre-discharge transthoracic echocardiography(TTE)showed only mild to moderate MR of these four patients and no postoperative complications were *** were no changes of TTE fi nding between one-month follow-up and ***:The successful NeoChord procedures in four Chinese indicate that the valve repair using the NeoChord system for Chinese population is feasible.

关键词： Mitral regurgitation Mitral valve repair NeoChord system

Comparison of Long-term Outcomes in Patients with Premature Triple-vessel Coronary Disease Undergoing Three Different Treatment Strategies： A Prospective Cohort Study

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Chinese Medical Journal 2018年第1期131卷 1-9页

作者： Jing-Jing Xu Yin Zhang lin Jiang Jian Tian Lei Song Zhan {1. Xin-Xing feng Xue-Yan zhao Yan-Yan zhao Dong wang Kai Sun lian-Jun Xu Ru liu Run-lin {1. Bo Xu Lei Song Jin-Qing Yuan department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China department of Endocrinology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China Medical Research and Biometrics Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China department of State Key Laboratory of Cardiovascular Disease State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China department of Hypertension Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China

Background： Patients with premature triple-vessel disease （PTVD） have a higher risk of recurrent coronary events and repeat revascularization： however, the long-term outcome of coronary artery bypass grafting （CABG）, percutaneous coronary intervention （PCI）, and medical therapy （MT） alone for PTVD patients is controversial. The aim of this study is to evaluate the long-term outcome of PTVD patients among these three treatment strategies, to find out the most appropriate treatment methods lbr these patients. Methods： One thousand seven hundred and ninety-two patients with PTVD （age： men 〈50 years and women _〈60 years） were enrolled between 2004 and 201.. The primary end point was all-cause death. The secondary end points were cardiac death, myocardial infarction, stroke, or repeat revascularization. Results： PCI, CABG, and MT alone were performed in 933 （52.1.）, 459 （25.6%）, and 400 （22.3%） patients. Both PCI and CABG were associated with lower all-cause death （4.6% vs. 4.1. vs. 1..5%, respectively, P 〈 0.01. and cardiac death （2.8% vs. 2.0% vs. 9.8%, respectively, P 〈 0.01.） versus MT alone. The rate of repeat revascularization in the CABG group was significantly lower than those in the PCI and MT groups. After adjusting for baseline factors, PCI and CABG were still associated with similar lower risk of all-cause death and cardiac death versus MT alone （all-cause death： hazard ratio [HR]： 0.35, 95% confidence interval [CI]： 0.23-0.53, P 〈 0.01.and HR： 0.35, 95% CI： 0.1.-0.70, P= 0.003, respectively, and cardiac death： HR： 0.32, 95% CI： 0.1.-0.54, P〈 0.01.and HR： 0.36, 95% CI：0.1.-0.93, P = 0.03, respectively）. Conclusions： PCI and CABG provided equal long-term benefits for all-cause death and cardiac death for PTVD patients. Patients undergoing MT alone had the worst long-term clinical outcomes.

关键词： Coronary Artery Bypass Grafting Medical Therapy: Percutaneous Coronary Intervention: Premature Coronary Heart Disease Triple-vessel Coronary Disease

Vascular endothelial growth factor expressing mesen-chymal stem cells improves cardiac function in chronic myocardial infarction in pigs

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Chinese Medical Journal 2006年第19期119卷 1664-1668页

作者： YI Fu GUO Wen-yi Lue An-lin {1. Hai-chang li Hu li Wei-jie liU Bing ZHANG Dian-xin LUAN Rong-hua CHENG He-xiang li Fei QIN Tao zhao Zhi-jing gao feng JIA Guo-liang department of Cardiology Xijing Hospital Fourth Military Medical University Xi＇an 710032 China department of Physiology Fourth Military Medical University Xi＇ an 710032 China

Transplantation of mesenchymal stem cells （MSCs） for myocardial reconstruction has shown promise in both animal models and human phase 1.clinical studies. Vascular endothe{1.al growth factor （VEGF） is a strong therapeutic agent for treating ischaemia by inducing angiogenesis. The feasibi{1.ty of ex vivo MSCs mediated gene transfer is documented. Matsumoto and colleagues have recently reported genetically engineered MSCs carrying VEGF1.5 de{1.very for revascularization in a model of acute myocardial infarction （MI）. The promising data from our laboratory in both angiogenesis and MSCs transplantation in cunicular heart model of acute MI have prompted us to attempt the combined and simultaneous app{1.cation of the two strategies.

关键词： myocardial infarction mesenchymal stem cell transplantation vascular endothelial growth factor ventricular function

Using machine learning to aid treatment decision and risk assessment for severe three-vessel coronary artery disease

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Journal of Geriatric Cardiology 2022年第5期19卷 367-376页

作者： liu JIE Xin-Xing feng Yan-feng DUAN Jun-Hao liU Ce ZHANG lin JIANG lian-Jun XU Jian TIAN Xue-Yan zhao Yin ZHANG Kai SUN Bo XU Wei zhao Ru-Tai HUI Run-lin gao Ji-Zheng wang Jin-Qing YUAN Xin HUANG Lei SONG State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Endocrinology and Cardiovascular Disease Centre Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina department of Endocrinology Fuwai HospitalChinese Academy of Medical SciencesShenzhenChina Nanjing TooBoo Technology Co. Ltd.NanjingChina department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiomyopathy Ward Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Information Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center for Cardiovascular Diseases Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Solar activity Prediction Center National Astronomical ObservatoriesChinese Academy of SciencesBeijingChina

BACKGROUND Three-vessel disease(TVD)with a SYNergy between PCI with TAXus and cardiac surgery(SYNTAX)score of≥23 is one of the most severe types of coronary artery *** aimed to take advantage of machine learning to help in de-cision-making and prognostic evaluation in such *** We analyzed 3786 patients who had TVD with a SYNTAX score of≥23,had no history of previous revascularization,and underwent either coronary artery bypass grafting(CABG)or percutaneous coronary intervention(PCI)after *** patients were randomly assigned to a training group and testing *** C4.5 decision tree algorithm was applied in the training group,and all-cause death after a median follow-up of 6.6 years was regarded as the class *** The decision tree algorithm selected age and left ventricular end-diastolic diameter(LVEDD)as splitting features and divided the patients into three subgroups:subgroup 1.age of≤67 years and LVEDD of≤53 mm),subgroup 2(age of≤67 years and LVEDD of>53 mm),and subgroup 3(age of>67 years).PCI conferred a patient survival benefit over CABG in sub-group *** was no significant difference in the risk of all-cause death between PCI and CABG in subgroup 1.and subgroup 3 in both the training data and testing *** the total study population,the multivariable analysis revealed significant dif-ferences in the risk of all-cause death among patients in three *** The combination of age and LVEDD identified by machine learning can contribute to decision-making and risk assessment of death in patients with severe *** present results suggest that PCI is a better choice for young patients with severe TVD characterized by left ventricular dilation.

关键词： coronary testing treatment

An efficient route to prepare suspended monolayer for feasible optical and electronic characterizations of two-dimensional materials

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InfoMat 2022年第2期4卷 126-138页

作者： Yuan Huang Yun-Kun wang Xin-Yu Huang Guan-Hua Zhang Xu Han Yang Yang Yunan {1. Lei Meng Yushu wang Guang-Zhou Geng li-Wei liu lin zhao Zhi-Hai Cheng Xin-feng liu Ze-feng Ren Hui-Xia Yang Yufeng Hao Hong-Jun {1. Xing-Jiang Zhou Wei Ji Ye-liang wang Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijingChina Beijing National Laboratory for Condensed Matter physics Institute of PhysicsChinese Academy of SciencesBeijingChina Songshan Lake Materials Laboratory DongguanChina State Key Laboratory for Artificial Microstructure and Mesoscopic physics School of PhysicsPeking UniversityBeijingChina Frontiers Science Center for Nanooptoelectronics&Collaborative Innovation Center of Quantum Matter BeijingChina State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanChina Minzu university of{1. BeijingChina National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional MaterialsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingChina School of Information and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijingChina department of {1. and Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Renmin University of ChinaBeijingChina National Center for Nanoscience and Technology(NCNST)of china BeijingChina Haian Institute of New Technology Nanjing UniversityHaianChina university of Chinese Academy of Sciences BeijingChina

Two-dimensional(2D)materials are highly sensitive to substrates,interfaces,and the surrounding *** 2D materials are free from substrate-induced effects,thus an ideal approach to study their intrinsic ***,it is very challenging to prepare large-area suspended 2D materials with high *** we report a universal method,based on pretreatments of densely patterned hole array substrates with either oxygenplasma or gold film deposition,to prepare large-area suspended mono-and few-layer 2D *** structural,optical,and electrical characterization tools were used to fully evaluate the improved performance of various suspended 2D *** of these observations reported in this study are:(1.Observation of a new Raman low frequency mode for the suspended MoS_(2);(2)Significantly stronger photoluminescence(PL)and second harmonic generation(SHG)signals of suspended WSe_(2),which enables the study of new optical transition processes;(3)The low energy electron diffraction pattern on suspended MoS_(2) also exhibits much sharper spots than that on the supported area;and(4)The mobility of suspended graphene device approaches 300000 cm^(2) V^(-1. s^(-1.,which is desirable to explore the intrinsic properties of *** work provides an innovative and efficient route for fabricating suspended 2D materials,and we expect that it can be broadly used for studying intrinsic properties of 2D materials and in applications of hybrid active nanophotonic and electronic devices.

关键词： mechanical exfoliation photoluminescence Raman spectrum suspended 2D materials