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Triterpene saponins with XOD inhibitory activity from the roots of Ilex pubescens

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Chinese Chemical Letters 2011年第6期22卷 697-700页

作者： Li Ping lin Wei qu Jing Yu Liang Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A new triterpene saponin with 28-nor-urs-12（13）,18（17）-dien-3β-ol as aglycone,named ilexsaponin C（1） was isolated from the roots of Ilex pubescens,together with three known saponins 2,3 and *** structure of 1 was elucidated on the basis of spectral analysis including 1D and 2D NMR and *** 1 and 4 exhibited significant XOD inhibitory activity in the test.

关键词： Triterpene saponin Ilex pubescens Ilexsaponin C Xanthine oxidase

Modified physiological and operative score for the enumeration of mortality and morbidity risk assessment model in general surgery

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World Journal of Gastroenterology 2007年第38期13卷 5090-5095页

作者： Lian-An Ding Li-qun Sun Shuang-Xi Chen lin-lin qu Dong-Fang Xie Department of General Surgery Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China Department of ICU Haici Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China

AIM: To establish a scoring system for predicting the incidence of postoperative complications and mortality in general surgery based on the physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM), and to evaluate its efficacy. METHODS: Eighty-four patients with postoperative complications or death and 172 patients without postoperative complications, who underwent surgery in our department during the previous 2 years, were retrospectively analyzed by logistic regression. Fifteen indexes were investigated including age, cardiovascular function, respiratory function, blood test results, endocrine function, central nervous system function, hepatic function, renal function, nutritional status, extent of operative trauma, and course of anesthesia. Modified POSSUM (M-POSSUM) was developed using significant risk factors with its efficacy evaluated. RESULTS: The significant risk factors were found to be age, cardiovascular function, respiratory function, hepatic function, renal function, blood test results, endocrine function, nutritional status, duration of operation, intraoperative blood loss, and course of anesthesia. These factors were all included in the scoring system. There were significant differences in the scores between the patients with and without postoperative complications, between the patients died and survived with complications, and between the patients died and survived without complications. The receiver operating characteristic curves showed that the M-POSSUM could accurately predict postoperative complications and ***: M-POSSUM correlates well with postoperative complications and mortality, and is more accurate than POSSUM.

关键词： Physiological and operative severity score for the enumeration of mortality and morbidity Postoperative morbidity Mortality Preoperative assessment General surgery Critical illness

Dynamic characteristics of a shrouded blade with impact and friction

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Frontiers of Mechanical Engineering 2020年第2期15卷 209-226页

作者： Xumin GUO Jin ZENG Hui MA Chenguang ZHAO lin qu Bangchun WEN School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Key Laboratory of Vibration and Control of Aero-Propulsion System Ministry of Education Northeastern UniversityShenyang 110819China

A simplified computational model of a twisted shrouded blade with impact and friction is *** this model,the shrouded blade is simulated by a flexible Timoshenko beam with a tip-mass,and the effects of centrifugal stiffening,spin softening,and Coriolis force are *** force is simulated using a linear spring model,and friction force is generated by a tangential spring model under sticking state and a Coulomb friction model under sliding *** proposed model is validated by a finite element ***,the effects of initial gap and normal preload,coefficient of friction,and contact stiffness ratio(the ratio of tangential contact stiffness to normal contact stiffness)on system vibration responses are *** show that resonant peaks become inconspicuous and impact plays a dominant role when initial gaps are large between adjacent *** contrast,in small initial gaps or initial normal preloads condition,resonant speed increases sharply,and the optimal initial normal preloads that can minimize resonant amplitude becomes *** of friction affects the optimal initial normal preload,but it does not affect vibration responses when the contact between shrouds is under full *** resonant amplitude decreases with the increase of contact stiffness ratio,but the optimal initial normal preload is unaffected.

关键词： twisted shrouded blade dynamic analysis impact friction separate-stick-slip motion

Gastric plexiform fibromyxoma:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5639-5644页

作者： Jin-Yu Pei Bin Tan Peng Liu Guang-Hua Cao Zu-Sen Wang lin-lin qu Department of Hepatopancreatobiliary Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266555Shandong ProvinceChina Medical College Qingdao UniversityQingdao 266071Shandong ProvinceChina

BACKGROUND Plexiform fibromyxoma(PF)is a rare mesenchymal tumor of the *** clinical features of PF frequently include upper abdominal pain,abdominal discomfort,hematemesis,melena,pyloric obstruction and an upper abdominal *** herein report a case of PF resected by laparoscopic radical distal gastrectomy plus Roux-en-Y *** SUMMARY The patient was admitted to hospital,due to a 1-wk history of an abdominal space-occupying lesion identified during a health *** underwent complete resection by laparoscopic radical distal gastrectomy plus Roux-en-Y *** the operation,the tumor was located in the anterior wall of the gastric antrum(approximately 7 cm×6 cm×5.5 cm)and did not show evidence of invasion of the *** showed that the tumor cells were oval fibroblast-like and spindle-shaped cells,with numerous thin-walled blood vessels and abundant myxoid *** atypia and mitosis were both *** showed that the tumor cells were immunoreactive for smooth muscle actin,S-100 and CD-10,but were negative for CD-117,CD-34,DOG-1,and *** this case,S-100 was positive and no significant disease was observed during the follow-up *** The fact that PF is a rare tumor with only a few cases in this region can lead to misdiagnosis of this entity and pose a real diagnostic challenge for general surgeons and pathologists when encountering such patients and differentiating PF from other primary tumors of gastric mesenchymal *** report may help increase awareness of this rare,but important new disease entity.

关键词： Gastric plexiform fibromyxoma Plexiform fibromyxoma Immunohistochemistry Operation Mesenchymal tumors of stomach Stomach Case report

Carotid-cavernous fistula following mechanical thrombectomy of the tortuous internal carotid artery:A case report

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World Journal of Clinical Cases 2023年第25期11卷 6005-6011页

作者： lin-Zhuo qu Guang-Hui Dong En-Bo Zhu Ming-quan lin Guang-lin Liu Hong-Jian Guan Department of Medicine Yanbian UniversityYanji 133000Jilin ProvinceChina Department of Neurology Affiliated Hospital of Yanbian UniversityYanji 133000Jilin ProvinceChina

BACKGROUND A carotid-cavernous fistula(CCF)is an abnormal connection between the internal carotid artery(ICA)and the cavernous *** direct CCFs typically result from trauma or as an iatrogenic complication of neuroendovascular procedures,they can occur as surgery-related complications after mechanical thrombectomy(MT).With the widespread use of MT in patients with acute ischemic stroke complicated with large vessel occlusion,it is important to document CCF following MT and how to avoid *** this study,we present a case of a patient who developed a CCF following MT and describe in detail the characteristics of ICA tortuosity in this *** SUMMARY A 60-year-old woman experienced weakness in the left upper and lower limbs as well as difficulty speaking for 4 *** neurological examination revealed left central facial paralysis and left hemiplegia,with a National Institutes of Health Stroke Scale score of *** magnetic resonance imaging revealed an acute cerebral infarction in the right basal ganglia and radial *** resonance angiography demonstrated an occlusion of the right ICA and middle cerebral *** subtraction angiography demonstrated distal occlusion of the cervical segment of the right *** performed suction combined with stent ***,postoperative angiography was performed,which showed a right *** month later,CCF embolization was performed,and the patient’s clinical symptoms have significantly improved 5 mo after the *** Although a CCF is a rare complication after MT,it should be *** the tortuosity of the internal carotid-cavernous sinus may help predict the complexity of MT and avoid this complication.

关键词： Carotid-cavernous fistula Complication Mechanical thrombectomy Internal carotid artery Tortuosity Case report

Use of the DSI/Ponemah jacketed external telemetry system for ECG assessments in dog telemetry

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中国药理学与毒理学杂志 2013年第3期 601-602页

作者： WU Rui qu lin-hai Sue McPHERSON Steve MASON Safety Pharmacology WuXi AppTec(Suzhou) Co.Ltd.

OBJECTIVE To demonstrate that the DSI /Ponemah Jet System(v5.00) can generate high quality ECG data with current methods,enabling cardiovascular function to be assessed in free moving dogs in their home *** Four male beagle dogs were used on this *** electrodes were placed on each animal and were connected to each JET *** JET device was then placed into a pocket of an externally worn animal jacket for each *** JET device transmits to a Bluetooth? *** Bluetooth? receiver can receive signals from up to 6 JET devices depending upon the device *** JET device can transmit data up to 10 meters with negligible interference and no cross-talk exists between *** animals underwent acclimatization to jackets prior to commencement of *** dog was placed into a pen and ECG measurements taken simultaneously using the DSI /Ponemah Jet *** were recorded for 1 hour pre-dose and continually for the following 23 hours under control conditions,then dosed with ascending doses of Moxifloxacin at intervals of 48 hours between each *** AND CONCLUSION Prolonged QT and QTcV(Van de Water's correction) interval was observed for animals dosed at 100 mg·kg-1 from 4-23 h *** QTcV effects(19% increase with 100 mg·kg-1 Moxifloxacin vs control).The DSI telemetry system performed well when testing the dog to the known pharmacological profile of *** sensitively and efficiently acquired ECG data from the beagle dogs and demonstrated the sensitivity of the system to detect test article induced QT *** allows a colony of dogs to be dedicated for toxicology and safety pharmacology *** DSI /ponemah JET system enables flexibility in study design and can be utilized on a range of study types to facilitate high quality ECGs and reduce the requirement for repeat dosing safety pharmacology *** data generated from this investigation demonstrate the DSI /ponemah JET system(v5.

关键词： ECG dog

Albumin–bilirubin grade as a predictor of survival in hepatocellular carcinoma patients with thrombocytopenia

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1763-1772页

作者： Zhong-Ran Man Xuan-Kun Gong Kang-lin qu Qing Pang Bin-quan Wu Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery Anhui No.2 Provincial People’s HospitalHefei 230041Anhui ProvinceChina

BACKGROUND The models for assessing liver function,mainly the Child–Pugh(CP),albuminbilirubin(ALBI),and platelet–ALBI(PALBI)classifications,have been validated for use in estimating the prognosis of hepatocellular carcinoma(HCC)***,thrombocytopenia is a common finding and may influence the prognostic value of the three models in *** To investigate and compare the prognostic performance of the above three models in thrombocytopenic HCC *** A total of 135 patients with thrombocytopenic HCC who underwent radical surgery were retrospectively *** scores on the CP,ALBI and PALBI classifications were estimated ***–Meier curves with logrank tests and Cox regression models were used to explore the significant factors associated with overall survival(OS)and recurrence-free survival(RFS).RESULTS The preoperative platelet counts were significantly different among the CP,ALBI and PALBI *** a median follow-up of 28 mo,39.3%(53/135)of the patients experienced postoperative recurrence,and 36.3%(49/135)*** analysis suggested thatα-fetoprotein levels,tumor size,vascular invasion,and ALBI grade were significant predictors of OS and *** to the multivariate Cox regression model,ALBI was identified as an independent prognostic ***,CP and PALBI grades were not statistically significant prognostic *** The ALBI grade,rather than CP or PALBI grade,is a significant prognostic indicator for thrombocytopenic HCC patients.

关键词： Hepatocellular carcinoma Thrombocytopenia Child-Pugh Albumin-bilirubin Platelet-albumin-bilirubin

Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in glioma U87 cells

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Neural Regeneration Research 2010年第17期5卷 1319-1323页

作者： Fei Zhong Xiangyuan Wu Chunkui Shao qu lin Min Dong Jingyun Wen Xiaokun Ma Li Wei Department of Medical Oncology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Pathology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

Studies have shown that tumor necrosis factor-related apoptosis-inducing ligand（TRAIL）exhibits strong induction of apoptosis in human glioma *** remains unclear whether the mitochondrion pathway,an important apoptosis signaling pathway,is involved in TRAIL-induced glioma cell *** the present study,in vitro cultured human glioma U87 cells were treated with human recombinant soluble *** of glioma U87 cells,mitochondrial transmembrane potential（Δψm）,cytoplasmic cytochrome c concentration and changes in caspase-3,-8 and-9 activity following human recombinant soluble TRAIL treatment were investigated to determine the mechanism of glioma U87 cell apoptosis induced by ***,blocking caspase-8resulted in TRAIL-induced mitochondrion pathway activation,suggesting that TRAIL,through activating caspase-8,initiated a series of mitochondrial events and resulted in apoptosis of glioma U87 cells.

关键词： tumor necrosis factor-related apoptosis-inducing ligand glioma apoptosis mitochondria neural regeneration

Immunotherapy combined with antiangiogenic agents in patients with advanced malignant pleural mesothelioma: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8284-8290页

作者： Tian-Tian Xuan Guang-Yi Li Si-Bo Meng Zhan-Mei Wang lin-Li qu Department of Medical Oncology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266035Shandong ProvinceChina Department of Respiratory Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266035Shandong ProvinceChina

BACKGROUND Malignant pleural mesothelioma has limited therapeutic options and a poor outcome. Antiangiogenic agents might increase the efficacy of immunotherapy as second-line treatment of advanced-stage *** SUMMARY A patient with stage ⅢB pleural mesothelioma received second-line treatment with a combination of pembrolizumab, bevacizumab and chemotherapy following standard chemotherapy under the guidance of second-generation sequencing. He achieved a partial response after four cycles of treatment with progression-free survival of 5 mo. Pembrolizumab was suspended due to grade 2 immunerelated pneumonia, which was resolved by oral ***, disease progression was observed after immunotherapy rechallenge and anlotinib therapy. The patient had disease progression, multiorgan dysfuntion and died suddenly in October *** The combination of immune checkpoint inhibitor, anti-angiogenic agents and chemotherapy showed effective response for advanced pleural mesothelioma, but with adverse reactions.

关键词： Pleural mesothelioma Immune checkpoint inhibitor Next-generation Sequencing Immunerelated pneumonia Immunotherapy rechallenge Case report