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Spatial distribution of dissolved Pb,Hg,Cd,Cu and As in the Bohai Sea

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Journal of Environmental Sciences 2007年第9期19卷 1061-1066页

作者： WANG chang-you WANG Xiu-lin College of Chemistry and Chemical Engineering Ocean University of China Qingdao 266003 China.

Characteristics of the spatial distribution of selected dissolved heavy metals were analyzed during large scale surveys from August t2 to 25, 2003 in the Bohai Sea. Dissolved Pb was the only element with average concentrations higher than the grade-one sea water quality standard of China. The spatial distribution of dissolved Pb in surface water was similar to those of Cd, Cu and As, where the isopleths generally indicated decreasing values from the bays to the central areas. Only for Hg did the high concentrations not only appear in Liaodong Bay, Bohai Bay and Laizhou Bay, but also in the Central Area, viz. not only in inshore but also in offshore areas. Vertical distributions of dissolved Pb, Cd, Cu and As were largely uniform, while that of dissolved Hg increased with depth. We infer that the input of pollutants from land was the main influencing factor for the detected distribution patterns of dissolved heavy metals, followed by the dynamics of sea water, release from bottom sediments and biochemical processes. Comparing with historical data, average concentrations of dissolved heavy metals appear to decline in recent years.

关键词： dissolved heavy metals spatial distribution pollution surveys Bohai Sea

ESTIMATED AND EXACT SYSTEM RELIABILITIES OF A MAINTAINABLE COMPUTER NETWORK

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Journal of Systems Science and Systems Engineering 2011年第2期20卷 229-248页

作者： Yi-Kuei lin Ping-Chen chang Department of Industrial Management National Taiwan University of Science & Technology Taipei 106 Taiwan China

This paper presents an algorithm to evaluate estimated and exact system reliabilities for a computer network in the cloud computing *** the quality of service（QOS） viewpoint,the computer network should be maintained when falling to a specific state such that it cannot afford enough capacity to satisfy ***,the transmission time should be concerned as ***,the data can be sent through several disjoint minimal paths simultaneously to shorten the transmission *** the maintenance budget B and time constraint T,we evaluate the system reliability that d units of data can be sent from the cloud to the client through multiple *** procedures are integrated in the proposed algorithm-an estimation procedure for estimated system reliability and an adjusting procedure utilizing the branch-and-bound approach for exact system ***,the estimated system reliability with lower bound and upper bound,and exact system reliability are computed by applying the recursive sum of disjoint products（RSDP） algorithm.

关键词： System reliability maintenance network flows branch-and-bound approach estimation

PREDECESSOR-SET TECHNIQUE FOR RELIABILITY EVALUATION OF A STOCHASTIC MANUFACTURING SYSTEM

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Journal of Systems Science and Systems Engineering 2015年第2期24卷 190-210页

作者： Yi-Kuei lin Ping-Chen chang Department of Industrial Management National Taiwan University of Science & Technology

This paper studies the reliability evaluation of a stochastic manufacturing system with multiple production lines in parallel. Multiple repairs and different failure rates, never simultaneously addressed in earlier works, are taken into account. First, a revised graphical methodology integrating transformation and decomposition is utilized to construct the stochastic manufacturing system as a multi-state manufacturing network （MSMN）. In particular, a ＂predecessor-set＂ technique is proposed to deal with multiple repairs. An algorithm is proposed to generate the lowest capacity vectors （LCVs） that stations should provide to satisfy the workloads. Subsequently, the system reliability of the MSMN, which is defined as the probability of demand satisfaction, is calculated in terms of the LCVs. A real case of a printed circuit board manufacturing system is utilized to demonstrate how the system reliability can be evaluated. A further decision making issue is addressed based on the derived system reliability.

关键词： Multi-state manufacturing network (MSMN) predecessor-set lowest capacity vector(LCV) different failure rates multiple repairs system reliability

Priority-sequence of mineral resources' development and utilization based on grey relational analysis method

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International Journal of Mining Science and Technology 2016年第3期26卷 395-400页

作者： Wang ying Zhang chang Jiang Gaopeng School of Management China University of Mining & Technology

Generally, the sequence decision of the development and utilization of Chinese mineral resources is based on national and provincial overall plan of the mineral resources. Such plan usually cannot reflect the relative size of the suitability of the development and utilization of mineral resources. To solve the problem, the paper has selected the gift condition, the market condition, the technological condition,socio-economic condition and environmental condition as the starting-points to analyze the influential factors of the priority-sequence of mineral resources' development and utilization. The above 5 conditions are further specified into 9 evaluative indicators to establish an evaluation indicator system. At last,we propose a decision model of the priority sequence based on grey relational analysis method, and figure out the observation objects by the suitability index of development. Finally, the mineral resources of a certain province in China were analyzed as an example. The calculation results indicate that silver(2.0057), coal(1.9955), zinc(1.9442), cement limestone(1.9077), solvent limestone(1.5624) and other minerals in the province are suitable for development and utilization.

关键词： Mineral resources Development and utilization Priority-sequence Grey relational analysis method

New Model for Image Restoration with Different Boundary Conditions

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Acta Mathematicae Applicatae Sinica 2010年第3期26卷 369-380页

作者： Yu-ying Shi Qian-shun chang Department of Mathematics and Physics North China Electric Power University Beijing 102206 China Institute of Applied Mathematics Academy of Mathematics and Systems Science Beijing 100190 China

In this paper, we propose a new time-dependent model for solving total variation （TV） minimization problems in image restoration. The main idea is applying a priori smoothness on the solution image. Five different B... 详细信息

关键词： image restoration Dirichlet BCs periodic BCs reflecting BCs antireflective BCs mean BCs

Intensified bioleaching of low-grade molybdenite concentrate by ferrous sulfate and pyrite

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Rare Metals 2015年第3期34卷 207-214页

作者： Juan Yu Hong-ying Yang lin-lin Tong Jun Zhu School of Metallurgy Engineering Xi’an University of Architecture and Technology School of Materials & Metallurgy Northeastern University

Intensifying effects of ferrous sulfate and pyrite on bioleaching of low-grade molybdenite concentrate were studied in this paper. The experimental results show that the oxidation dissolution of molybdenite can be accelerated with the addition of either ferrous sulfate or pyrite in bi- oleaching medium. Pyrite has better enhancing effect than ferrous sulfate, and the highest molybdenum leaching rate in pyrite-added solutions is 20.85 %, increasing by 12.64 % compared with that in 9 K leaching system. Molybdenum leaching rate does not increase linearly with the increase of the addition of either ferrous sulfate or pyrite in each type solution. Great amounts of [NH4Fe3（SO4）2（OH）6] and [KFe3（SO4）2（OH）6] with different morphologies will be deposited on molybdenite ores when the additions of Fe from ferrous sulfate or pyrite exceed that from 9 K leaching system by 0.5 times, and these deposits hinder the oxidation dissolution of molybdenite to some extent.

关键词： Low-grade molybdenite concentrate Bio-oxidation Intensified bioleaching Ferrous sulfate Pyrite

Involvement of lncRNAs in the tumor microenvironment:a new property of tumor immunity

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Cancer Biology & Medicine 2023年第8期20卷 553-561页

作者： Qingyu lin Jiaqi Zhu ying Hu School of Life Science and Technology Harbin Institute of TechnologyHarbin 150001China Zhengzhou Research Institute of Harbin Institute of Technology Zhengzhou 450000China Key Laboratory of Science and Engineering for the Multi-modal Prevention and Control of Major Chronic Diseases Ministry of Industry and Information TechnologyZhengzhou 450000China School of Astronautics Harbin Institute of TechnologyHarbin 150001China

Immune checkpoint blockade(ICB)has achieved durable clinical responses and has significantly improved the overall survival of cancer *** the ICB agents,programmed death 1(PD-1)/programmed death ligand 1(PD-L1)antibodies are used to treat various human tumors by blocking PD-1/PD-L1 *** response rates with low autoimmune toxicity have been reported in 20%–30%of non-selected patients1;however,most patients fail to respond to PD-1/PD-L1 blockade or acquire resistance during therapy through unknown mechanisms1.

关键词： immunity death patients

Effect of tubastatin A on NLRP3 inflammasome activation in macrophages under hypoxia/ reoxygenation conditions

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World Journal of Emergency Medicine 2024年第4期15卷 289-296页

作者： Hao Li chang Liu ying Cui Panpan chang Wei Chong Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Trauma Medicine Center Peking University People's HospitalBeijing 100871China Key Laboratory of Trauma and Neural Regeneration Peking UniversityBeijing 100871China National Center for Trauma Medicine of China Beijing 100871China

BACKGROUND:There are currently no effective drugs to mitigate the ischemia/reperfusion injury caused by fluid resuscitation after hemorrhagic shock(HS).The aim of this study was to explore the potential of the histone deacetylase 6(HDAC6)-specific inhibitor tubastatin A(TubA)to suppress nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation in macrophages under hypoxia/reoxygenation(H/R)***:The viability of RAW264.7 cells subjected to H/R after treatment with different concentrations of TubA was assessed using a cell-counting kit-8(CCK8)***,2.5μmol/L TubA was used with RAW264.7 cells under H/R ***264.7 cells were divided into three groups,namely the control,H/R,and TubA *** levels of reactive oxygen species(ROS)in the cells were detected using fluorescence *** protein expression of HDAC6,heat shock protein 90(Hsp90),inducible nitric oxide synthase(iNOS),NLRP3,gasdermin-D(GSDMD),Caspase-1,GSDMD-N,and Caspase-1 p20 was detected by western *** levels of interleukin-1β(IL-1β)and IL-18 in the supernatants were detected using enzyme-linked immunosorbent assay(ELISA).RESULTS:HDAC6,Hsp90,and iNOS expression levels were significantly higher(P<0.01)in the H/R group than in the control group,but lower in the TubA group than in the H/R group(P<0.05).When comparing the H/R group to the control group,ROS levels were significantly higher(P<0.01),but significantly reduced in the TubA group(P<0.05).The H/R group had higher NLRP3,GSDMD,Caspase-1,GSDMD-N,and Caspase-1 p20 expression levels than the control group(P<0.05),however,the TubA group had significantly lower expression levels than the H/R group(P<0.05).IL-1βand IL-18 levels in the supernatants were significantly higher in the H/R group compared to the control group(P<0.01),but significantly lower in the TubA group compared to the H/R group(P<0.01).CONCLUSION:TubA inhibited the expression of HDAC6,Hsp90,and iNOS in macrophages

关键词： Hemorrhagic shock Hypoxia/reoxygenation Macrophage NLRP3 Tubastatin A

NUMERICAL SIMULATION OF DEFORMATION BEHAVIOR OF 22MnB5 BORON STEEL AT ELEVATED TEMPERATURES AND EXPERIMENTAL VERIFICATION

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Acta Mechanica Solida Sinica 2014年第6期27卷 579-587页

作者： Dan Zhao Yiguo Zhu Liang ying Ping Hu ying chang Wanxi Zhang State Key Laboratory of Structural Analysis for Industrial Equipment Faculty of Vehicle Engineering and Mechanics Dalian University of Technology

The effects of strain, strain rate and temperature on the mechanical behavior of 22MnB5 boron steel deformed isothermally under uniaxial tension tests and the experimental characterization of 22MnB5 boron steel in the austenitic region have been investigated. Based on the crystal plasticity theory and thermal kinematics, an improved integration model is presented. In this model, the elastic deformation gradient is the integration variable of the governing equation, which contains not only the elastic deformation but also the thermal effects. In the coupled thermo- mechanical process, this model can reveal the evolution of microstructures such as the rotation of a single crystal and the slip systems in each of them. The plastic behavior of the boron steel can be well described by the presented model.

关键词： crystal plasticity integration model 22MnB5 boron steel high temperature de-formation