检索结果-南通市图书馆

无创呼吸机对慢阻肺急性发作期患者临床症状及二氧化碳分压的影响

在线全文

学校读者我要写书评

暂无评论

四川生理科学杂志 2024年第10期46卷 2248-2250,2270页

作者：雷文南汪普行高应亮鄱阳县人民医院内科江西上饶333100

目的:探讨无创呼吸机对慢阻肺急性发作期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者临床症状及二氧化碳分压(Partial pressure of carbon dioxide,PaCO_(2))的影响。方法:选取2021年1月至2023年12月本院收治的60例AECOPD患者作为研究对象,按照治疗方式分为观察组和对照组,各30例。对照组有创采用呼吸机治疗,观察组采用无创呼吸机治疗。比较两组治疗疗效。采用改良版英国医院研究委员会呼吸困难量表(Modified medical British research council,mMRC)和急性生理学和慢性健康状况评价II(Acute physiology and chronic health e-valuationⅡ,APACHEII)评分比较两组患者临床症状和健康状况。比较两组患者治疗前后血气指标[动脉血氧分压(Partial pressure of oxygen in artery,PaO_(2))、PaCO_(2)]和炎症因子[白介素-8(Interleukine-8,IL-8)和基质金属蛋白酶-9(Matrix metalloprotein-9,MMP-9)]。比较两组并发症发生率。结果:两组治疗有效率无明显差异(P>0.05)。治疗后,观察组PaO_(2)明显高于对照组,而mMRC、APACHEII评分、PaCO_(2)、IL-8和MMP-9水平、并发症发生率均明显低于对照组(P<0.05)。结论:无创呼吸机治疗AECOPD患者与有创呼吸机具有同样的疗效,但是其能更好的恢复血气指标,降低炎症反应,改善临床症状和健康状况,且并发症少。

关键词：无创呼吸机慢阻肺急性发作期临床症状二氧化碳分压

Fooling intrusion detection systems using adversarially autoencoder

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2021年第3期7卷 453-460页

作者： Junjun Chen Di Wu ying Zhao Nabin Sharma Michael Blumenstein Shui yu College of Information Science and Technology Beijing University of Chemical TechnologyBeijing100029China School of Computer Science University of Technology SydneyUltimo2007Australia Centre for Artificial Intelligence University of Technology SydneyUltimo2007Australia

Due to the increasing cyber-attacks,various Intrusion Detection Systems(IDSs)have been proposed to identify network *** existing machine learning-based IDSs learn patterns from the features extracted from network traffic flows,and the deep learning-based approaches can learn data distribution features from the raw data to differentiate normal and anomalous network *** having been used in the real world widely,the above methods are vulnerable to some types of *** this paper,we propose a novel attack framework,Anti-Intrusion Detection AutoEncoder(AIDAE),to generate features to disable the *** the proposed framework,an encoder transforms features into a latent space,and multiple decoders reconstruct the continuous and discrete features,***,a generative adversarial network is used to learn the flexible prior distribution of the latent *** correlation between continuous and discrete features can be kept by using the proposed training *** conducted on NSL-KDD,UNSW-NB15,and CICIDS2017 datasets show that the generated features indeed degrade the detection performance of existing IDSs dramatically.

关键词： Intrusion detection Cyber attacks Autoencoder Generative adversarial networks

Expression of MMP-9 in hepatic sinusoidal obstruction syndrome induced by Gynura segetum

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 68-75页

作者： Xia-zhen yu Tao JI Xue-li BAI liang liang Lin-yan WANG Wei CHEN Ting-bo liang Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Surgery Changhai Hospital the Second Military Medical University Shanghai 200433 China The Children 's Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Background and objective： Hepatic sinusoidal obstruction syndrome （HSOS） is characterized by painful hepatomegaly, ascites, increased body weight, and jaundice. Gynura segetum （Compositae）, a plant widely used in Chinese traditional medicine, often leads to the development of HSOS. However, the mechanism is unclear. The aim was to study the role of matrix metalloproteinase-9 （MMP-9） in the onset of HSOS induced by Gynura segetum. Methods： Twenty-five male Sprague-Dawley rats were randomly divided into two groups. Twenty were exposed to 600 mg/kg daily Gynura segetum extract solution for three weeks; five control rats were exposed to tap water alone. Liver sections were evaluated by light microscopy with a modified scoring system. Routine transmission electron microscopy （TEM） methods were used to evaluate the ultrastructual features of fixed liver tissue, and blood samples were collected to determine liver enzyme concentrations. MMP-9 expression was assessed by both immunohisto- chemical staining and enzyme-linked immunosorbent assay （ELISA） methods. Results： A stable and reproducible rat model of HSOS was achieved by long-term exposure to Gynura segetum extract. The treated rats presented clinical symptoms and the histopathological manifestation of HSOS, including abnormal liver enzyme concentrations （alanine aminotransferase （ALT）：（84.8＋13.62） vs. （167.0±72.63） U/L, P〈0.05; aspartate aminotransferase （AST）：（27.6±6.31） vs. （232.8±108.58） U/L, P〈0.05）. Hematoxylin and eosin （H＆E） staining and TEM together revealed deposition of red blood cells, the damage and destruction of hepatic sinusoidal endothelial cells, collapse of hepatic sinusoids, hem- orrhage of subendothelial cells, atrophy and destruction of hepatocytes, etc. Compared with controls, the expression of MMP-9 in the blood sample, the lung and liver tissues of HSOS rats was increased. Conclusions： MMP-9 may have an important role in early patholoclical chanqes of HSOS, and thus the onset of the disease.

关键词： Hepatic sinusoidal obstruction syndrome Gynura segetum (Compositae) Sinusoidal endothelial cells Matrix metalloproteinase-9

Effect of Zn particles on ductility of the accumulative roll-bonding composites

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2015年第10期58卷 107-108页

作者： LIU Chongyu MA MingZhen LIU RiPing yu liang LUO Kun Key Laboratory of New Processing Technology for Nonferrous Metal & Materials Ministry of Education Guilin University of Technology State Key Laboratory of Metastable Materials Science and Technology Yanshan University Guangxi Key Laboratory of Universities for Clean Metallurgy and Comprehensive Utilization of Non-ferrous Metal Resources

Over the last five years, accumulative roll bonding （ARB） has been used to produce aluminum-based metal matrix composites （AMMCs） with ultrafine-grained （UFG） structure. Al/Al2O3 [1-3], Al/SiC [4], Al/B4C [5,6], and Al/WC [7] are currently fabricated using ARB because of the resulting highly uniform reinforced particle distribution. ARB composites have higher strength but poorer ductility than unreinforced UFG matrix because stress is concentrated in the reinforced phase-Al matrix interface during tensile process. In the present study, we introduced Al-Zn regions to AI matrix by ARB to obtain AMMCs with high strength and ductility. The dissolution and precipitation of Zn atoms in Al matrix, as well as the effects of Zn on the ductility of AMMCs, were also analyzed.

关键词：铝基复合材料颗粒分布塑性累积 Al/SiC 轧制锌铝/氧化铝

在线全文

学校读者我要写书评

暂无评论

一种用于可再生能源的新型升降压变换器

电力电子技术 2024年第6期58卷 77-79,84页

作者：梁鹰杨区峻豪石丽梅广东海洋大学电子与信息工程学院广东湛江524088

针对可再生能源发电装置输出电压波动大、输出电能难以存储的情况,此处提出了一种输入、输出连续的新型升降压变换器,采用开关电感结构,实现了低电感电流纹波、宽电压转换比和低开关管电压应力。此处在连续导通模式(CCM)下对变换器进行... 详细信息

针对可再生能源发电装置输出电压波动大、输出电能难以存储的情况,此处提出了一种输入、输出连续的新型升降压变换器,采用开关电感结构,实现了低电感电流纹波、宽电压转换比和低开关管电压应力。此处在连续导通模式(CCM)下对变换器进行了详细的工作原理分析和稳态特性推导。为验证所提变换器的可行性,搭建了一台输入12~80V,输出48V,功率100W的实验样机,在升压模式和降压模式下测得最大效率分别为92.62%,95.78%。

关键词：变换器输入、输出连续可再生能源

硫缺陷型In_(2)S_(3)光催化剂高效分解水制氢研究

在线全文

学校读者我要写书评

暂无评论

分子催化（中英文） 2024年第3期38卷 215-223,I0001,I0002页

作者：王凤娇闫良霖耿来红刘建华毕迎普董国俊中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室甘肃兰州730000 中国科学院大学北京100049 兰州大学资源环境学院甘肃兰州730000 甘肃省化工研究院有限责任公司甘肃兰州730000

缺陷工程被认为是提高光催化剂分解水制氢性能的关键策略之一,然而有关缺陷诱导半导体材料电子结构演变并增强光生载流子传输机制尚不明确.我们通过简单的一步水热合成法成功构建了富含S缺陷的In_(2)S_(3)半导体光催化剂(V_(S)-In_(2)S_... 详细信息

缺陷工程被认为是提高光催化剂分解水制氢性能的关键策略之一,然而有关缺陷诱导半导体材料电子结构演变并增强光生载流子传输机制尚不明确.我们通过简单的一步水热合成法成功构建了富含S缺陷的In_(2)S_(3)半导体光催化剂(V_(S)-In_(2)S_(3)),在模拟太阳光辐照下其光催化分解水产氢性能相比传统的In_(2)S_(3)(P-In_(2)S_(3))提升了近一个数量级(达到221.18μmol∙g^(−1)∙h^(−1)).此外,利用自主研发的原位X射线光电子能谱(SI-XPS)结合相关密度泛函理论计算证实:S缺陷可诱导强还原性的低价态In(In^((3−x)+))暴露,进而增强In位点对H_(2)O的吸附和活化能力,因此,S缺陷型In_(2)S_(3)表现出显著增强的光催化析氢活性.此外,可视化观测到H_(2)分子在原位光照下脱质子转化为OH的分解水制氢过程.该研究为缺陷型光催化剂设计及光催化分解水反应机制和过程研究提供了一定的见解.

关键词：光催化 S缺陷硫化铟电子结构析氢反应

Immune modulatory function of abundant immune-related microRNAs in microvesicles from bovine colostrum

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2013年第3期4卷 197-210页

作者： Qi Sun Xi Chen Jianxiong yu Ke Zen Chen-yu Zhang liang Li Jiangsu Engineering Research Center for microRNA Biology and Biotechnology State Key Laboratory of Pharmaceutical BiotechnologyNanjing University School of Life SciencesNanjing 210093China Department of Virology University of California School of Public HealthBerkeleyCA 94720USA

Colostrum provides essential nutrients and immunologically active factors that are beneficial to *** previous work demonstrated that milk contains large amounts of miRNA that is largely stored in milk-derived microvesicles(MVs).In the present study,we found that the MVs from colostrum contain signifi cantly higher levels of several immune-related *** hypothesized that the colostrum MVs may transfer the immune-related miR-NAs into cells,which contribute to its immune modulatory *** isolated colostrum MVs by ultracentrifugation and demonstrated several immune modulation features associated with *** also provide evidence that the physical structure of milk-derived MVs is essential for transfer miRNAs and following immune modulation ***,we found that colostrum powder-derived MVs also contains higher levels of immune-related miRNAs that display similar immune modulation *** together,these results show that MV-containing immunerelated miRNAs may be a novel mechanism by which co-lostrum modulates body immune response.

关键词： colostrum miRNAs microvesicles immune modulation

在线全文

学校读者我要写书评

暂无评论

云南短头熊蜂体色模式多态性地理分布格局

昆虫学报 2024年第1期67卷 102-115页

作者：梁铖秦加敏宗德琴李雨时丁桂玲黄家兴云南省农业科学院蚕桑蜜蜂研究所蒙自661101 中国农业科学院蜜蜂研究所农业农村部授粉昆虫生物学重点开放实验室北京100093

【目的】熊蜂是自然环境中一类重要的传粉昆虫,其体表通常覆盖着颜色鲜亮的体毛,从而形成明显的体色模式。本研究旨在探明云南短头熊蜂Bombus breviceps体色模式多态性的地理分布格局,为熊蜂遗传进化及环境适应性研究提供基础数据。【... 详细信息

【目的】熊蜂是自然环境中一类重要的传粉昆虫,其体表通常覆盖着颜色鲜亮的体毛,从而形成明显的体色模式。本研究旨在探明云南短头熊蜂Bombus breviceps体色模式多态性的地理分布格局,为熊蜂遗传进化及环境适应性研究提供基础数据。【方法】通过检视2017-2021年在云南和贵州共127个采样点采集的957头短头熊蜂标本[包括雌成蜂898头(蜂王103头、工蜂795头)以及雄成蜂59头],绘制雌、雄成蜂体色模式图,分析体色模式的类型及优势度。基于不同体节的体色组成对体色模式进行系统聚类,基于经纬度0.5°×0.5°单元格内体色类群组成分析云南短头熊蜂体色模式的地理分布格局。【结果】短头熊蜂胸部背板体毛的颜色在黑色、灰黄色和橙黄色间过渡变化,腹部背板体毛颜色有黑色、灰黄色、黄色和深棕色,腹部第1背板体毛均为黄色,黄色体毛由第1背板向后逐节延伸最多至第3背板的整节,第2,3背板的体毛为黄色、黑色或灰黄色,而深棕色体毛由腹部第6背板向前逐节延伸最多至第3背板的下半节;雌成蜂有81种体色模式,其中工蜂有80种,蜂王有13种,其中12种与工蜂相同,雄成蜂有37种体色模式,其中28种与雌成蜂相似。雌成蜂的81种体色模式中,优势体色模式有2种,丰盛体色模式有5种,常见体色模式有10种,稀少体色模式有64种。雌成蜂体色模式可聚为3个体色类群,即:A类群(黑胸棕尾),B-1类群(橙胸黑尾)和B-2类群(橙胸棕尾)。云南短头熊蜂体色模式的地理分布可划分为云南高原西部(Ⅰ)和云南高原东部(Ⅱ)2个大区。Ⅰ区进一步可分为滇中亚热带高原区(Ⅰ1)和滇西南热带低山宽谷区(Ⅰ2);Ⅱ区进一步可分为滇东南亚热带岩溶山地河谷区(Ⅱ1)和滇东北亚热带中山河谷区(Ⅱ2)。A体色类群仅分布于Ⅰ1小区,Ⅰ2小区仅有B-2类群分布,而B-1类群仅分布于Ⅱ区,且同域分布有B-2类群。体色模式多态性高低与分布地经纬度无明显相关性,云南高原中部24.00°-24.50°N,102.50°-103.00°E方格内的体色模式多态性最高,达18种;A体色类群分布地平均海拔[(1951±311)m]极显著高于B-1[(1568±352)m]和B-2[(1556±534)m]类群分布地平均海拔。【结论】云南短头熊蜂体色模式多态性丰富,可划分为3个主要的体色类群,其地理分布与气候区划、地型地貌和土地利用类型相关,地理区划特征明显,同区域内体色模式多态性向优势模式趋同。本研究结果对深入挖掘中国本土熊蜂资源和物种多样性保护具有重要意义,为不同生境利用与发展熊蜂提供技术支撑。

关键词：短头熊蜂体毛体色模式聚类分析地理分布

锰氧化物/明胶基多孔碳球复合催化剂催化分解臭氧性能研究

在线全文

学校读者我要写书评

暂无评论

中国国境卫生检疫杂志 2024年第3期47卷 224-227页

作者：慈颖于鹰畅王思于珊珊张珊中国检验检疫科学研究院北京100176

目的制备锰氧化物/明胶基多孔碳球复合催化剂,研究其催化分解臭氧的性能。方法通过化学共沉积法制备拥有不同孔径特征的锰氧化物负载的明胶基多孔碳球催化剂(Mn-GBC-4,Mn-GBC-1,Mn-GBC-2,Mn-GBC-3),对其微观结构进行X射线衍射、BET比表... 详细信息

目的制备锰氧化物/明胶基多孔碳球复合催化剂,研究其催化分解臭氧的性能。方法通过化学共沉积法制备拥有不同孔径特征的锰氧化物负载的明胶基多孔碳球催化剂(Mn-GBC-4,Mn-GBC-1,Mn-GBC-2,Mn-GBC-3),对其微观结构进行X射线衍射、BET比表面积分析、扫描电子显微镜表征,并研究其在分解臭氧时的抗湿性能及寿命。结果制备的复合催化剂Mn-GBC-1在常温常压、空气相对湿度40%、20000h-1空速条件下,对臭氧的分解率可达97%,且催化剂寿命具有高稳定性,最高为200 h。结论制备的锰氧化物/明胶基多孔碳球复合催化剂具有优良的臭氧分解性能,为开发更高效的臭氧分解催化剂提供了新思路。

关键词：臭氧催化分解锰氧化物明胶基多孔碳球催化剂