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Removal and transformation of dissolved organic matter in secondary effluent during granular activated carbon treatment

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第7期9卷 994-1003页

作者： liang-liang WEI qing-liang ZHAO Shuang XUE Ting JIA State Key Laboratory of Urban Water Resources and Environments （SKL UWRE） School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China

This paper focused on the removal and transformation of the dissolved organic matter （DOM） in secondary effluent during the granular activated carbon （GAC） treatment. Using XAD-8/XAD-4 resins, DOM was fractionated into five classes： hydrophobic acid （HPO-A）, hydrophobic neutral （HPO-N）, transphilic acid （TPI-A）, transphilic neutral （TPI-N） and hydrophilic fraction （HPI）. Subsequently, the water quality parameters of dissolved organic carbon （DOC）, absorbance of ultraviolet light at 254 nm （UV-254）, specific ultraviolet light absorbance （SUVA） and trihalomethane formation potential （THMFP） were analyzed for the unfractionated and fractionated water samples. The results showed that the order of the DOC removal with respect to DOM fractions was observed to be HPI〉HPO-A〉HPO-N〉TPI-A〉TPI-N. During the GAC treatment, the THMFP of the unfractionated water samples decreased from 397.4 μg/L to 176.5 μg/L, resulting in a removal efficiency of 55.6%. The removal order of the trilaalomethanes （THMs） precursor was as follows： HPO-A〉TPI-A〉TPI-N〉HPO-N〉HPI. By the GAC treatment, the specific THMFP of HPO-A, TPI-A, TPI-N and the original unfractionated water samples had a noticeable decrease, while that of HPO-N and HPI showed a converse trend. The Fourier transform infrared （FTIR） results showed that the hydroxide groups, carboxylic acids, aliphatic C-H were significantly reduced by GAC treatment.

关键词： Dissolved organic matter (DOM) Fractionation Trihalomethane formation potential (THMFP) Specific THMFP Fourier-transform infrared (FTIR)

Application of vascular endothelial cells in stem cell medicine

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World Journal of Clinical Cases 2021年第35期9卷 10765-10780页

作者： qing-qing liang Lei Liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina

Stem cell medicine is gaining momentum in the development of therapy for various end-stage *** search for new seed cells and exploration of their application prospects are topics of interest in stem cell *** recent years,vascular endothelial cells(VECs)have attracted wide attention from ***,which form the inner lining of blood vessels,are critically involved in many physiological functions,including permeability,angiogenesis,blood pressure regulation,immunity,and pathological development,such as atherosclerosis and malignant *** have significant therapeutic effects and broad application prospects in stem cell medicine for the treatment of various refractory diseases,including atherosclerosis,myocardial infarction,diabetic complications,hypertension,coronavirus disease 2019,and malignant *** the one hand,VECs and their extracellular vesicles can be directly used for the treatment of these *** the other hand,VECs can be used as therapeutic targets for some ***,there are still some obstacles to the use of VECs in stem cell *** this review,advances in the applications and challenges that come with the use of these cells are discussed.

关键词： Vascular endothelial cells Stem cell medicine Angiogenesis Atherosclerosis Tissue defects Refractory diseases

Peculiar Quantum Phase Transitions and Hidden Supersymmetry in a Lipkin-Meshkov-Glick Model

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Communications in Theoretical Physics 2009年第5期51卷 881-884页

作者： CHEN Gang liang Jiu-qing Institute of Theoretical Physics Shanxi University Taiyuan 030006 China Department of Physics Shaoxing College of Arts and Sciences Shaoxing 312000 China

In this paper we theoretically report an unconventional quantum phase transition of a simple Lipkin- Meshkow-Glick model： an interacting collective spin system without external magnetic field. It is shown that this model with integer-spin can exhibit a flrst-order quantum phase transition between different disordered phases, and more intriguingly, possesses a hidden supersymmetry at the critical point. However, for half-integer spin we predict another flrst-order quantum phase transition between two different long-range-ordered phases with a vanishing energy gap, which is induced by the destructive topological quantum interference between the intanton and anti-instanton tunneling paths and accompanies spontaneously breaking of supersymmetry at the same critical point. We also show that, when the total spin-value varies from half-integer to integer this model can exhibit an abrupt variation of Berry phase from π to zero.

关键词： Lipkin-Meshkov-Glick model quantum phase transition supersylnmetry

All types of base conversions allowed by base editors

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Science China(Life Sciences) 2024年第2期67卷 431-433页

作者： Shun-qing liang Wen Xue RNA Therapeutics Institute UMass Chan Medical SchoolWorcester 01655USA Department of Molecular Cell and Cancer BiologyUMass Chan Medical SchoolWorcester 01655USA Department of Molecular Medicine UMass Chan Medical SchoolWorcester 01655USA Li Weibo Institute for Rare Diseases Research UMass Chan Medical SchoolWorcester 01655USA

Base editors(BEs) hold great promise as tools for introducing single-base-pair changes in both basic research and therapeutic applications(Rees and Liu,2018).Base editors are composed of a Cas9 nickase fused to a DNA-modifying enzyme,which chemically modifies nucleobases within a specific targeting window near the Cas9-binding site.

关键词： base bases allowed

Manipulation of the host cell membrane by humanγ-herpesviruses EBV and KSHV for pathogenesis

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Virologica Sinica 2016年第5期31卷 395-405页

作者： Fang Wei qing Zhu Ling Ding qing liang Qiliang Cai Sheng Yushou Center of Cell Biology and Immunology School of Life Sciences and Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Medical Molecular Virology(Ministries of Education and Health) School of Basic Medical SciencesFudan UniversityShanghai 200032China

The cell membrane regulates many physiological processes including cellular communication,homing and metabolism. It is therefore not surprising that the composition of the host cell membrane is manipulated by intracellular pathogens. Among these, the human oncogenic herpesviruses Epstein–Barr virus(EBV) and Kaposi's sarcoma-associated herpesvirus(KSHV)exploit the host cell membrane to avoid immune surveillance and promote viral *** evidence has shown that both EBV and KSHV directly encode several similar membrane-associated proteins, including receptors and receptor-specific ligands(cytokines and chemokines), to increase virus fitness in spite of host antiviral immune responses. These proteins are expressed individually at different phases of the EBV/KSHV life cycle and employ various mechanisms to manipulate the host cell membrane. In recent decades, much effort has been made to address how these membrane-based signals contribute to viral tumorigenesis. In this review, we summarize and highlight the recent understanding of how EBV and KSHV similarly manipulate host cell membrane signals, particularly how remodeling of the cell membrane allows EBV and KSHV to avoid host antiviral immune responses and favors their latent and lytic infection.

关键词： cell membrane remodeling Epstein-Barr virus(EBV) Kaposi’s sarcoma-associated herpesvirus(KSHV)

Longitudinal Magnetoresistance Effect at Low Temperature in Silver Telluride Thin Films

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Chinese Physics Letters 1999年第10期16卷 756-757页

作者： liang Bing-qing WANG Yin-jun State Key Laboratory for Magnetism Institute of Physics and Center for Condensed Matter PhysicsChinese Academy of SciencesBeijing 100080

Large longitudinal magnetoresistance(LMR)was observed in nonmagnetic silver telluride *** magnitude of the LMR is not simply dependent on T and H,for example,multi-peaks of p at low held and low temperature appear in the Ag-Te *** both of-△ρ/ρand a transition from-△ρ/ρto+△ρ/ρexist in Ag-Te Sims,the magnetoresistance(MR)behavior of the Ag-Te Sim does not like the bulk Ag-Te,but likes the doped ***-27%of LMR was observed at low Seld in the Ag-Te Sims,while it could be negligible in the doped *** MR behavior in Ag-Te Sims is discussed by means of a formation of impurity bands in the films.

关键词： resistance Silver silver

Traditional Chinese medicine for prevention and treatment of hepatocellular carcinoma: A focus on epithelial-mesenchymal transition

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Journal of Integrative Medicine 2021年第6期19卷 469-477页

作者： Jia-jia Li qing liang Guang-chun Sun Department of Pharmacy Shanghai Fifth People’s HospitalFudan UniversityShanghai 200240China

Hepatocellular carcinoma(HCC)is one of the most prevalent malignant cancers *** transition(EMT),which endows epithelial cells with mesenchymal properties,plays an important role in the early stages of *** cancer therapies have promising effects,but issues remain,such as high rates of metastasis and drug ***,exploring and evaluating new therapies is an urgent *** Chinese medicines(TCMs)have been acknowledged for their multi-target and coordinated intervention effects against *** evidence indicates that TCM can inhibit the malignancy of cells and the progression of EMT in ***,studies on the effects of TCM on EMT in HCC are *** this review,we summarized recent developments in anti-EMT TCMs and formulae,focusing on their underlying pharmacological mechanisms,to provide a foundation for further research on the exact mechanisms through which TCM affects EMT in HCC.

关键词： Traditional Chinese medicine Chinese medicine formulae Hepatocellular carcinoma Epithelial-mesenchymal transition Metastasis Cancer therapy

Crust and Upper Mantle Density Structures beneath the Eastern Tianshan Region and Its Tectonic Implications

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Journal of Earth Science 2024年第3期35卷 828-838页

作者： Yiming Liu Chao Chen qing liang Zhengwang Hu Hubei Subsurface Multi-Scale Imaging Key Laboratory School of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China

The deformation mechanisms of the Tianshan orogenic belt(TOB)are one of the most important unresolved issues in the collision of the Indian and Eurasian *** better understand the lithospheric deformation of the eastern Tianshan orogenic belt,we combined the S-wave tomography and gravity data to develop a three-dimensional(3D)density model of the crust and upper mantle beneath the eastern Tianshan *** show that the crust of the eastern Tianshan is mainly characterized by positive density anomalies,revealing widespread subduction-related magmatism during the *** however have also observed extensive low-density anomalies beneath the eastern Tianshan at depths deeper than~100 km,which is likely linked to a relatively hot *** most fundamental differences of the lithosphere within the eastern Tianshan occur in the uppermost *** uppermost mantle layers in the Bogda Shan and Harlik Shan are relatively *** is likely associated with an eclogite body in the uppermost *** most significant negative anomaly of the uppermost mantle is however found in the Jueluotage tectonic belt and the central Tianshan Block and is possibly associated with depleted mantle *** suggest that these differences related to compositional changes may control the strength of the lithospheric mantle and have affected the uplift of the northern and southern segments of the eastern Tianshan after the Permian.

关键词： constrained inversion gravity anomaly three-dimensional lithospheric density structure eastern Tianshan geodynamics geophysics.

Interactions between amphiphilic nanoparticles coated with striped hydrophilic/hydrophobic ligands and a lipid bilayer

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Communications in Theoretical Physics 2023年第6期75卷 127-137页

作者： Lijuan Sun Yu Cao Xiaojie Chen qing liang Department of Physics and Key Laboratory of Solid Optoelectronic Devices of Zhejiang Province Zhejiang Normal UniversityJinhua 321004China Department of Industrial Automation Guangdong Polytechnic CollegeZhaoqing 526100China

Due to their unique physicochemical properties,nanoparticles play an important role in the fields of nanomedicine and so *** this paper,the interactions between the nanoparticles coated with striped hydrophilic and hydrophobic ligands and a lipid bilayer are investigated by using the coarse-grained molecular dynamics *** study focuses on the effects of the density of the ligands,the ratio of the hydrophilic ligands to the hydrophobic ligands,and the rigidity of the ligands on the interactions of the nanoparticles with the lipid *** results show that the nanoparticles interact with the lipid bilayer in two different *** nanoparticle with a small size,a large ratio of hydrophilic ligands to the hydrophobic ligands,and flexible ligands can readily be inserted into the lipid bilayer,and the nanoparticle rotation is very crucial to the insertion of the nanoparticle into the ***,the nanoparticle with a large size,a small ratio of hydrophilic ligands to hydrophobic ligands,and rigid ligands can only be adsorbed on the surface of the lipid *** work provides an effective method to modulate the interactions of the amphiphilic nanoparticles with the lipid bilayers and some insights into the applications of the nanoparticles in drug delivery,cell imaging,etc.

关键词： biomembrane nanoparticle molecular dynamics interaction