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Studies on the Reaction of Substituted 6-Nitrocoumarin with Anilines

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chinese Chemical Letters 1999年第10期10卷 811-812页

作者： Long Fei XIE Shi Ping XU Song XU Lan Min LI(institute of materia medica, chinese academy of medical sciencesand Peking Union medical College, beijing 100050) chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Beijing 100050 Peoples R China

3-Acetyl-7-hydroxy-8-methyl-6-nitrocoumarin reacted with substituted anilines, and fission of the heterocyclic ring occurred.

关键词： 6-nitrocoumarin heterocyclic ring fission Schiff base hydrazone

A MILD AND REGIOSPECIFIC OXIRANE RING OPENING TO PRECURSORS FOR PROSTANOID CONGENERS

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chinese Chemical Letters 1993年第9期4卷 757-758页

作者： Ai Lian ZHENG Yuan Liu WU institute of materia medica,chinese academy of medical sciences,beijing 100050

A stereoselective and regiospecific synthesis of procursors(2),(4),(6)and(7)of prostacyclin analogues from 2,3-epoxylbicyclo[3.2.0]hept-6-one(1)are described.

关键词： MILD A MILD AND REGIOSPECIFIC OXIRANE RING OPENING TO PRECURSORS FOR PROSTANOID CONGENERS

New Stereoselective Synthesis of 4-Butyl-α-agarofuran

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chinese Chemical Letters 2003年第9期14卷 881-882页

作者： Chun LI, Da Li YIN, Hui Qin HUANG, Xiang Hong WU, Ji Yu GUOinstitute of materia medica, chinese academy of medical sciences & Peking Union medical College, beijing 100050 institute of materia medica Chinese Academy of Medical Sciences & Peking Union Medical College

A potent anxiolytic 4-butyl-α-agarofuran (AF-5) was synthesized from (+)dihydro-carvone. Acid catalyzed hydration of (+)dihydrocarvone and interconversion with β-O-ketone 8 and the key intermediate α,β-unsaturated... 详细信息

关键词： AF-5 stereoselective synthesis.

PRELIMINARY STUDIES ON THE KINETIC RESOLUTION OF METHYL ERYTHRO-PHENYLGLYCERATE AND METHYL t-EPOXYCINNAMATE BY PLE

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chinese Chemical Letters 1992年第2期3卷 95-96页

作者： Jin Fa DU, Jin ZHOU and Liang HUANG~* institute of materia medica, chinese academy of medical sciences beijing, 100050

PLE(pig liver esterase) catalyzed hydrolysis of the title compounds demonstrated that the α-carbon with S configuration hydrolyzed faster than the R configuration and α-carbon controlled the stereoselectivity. The p... 详细信息

关键词： PRELIMINARY STUDIES ON THE KINETIC RESOLUTION OF METHYL ERYTHRO-PHENYLGLYCERATE AND METHYL t-EPOXYCINNAMATE BY PLE ZR

Reactivity of C-10 Function in Sinenxan A and Its Derivatives

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chinese Chemical Letters 1997年第12期8卷 0-0,0-0页

作者： Fen Mei YAO Dong Hui WANG Guang Yan HUANG Ji Yu GUO xiao tian LIANG(institute of materia medica, chinese academy of medical sciences & Peking Union Modical College, beijing 100050,China) chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Beijing 100050 Peoples R China

The allylic nature of C-10 in sinenxan A (1) leads to facile SN1 and eliminion reactions

关键词： Reactivity of C-10 Function in Sinenxan A and Its Derivatives

SALVIANOLIC ACID G,A CAFFEIC ACID DIMER WITH A NOVEL TETRACYCLIC SKELETON

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chinese Chemical Letters 1991年第1期2卷 17-18页

作者： Chun Bo AI Lian Niang LI institute of materia medica,chinese academy of medical sciences,beijing 100050,China

Salvianolic acid G,a caffeic acid dimer with a novel tetracyclic skeleton was isolated from the roots of Salvia *** structure was elucidated by chemical and spectral analysis,especially by 2D NMR analysis.

关键词： ACID OCH SALVIANOLIC ACID G,A CAFFEIC ACID DIMER WITH A NOVEL TETRACYCLIC SKELETON

Synthesis of 2S-Hydroxymethyl-3R, 4R-dihydroxypyrrolidine

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chinese Chemical Letters 1999年第8期10卷 651-652页

作者： Zhen CHEN Ren Yun WANG Li Lian ZHU xiao tian LIANG (institute of materia medica. Peking Union medical College) (The chinese academy of medical sciences, Bejing 100050) chinese Acad Med Sci Inst Mat Med Peking Union Med Coll Beijing 100050 Peoples R China

The sythesis of 2S-hydroxymethyl-3R, 4R-dihydroxypyrrolidine from D-arabinose was described in this paper.

关键词： polydroxylated pyrrolidine 2S-hydroxymethyl-3R 4R-dihydroxypyrrolidine D-arabinose

BIOTRANSFORMATION　OF　2α，5α，10β，14β－TETRA－ACETOXY－4（20），11－TAXADIENE　BY　THE　FUNGIJS　CUNNINGHAMELLA　ECHINULATA

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chinese Chemical Letters 1996年第6期7卷 543-544页

作者： Shang Hut HU Xu Fang tian Wei Hua ZHU and Qi Cheng FANG(institute of materia medica, chinese academy or medical sciencesand Peking Union medical College, beijing 1000050) institute of materia medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050

?5α,10β,14β-Tetra-acctoxy-4(20).11-taxadicne (1) could be regioselectively transfonnedinto 6α 10β-dihydroxy-2α,5α,14β-triacetoxy-4(20). 11- taxadiene (2) by Cunninghamella echinnlata infair yield. 6βM.10β-Dihydroxy-2α,5α,14β-triacet 11-taxadienc (3). 10β-hydroxy-2α,5α,14β-triacetoxy-4(20).11-taxadiene (4), 10 β-hyboxy-4β,20-epoxy -2α,5α,14β-triacetoxy- tax - 11- ene (5)asminor prpducts were also isolated

关键词： TETRA OF FUNGIJS THE CUNNINGHAMELLA ECHINULATA BY ACETOXY BIOTRANSFORMATION

Pharmacological Studies of Meisoindigo: Absorption and Mechanism of Action

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Biomedical and Environmental sciences 1991年第3期4卷 332-337页

作者： Jl XlUJUAN, LIU xiaoMEI, LI KUN, CHEN RUIHUAN, AND WANG LONGGUIinstitute of materia medica, chinese academy of medical sciences, beijing 100050, China. institute of materia medica Chinese Academy of Medical Sciences Beijing.

Meisoindigo, an indirubin derivative, is a new type of cancer chemotherapeutic agent. It exhibited higher activity against rodent tumors than indirubin itself. Experiments have shown the improved absorption of meisoindigo, compared to indirubin to be one of the major reasons for the enhancement of antitumor activity. Studies on the mechanism of meisoindigo action indicate that it strongly inhibits DNA biosynthesis in tumor cells. Strong inhibition of the drug on assembly of microtubule protein was also obtained. By means of FCM technique the effects of meisoindigo on mouse leukemia L1210 cell cycle were examined. Experimental results showed that under the action of meisoindigo the S phase cells accumulated and the traverse of the cells in G2 + M phase to G1 phase may also be blocked to some extent.

关键词： Absorption and Mechanism of Action Pharmacological Studies of Meisoindigo