检索结果-南通市图书馆

合成MRI定量参数区分三阴性与非三阴性乳腺癌的价值

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中国临床医学影像杂志 2024年第2期35卷 90-95页

作者：李芹李方正于海童吴莎莎牛庆亮潍坊市中医院影像中心山东潍坊261041 潍坊医学院影像学院山东潍坊262100

目的:探讨合成MRI定量参数区分三阴性乳腺癌(TNBC)与非TNBC的价值。方法:回顾性收集经病理证实的186例乳腺病变患者,术前均完成乳腺常规与合成MRI检查。采用ICC和Bland-Altman图分析不同观察者获得合成MRI定量参数的一致性。单、多因素l... 详细信息

目的:探讨合成MRI定量参数区分三阴性乳腺癌(TNBC)与非TNBC的价值。方法:回顾性收集经病理证实的186例乳腺病变患者,术前均完成乳腺常规与合成MRI检查。采用ICC和Bland-Altman图分析不同观察者获得合成MRI定量参数的一致性。单、多因素logistic回归分析合成MRI定量参数区分TNBC与非TNBC的价值,并绘制受试者工作特征曲线(ROC),计算曲线下面积(AUC)及敏感度、特异度。结果:基于3D-ROI获得的T_(1)、T_(2)和PD值的一致性ICC_(3D)(0.994、0.996和0.989)优于2D-ROI (0.848、0.850、0.898)。T_(1)-均值、T_(2)-均值联合模型区分TNBC与Luminal A型乳腺癌ROC曲线的AUC值为0.79(95%CI:0.65~0.88),敏感度为56.67%,特异度为88.00%。T_(2)-均值区分TNBC与Luminal B型乳腺癌ROC曲线的AUC值为0.74(95%CI:0.64~0.82),敏感度为63.66%,特异度为80.88%。PD-均值区分TNBC与HER2过表达型乳腺癌ROC曲线的AUC值为0.70(95%CI:0.55~0.82),敏感度为80.00%,特异度为55.00%。结论:不同观察者基于3D-ROI获得的合成MRI定量参数的可重复性高于2D-ROI;合成MRI定量参数可以为区分TNBC与非TNBC提供帮助。

关键词：乳腺肿瘤磁共振成像

大兴凸起东缘断裂的三维建模及其最大潜在地震评估

在线全文

学校读者我要写书评

暂无评论

地震地质 2024年第4期46卷 802-820页

作者：张雅静李正芳周本刚肖海波中国地震局地质研究所北京100029 中国电建集团北京勘测设计研究院有限公司北京100024

通过最新的浅部地震反射剖面和钻孔资料发现了大兴凸起东缘断裂全新世活动的证据,这一发现改变了近几十年以来认为的其晚第四纪以来没有活动的结论,对北京市地震灾害风险普查工作具有重要的应用价值,同时也对大兴凸起东缘断裂最大潜在... 详细信息

通过最新的浅部地震反射剖面和钻孔资料发现了大兴凸起东缘断裂全新世活动的证据,这一发现改变了近几十年以来认为的其晚第四纪以来没有活动的结论,对北京市地震灾害风险普查工作具有重要的应用价值,同时也对大兴凸起东缘断裂最大潜在地震的震级上限评估提出了新的挑战。文中通过收集和整理多条地震浅层物探剖面和地震深反射剖面,利用SKUA-GOCAD三维建模软件构建了大兴凸起东缘断裂的三维模型,模拟了大兴凸起东缘断裂在三维空间中的展布情况,揭示了该断裂的几何学特征及深浅构造关系。通过将大兴凸起东缘断裂和与其呈右阶排列的夏垫断裂进行构造类比,对大兴凸起东缘断裂深、浅部的构造特征进行了讨论,认为大兴凸起东缘断裂是一条深浅共存的活动断裂,并利用震级-破裂尺度经验关系式综合估计该断裂上可能诱发的最大潜在地震为7.5级。这一结论对首都圈南部地区开展震灾防治工作具有重要的科学指导意义。

关键词：大兴凸起东缘断裂地震反射剖面 SKUA-GOCAD三维模型最大潜在地震

维普期刊数据库博看期刊

Effects of γ-Ray Irradiation on the Fatigue Strength, Thermal Conductivities and Thermal Stabilities of the Glass Fibres/Epoxy Resins Composites

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2018年第1期31卷 105-112页

作者： li-fang zheng Lu-Ning Wang Zhao-Zhong Wang li Wang School of Mechanical Engineering University of Science and Technology Beijing School of Materials Science and Engineering University of Science and Technology Beijing

Glass fibres/epoxy resins composites have been performed as ideal materials to make support instruments for high-energy and nuclear physics experiments. The effects of the 3,-ray irradiation on the fatigue strength, thermal conductivities and thermal stabilities of the glass fibres/epoxy resins composites were investigated. And a two-parameter fatigue life model was established to predict the fatigue life of the composites. Results revealed that the y-ray irradiation could probably result in the degradation of epoxy resins, but hardly damage to the glass fibres. And the γ-ray irradiation treatment could significantly affect the fatigue strength of the composites at a low-cycle fatigue stage, but seldom influence at a high-cycle fatigue stage. Furthermore, the fabricated glass fibres/epoxy resins composites after the γ-ray irradiation still presented excellent fatigue strength, ideal thermal conductivities, remarkable dimensional and thermal stabilities, which can meet the actual requirements of normal operation for supporting instruments under high-energy and nuclear physics experiments.

关键词： Epoxy resins composites Glass fibres Fatigue strength γ-Ray irradiation Thermal stabilities

Case Report:Recurrent severe vomiting due to hyperthyroidism

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第3期11卷 218-220页

作者： li-ying CHEN Bo ZHOU Zhou-wen CHEN li-zheng fang Department of Family Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Department of Family Medicine Community Health Services Center in Pengbu Town Hangzhou 310017 China

Thyrotoxicosis may present in many ways;severe vomiting as a prominent symptom of thyrotoxicosis is *** this paper,we report a 24-year-old Chinese male with hyperthyroidism who presented with recurrent severe *** patient had had intermittent vomiting for seven years and had lost approximately 15 kg of *** examinations revealed chronic gastritis and one occasion peptic *** was treated with antacid and proton pump inhibitors,but his symptoms had no *** presenting symptoms suggested hyperthyroidism and were confirmed by laboratory *** a month of propylthiouracil therapy,his symptoms were *** should be noted that hyperthyroidism patients can have unexplained vomiting,and that hyperthyroidism may coexist with peptic ulcer in rare *** of such atypical presentations of hyperthyroidism may help to make a correct diagnosis.

关键词： Vomiting Hyperthyroidism Peptic ulcer

Antioxidant activities of cold-nature Tibetan herbs are signifcantly greater than hot-nature ones and are associated with their levels of total phenolic components

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2015年第8期13卷 609-617页

作者： BAO Yan-fang li Ji-Yu zheng li-fang li Hong-Yu School of Pharmacy Lanzhou University School of life Sciences Lanzhou University

Tibetan medicinal plants have been used for more than 2 000 years. In order to find their differences in antioxidant activity, total phenolics and total flavonoids between "hot-nature" and "cold-nature" herbs, we investigated the antioxidant activities of 40 Tibetan herbs from Qinghai plateau, with 20 herbs in cold-nature and 20 herbs in hot-nature. Antioxidant capacities were evaluated by the following methods: scavenging ABTS?+(2, 2′azinobis-(3-ethylbenz-thiazoline-6-sulfonic acid), scavenging O2?-, and Ferric-reducing antioxidant power(FRAP). The effects on inhibition of mitochondrion lipid peroxidation were determined by measuring the formation of TBARS(Thiobarbituric acid reactive substrates). Total phenolics and flavonoids were estimated by Folin-Ciocalteu and Na NO2-Al(NO3)3-Na OH colorimetric methods. Interestingly, the cold-nature herbs displayed higher antioxidant activities than the hot-nature ones, corresponding to nearly three-fold higher total phenolic contents in the cold-nature herbs. Moreover, the antioxidant activities correlated linearly with the levels of total phenolics for both cold-nature and hot-nature herbs, but only with the levels of total flavonoids for the hot-nature herbs. The results suggested that the phenolic compounds, but not the flavonoids, play the major role in antioxidant capacities of the cold-nature herbs. These findings could shed new lights on the study the theory of Tibetan medicine.

关键词： Tibetan herbs Hot-cold nature Antioxidant activity Mitochondrion Phenolics Flavonoids

Comparison of an SMS text messaging and phone reminder to improve attendance at a health promotion center:A randomized controlled trial

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第1期9卷 34-38页

作者： Zhou-wen CHEN li-zheng fang li-ying CHEN Hong-lei DAI Department of General Practice Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Objective: To compare the efficacy of a short messaging service (SMS) text messaging and phone reminder to im-prove attendance rates at a health promotion center. Methods: A total of 1 859 participants who had scheduled appointments in the health promotion center of our hospital from April 2007 to May 2007 were enrolled in the study and randomly assigned into 3 groups: control (no reminder) group,SMS text messaging reminder group and telephone reminder group. Attendance rates and costs of interventions were collected. Results: A total of 1848 participants were eligible for analysis. Attendance rates of control,SMS and telephone groups were 80.5%,87.5% and 88.3%,respectively. The attendance rates were significantly higher in SMS and telephone groups than that in the control group,with odds ratio 1.698,95% confidence interval 1.224 to 2.316,P=0.001 in the SMS group,and odds ratio 1.829,95% confidence interval 1.333 to 2.509,P<0.001 in the telephone group. However,there was no difference between the SMS group and the telephone group (P=0.670). The cost effectiveness analysis showed that the cost per attendance for the SMS group (0.31 Yuan) was significantly lower than that for the telephone group (0.48 Yuan). Conclusion: SMS and telephone are effective reminders for improving attendance rate at a health promotion center. SMS reminder may be more cost-effective compared with the telephone reminder.

关键词： Reminder Short messaging service (SMS) Telephone Failure to attend (FTA) Randomized controlled trial (RCT)

Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 616-622页

作者： Zhou-wen CHEN li-ying CHEN Hong-lei DAI Jian-hua CHEN li-zheng fang Department of General Practice Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Objective： To investigate the relationship between alanine aminotransferase （ALT） levels and metabolic syndrome （MS） in nonalcoholic fatty liver disease （NAFLD）. Methods： A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study. The diagnosis of fatty liver was based on ultrasound imaging. MS was defined according to the criteria of the Adult Treatment Panel III. ALT, triglyceride （TG）, high density lipoprotein cholesterol （HDL-c）, fasting plasma glucose （FPG）, height, weight, waist circumference （WC）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were measured in each subject to analyze the relationship between MS and ALT activity Results：（1） The prevalence of NAFLD in men （30.94%） was significantly higher than that in women （15.65%）; （2） The incidence of MS in NAFLD （33.83%） was significantly greater than that in non-NAFLD （10.62%）; （3） Of the 6470 subjects with NAFLD, in the age-adjusted partial correlation analysis, there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex （P〈0.01）, except that ALT levels multiple stepwise regression analysis, SBP lost its significance, and had no correlation with HDL-c in women. Moreover, in the WC, body mass index （BMI）, age, DBP, TG and FPG were independently associated with ALT levels in both sexes （P〈0.05）. HDL-c remained significant and was independently related to ALT levels in men; （4） ALT levels were significantly higher in subjects with MS compared to those without MS （P〈0.001）. Mean ALT levels increased with the number of MS components in each sex （P〈0.05 for trend）. Conclusion： We found a strong relationship between ALT levels and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations.

关键词： Nonalcoholic fatty liver disease (NAFLD) Alanine aminotransferase (ALT) Metabolic syndrome (MS)

Clinical Observation on Acupuncture for Perimenopausal Syndrome

在线全文

学校读者我要写书评

暂无评论

Journal of Acupuncture and Tuina Science 2013年第3期11卷 147-150页

作者： zheng li-fang Jin Ya-bei Zhejiang University of Traditional Chinese Medicine Acupuncture Department Hangzhou Red Cross Hospital

Objective: To observe the clinical efficacy of acupuncture for perimenopausal syndrome. Methods: A total of 40 perimenopausal syndrome cases who met the inclusion criteria were randomized into an observation group and a control group, 20 in each group. Acupuncture combining with ginger-partitioned moxibustion was used in the observation group, whereas acupuncture was used in the control group. Modified Kupperman Index (KI) was evaluated respectively before and after treatment. In addition, the clinical efficacies in the two groups were compared. Results: The total effective rate in the observation group was higher than that in the control group (Plia and arthralgia or myalgia.

关键词： Acupuncture Therapy Acupuncture-moxibustion Therapy Indirect Moxibustion Perimenopausal Syndrome Menopausal Syndrome Ginger- partitioned Moxibustion

Bioactive compounds from Paecilomyces tenuipes regulating the function of the hypothalamo-hypophyseal system axis in chronic unpredictable stress rats

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2007年第12期120卷 1088-1092页

作者： YIN Yan-yan MING liang zheng li-fang KAN Hong-wei li Chun-ru li Wei-ping Department of Pharmacology Anhui Medical University Hefei 230032 China Research Center of Entomogenous Fungi Anhui Agricultural University Hefei 230024 China

Background A bioactive compound from Paecilomyces tenuipes （BCPT） has an inhibitory effect on monoamine oxidase A （MAO-A） and monoamine oxidase B （MAO-B） in vitro and in vivo, which indicates BCPT may be a potential antidepressant. In this study we aimed to study the antidepressant effects of BCPT in the chronic unpredictable stress （CUS） model in rats and explore underlying mechanisms in the hypothalamic-pituitary-adrenal （HPA） axis. Methods The antidepressant effects of BCPT were studied in the chronic unpredictable stress model in rats. Animals were housed isolated, except the control group. Rats were exposed daily to different random stressors from day 1 to 21. Awarding response was detected by calculating the 24-hour consumption of sucrose water. Cortisol （CORT） and adrenocorticotropic hormone （ATCH） contents in serum and arginine vasopressin （AVP） contents in the pituitary body were detected by radio immunoassays. Total RNA of hippocampus or hypothalamus was extracted and subjected to reverse transcription-polymerase chain reaction （RT-PCR） for the measurement of corticotrophin releasing hormone （CRH） mRNA or mineralocorticoid receptor （MR） mRNA and glucocorticoid receptor （GR） mRNA levels. Statistical analyses were performed using one way analysis of variance （ANOVA） followed by Student-Newman-Keuls （SNK） test. Results Chronic unpredictable stress resulted in reduction of sensitivity to reward and abnormality in the HPA axis in the animal model. BCPT improved the reward reaction as measured by increasing sucrose consumption, remarkably reduced serum CORT and ACTH levels and the AVP content in the pituitary body in the CUS-treated rats, decreased the expression of CRH mRNA, enhanced the expression of hippocampus MR mRNA, GR mRNA and decreased the ratio of MR/GR. Conclusions BCPT has potentially antidepressant-like activity and normalized the HPA axis hyperactivity in a CUS model of depression in rats. This may be an important mechanism of its antidepressan

关键词： Paecilomyces tenuipes depression stress hypothalamo-hypophyseal system