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Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao WANG Tong ZHANG Ya-nan CHEN Qian WANG yuan XING Yan-qing ZHENG Jun DUAN Chen-chen CHEN lijun ZHAO Hai-jun WANG Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver *** extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and *** alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides *** addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut *** review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine polysaccharides gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions

绿色信贷、偏向性技术进步与绿色转型发展研究——基于动态金融CGE模型的模拟分析

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技术经济与管理研究 2024年第4期 14-20页

作者：郭轶锋王涛李媛钰刘洁北京理工大学管理与经济学院北京100081 首都经济贸易大学财政税务学院北京100070

选取2017年中国地区投入产出表和2021年相关数据构建SAM表,刻画绿色信贷政策的传导路径,评估绿色信贷政策对企业创新的影响。研究发现:绿色信贷政策对抑制目标行业的投资行为较为有效,并在短期、中期内能减少造纸业、化工行业产出;从长... 详细信息

选取2017年中国地区投入产出表和2021年相关数据构建SAM表,刻画绿色信贷政策的传导路径,评估绿色信贷政策对企业创新的影响。研究发现:绿色信贷政策对抑制目标行业的投资行为较为有效,并在短期、中期内能减少造纸业、化工行业产出;从长期来看,目标行业投资、产出回升将抵消绿色信贷对抑制目标行业产出的效果。这表明在研究绿色信贷政策与企业绿色创新活动的关系时,应重视偏向性技术创新的作用,并动态追踪绿色信贷在短期、中期、长期的作用效果。

关键词：绿色信贷技术进步绿色创新低碳转型

LonP1 links Mitochondria–ER Interaction to Regulate Heart Function

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Research 2024年第1期2023卷 595-609页

作者： Yujie li Dawei Huang lianqun Jia Fugen Shangguan Shiwei Gong linhua Lan Zhiyin Song Juan Xu Chaojun Yan Tongke Chen Yin Tan Yongzhang liu Xingxu Huang Carolyn K.Suzuki Zhongzhou Yang Guanlin Yang Bin Lu The Affiliated Nanhua Hospital and School of Basic Medical Sciences Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China School of Laboratory Medicine and life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325035China National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangshaHunan 410008China Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Ministry of Education of ChinaLiaoning University of Traditional Chinese MedicineShenyangLiaoning 110847China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhanHubei 430072China Nanjing Maternity and Child Health Care Hospital Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical UniversityNanjing 210004China Animal Center Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Cardiology The First Affiliated Hospital of University of South ChinaHengyangHunanChina School of life Science and Technology Shanghai Tech UniversityShanghai 201210China Department of Microbiology Biochemistry and Molecular GeneticsNew Jersey Medical School-RutgersThe State University of New JerseyNewarkNJUSA State Key Laboratory of Pharmaceutical Biotechnology Department of CardiologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China

Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and *** particular,the mitochondria–endoplasmic reticulum(ER)membrane contact site(MAM)is known to regulate ion and lipid transfer,as well as signaling and organelle ***,the regulatory mechanisms of MAM formation and their function are still ***,we identify mitochondrial Lon protease(LonP1),a highly conserved mitochondrial matrix protease,as a new MAM tethering *** removal of LonP1 substantially reduces MAM formation and causes mitochondrial ***,deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER(UPR^(ER)).Consequently,cardiac-specific LonP1 deficiency causes aberrant metabolic reprogramming and pathological heart *** findings demonstrate that LonP1 is a novel MAM-localized protein orchestrating MAM integrity,mitochondrial dynamics,and UPR^(ER),offering exciting new insights into the potential therapeutic strategy for heart failure.

关键词： offering programming insight

Reproducibility study of intravoxel incoherent motion and apparent diffusion coefficient parameters in normal pancreas

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2031-2039页

作者： Xiang liu Yi-Feng Wang Xiao-Hui Qi Zhi-Lei Zhang Jiang-Yang Pan Xue-li Fan Yu Du Ying-Min Zhai Qi Wang Department of CT and MRI The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND The consistency of pancreatic apparent diffusion coefficient(ADC)values and intravoxel incoherent motion(IVIM)parameter values across different magnetic resonance imaging(MRI)devices significantly impacts the patient’s diagnosis and *** To explore consistency in image quality,ADC values,and IVIM parameter values among different MRI devices in pancreatic *** This retrospective study was approved by the local ethics committee,and informed consent was obtained from all *** total,22 healthy volunteers(10 males and 12 females)aged 24-61 years(mean,28.9±2.3 years)underwent pancreatic diffusion-weighted imaging using 3.0T MRI equipment from three *** independent observers subjectively scored image quality and measured the pancreas’s overall ADC values and signal-to-noise ratios(SNRs).Subsequently,regions of interest(ROIs)were delineated for the IVIM parameters(true diffusion coefficient,pseudo-diffusion coefficient,and perfusion fraction)using post-processing *** ROIs were on the head,body,and tail of the *** subjective image ratings were assessed using the kappa consistency *** correlation coefficients(ICCs)and mixed linear models were used to evaluate each device’s quantitative parameter ***,a pairwise analysis of IVIM parameter values across each device was performed using Bland-Altman *** The Kappa value for the subjective ratings of the different observers was 0.776(P0.05),and the ICCs for the ADC values from different devices were 0.870,0.707,and 0.808,respectively(P<0.05).Notably,only a few statistically significant inter-device agreements were observed for different IVIM parameters,and among t

关键词： Intravoxel incoherent motion Pancreas Image quality Consistency test

Metal-Free,Site-Selective C-H Fluorination of Heteroarenes Under Visible light

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CCS Chemistry 2024年第7期6卷 1681-1688页

作者： Cheng Huang Chang-Ming You Yu-Shu Qin Rui-Nan Ci Peng Xiao Sheng Tang Bin liu Zhenhong Wei li-Zhu Wu Hu Cai School of Chemistry and Chemical Engineering Nanchang UniversityNanchangJiangxi 330031 Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100190 School of Future Technology University of Chinese Academy of SciencesBeijing 100049

The site-selective C-H fluorination of heteroarenes is a straightforward approach to accessing valuable heteroaryl fluorides but remains a formidable ***,we report a general strategy for visible-light-induced C-H fluorination of heteroarenes via the merger of N-F fluorinating reagents and *** paramagnetic resonance experiments provide evidence for the homolytic cleavage of the N-F bond under blue light-emitting diode irradiation,which is the key step in the *** transformation is metal-free,photocatalysts-free,and site-selective under mild reaction conditions(ambient temperature,visible-light irradiation,tolerant to H2O).The robustness of this protocol has also been highlighted by late-stage modification of complex and medicinally relevant molecules.

关键词： selective C-H fluorination heteroaryl fluorides C(sp^(2))-F bond formation photochemistry radical chemistry

Sinonasal teratocarcinosarcoma involving the nasal cavity,unilateral paranasal sinuses,and intracranial invasion:A case report

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World Journal of Clinical Cases 2024年第25期12卷 5784-5790页

作者： li-yuan Fu Mi-Yang Yang Pei-Yun Ye Zhao-Chu Wang Chu-Jie Chen Hui li Shang-Wen Xu Department of Radiology 900th Hospital of Joint Logistics Support ForceFuzhou 350025Fujian ProvinceChina The First Clinical Medical College Fuzong Teaching HospitalFujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina

BACKGROUND Sinonasal teratocarcinosarcoma(SNTCS)is a rare and highly invasive neoplasm originating from the nasal cavity and ***,it exhibits an invasive behavior towards adjacent structures;however,in exceptional instances,it may infiltrate the intracranial *** to the tumor's rarity and lack of distinctive features on computed tomography(CT)and magnetic resonance imaging(MRI)images,SNTCS is often *** SUMMARY In this study,we present a case of SNTCS in a 56-year-old patient who exhibited unexplained cognitive impairment before *** and MRI scans revealed the presence of a mass in the right nasal cavity,with lesions extending to the right ethmoid sinus and right frontal ***,the patient underwent pathological examination for confirmation and received surgical intervention to excise the *** future advancement in our understanding of this disease will significantly contribute to the precise diagnosis and treatment of *** SNTCS is an exceptionally rare malignant tumor that originates from the nasal cavity and paranasal sinuses,presenting a diagnostic challenge due to its nonspecific imaging *** accurately delineates the location,morphological characteristics,size,internal structure,extent of surrounding involvement,and metabolic information of the *** aspects play a pivotal role in the precise localization and qualitative assessment of ***,a definitive diagnosis still requires a pathological biopsy.

关键词： Paranasal sinus Malignant tumor Sinonasal teratocarcinosarcoma Brain invasion Case report

“Unveiling the antiviral mechanism of Forsythia suspense: A comprehensive analysis of screening targets and components

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Journal of Chinese Pharmaceutical Sciences 2024年

作者： Na Sun Shuo Ma linxuan Jin Xin Zhang Miao Zhou Huanhuan Yang Wenqian li Xinru Wu Yanyan Hou Yuhan yuan Yu Zhang Penghua Shu Food and Pharmacy College， Xuchang University

list of Supporting InformationTable S1 The PDB ID， Resolution， and ligand of key antiviral target p

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State Estimator for linear High-Dimensional Systems With State Partition and Block-Dependent Compensation

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State Estimator for Linear High-Dimensional Systems With Sta...

基于弱耦合多芯少模光纤光斑分析的扰动传感研究

第35届中国过程控制会议

作者： Ke li Shunyi Zhao Fei liu Key Laboratory of Advanced Process Control for light Industry (Ministry of Education) Institute of Automation Jiangnan University

This paper proposes a Bayesian estimation scheme with block-dependent compensation for linear high-dimensional systems. The state vector is divided into blocks by considering the relationship of state variables in time series and physical interpretation to reduce the underlying computational cost. However, blocking states damages the original system and introduces systematic errors. Consequently, the divided state blocks are compensated by introducing distinct compensation coefficients to improve state estimation accuracy. Considering the difference and uniqueness of state blocks, the distinct compensation coefficients are adaptively adjusted and updated over time to ensure higher accuracy of state estimation. Simulation results of numerical example are used to evaluate the performance of the proposed algorithm. It shows that the proposed algorithm possesses moderate computational cost and higher estimation accuracy compared with the existing methods.

关键词： State estimation Bayesian inference Block-dependent compensation linear high-dimensional systems

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半导体光电 2024年第4期45卷 523-529页

作者：袁晖刘艳李广德庞乐之北京交通大学电子信息工程学院北京100044

提出了一种基于耦合多芯少模光纤(FM-MCF)光斑检测的光纤扰动传感器结构,并进行了实验验证。该传感器采用“单模光纤-多模光纤(MMF)-多芯少模光纤”的级联光纤结构,单模激光经过MMF进行光场发散后,FM-MCF中的7个芯子都能被照亮,因此在FM... 详细信息

提出了一种基于耦合多芯少模光纤(FM-MCF)光斑检测的光纤扰动传感器结构,并进行了实验验证。该传感器采用“单模光纤-多模光纤(MMF)-多芯少模光纤”的级联光纤结构,单模激光经过MMF进行光场发散后,FM-MCF中的7个芯子都能被照亮,因此在FM-MCF的末端可以用相机接收到具有7个子光斑的光斑图像。实验中在FM-MCF不同位置处施加扰动并同时采集光斑,之后基于神经网络对变化的光斑图样进行处理以实现扰动位置分类。基于FM-MCF芯内强耦合、芯间弱耦合的特性,利用该光纤结构以3 cm的空间分辨率实现了对15个扰动位置的99.46%的高精度分类,远高于仅采用MMF通过光斑检测进行扰动定位的结果。也测试了FM-MCF传感器同时检测扰动位置和强度的能力,识别分类准确率均接近100%。实验结果表明,所提出的传感器具有成本低、结构简单、易于解调和高精度的优点。

关键词：光纤光斑多芯少模光纤扰动传感卷积神经网络

针药结合对气阴两虚兼血瘀型2型糖尿病合并勃起功能障碍患者糖脂代谢及性激素的影响

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辽宁中医杂志 2024年第10期51卷 166-169页

作者：李向团李振王昊刘媛荀艳平唐山市中医医院河北唐山063000

目的探究针药结合对气阴两虚兼血瘀型2型糖尿病合并勃起功能障碍患者糖脂代谢及性激素的影响。方法选取唐山市中医医院2021年3月—2022年12月收治的气阴两虚兼血瘀型2型糖尿病合并勃起功能障碍患者75例,采用随机分组法分为对照组(37例)... 详细信息

目的探究针药结合对气阴两虚兼血瘀型2型糖尿病合并勃起功能障碍患者糖脂代谢及性激素的影响。方法选取唐山市中医医院2021年3月—2022年12月收治的气阴两虚兼血瘀型2型糖尿病合并勃起功能障碍患者75例,采用随机分组法分为对照组(37例)和治疗组(38例)。对照组给予他达拉非片联合中药复方汤剂口服;治疗组在对照组的基础上配合针灸治疗。观察两组中医证候、糖脂代谢水平、性激素水平及临床疗效。结果治疗后,治疗组各项中医证候积分均低于对照组(P0.05);治疗后,治疗组LH、E2水平均低于对照组(P<0.05)、T和FSH水平均高于对照组(P<0.05);治疗组治疗总有效率(89.47%)高于对照组(70.27%)(P<0.05)。结论针药结合在治疗气阴两虚兼血瘀型2型糖尿病合并勃起功能障碍患者时,可缓解相关不适症状,稳定糖脂代谢,改善性激素水平,提高临床疗效。

关键词：针药结合气阴两虚兼血瘀型 2型糖尿病勃起功能障碍