检索结果-南通市图书馆

Biomedical and Environmental Sciences 2009年第1期22卷 32-39页

作者： SHAO-liNG WANG ying li ying WEN YAN-feng CHEN li-XIN NA SONG-TAO li CHANG-HAO SUN Department of Nutrition and Food Hygiene Harbin Medical University No. 157 Baojian Road Harbin 150081 Heilongjiang China

Objective To investigate the attenuating effect of curcumin, an anti-inflammatory compound derived from dietary spice turmeric （Curcuma longa） on the pro-inflammatory insulin-resistant state in 3T3-L1 adipocytes. Methods Glucose uptake rate was determined with the [3H] 2-deoxyglucose uptake method. Expressions of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were measured by quantitative RT-PCR analysis and EliSA. Nuclear transcription factor kappaB p65 （NF-r,B p65） and mitogen-activated protein kinase （MAPKs） were detected by Western blot assay. Results The basal glucose uptake was not altered, and curcumin increased the insulin-stimulated glucose uptake in 3T3-L1 cells. Curcumin suppressed the transcription and secretion of TNF-α and IL-6 induced by palmitate in a concentration-dependent manner. Palmitate induced nuclear translocation of NF-kB. The activities of Jun NH2-terminal kinase ONK）, extracellular signal-regulated kinasel/2 （ERKI/2） and p38MAPK decreased in the presence of curcumin. Moreover, pretreatment with SP600125 （inhibitor of JNK） instead of PD98059 or SB203580 （inhibitor of ERKI/2 or p38MAPK, respectively） decreased the up-regulation of TNF-α induced by palmitate. Conelusion Curcumin reverses palmitate-induced insulin resistance state in 3T3-L1 adipocytes through the NF-kB and JNK pathway.

关键词： Curcumin Insulin resistance Inflammation Adipocyte Free fatty acids

Gapless indica rice genome reveals synergistic contributions of active transposable elements and segmental duplications to rice genome evolution

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2021年第10期14卷 1745-1756页

作者： Kui li Wenkai Jiang Yuanyuan Hui Mengjuan Kong li-ying feng li-Zhi Gao Pengfu li Shan Lu State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China Novogene Bioinformatics Institute Building 301Zone A10 Jiuxianqiao North RoadChaoyang DistrictBeijing 100083China Institution of Genomics and Bioinformatics South China Agricultural UniversityGuangzhou 510642China Shenzhen Research Institute of Nanjing University Shenzhen 518000China

The ultimate goal of genome assembly is a high-accuracy gapless ***,we report a new assembly pipeline that is used to produce a gapless genome for the indica rice cultivar Minghui *** resulting 397.71-Mb final assembly is composed of 12 contigs with a contig N50 size of 31.93 *** chromosome is represented by a single contig and the genomic sequences of all chromosomes are *** evaluation of this gapless genome assembly showed that gene regions in our assembly have the highest completeness compared with the other 15 reported high-quality rice *** comparison with the japonica rice genome revealed that the gapless indica genome assembly contains more transposable elements(TEs)and segmental duplications(SDs),the latter of which produce many duplicated genes that can affect agronomic traits through dose effect or sub-/*** insertion of TEs can also affect the expression of duplicated genes,which may drive the evolution of these ***,we found the expansion of nucleotide-binding site with leucine-rich repeat disease-resistance genes and cis-zeatin-O-glucosyltransferase growth-related genes in SDs in the gapless indica genome assembly,suggesting that SDs contribute to the adaptive evolution of rice disease resistance and developmental ***,our findings suggest that active TEs and SDs synergistically contribute to rice genome evolution.

关键词： evolution gapless genome rice segmental duplications transposable elements

Synthesis of novel quaternary ammonium surfactants containing adamantane

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2012年第6期23卷 653-656页

作者： Jian Wei Guo Xing Zhong Hua Zhu li Juan feng ying De Cui Faculty of Chemical Engineering ＆ light Industry Guangdong University of Technology Guangzhou 510006 China

A series of novel quaternary ammonium surfactants containing adamantane were designed and synthesized from 1-adamanta- necarboxylic acid. The structures of target surfactants were confirmed by 1H NMR, elements analysis and FFIR. Surface properties of these surfactants were investigated. Due to the lipophilicity of adamantane, the critical micelle concentration （CMC） and C2o values of the synthesized quaternary ammonium surfactants are lower than that of conventional quaternary ammonium surfactants.

关键词： Adamantane Synthesis Quaternary ammonium surfactants 1-(Alkyldimethylammoniamethyl) adamantane bromide

Pressure-Induced Amorphous Transition of li_(2)Ge_(7)O_(15) Crystal

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 1996年第7期13卷 534-536页

作者： CHEN liang-chen GU Hui-cheng WANG li-jun li feng-ying CHE Rong-zheng ZHOU Lei XIU li-song LAN Guo-xiang Institute of Physics Chinese Academy of SciencesBeijing 100080 BSRF Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100039 Department of Physics Nankai UniversityTianjin 300071

Pressure-induced amorphous transition of li_(2)Ge_(7)O_(15)(LGO)crystal has been investigated by using in situ high pressure energy dispersive x-ray diffraction with synchrotron radiation at the pressure up to 21.6 *** anvils were used to generate high *** was measured in terms of the diffraction of Pt as an internal pressure *** crystal structure of LGO is an orthorhombic lattice at atmospheric *** to the high pressure x-ray diffraction results,new diffraction lines begin to appear and LGO undergoes an intermediate phase transition at the pressure of 12.9 ***,the diffraction lines disappear wholly and LGO becomes an amorphous phase at the pressure of above 14.8 *** amorphous transition is irreversible.

关键词： amorphous transition Transition

The Use of Zein and Shuanghuangbu for Periodontal Tissue Engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2010年第3期2卷 142-148页

作者： Yan-zhi Xu Jing-jing Wu Yan-ping Chen Jian liu Na li feng-ying Yang Department of Stomatology the Fourth Hospital of Hebei Medical University Shijiazhuang China

Aim Tissue engineering is a promising area with a broad range of applications in the fields of regenerative medicine and human health. The emergence of periodontal tissue engineering for clinical treatment of periodontal disease has opened a new therapeutic avenue. The choice of scaffold is crucial. This study was conducted to prepare zein scaffold and explore the suitability of zein and Shuanghuangbu for periodontal tissue *** A zein scaffold was made using the solvent casting/particulate leaching method with sodium chloride （NaC1） particles as the porogen. The physical properties of the zein scaffold were evaluated by observing its shape and determining its pore structure and porosity. Cytotoxicity testing of the scaffold was carried out via in vitro cell culture experiments, including a liquid extraction experi- ment and the direct contact assay. Also, the Chinese medicine Shuanghuangbu, as a growth factor, was diluted by scaffold extract into different concentrations. This Shuanghuangbu-scaffold extract was then added to periodontal ligament cells （PDLCs） in order to determineits effect on cell proliferation. Results The zein scaffold displayed a sponge-like structure with a high porosity and sufficient thickness. The porosity and pore size of the zein scaffold can be controlled by changing the porogen particles dosage and size. The porosity was up to 64.1%-78.0%. The pores were well-distributed, interconnected, and porous. The toxicity of the zein scaffold was graded as 0-1. Furthermore, PDLCs displayed full stretching and vigorous growth under scanning electronic microscope （SEM）. Shuanghuangbu-scaffold extract could reinforce proliferation activity of PDLCs compared to the control group, especially at 100 μ***^-1 （P〈0.01）. Conclusion A zein scaffold with high porosity, open pore wall structure, and good biocompatibility is conducive to the growth of PDLCs. Zein could be used as scaffold to repair periodontal tissue defects. Also, Shuanghu

关键词： zein periodontal tissue engineering scaffold,periodontal ligament cells Shuanghuangbu

Elastic Behaviors of Bulk Metallic Glass Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) Investigated by Using Ultrasonic Technique

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 1997年第12期14卷 920-923页

作者： WANG Ru-ju QIN Zhi-cheng li feng-ying XIE Hong-sen Institute of Physics Chinese Academy of SciencesBeijing 100080 Institute of Geochemistry Chinese Academy of SciencesGuiyang 550002

The acoustic velocity,attenuation,and their pressure dependence of a bulk metallic glass Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) have been measured under pressures up to 0.5 GPa at room temperature using the pulse echo overlap *** sample was prepared from melt by quenching into liquid *** modulus,Young’s modulus,shear modulus,and Poisson’s ratio were derived,other elastic properties and vibrational anharmonicity were also discussed.

关键词： modulus Bulk Elastic

Third Order Elastic Constants and Anharmonic Properties of the Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) Bulk Metallic Glass

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2001年第3期18卷 414-415页

作者： WANG Ru-Ju li feng-ying QIN Zhi-Cheng WANG Wei-Hua Institute of Physics Chinese Academy of SciencesBeijing 100080

The longitudinal velocity Vl and shear velocity Vs of ultrasonic wave propagated along arbitrary three perpendicular directions of the Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) bulk metallic glass(Zr/Ti BMG)have been measured at ambient pressure,under hydrostatic pressure(up to 0.5 GPa)and uniaxial compression(up to 70 MPa)using the pulse echo overlap *** third order elastic constants and the Grüneisen parameter related to the anharmonic properties were derived and *** was found that the BMG with marked different microstructural characteristics comparing with the amorphous carbon exhibited different behaviours related to shear vibratory under high pressure.

关键词： Elastic harmonic hydrostatic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

多元T型阵列探测器原理与性能

光子学报 2015年第11期44卷 42-48页

作者：李健文化锋 li ying-feng 宁波大学信息科学与工程学院浙江宁波315211 Atech Systems 6110 W. Highway 290 Austin TX 78735 USA

针对行波探测器阵列只合成多个光电二极管的输出功率而不能提高工作带宽的问题,提出了一种多元T型电路结构的阵列探测器.通过在各个光电二极管支路串联电容降低等效电容,减小结电容对探测器截止频率的影响,再用电感连接各个光电二极管... 详细信息

针对行波探测器阵列只合成多个光电二极管的输出功率而不能提高工作带宽的问题,提出了一种多元T型电路结构的阵列探测器.通过在各个光电二极管支路串联电容降低等效电容,减小结电容对探测器截止频率的影响,再用电感连接各个光电二极管支路构成T型滤波器电路结构,在合成多个光电二极管输出功率的同时增加了工作带宽.仿真结果表明,在光电二极管支路串联与光电二极管结电容相等大小的电容时,四元T型阵列探测器相比四元行波探测器阵列输出功率减少了一半,但工作带宽提高了一倍,而相比于传统探测器则在输出功率和工作带宽上都提高了一倍,此外八元T型阵列探测器与四元行波探测器阵列输出功率相同,工作带宽提高了一倍.

关键词：光电探测器功率合成行波探测器阵列 T型电路结构工作带宽

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI Zhi-feng li Meng-ya ZHONG Yue-long JIANG li-ying feng Jie ZHA Jing-wei YAO Yin li Xian-ming DENG Bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p53

B→ X8γ, X8l＋l- Decays and Constraints on Mass Insertion Parameters in MSSM

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2006年第4X期46卷 687-696页

作者： XIAO Zhen-Jun li feng-ying ZOU Wen-Jun Department of Physics and Institute of Theoretical Physics~ Nanjing Normal University Nanjing 210097 China

In this paper, we study the upper bounds on the mass insertion parameters （δAB^q）ij in the minimal super symmetric standard model. We found that the information from the measured branching ratio of B→ X8γ, X8l＋l- decay can help us to improve the upper bounds on the mass insertions parameters （δAB^u,d）3j,i3 Some regions allowed by the data of Br（B→ X8γ） are excluded by the requirement of an SM-like C7γ （rnb） imposedby the data of Br（B→ X8γ, X8l＋l- ）.

关键词： B meson decay the minimal supersymmetric standard model mass insertion