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STING mediates microglial pyroptosis via interaction with NLRP3 in cerebral ischaemic stroke

Stroke & Vascular Neurology 2024年第2期9卷 153-164页

作者： Wenyu li Nan Shen lingqi Kong Hongmei Huang Xinyue Wang yan Zhang Guoping Wang Pengfei xu Wei Hu Department of Neurology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina

background Ischaemia-evoked neuroinflammation is a critical pathogenic event following ischaemic *** D(GSDMD)-associated pyroptosis represents a type of inflammation-associated programmed cell death,which can exacerbate neuroinflammatory responses and brain *** of interferon genes(STING)was recently described as a vital innate immune adaptor protein associated with ***,the regulatory effects of STING on microglial pyroptosis post-stroke have not been well *** STING-knockout and wild-type(WT)mice were subjected to middle cerebral artery occlusion(MCAO).STING small interfering RNA(siRNA)was transfected into BV2 cells before oxygen-glucose deprivation/reoxygenation(OGD/R).STING-overexpressing adeno-associated virus(AAV)and NOD-like receptor family pyrin domain containing 3(NLRP3)siRNA were administered by stereotaxic injection.2,3,5-Triphenyl tetrazolium chloride(TTC)staining,TdT-mediated dUTP nick end labeling(TUNEL)staining,Fluoro-Jade C(FJC)staining,neurobehavioural tests,immunohistochemistry,cytokine antibody array assay,transmission electron microscopy,immunoblot,Enzyme-linked immunosorbent assay(EliSA)and quantitative real-time polymerase chain reaction(qRT-PCR)were carried ***-immunoprecipitation assays were used to investigate the interplay between STING and *** STING expression was increased after MCAO and mainly detected on *** deletion alleviated brain infarction,neuronal damage and neurobehavioural impairment in mice subjected to *** knockout suppressed microglial activation and the secretion of inflammatory chemokines,accompanied by mitigation of microglial *** upregulation of microglial STING by AAV-F4/80-STING aggravated brain injury and microglial ***,co-immunoprecipitation showed that STING bound to NLRP3 in *** of NLRP3 siRNA reversed AAV-F4/80-STING-induced deterioration of microglial pyropt

关键词： NLRP3 cerebral inflammation

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Perception of fundamental science to boost lithium metal anodes toward practical application

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Green Energy & Environment 2024年第3期9卷 454-472页

作者： Jinkun Wang li Wang Hong xu li Sheng Xiangming He Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing100084China

As a key material for lithium metal batteries(LMBs),lithium metal is one of the most promising anode materials to break the bottleneck of battery energy density and a commonly used active material for reference *** lithium anodes are regarded as the holy grail of lithium batteries,decades of exploration have not led to the successful commercialization of LMBs,due mainly to the challenges related to the inherent properties of lithium *** pave the way for further investigation,herein,a comprehensive review focusing on the fundamental science of lithium are ***,the natures of lithium atoms and their isotopes,lithium clusters and lithium crystals are revisited,especially their structural and energetic ***,the electrochemical properties of lithium metal are *** important concepts and scientific questions,including the electronic structure of lithium,influence of high pressure and low temperature on the properties of lithium,factors influencing lithium deposition,generation of lithium dendrites,and electrode potential of lithium in different electrolytes,are explained and analyzed in *** to improve the performance of lithium anodes and thoughtfulness about the electrode potential in lithium battery research are proposed.

关键词： lithium Cluster Crystal Physicochemical property Fundamental science

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Magnetic and luminescent properties of bifunctional composite Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+)

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Journal of Rare Earths 2024年第8期42卷 1568-1576,I0006页

作者： Zhiqi liang Zhili Zhang liu li Wen xu Decai li School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing100044China Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale Beijing100044China State Key Laboratory of Tribology Tsinghua UniversityBeijing100084China

As a kind of non-destructive testing method,magnetic particle inspection is widely used in the fields of aviation and high-speed *** properties of magnetic fluorescent bifunctional composites,such as fluorescence intensity and magnetic properties,have increasing demands in magnetic particle *** earth compounds offer potential as novel materials for fluorescent magnetic bifunctional composites due to their excellent optical properties and extremely narrow emission *** this work,the rare earth fluorescent material Y_(2)O_(2)S:Eu^(3+) was synthesized by solid-state reaction ***_(3)O_(4)nanoparticles prepared by hydrothermal method were uniformly coated on the Y_(2)O_(2)S:Eu^(3+) particles through physical adsorption of *** obtained Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) exhibits dark red color under the ultraviolet *** additio n,X-ray diffractio n,morphology,photoluminescence and hyste resis loop of Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) were *** luminescence mechanism of Y_(2)O_(2)S:Eu^(3+) is described in detail Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) displays good paramagnetism and has a good controllability under a magnetic *** magnetic particle inspection of Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) was performed using a 4-pole electromagnet and a test piece *** magnetic fluorescent bifunctional composite presented in this work can be applied for non-destructive testing.

关键词： Bifunctional material Fe_(3)O_(4) Y_(2)O_(2)S:Eu^(3+) Luminescence Solid-state reaction Rare earths

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Metal nutrition and transport in the process of symbiotic nitrogen fixation

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Plant Communications 2024年第4期5卷 36-51页

作者： Yuan li Qian liu Dan-xun Zhang Zhuo-yan Zhang Ao xu Yuan-Long Jiang Zhi-Chang Chen Haixia Institute of Science and Technology Fujian Agriculture and Forestry UniversityFuzhou 350002China These authors contributed equally to this article.

Symbiotic nitrogenfixation(SNF)facilitated by the interaction between legumes and rhizobia is a well-documented and eco-friendly alternative to chemical nitrogen *** plants obtainfixed nitrogen from rhizobia by providing carbon and mineral *** mineral nutrients,which are mostly in the form of metal ions,are implicated in various stages of the SNF *** review describes the functional roles played by metal ions in nodule formation and nitrogenfixation and specifically addresses their trans-port mechanisms and associated transporters within root *** research directions and poten-tial strategies for enhancing SNF efficiency are also discussed.

关键词： metal ion transport legume nodule nitrogenfixation

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Redox-Active Dihydrophenazine-Based Macrocycle:Synthesis,Conformation-Adaptive Behavior and Host-Guest Complexation with Tetracyanoquinodimethane

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Chinese Journal of Chemistry 2024年第16期42卷 1895-1900页

作者： Qiong-yan Hong Bin Huang Meng-Xiang Wu lin xu Xiao-li Zhao xueliang Shi Hai-Bo yang Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular&Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal University3663 N.Zhongshan RoadShanghai 200062China

A novel macrocycle based on conformation-adaptive and electron-rich dihydrophenazine was designed and *** the one hand,the macrocycle showed host-guest interactions with tetracyanoquinodimethane(TCNQ)driving by charge transfer interaction between ***,host-guest complexation was accompanied by fluorescence quenching and conformational change of the *** the other hand,the oxidation of the macrocycle resulted in its diradical cation analogue and induced the release of the guest molecule TCNQ,thereby accomplishing reversible binding ***,this work wellillustrates the chemical and structural versatility of dihydrophenazine in the synthesis of macrocycles and their host-guest chemistry.

关键词： Dihydrophenazine Macrocycle Conformational adaptation Redox-active Host-guest interactions Charge transfer interaction Organic radical Supramolecular chemistry

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Combined application of CIRCLE Software and Topo-LASIK for SMILE enhancement

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 206-209页

作者： Bing-Qing Sun Hai-Peng xu Xing-Tao Zhou Mei-yan li Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200031China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care Shanghai 200031China

Dear Editor,We present a case of combined application of CIRCLE software(Carl Zeiss Meditec AG,Germany)and topography-guided laser-assisted in situ keratomileusis(Topo-LASIK)for small-incision lenticule extraction(SMILE)*** is a safe,minimally invasive corneal laser surgery using a femtosecond laser to create an extractable stromal lenticule.

关键词： laser application Zeiss

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Friction between a single platelet and fibrinogen

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Friction 2024年第10期12卷 2344-2354页

作者： Yuhe WANG yan li Shuguang ZHANG Haosheng CHEN Yongjian li State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Key Laboratory of Agricultural Information Acquisition Technology Ministry of Agriculture and Rural AffairsChina Agricultural UniversityBeijing 100083China

Friction has been considered to mediate physiological activities of cells,however,the biological friction between a single cell and its ligand-bound surface has not been thoroughly ***,we established a friction model for single cells based on an atomic force microscopy(AFM)combined with an inverted fluorescence microscopy(IFM)to study the friction between a highly sensitive platelet and fibrinogen-coated *** study revealed that the friction between the platelet and fibrinogen-coated tip is mainly influenced by specific ligand–receptor ***,we modeled the biological friction,which consists of specific interaction,non-specific interaction,and mechanical ***,the results suggested that the velocity can also affect specific ligand–receptor interactions,resulting in the friction change and platelet adhesion to fibrinogen *** study built a friction model between a single cell and its ligand-bound surface and provided a potential method to study the biological friction by the combination of AFM and IFM.

关键词： friction single cell platelet fibrinogen atomic force microscopy(AFM)

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An interpretable graph convolutional neural network based fault diagnosis method for building energy systems

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Building Simulation 2024年第7期17卷 1113-1136页

作者： Guannan li Zhanpeng Yao liang Chen Tao li Chengliang xu School of Urban Construction Wuhan University of Science and TechnologyWuhan 430065China Anhui Province Key Laboratory of Intelligent Building and Building Energy-saving Anhui Jianzhu UniversityHefei 230601China State Key Laboratory of Green Building in Western China Xi'an University of Architecture&TechnologyXi'an 710055China Key Laboratory of Low-grade Energy Utilization Technologies and Systems(Chongqing University) Ministry of Education of ChinaChongqing UniversityChongqing 400044China Hubei Provincial Engineering Research Centre of Urban Regeneration Wuhan University of Science and TechnologyWuhan 430081China

Due to the fast-modeling speed and high accuracy,deep learning has attracted great interest in the field of fault diagnosis in building energy systems in recent ***,the black-box nature makes deep learning models generally difficult to *** order to compensate for the poor interpretability of deep learning models,this study proposed a fault diagnosis method based on interpretable graph neural network(GNN)suitable for building energy *** method is developed by following three main steps:(1)selecting NC-GNN as a fault diagnosis model for building energy systems and proposing a graph generation method applicable to the model,(2)developing an interpretation method based on InputXGradient for the NC-GNN,which is capable of outputting the importance of the node features and automatically locating the fault related features,(3)visualizing the results of model interpretation and validating by matching with expert knowledge and maintenance *** was performed using the public ASHRAE RP-1043 chiller fault *** diagnosis results show that the proposed method has a diagnosis accuracy of over 96%.The interpretation results show that the method is capable of explaining the decision-making process of the model by identifying fault-discriminative *** almost all seven faults,their fault-discriminative features were correctly identified.

关键词： fault diagnosis graph neural network building energy system InputXGradient feature interpretation

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Aerodynamic Performance of Three Flapping Wings with Unequal Spacing in Tandem Formation

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Journal of Bionic Engineering 2024年第4期21卷 1662-1676页

作者： Min Chang Ziyi xu Zengshuang Chen li li xueguang Meng Unmanned System Research Institute National Key Laboratory of Unmanned Aerial Vehicle TechnologyNorthwestern Polytechnical UniversityXi’an710072People’s Republic of China State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an710049People’s Republic of China Xi’an Aeronautics Computing Technique Research Institute Aviation Industry Corporation of ChinaXi’an710076People’s Republic of China

To better understand the aerodynamic reasons for highly organized movements of flying organisms,the three-flapping wing system in tandem formation was studied numerically in this *** from previous relevant studies on the multiple flapping wings that are equally spaced,this study emphasizes the impact of unequal spacing between individuals on the aerodynamics of each individual wing as well as the whole *** is found that swapping the distance between the first and second wing with the distance between the second wing and the rearmost wing does not affect the overall aerodynamic performance,but significantly changes the distribution of aerodynamic benefits across each *** the whole flapping cycle,three effects are at *** narrow channel effect and the downwash effect can promote and weaken the wing lift,respectively,while the wake capture effect can boost the *** also shows that these effects could be manipulated by changing the spacing between adjacent *** findings provide a novel way for flow control in tandem formation flight and are also inspiring for designing the formation flight of bionic aircraft.

关键词： Three flapping wings Unequal spacing Aerodynamic performance Tandem formation

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Tal6b/AvrXa27A,a hidden TALE targeting the susceptibility gene OsSWEET11a and the resistance gene Xa27 in rice

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Plant Communications 2024年第2期5卷 122-134页

作者： Zhengyin xu Xiameng xu Ying li linlin liu Qi Wang Yijie Wang Yong Wang Jiali yan Guanyun Cheng lifang Zou Bo Zhu Gongyou Chen Shanghai Collaborative Innovation Center of Agri-Seeds School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong UniversityShanghai 200240China

Xanthomonas oryzae ***(Xoo)secretes transcription activator-like effectors(TALEs)to activate rice susceptibility(S)genes,causing bacterial blight(BB),as well as resistance(R)genes,leading to de-fense against *** activation follows a gene-for-gene paradigm that results in an arms race between the TALE of the pathogen and effector-binding elements(EBEs)in the promoters of host *** this study,we characterized a novel TALE,designated Tal6b/AvrXa27A,that activates the rice S gene OsSWEET11a and the rice R gene ***6b/AvrXa27A is a member of the AvrXa27/TalAO class and contains 16 repeat variable diresidues(RVDs);one RVD is altered and one is deleted in Tal6b/AvrXa27A compared with AvrXa27,a known avirulence(avr)effector of ***6b/AvrXa27A can transcriptionally activate the expression of Xa27 and OsSWEET11a via EBEs in their corresponding promoters,leading to effector-triggered immunity and susceptibility,*** 16 RVDs in Tal6b/AvrXa27A have no obvious similarity to the 24 RVDs in the effector PthXo1,but EBETal6b and EBEPthXo1 are overlapped in the OsSWEET11a ***6b/AvrXa27A is prevalent among Asian Xoo isolates,but PthXo1 has only been reported in the Philippine strain *** editing of EBETal6b in the OsSWEET11a pro-moter further confirmed the requirement for OsSWEET11a expression in Tal6b/AvrXa27A-dependent susceptibility to ***,Tal6b/AvrXa27A resulted in higher transcription of Xa27 than of OsSWEET11a,which led to a strong,rapid resistance response that blocked disease *** suggest that Tal6b/AvrXa27A has a dual function:triggering resistance by activating Xa27 gene expression as an avirulence factor and inducing transcription of the S gene OsSWEET11a,resulting in ***,Tal6b/AvrXa27A,but not AvrXa27,can bind to the promoter of *** underlying recognition mechanism for this binding remains unclear but appears to deviate from the currently accepted TALE code.

关键词： Xanthomonas oryzae pv.oryzae TALE AvrXa27 tal6b Xa27 OsSWEET11a

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