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Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

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World Journal of Gastroenterology 2024年第30期30卷 3584-3608页

作者： Meng-Yuan Niu Geng-Ting Dong Yi li Qing Luo liu Cao xi-Min wang Qi-Wen wang Yi-Ting wang Zhe Zhang xi-Wen Zhong Wei-Bo Dai Le-Yu li Pharmacology Laboratory Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina Department of Endocrinology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina

BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging *** has been identified to have therapeutic effects on type 2 diabetes mellitus(T2DM)in clinical ***-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with ***,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further *** To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in *** HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell ***,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 *** FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in *** experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte *** FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD.

关键词： Fanlian Huazhuo Formula Nonalcoholic fatty liver disease Autophagy Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress

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Ceria nanoparticles: biomedical applications and toxicity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 361-388页

作者： xiaoxuan FU Peng li xi CHEN Yuanyuan MA Rong wang Wenxuan JI Jiakuo GU Bowen SHENG Yizhou wang Zhuhong ZHANG School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China Department of Nephrology Yantai Yuhuangding HospitalQingdao UniversityYantai 264005China Institute of Crop Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China

Ceria nanoparticles(CeO_(2) NPs)have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation,cancer therapy,photocatalytic degradation of pollutants,sensors,*** methods,including gas phase,solid phase,liquid phase,and the newly proposed green synthesis method,have been reported for the synthesis of CeO_(2) *** to the wide application of CeO_(2) NPs,concerns about their adverse impacts on human health have been *** review covers recent studies on the biomedical applications of CeO_(2) NPs,including their use in the treatment of various diseases(e.g.,Alzheimer's disease,ischemic stroke,retinal damage,chronic inflammation,and cancer).CeO_(2) NP toxicity is discussed in terms of the different systems of the human body(e.g.,cytotoxicity,genotoxicity,respiratory toxicity,neurotoxicity,and hepatotoxicity).This comprehensive review covers both fundamental discoveries and exploratory progress in CeO_(2) NP research that may lead to practical developments in the future.

关键词： Ceria nanoparticle Synthetic method Biomedical application Oxidative stress Toxicity

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Boosting Hydrogen Storage Performance of MgH_(2) by Oxygen Vacancy-Rich H-V_(2)O_(5) Nanosheet as an Excited H-Pump

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Nano-Micro Letters 2024年第8期16卷 398-416页

作者： li Ren Yinghui li Zi li xi lin Chong Lu Wenjiang Ding Jianxin Zou National Engineering Research Center of light Alloys Net Forming&State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Shanghai Engineering Research Center of Mg Materials and Applications&School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Center of Hydrogen Science Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Instrumental Analysis Center of SJTU Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

MgH_(2) is a promising high-capacity solid-state hydrogen storage material,while its application is greatly hindered by the high desorption temperature and sluggish ***,intertwined 2D oxygen vacancy-rich V_(2)O_(5) nanosheets(H-V_(2)O_(5))are specifically designed and used as catalysts to improve the hydrogen storage properties of MgH_(2).The as-prepared MgH_(2)-H-V_(2)O_(5) composites exhibit low desorption temperatures(Tonset=185℃)with a hydrogen capacity of 6.54 wt%,fast kinetics(Ea=84.55±1.37 kJ mol^(-1) H_(2) for desorption),and long cycling ***,hydrogen absorption can be achieved at a temperature as low as 30℃ with a capacity of 2.38 wt%within 60 ***,the composites maintain a capacity retention rate of~99%after 100 cycles at 275℃.Experimental studies and theoretical calculations demonstrate that the in-situ formed VH_(2)/V catalysts,unique 2D structure of H-V_(2)O_(5) nanosheets,and abundant oxygen vacancies positively contribute to the improved hydrogen sorption ***,the existence of oxygen vacancies plays a double role,which could not only directly accelerate the hydrogen ab/de-sorption rate of MgH_(2),but also indirectly affect the activity of the catalytic phase VH_(2)/V,thereby further boosting the hydrogen storage performance of MgH_(2).This work highlights an oxygen vacancy excited“hydrogen pump”effect of VH_(2)/V on the hydrogen sorption of Mg/MgH_(2).The strategy developed here may pave a new way toward the development of oxygen vacancy-rich transition metal oxides catalyzed hydride systems.

关键词： Hydrogen storage MgH_(2) V_(2)O_(5)nanosheets Oxygen vacancies VH_(2)

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Coupled Cross-Flow/in-line Vortex-Induced Vibration Responses of a Catenary-Type Riser Subjected to Uniform Flows

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Journal of Ocean University of China 2024年第5期23卷 1202-1212页

作者： li xiaomin CAO xi li Fuheng YANG Zhiwen College of Engineering Ocean University of ChinaQingdao 266404China College of Hydrodynamic Engineering Tianjin Research Institute for Water Transport EngineeringM.O.TTianjin 300456China

A three-dimensional numerical scheme was developed to investigate the vortex-induced vibration(VIV)of a catenary-type riser(CTR)in the in-line(IL)and cross-flow(CF)*** using the vector form intrinsic finite element method,the CTR was discretized into a finite number of spatial particles whose motions satisfy Newton’s second *** Van der Pol oscillator was used to simulate the effect of vortex *** coupling equations of structural vibration and wake oscillator were solved using an explicit central differential *** numerical model was verified with the published *** VIV characteristics of the CTR subjected to uniform flows,including displacement,frequency,standing wave,traveling wave,motion trajectory,and energy transfer,were studied *** numerical results revealed that the multimode property occurs in the CF-and IL-direction VIV responses of the *** increase in the flow velocity has slight effects on the maximum VIV *** to structural nonlin-earity,the double-frequency relationship in the CF and IL directions is rarely ***,the vibration trajectories display the shape of an inclined elliptical ***,the negative energy region is inconspicuous under the excitation of the uniform flow.

关键词： vortex-induced vibration vector form intrinsic finite element catenary-type riser wake oscillator equation

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Highly dispersive tetrahedral vanadium species on pure silica ZSM-12 zeolite boosting the selective oxidation of cyclohexane into cyclohexanone

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Science China Chemistry 2024年第7期67卷 2206-2214页

作者： Menglin xie Ting li Chao Wu xiaoling liu Jinling Ni Siqin Yao Yu Zhou Shibo xi Jun wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Institute of Sustainability for Chemicals Energy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)Singapore 627833Republic of Singapore College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

The selective oxidation of cyclohexane is a promising green route for the production of KA oil(cyclohexanol and cyclohexanone),but remains a huge challenge to design high-performing heterogeneous catalysts under mild ***,a pure silica ZSM-12(MTW topology)zeolite was applied as the support to immobilize highly dispersive tetrahedrally coordinated vanadium(V)species and the constructed catalyst 1%V/SZ-12 exhibited high efficiency in the fast and selective oxidation of cyclohexane into cyclohexanone with H_(2)O_(2).The reaction completed within 30 s,affording the selectivity of 99%towards cyclohexanone and the extremely high turnover frequency(TOF)of 5,891 h^(-1).1%V/SZ-12 was facilely reused with stable activity and feasibly extended to the oxidation of various cyclohexane *** one-dimensional 12-membered ring microchannels contributed to the formation and accessibility of tetrahedrally coordinated high valent V5+species as the robust active centers,which activated H_(2)O_(2) to generate V–O–O·,the active oxygen species for the electrophilic attack on cyclohexane to produce cyclohexanone as the sole product.

关键词： zeolite metal doping cyclohexane oxidation heterogeneous catalysis

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Carbon emission reduction:Contribution of photovoltaic power and practice in China

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China Geology 2024年第2期7卷 371-376页

作者： liang wang li-qiong Jia Geng xie xi-jie Chen Yang liu Natural Resources Integrated Survey Command Center China Geological SurveyMinistry of Natural ResourcesBeijing 100055China Development and Research Center China Geological SurveyMinistry of Natural ResourcesBeijing 100037China Center for Geophysical Survey China Geological SurveyLangfang 065000China

As a clean and renewable form of energy,photovoltaic(PV)power generation converts solar energy into electrical energy,reducing the consumption of fossil fuels and significantly lowering greenhouse gas *** the global t... 详细信息

关键词： convert power emissions

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Valuation and comparison of the actual and optimal control strategy in an emerging infectious disease:Implication from a COVID-19 transmission model

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Infectious Disease Modelling 2024年第2期9卷 354-372页

作者： lili liu xi wang Ou liu Yazhi li Zhen Jin Sanyi Tang xia wang Shanxi Key Laboratory of Mathematical Techniques and Big Data Analysis on Disease Control and Prevention Complex Systems Research CenterShanxi UniversityTaiyuan030006China School of Mathematical Sciences Shanxi UniversityTaiyuan030006China School of Mathematics and Statistics Qiannan Normal University for NationalitiesGuizhouDuyun558000China School of Mathematics and Statistics Shaanxi Normal UniversityXi'an710119China

To effectively combat emerging infectious diseases like COVID-19,it is crucial to adopt strict prevention and control measures promptly to effectively contain the spread of the *** this paper,we propose a transmission model to investigate the influence of two control strategies:reducing contact numbers and improving medical *** examine these strategies in terms of constant control and time-varying *** sensitivity analysis on two reproduction numbers of the model with constant control,we demonstrate that reducing contact numbers is more effective than improving medical ***,these two constant controls significantly influence the peak values and timing of ***,intensifying control measures can reduce peak values,albeit at the expense of delaying the peak *** the model with time-varying control,we initially explore the corresponding optimal control problem and derive the characteristic expression of optimal ***,we utilize real data from January 10th to April 12th,2020,in Wuhan city as a case study to perform parameter estimation by using our proposed improved *** findings illustrate that implementing optimal control measures can effectively reduce infections and deaths,and shorten the duration of the ***,we numerically explore that implementing control measures promptly and increasing intensity to reduce contact numbers can make actual control be more closer to optimized ***,we utilize the real data from October 31st to November 18th,2021,in Hebei province as a second case study to validate the feasibility of our proposed suggestions.

关键词： Emerging epidemic Transmission model Sensitivity analysis Actual control Optimal control

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Application of GNSS-PPP on Dynamic Deformation Monitoring of Offshore Platforms

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China Ocean Engineering 2024年第2期38卷 352-361页

作者： YU li-na xiONG Kuan GAO xi-feng li Zhi FAN li-long ZHANG Kai Institute of Ocean Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China China Railway Construction Bridge Engineering Bureau Group Co.LTD Tianjin 300300China School of Civil Engineering Tianjin UniversityTianjin 300072China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Precision Blasting Jianghan UniversityWuhan 430056China

The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe *** Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively ***,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains ***,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore *** address these concerns,vibration table tests with different amplitudes and frequencies are *** results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with ***,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of *** monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN *** comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load *** research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.

关键词： GNSS-PPP offshore platform dynamic deformation monitoring improved CEEMDAN de-noising

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Data-driven Predictive Voltage Control for Distributed Energy Storage in Active Distribution Networks

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 1876-1886页

作者： Yanda Huo Peng li Haoran Ji Hao Yu Jinli Zhao Wei xi Jianzhong Wu Chengshan wang School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China Digital Power Grid Research Institute China Southern Power GridGuangzhou 510630China School of Engineering Cardiff UniversityCardiff CF243AAU.K.

Integration of distributed energy storage(DES)is beneficial for mitigating voltage fluctuations in highly distributed generator(DG)-penetrated active distribution networks(ADNs).Based on an accurate physical model of ADN,conventional model-based methods can realize optimal control of ***,absence of network parameters and complex operational states of ADN poses challenges to model-based *** paper proposes a data-driven predictive voltage control method for ***,considering time-series constraints,a data-driven predictive control model is formulated for DES by using measurement ***,a data-driven coordination method is proposed for DES and DGs in each *** boundary information interaction,voltage mitigation effects can be improved by interarea coordination ***,control performance is tested on a modified IEEE 33-node test *** studies demonstrate that by fully utilizing multi-source data,the proposed predictive control method can effectively regulate DES and DGs to mitigate voltage violations.

关键词： Distribution network distributed energy storage(DES) distributed generators(DGs) data-driven predictive voltage control

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A NAC transcription factor MNAC3-centered regulatory network negatively modulates rice immunity against blast disease

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Journal of Integrative Plant Biology 2024年第9期66卷 2017-2041页

作者： Hui wang Yan Bi Yuqing Yan xi Yuan Yizhou Gao Muhammad Noman Dayong li Fengming Song National Key Laboratory for Rice Biology and Breeding Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Institute of BiotechnologyZhejiang UniversityHangzhou 310058China College of Chemistry and life Sciences Zhejiang Normal UniversityJinhua 321004China

NAC transcription factors(TFs)are pivotal in plant immunity against diverse ***,we report the functional and regulatory network of MNAC3,a novel NAC TF,in rice ***3,a transcriptional activator,negatively modulates rice immunity against blast and bacterial leaf blight diseases and pathogen-associated molecular pattern(PAMP)-triggered immune ***3 binds to a CACG cis-element and activates the transcription of immune-negative target genes OsINO80,OsJAZ10,and *** negative function of MNAC3 in rice immunity depends on its transcription of downstream genes such as OsINO80 and ***3 interacts with immunity-related OsPP2C41(a protein phosphatase),ONAC066(a NAC TF),and OsDjA6(a DnaJ chaperone).ONAC066 and OsPP2C41 attenuate MNAC3 transcriptional activity,while OsDjA6 promotes *** of MNAC3 at S163 is critical for its negative functions in rice ***2C41,which plays positive roles in rice blast resistance and chitin-triggered immune responses,dephosphorylates MNAC3,suppressing its transcriptional activity on the target genes OsINO80,OsJAZ10,and OsJAZ11 and promoting the translocation of MNAC3 from nucleus to *** results establish a MNAC3-centered regulatory network in which OsPP2C41 dephosphorylates MNAC3,attenuating its transcriptional activity on downstream immune-negative target genes in ***,these findings deepen our understanding of molecular mechanisms in rice immunity and offer a novel strategy for genetic improvement of rice disease resistance.

关键词： NAC transcription factor MNAC3 OsINO80 OsJAZ10 OsJAZ11 protein phosphatase OsPP2C41 rice immunity

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