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Two stages power generation test of the hot dry rock exploration and production demonstration project in the Gonghe Basin,northeastern Qinghai-Tibet plateau,China

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China Geology 2024年第3期7卷 409-421页

作者： Er-yong Zhang Dong-guang Wen Gui-ling Wang Xian-peng Jin lin-you Zhang Hai-dong Wu Wen-shi Wang Cheng-ming Ye Wei Weng Kuan li Jin-sheng Wu Xian-chun Tang Chong-yuan Zhang Qing-da Feng Sheng lian li-sha hu Gui-lin Zhu Xing-long Xie Bin Wu Dan Wang Xue Niu Zhao-xuan Niu Dong-lin liu hui Zhang Wen-hao Xu Shu-qing Yao li Yang Center for Hydrogeology and Environmental Geology Survey China Geological SurveyMinistry of Natural ResourcesTianjin 300304China Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesChina Geological SurveyShijiazhuang 050061China Institute of Exploration Techniques Chinese Academy of Geological SciencesChina Geological SurveyLangfang 065000China Institute of Exploration Engineering China Geological SurveyMinistry of Natural ResourcesBeijing 100083China Institute of Exploration Technology Chinese Academy of Geological SciencesChengdu 611734China Chinese Academy of Geological Sciences China Geological SurveyBeijing 100037China Institute of Geomechanics Chinese Academy of Geological SciencesChina Geological SurveyBeijing 100081China Geoscience Documentation Center China Geological SurveyMinistry of Natural ResourcesBeijing 100083China

The Hot Dry Rock(HDR)is considered as a clean and renewable energy,poised to significantly contribute to the global energy decarbonization *** HDR projects worldwide have accumulated valuable experience in efficient drilling and completion,reservoir construction,and fracture *** 2019,China Geological Survey(CGS)initiated a demonstration project of HDR exploration and production in the Gonghe Basin,aiming to overcome the setbacks faced by HDR *** the ensuing four years,the Gonghe HDR project achieved the first power generation in 2021,followed by the second power generation test in *** establishing the primary well group in the initial phase,two directional wells and one branch well were *** progress was made in successfully constructing the targeted reservoir,realizing inter-well connectivity,power generation and grid connection,implementing of the real-time micro-seismic monitoring.A closed-loop technical validation of the HDR exploration and production was ***,many technical challenges remain in the process of HDR industrialization,such as reservoir fracture network characterization,efficient drilling and completion,multiple fracturing treatment,continuous injection and production,as well as mitigation of induced seismicity and numerical simulation technology.

关键词： Power generation Hot dry rock(HDR) Enhanced geothermal system(EGS) Genesis mechanism Gonghe Basin Directional drilling Reservoir construction Circulation test Induced seismicity Clean energy exploration engineering

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Protectin DX Exhibits Protective Effects in Mouse Model of lipopolysaccharide-Induced Acute Lung Injury

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Chinese Medical Journal 2018年第10期131卷 1167-1173页

作者： Wen Tan lin Chen Ya-Xin Wang li-sha hu Wei Xiong You shang shang-Long Yao Department of Anesthesiology Institute of Anesthesiology and Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China Department of Critical Care Medicine Institute of Anesthesiology and Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China Department of Cardiac Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background：Acute lung injury （Ali） is a severe disease with high mortality and poor *** DX （PDX）,a pro-resolving lipid mediator,exhibits protective effects in *** experiment aimed to explore the effects and related mechanisms of PDX in mice with Ali induced by lipopolysaccharide （LPS）.Methods：BALB/c mice were randomly divided into five groups：sham,LPS,LPS plus 1 ng ofPDX （LPS ＋ PDX-1 ng）,LPS plus 10 ng ofPDX （LPS ＋ PDX-10 ng）,and LPS plus 100 ng ofPDX （LPS ＋ PDX-100 ng）.Bronchoalveolar lavage fluids （BALFs） were collected after 24 h,and total cells,polymorphonuclear leukocytes,monocyte-macrophages,and lymphocytes in BALF were *** concentration of interleukin （IL）-1 β3,IL-6,IL-10,tumor necrosis factor-alpha （TNF-α）,macrophage inflammatory protein （MIP）-1 cα,and MIP-2 in BALF was determined,and histopathological changes of the lung were *** concentration of protein in BALF and lung wet/dry weight ratios were detected to evaluate pulmonary *** determining the optimal dose of PDX,neutrophil-platelet interactions in whole blood were evaluated by flow ***：The highest dose of PDX （100 ng/mouse） failed to provide pulmonary protective effects,whereas lower doses of PDX （1 ng/mouse and 10 ng/mouse）,especially 1 ng PDX,alleviated pulmonary histopathological changes,mitigated LPS-induced Ali and pulmonary edema,inhibited neutrophil infiltration,and reduced pro-inflammatory mediator （IL-1β,IL-6,TNF-α,and MIP-lα） ***,1 ng PDX exhibited pro-resolving functions in Ali including upregulation of monocyte-macrophage numbers and anti-inflammatory mediator IL-l 0 *** flow cytometry results showed that PDX could inhibit neutrophil-platelet interactions in ***：PDX exerts protective effects in LPS-inducedAli by mitigating pulmonary inflammation and abrogating neutrophil-platelet interactions.

关键词： Acute Lung Injury Blood Platelets lipopolysaccharide Neutrophils Protectin DX

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Resolvin D1 Induces mTOR-independent and ATG5-dependent Autophagy in BV-2 Microglial Cells

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Current Medical Science 2023年第6期43卷 1096-1106页

作者： shang-wen PAN li-sha hu Han WANG Rui-ting li Ya-jun HE You shaNG Zhong-liang DAI li-xin CHEN Wei XIONG Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Qingdao Women and Children’s HospitalQingdao UniversityQingdao266034China Department of Anesthesiology The Second Clinical Medical College(Shenzhen People’s Hospital)Jinan UniversityShenzhen518020China Department of Pharmacology Medical CollegeJinan UniversityGuangzhou510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou510632China

Objective The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral *** is a catabolic process responsible for maintaining cellular *** recent years,autophagy has been demonstrated to play an important role in *** D1(RvD1)is a promising therapeutic mediator that has been shown to exert substantial anti-inflammatory and proresolving ***,whether RvD1-mediated resolution of inflammation in microglia is related to autophagy regulation needs further *** present study aimed to explore the effect of RvD1 on microglial autophagy and its corresponding *** Mouse microglial cells(BV-2)were cultured,treated with RvD1,and examined by Western blotting,confocal immunofluorescence microscopy,transmission electron microscopy,and flow *** RvD1 promoted autophagy in both BV-2 cells and mouse primary microglia by favoring the maturation of autophagosomes and their fusion with ***,RvD1 had no significant effect on the activation of mammalian target of rapamycin(mTOR)***,RvD1-induced mTOR-independent autophagy was confirmed by observing reduced cytoplasmic calcium levels and suppressed calcium/calmodulin-dependent protein kinase II(CaMK II)***,by downregulating ATG5,the increased phagocytic activity induced by RvD1 was demonstrated to be tightly controlled by ATG5-dependent *** The present work identified a previously unreported mechanism responsible for the role of RvD1 in microglial autophagy,highlighting its therapeutic potential against neuroinflammation.

关键词： resolvin D1 microglia mTOR-independent autophagy ATG5-dependent autophagy phagocytosis

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An improved interval model updating method via adaptive Kriging models

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 497-514页

作者： sha WEI Yifeng CHEN hu DING liqun CHEN shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China shanghai Institute of Aircraft Mechanics and Control Shanghai 200092China

Interval model updating(IMU)methods have been widely used in uncertain model updating due to their low requirements for sample ***,the surrogate model in IMU methods mostly adopts the one-time construction *** makes the accuracy of the surrogate model highly dependent on the experience of users and affects the accuracy of IMU ***,an improved IMU method via the adaptive Kriging models is *** method transforms the objective function of the IMU problem into two deterministic global optimization problems about the upper bound and the interval diameter through universal grey *** optimization problems are addressed through the adaptive Kriging models and the particle swarm optimization(PSO)method to quantify the uncertain parameters,and the IMU is *** the construction of these adaptive Kriging models,the sample space is gridded according to sensitivity *** sampling is then performed in key subspaces based on the maximum mean square error(MMSE)*** interval division coefficient and random sampling coefficient are adaptively adjusted without human interference until the model meets accuracy *** effectiveness of the proposed method is demonstrated by a numerical example of a three-degree-of-freedom mass-spring system and an experimental example of a butted cylindrical *** results show that the updated results of the interval model are in good agreement with the experimental results.

关键词： interval model updating(IMU) non-probabilistic uncertainty adaptive Kriging model surrogate model grey number

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Quantitative effect of kerogen type on the hydrocarbon generation potential of Paleogene lacustrine source rocks,liaohe Western Depression,China

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Petroleum Science 2024年第1期21卷 14-30页

作者： sha-sha hui Xiong-Qi Pang Fu-Jie Jiang Chen-Xi Wang Shu-Xing Mei Tao hu Hong Pang Min li Xiao-Long Zhou Kan-Yuan Shi State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Exploration and Development Research Institute PetroChina Liaohe Oilfield CompanyPanjin 124010LiaoningChina

Kerogen types exert a decisive effect on the onset and capacity of hydrocarbon generation of source *** source rocks in the liaohe Western Depression are characterized by thick deposition,high total organic carbon(TOC)content,various kerogen types,and a wide range of thermal ***,their hydrocarbon generation potential and resource estimation can be *** this study,geochemical tests,numerical analysis,hydrocarbon generation kinetics,and basin modeling were integrated to investigate the differential effects of kerogen types on the hydrocarbon generation potential of lacustrine source *** hydrocarbon generation and expulsion(HGE)models of different kerogen types were established quantitatively upon abundant Rock-Eval/TOC/vitrinite reflectance(R_(o))*** sets of good-excellent source rocks deposited in the fourth(Es4),third(Es3),and first(Es1)members of Paleogene shahejie Formation,are predominantly types I-II_(1),II_(1)-II_(2),and II-III,*** activation energy of types I-II_(2)kerogen is concentrated(180-230 kcal/mol),whereas that of type III kerogen is widely distributed(150-280 kcal/mol).The original hydrocarbon generation potentials of types I,II_(1),II_(2),and III kerogens are 790,510,270,and 85 mg/g TOC,*** Ro values of the hydrocarbon generation threshold for type I-III source rocks gradually increase from 0.42%to 0.74%,and Ro values of the hydrocarbon expulsion threshold increase from 0.49%to 0.87%.Types I and II_(1)source rocks are characterized by earlier hydrocarbon generation,more rapid hydrocarbon expulsion,and narrower hydrocarbon generation windows than types II_(2)and III source *** kerogen types also affect the HGE history and resource *** types(conventional,tight,and shale oil/gas)and three levels(realistic,expected,and prospective)of hydrocarbon resources of different members in the liaohe Western Depression are *** suggest that t

关键词： Kerogen type Hydrocarbon generation potential Lacustrine source rocks liaohe western depression

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Detection and analysis of landslide geomorphology based on UAV vertical photogrammetry

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Journal of Mountain Science 2024年第4期21卷 1190-1214页

作者： BI Rui GAN Shu YUAN Xiping li Kun li Raobo LUO Weidong CHEN Cheng GAO sha hu lin Zhu Zhifu School of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093China Plication Engineering Research Center of Spatial Information Surveying and Mapping Technology in Plateau and Mountainous Areas Set by Universities in Yunnan Province Kunming 650093China West Yunnan University of Applied Sciences Key Laboratory of Mountain Real Scene Point Cloud Data Processing and Application for Universities in Yunnan ProvinceDali 671006China

High-resolution landslide images are required for detailed geomorphological analysis in complex topographic environment with steep and vertical landslide *** study proposed a vertical route planning method for unmanned aerial vehicles(UAVs),which could achieve rapid image collection based on strictly calculated route *** effectiveness of this method was verified using a DJI Mavic 2 Pro,obtaining high-resolution landslide images within the Dongchuan debris flow gully,in the Xiaojiang River Basin,Dongchuan District,Yunnan,China.A three-dimensional(3D)model was constructed by the structure-from-motion and multi-view stereo(SfM-MVS).Micro-geomorphic features were analyzed through visual interpretation,geographic information system(GIS),spatial analysis,and mathematical statistics *** results demonstrated that the proposed method could obtain comprehensive vertical information on landslides while improving measurement *** 3D model was constructed using the vertically oriented flight route to achieve centimeter-level accuracy(horizontal accuracy better than 6 cm,elevation accuracy better than 3 cm,and relative accuracy better than 3.5 cm).The UAV technology could further help understand the micro internal spatial and structural characteristics of landslides,facilitating intuitive acquisition of surface *** slope of landslide clusters ranged from 36°to 72°,with the majority of the slope facing east and *** elevation levels were relatively consistent while middle to lower elevation levels gradually decreased from left to right with significant variations in lower elevation *** the rainy season,surface runoff was abundant,and steep topography exacerbated changes in surface *** route method is suitable for unmanned aerial vehicle(UAV)landslide surveys in complex mountainous *** geomorphological analysis methods used will provide references for identifying and describing topographic

关键词： UAV Landslide Vertical route SfM-MVS Topographic features

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Semantic Consistency and Correctness Verification of Digital Traffic Rules

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Engineering 2024年第2期33卷 47-62页

作者： Lei Wan Changjun Wang Daxin Luo Hang liu sha Ma Weichao hu Policy Standardand Patent DepartmentIntelligent Automotive Solution BUHuawei Technologies Co.Ltd.Beijing 100094China Research Institute for Road Safety of the Ministry of Public Security Beijing 100062China

The consensus of the automotive industry and traffic management authorities is that autonomous vehicles must follow the same traffic laws as human *** formal or digital methods,natural language traffic rules can be translated into machine language and used by autonomous *** this paper,a translation flow is *** the translation,a deeper examination is required,because the semantics of natural languages are rich and complex,and frequently contain hidden *** issue of how to ensure that digital rules are accurate and consistent with the original intent of the traffic rules they represent is both significant and *** response,we propose a method of formal verification that combines equivalence verification with model *** and reassuring digital traffic rules can be obtained by utilizing the proposed traffic rule digitization flow and verification *** addition,we offer a number of simulation applications that employ digital traffic rules to assess vehicle *** experimental findings indicate that our digital rules utilizing metric temporal logic(MTL)can be easily incorporated into simulation platforms and autonomous driving systems(ADS).

关键词： Autonomous driving Traffic rules Digitization Formalization Verification

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A Web-like Three-dimensional Binder for Silicon Anode in lithium-ion Batteries

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Energy & Environmental Materials 2024年第1期7卷 21-27页

作者： liyuan li Tao li Yifan sha Baozeng Ren Lan Zhang Suojiang Zhang CAS Key Laboratory of Green Process and Engineering Beijing Key Laboratory of Ionic Liquids Clean ProcessState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Langfang Green Industrial Technology Center Langfang 065001China Henan Key Laboratory of Energy Storage Materials and Processes Zhengzhou Institute of Emerging Industrial TechnologyZhengzhou 450003China

Si anode is of paramount importance for advanced energy-dense lithium-ion batteries(liBs).However,the large volume change as well as stress generates during its lithiation-delithiation process poses a great challenge to the long-term cycling and hindering its *** this work,a composite binder is prepared with a soft component,guar gum(GG),and a rigid linear polymer,anionic polyacrylamide(APAM).Rich hydroxy,carboxyl,and amide groups on the polymer chains not only enable intermolecular crosslinking to form a web-like binder,A2G1,but also realize strong chemical binding as well as physical encapsulating to Si *** resultant electrode shows limited thickness change of merely 9%on lithiation and almost recovers its original thickness on *** demonstrates high reversible capacity of 2104.3 mAh g^(-1)after 100 cycles at a current density of 1800 mA g^(-1),and in constant capacity(1000 mAh g^(-1))test,it also shows a long life of 392 ***,this soft-hard combining web-like binder illustrates its great potential in the future applications.

关键词： anionic polyacrylamide lithium-ion batteries Si anode thickness change web-like binder

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A vertical track nonlinear energy sink

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 931-946页

作者： Meng li hu DING shanghai Key Laboratory of Mechanics in Energy Engineering School of Mechanics and Engineering ScienceShanghai Frontier Science Center of MechanoinformaticsShanghai UniversityShanghai 200444China

Eliminating the effects of gravity and designing nonlinear energy sinks(NESs)that suppress vibration in the vertical direction is a challenging task with numerous damping *** this paper,the dynamic design of a vertical track nonlinear energy sink(VTNES)with zero linear stiffness in the vertical direction is proposed and realized for the first *** motion differential equations of the VTNES coupled with a linear oscillator(LO)are *** the strong nonlinearity considered of the VTNES,the steady-state response of the system is analyzed with the harmonic balance method(HBM),and the accuracy of the HBM is verified *** this basis,the VTNES prototype is manufactured,and its nonlinear stiffness is *** damping effect and dynamic characteristics of the VTNES are studied theoretically and *** results show that the VTNES has better damping effects when strong modulation responses(SMRs)***,even for small-amplitude vibration,the VTNES also has a good vibration suppression *** sum up,in order to suppress the vertical vibration,an NES is designed and developed,which can suppress the vertical vibration within certain ranges of the resonance frequency and the vibration intensity.

关键词： track nonlinear energy sink(TNES) vertical direction gravity nonlinear stiffness harmonic balance method(HBM) vibration control

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Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

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Chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： li Zhong-hao PU Xiao-qi li sha-sha DONG Xiao-ke ZHANG Guo-qiang WANG Yu liU Jin-min Department of Emergency China-Japan Friendship HospitalBeijing100029China Department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China Department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from PubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2,3,5-triphenyltetrazolium hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(Plin receptor(APJ)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway were increased by TRQ(Pling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection Chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness

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