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“一边是海水一边是火焰”——休克的早期液体复苏

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中国危重病急救医学 2009年第5期21卷 257-258页

作者：李银平沈中阳天津市天和医院 300050 天津市第一中心医院东方器官移植中心天津市器官移植研究所 300192

自从1737年法国外科医生Henri Francois Le Drank在其论文《A treatise of reflections drawn from ex-perience with gunshot wounds》呻创造了单词“choc”，1743年英国医生Clarke将“ehoc”译为“shock”，“休克”一词正式进入医学典籍。目前，对休克的定义，生理学家、医疗辅助人员等都有不同的专业解读。对于临床医师，休克则被认为是：有效组织灌注显著且普遍降低，导致可逆性细胞损伤；如果组织灌注不足持续存在，细胞损伤将进入不可逆状态。

关键词：早期液体复苏休克火焰海水外科医生组织灌注细胞损伤医学典籍

Decentralized fault diagnosis of discrete-event systems with unreliable sensors using linear temporal logic

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Science China(Information Sciences) 2025年第1期68卷 322-341页

作者： Weijie DONG Shaoyuan li Xiang yin Key Laboratory of System Control and Information Processing Ministry of EducationDepartment of Automation Shanghai Jiao Tong University

In this paper,we investigate a decentralized diagnosis problem of a discrete-evnt system(DES) subject to unreliable sensors,where the sensor observations of local diagnosers may be non-deterministic as a result of possible *** studies on decentralized robust diagnosis can only deal with different types of sensor failures separately,e.g.,all sensors suffer from the same type of sensor failures such as intermittent sensor failures or permanent sensor ***,since sensors of different local diagnosers may face different external environments and have different internal characteristics,sensors corresponding to different local diagnosers may also have their own fault *** this paper,we propose a flexible framework of decentralized diagnosis for DES subject to unreliable sensors such that sensors of different local diagnosers are permitted to have different types of sensor *** this end,we extend the existing decentralized diagnosis framework to the case where there exist common sensors broadcasting their observations to all local *** apply linear temporal logic(LTL) to constrain infinite behaviors of private sensors of local diagnosers and common ***,a new notion of φ-codiagnosability is proposed as the necessary and sufficient condition for the existence of a decentralized diagnoser that works correctly under sensors,satisfying LTL-based sensor ***,we provide an effective approach to verify the φ-codiagnosability.

关键词： discrete event systems decentralized diagnosis codiagnosability automata

抗NMDA受体脑炎患者临床表现、并发症及相关影响因素分析

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四川大学学报（医学版） 2018年第6期49卷 979-982页

作者：袁平乔李佳张乐李劲梅李银萍杨蓉四川大学华西医院神经内科成都610041

目的分析抗N-甲基-D-天冬氨酸(NMDA)受体脑炎患者临床表现及并发症情况,并探讨其相关影响因素。方法回顾性收集确诊为抗NMDA受体脑炎患者的临床资料,根据患者临床症状复杂程度分为临床症状≥4种组(96例,67.1%)和<4种组(47例,32.9%),以... 详细信息

目的分析抗N-甲基-D-天冬氨酸(NMDA)受体脑炎患者临床表现及并发症情况,并探讨其相关影响因素。方法回顾性收集确诊为抗NMDA受体脑炎患者的临床资料,根据患者临床症状复杂程度分为临床症状≥4种组(96例,67.1%)和<4种组(47例,32.9%),以及根据患者并发症发生情况分为有并发症组(109例)和无并发症组(34例),单因素及多因素分析其相关影响因素。结果共纳入抗NMDA受体脑炎患者143例,130例(90.9%)患者具有精神障碍,120例(83.9%)患者出现癫痫发作。并发症中,以肺部感染(84例,58.7%)和胃肠道功能紊乱(70例,49.0%)最为常见。单因素分析显示,患者临床症状复杂程度与脑电图异常、脑脊液(CSF)和血清中均出现抗NMDA受体抗体阳性有关。患者有并发症组与无并发症组在癫痫、意识障碍、入院时日常生活能力(ADL)评分和住院时间等的差异有统计学意义(P<0.05)。多因素分析显示,脑电图异常是影响患者临床症状复杂程度的预测因素[比值比(OR=2.620,P<0.05];运动障碍和患者入院时的低ADL评分是影响患者并发症的独立危险因素(OR值分别为4.338、0.980,P<0.05)。结论脑电图结果显示异常的抗NMDA受体脑炎患者临床症状复杂程度高于脑电图正常的患者;抗NMDA受体脑炎患者并发症的发生率高,运动障碍和患者入院时较差的生活自理能力是患者出现并发症的独立危险因素。

关键词：抗NMDA受体脑炎并发症因素分析

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盐穴储气库微渗层注浆封堵试验研究

岩土力学 2022年第S1期43卷 23-34页

作者：刘元玺李银平施锡林赵凯中国科学院武汉岩土力学研究所岩土力学与工程国家重点试验室湖北武汉430071 中国科学院大学北京100049 中国科学院武汉岩土力学研究所环境岩土工程湖北省重点实验室湖北武汉430071

我国盐穴地下储气库大多建造在具有不同渗透性的层状盐岩地层中,因此保证储库拥有良好的密闭性至关重要。针对盐穴井筒“裸眼段”意外跨越微渗地层而导致储气库密闭性失效的问题,自主研发了渗漏地层注浆封堵试验平台,并结合现场地质渗... 详细信息

我国盐穴地下储气库大多建造在具有不同渗透性的层状盐岩地层中,因此保证储库拥有良好的密闭性至关重要。针对盐穴井筒“裸眼段”意外跨越微渗地层而导致储气库密闭性失效的问题,自主研发了渗漏地层注浆封堵试验平台,并结合现场地质渗漏情况设计了注浆封堵可行性试验方案。在确定了兼具流动性和填充密实性的浆液配合比后,开展了超细水泥封堵岩芯的试验研究。结果表明,超细水泥可以有效填充岩芯孔隙并降低其渗透率,注浆后岩芯孔隙率和渗透率降幅分别达到近16%和95%。封堵试验数据显示浆液封堵范围与注浆时间呈幂函数关系,浆液流型满足幂律流,而非牛顿流。该研究成果可为盐穴储气库微渗地层注浆封堵提供必要的理论和试验依据,对类似密闭性失效井筒的二次利用具有重要意义。

关键词：盐穴地下储气库微渗地层超细水泥注浆渗流运移

基于等误差阿基米德螺线法的涡旋型线的拟合算法研究

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组合机床与自动化加工技术 2019年第6期 17-19页

作者：刘涛李银萍兰州理工大学机电工程学院

为了实现涡旋型线的高精度和高效率加工,建立了三段基圆渐开线组合型线的数学模型,利用等误差阿基米德螺线方法对该组合型线进行逼近,并将此方法与等间距阿基米德螺线拟合方法进行了对比分析,结果表明:在保证误差合理范围内,采用等误差... 详细信息

为了实现涡旋型线的高精度和高效率加工,建立了三段基圆渐开线组合型线的数学模型,利用等误差阿基米德螺线方法对该组合型线进行逼近,并将此方法与等间距阿基米德螺线拟合方法进行了对比分析,结果表明:在保证误差合理范围内,采用等误差阿基米德螺线法拟合涡旋型线比等间距阿基米德螺线拟合方法计算的节点数少43.5%,可以快速准确地确定拟合节点,有效提高加工效率和加工精度,该方法具有一定的实用性。

关键词：涡旋型线拟合阿基米德螺线等误差

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang Song Mao yini li Dongzhen Yu Xiaoyan li Yazhi Xing Haibo Shi Shankai yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng yin Shihua li Xiao-Jiang li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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炎症、内皮、凝血与脓毒症

中国危重病急救医学 2009年第9期21卷 573-576页

作者：郑贵军(综述) 孙茜(综述) 李银平(审校) 河北省涿州市人民医院 072750 天津市天和医院 300050

脓毒症临床特征主要表现为全身炎症反应综合征（SIRS）与多器官功能障碍综合征（MODS），其病理过程复杂，涉及大量细胞、炎症介质与凝血系统的激活，其中内皮细胞功能的改变起着至关重要的作用。现就与内皮细胞有关的炎症、凝血在脓毒... 详细信息

脓毒症临床特征主要表现为全身炎症反应综合征（SIRS）与多器官功能障碍综合征（MODS），其病理过程复杂，涉及大量细胞、炎症介质与凝血系统的激活，其中内皮细胞功能的改变起着至关重要的作用。现就与内皮细胞有关的炎症、凝血在脓毒症中的作用，以及内皮损伤的分子机制和内皮在脓毒症治疗中的潜在价值进行综述。

关键词：脓毒症炎症凝血功能

“One stone, two birds”: Salt template enabling porosity engineering and single metal atom coordinating toward high-performance zinc-ion capacitors

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Journal of Energy Chemistry 2025年第1期100卷 637-645页

作者： Chunliu Zhu Huanyu liang ping li Chenglong Qiu Jingyi Wu Jingwei Chen Weiqian Tian Yue Zhu Zhi li Huanlei Wang School of Materials Science and Engineering Ocean University of China Department of Chemical and Materials Engineering University of Alberta

Zinc-ion hybrid capacitors （ZIHCs） have received increasing attention as energy storage devices owing to their low cost,high safety,and environmental ***,their progress has been hampered by low energy and power density,as well as unsatisfactory long-cycle stability,mainly due to the lack of suitable electrode *** this context,we have developed manganese single atoms implanted in nitrogen-doped porous carbon nanosheets （MnSAs/NCNs） using a metal salt template method as cathodes for *** metal salt serves a dual purpose in the synthesis process:It facilitates the uniform dispersion of Mn atoms within the carbon matrix and acts as an activating agent to create the porous *** applied in ZIHCs,the MnSAs/NCNs electrode demonstrates exceptional performance,including a high capacity of 203 m Ah g-1,an energy density of 138 Wh kg-1at 68 W kg-1,and excellent cycle stability with 91%retention over 10,000 *** calculations indicate that the introduced Mn atoms modulate the local charge distribution of carbon materials,thereby improving the electrochemical *** work demonstrates the significant potential of carbon materials with metal atoms in zinc-ion hybrid capacitors,not only in enhancing electrochemical performance but also in providing new insights and methods for developing high-performance energy storage devices.

关键词： Zinc ion hybrid capacitors Cathodes Carbon materials Heteroatoms Single atoms