检索结果-南通市图书馆

Hybrid argon plasma coagulation for the treatment of Barrett’s esophagus:A prospective,multicenter study

World Journal of Clinical Cases 2024年第19期12卷 3866-3872页

作者： Dong Wang Yan Chen Feng Ji Jian-Wei Hu ping-Hong Zhou Shu-Chang Xu Ying Chen li-ping ye Guo-liang ye Rui li Zhao-Shen li Department of Gastroenterology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200011China Department of Gastroenterology Changhai HospitalShanghai 200438China Department of Gastroenterology The First Affiliated Hospital Zhejiang University School of MedicineHangzhou 311399Zhejiang ProvinceChina Endoscopy Center Zhongshan HospitalFudan UniversityShanghai 200032China Endoscopy Center Tongji Hospital of Tongji UniversityShanghai 200092China Department of Gastroenterology Taizhou Hospital of Zhejiang ProvinceTaizhou 318001Zhejiang ProvinceChina Department of Gastroenterology The Affiliated Hospital of Medicine SchoolNingbo UniversityNingbo 315021Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND The incidence of Barrett’s esophagus(BE)in China is lower compared to the Western ***,studies conducted in the Chinese population has been *** current treatment options available for BE treatment includes argon plasma coagulation(APC),radiofrequency ablation and cryoablation,all with varying degrees of *** To determine the efficacy and safety of HybridAPC in the treatment of *** The study cohort consisted of patients with BE who underwent HybridAPC ablation *** procedures were performed by seven endoscopists from different tertiary *** duration of the procedure,curative rate,complications and recurrent rate by 1-year follow-up were *** Eighty individuals were enrolled for treatment from July 2017 to June 2020,comprising of 39 males and 41 females with a median age of 54 years(range,30 to 83 years).The technical success rate of HybridAPC was 100%and the overall curative rate was 98.15%.No severe complications occurred during the *** cases were classified as short-segment BE and long-segment *** with short-segment BE were all considered cured without ***-six patients completed the one-year follow-up without ***-four percent had mild dysplasia which were all resolved with one post-procedural *** mean duration of the procedure was 10.94±6.52 *** Treatment of BE with HybridAPC was found to be a simple and quick procedure that is safe and effective during the short-term follow-up,especially in cases of short-segment *** technique could be considered as a feasible alternative ablation therapy for BE.

关键词： Barrett’s esophagus Hybrid argon plasma coagulation Ablation treatment Prospective study Multicenter study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新世纪以来革命历史题材电影的文化记忆书写

引用

北京社会科学 2024年第1期 27-37页

作者：李掖平贺翔宇山东师范大学新闻与传媒学院

运用文化记忆理论和电影叙事学研究等方法,对新世纪以来革命历史题材电影以激活文化记忆为核心的叙事策略进行研究发现:在价值取向方面,这类电影始终紧扣传统伦理价值观与革命伦理价值观在道义性上的内在耦合;在人物形象塑造与情节设计... 详细信息

运用文化记忆理论和电影叙事学研究等方法,对新世纪以来革命历史题材电影以激活文化记忆为核心的叙事策略进行研究发现:在价值取向方面,这类电影始终紧扣传统伦理价值观与革命伦理价值观在道义性上的内在耦合;在人物形象塑造与情节设计方面,深探传统文化资源进行类型更新,借助共同文化经验实现从情感认同到文化认同;在叙事空间建构方面,以“记忆之场”的叙事空间建构,通过对观众的共情呼唤,引领观众激活潜藏于心中的革命历史记忆,最终实现国家和民族的政治认同与文化认同。

关键词：革命历史题材电影文化记忆叙事策略国家认同

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

国际教育科研影响力评价的设计导向、实施保障与经验启示

引用

南通大学学报（社会科学版） 2024年第4期40卷 145-158页

作者：张楠王光明李业平天津师范大学教育学部西南大学教育学部天津市教育科学研究院美国德克萨斯农工大学教学与文化系

教育科研影响力是国际社会衡量国家教育科研实力、监测国家教育科研经费投入回报的重要指标。研究采用文本分析和社会网络分析方法,对英国、荷兰、澳大利亚等八个国家教育学领域现行使用的科研影响力评价体系进行分析。国际教育科研影... 详细信息

教育科研影响力是国际社会衡量国家教育科研实力、监测国家教育科研经费投入回报的重要指标。研究采用文本分析和社会网络分析方法,对英国、荷兰、澳大利亚等八个国家教育学领域现行使用的科研影响力评价体系进行分析。国际教育科研影响力评价的设计导向包括导向协同设计,加强科研创新转化的前端驱动;注重跨学科研究,推动知识生产模式的现代转型;关注生成性互动,重视影响力产生的中介要素;评价非学术影响,拓宽教育科研影响的作用范畴;落实质量融合,提升教育科研评价结果的公信力;探索案例循证,鼓励教育科研成果的深层叙事表达。国际教育科研影响力评价的实施保障包括政策制度保障、人才素养保障、技术环境保障、评价伦理保障。中国特色教育科研影响力评价应加强教育科研影响评价的顶层设计;加强教育学跨学科研究影响力评价的设计;探索教育科研影响力评价案例研究的设计;完善评价的数智环境保障。

关键词：教育科研设计导向实施保障评价体系

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Role of ferroptosis in colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2023年第2期15卷 225-239页

作者： Ya-Qi Song Xiao-Dan Yan Yi Wang Zhen-Zhen Wang Xin-li Mao li-ping ye Shao-Wei li Taizhou Hospital of Zhejiang Province Zhejiang UniversityLinhai 317000Zhejiang ProvinceChina Department of Gastroenterology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Institute of Digestive Disease Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Key Laboratory of Minimally Invasive Techniques&Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina

Colorectal cancer(CRC)is the second deadliest cancer and the third-most common malignancy in the ***,chemotherapy,and targeted therapy have been widely used to treat CRC,but some patients still develop resistance to these *** is a novel non-apoptotic form of cell *** is an iron-dependent non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species and has been suggested to play a role in reversing resistance to anticancer *** review summarizes recent advances in the prognostic role of ferroptosis in CRC and the mechanism of action in CRC.

关键词： Ferroptosis Colorectal cancer System Xc− Glutathione Glutathione peroxidase 4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Double casing warhead with sandwiched charge:The axial distribution of fragments velocities

引用

Defence Technology（防务技术） 2024年第4期34卷 201-216页

作者： ping ye Yongxiang Dong Qitian Sun Peizhuo Shi Wang Yao Yongnan li Yujing li Mingze li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

The double casing warhead with sandwiched charge is a novel fragmentation warhead that can produce two groups of fragments with different velocity,and the previous work has presented a calculation formula to determine the maximum fragment *** current work builds on the published formula to further develop a formula for calculating the axial distribution characteristics of the fragment *** this type of warhead,the simulation of the dispersion characteristics of the detonation products at different positions shows that the detonation products at the ends have a much larger axial velocity than those in the middle,and the detonation products have a greater axial dispersion velocity when they are closer to the central *** loading process and the fragment velocity vary with the axial position for both casing layers,and the total velocity of the fragments is the vector sum of the radial velocity and the axial *** the same axial position,the acceleration time of the inner casing is greater than that of the outer *** the same casing,the fragments generated at the ends have a longer acceleration time than the fragments from the *** proposed formula is validated with the X-ray radiography results of the four warheads previously tested experimentally and the 3D smoothedparticle hydrodynamics numerical simulation results of several series of new warheads with different *** formula can accurately and reliably calculate the fragment velocity when the lengthto-diameter ratio of the charge is greater than 1.5 and the thickness of the casing is less than 20%its inner *** work thus provides a key reference for the theoretical analysis and the design of warheads with multiple casings.

关键词： Double casing warhead Sandwiched charge Fragment velocity Rarefaction wave Gurney formula Explosive loading

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Global precipitation change during the Holocene:a combination of records and simulations

引用

Frontiers of Earth Science 2024年第1期18卷 112-126页

作者： Wangting ye Yu li Key Laboratory of Western China᾽s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesCenter for Hydrologic Cycle and Water Resources in Arid RegionLanzhou UniversityLanzhou 730000China

Precipitation can shape our climate both in the present and the *** though we have made significant advances in studying the mechanisms of millennial-scale climate changes through high-resolution records,we still cannot quantitatively characterize the global spatiotemporal precipitation variations within the ***,we developed a new approach to integrating data from 349 globally distributed records and climate models to reconstruct regional and global precipitation patterns over the last 12000 *** results reveal that precipitation reconstructions can be divided into monsoon-driven and westerly driven *** results suggest that an arid climate was experienced in the late glacial and early Holocene epoch(~12−7.4 cal ka BP),attaining a middle Holocene optimum(~7.4−3.5 cal ka BP),and drier after the middle *** to our reconstructions,the global precipitation reconstruction increased from the early Holocene until 3.8 cal ka BP and then subsequently *** addition,our reconstructions better reproduce the low-frequency events and extreme precipitation at the millennial scale in the hemispheres,but the performance of the reconstructions in the equatorial Pacific and the Southern Hemisphere of Africa and the Americas is *** resolution of the record and the simulation capability of the climate model remain important means to improve our understanding of past climate change.

关键词： Holocene equatorial glacial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigations of Water Flow Behaviors Induced by Local Temperature Variations through a Single Rough Fracture for the Enhanced Geothermal Systems

引用

Journal of Thermal Science 2024年第3期33卷 1055-1064页

作者： li Jiawei ye lin Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China School of Power and Energy Northwestern Polytechnical UniversityXi’an710072China

In recent years,Enhanced Geothermal System(EGS)technologies have been applied to the geothermal resources production in the Hot Dry Rock(HDR).The core of EGS technologies is to adopt hydraulic fracturing in the reservoir to create a connected network of discrete fractures with the consideration of water as a working fluid for hydraulic fracturing and heat *** paper investigates the characteristics of water flow behaviors through a single rough fracture under different temperature and pressure conditions.A single fracture model with rough fracture surfaces is constructed and then characterized,and influences of the anisotropic factor on the average tortuosity and frictional resistance coefficient of water flow through a single fracture with rough surfaces have been compared and *** consideration of other impacting factors(temperature,pressure,fracture roughness),the impact of mass flow rate has also been *** simulation results present that changes of average tortuosity for water flow through a single rough facture are mainly affected by *** can be observed that higher temperature leads to larger average tortuosity but the frictional resistance coefficient shows an opposite *** for pressure conditions,it is found that effects of pressure on average tortuosity and frictional resistance coefficient is very small,which can be neglected under high pressure ***,the average tortuosity shows a progressively linear relationship with the mass flow *** the contrary,the frictional resistance coefficient has a negative relationship with the mass flow *** is revealed that when the mass flow rate reaches a critical point,the influences of temperature on the frictional resistance coefficient will be *** of single rough fractures with different anisotropic factors show that values of average tortuosity and frictional resistance coefficient have positive relationships with the increase

关键词： single rough fracture tortuosity frictional resistance enhanced geothermal system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Encouraging Solution to the Problem of Synthesizing Protein α-Thioester

引用

Chinese Journal of Chemistry 2024年第10期42卷 1114-1120页

作者： Xinliang liu Zijun Gao Jie Zhao Farong ye ping Huang ping Wang Center for Chemical Glycobiology Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsFrontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringZhangjiang Institute for Advanced StudyShanghai JiaoTongUniversityShanghai 200240China Shenzhen Research Institute of Shanghai Jiao Tong University ShenzhenGuangdong 518057China

Expressed protein ligation(EPL)provides a powerful tool to access large-size proteins with precise *** methods for constructing the critical protein thioester for EPL have predominantly relied on the recombinant intein fusion expressed in Escherichia coli(***).Despite its powerful applications,the expression of thioester derived from eukaryotic protein in *** inherently suffers from its limited solubility,the inactivity of intein,premature hydrolysis and low *** overcome these obstacles,we present herein the facile one-flask synthesis of inaccessible proteinα-thioester via a SUMO-protein-intein(SPI)sandwich *** utility of SUMO enhances the protein fusion yield and solubility,prevents premature hydrolysis and simplifies the purification *** inaccessible protein thioester with internal Cys residues can be readily produced and is compatible with the EPL-desulfurization protocol used to prepare complex proteins,which is otherwise difficult to obtain using traditional *** utility has been highlighted through the synthesis of human granulocyte colony-stimulating factor(G-CSF).

关键词： Desulfurization Glycoproteins Glycopeptides Protein expression Peptide thioester

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeting tau in Alzheimer's disease:from mechanisms to clinical therapy

引用

Neural Regeneration Research 2024年第7期19卷 1489-1498页

作者： Jinwang ye Huali Wan Sihua Chen Gong-ping liu Shenzhen Key Laboratory of Marine Biotechnology and Ecology College of Life Sciences and OceanographyShenzhen UniversityShenzhenGuangdong ProvinceChina Department of Laboratory Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Co-innovation Center of Neurodegeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Pathophysiology School of Basic Medicine and the Collaborative Innovation Center for Brain ScienceKey Laboratory of Ministry of Education of China and Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older *** features of Alzheimer’s disease include extra cellular aggregation of amyloid-βplaques and the accumulation of neurofibrillary tangles,fo rmed by tau protein,in the *** there are amyloid-β-ta rgeting therapies for the treatment of Alzheimer’s disease,these therapies are costly and exhibit potential negative side *** evidence suggests significant involvement of tau protein in Alzheimer’s disease-related *** an important microtubule-associated protein,tau plays an important role in maintaining the stability of neuronal microtubules and promoting axonal *** fact,clinical studies have shown that abnormal phosphorylation of tau protein occurs before accumulation of amyloid-βin the *** therapeutic strategies targeting tau protein have begun to emerge,and are considered possible methods to prevent and treat Alzheimer’s ***,abnormalities in post-translational modifications of the tau protein,including aberrant phosphorylation,ubiquitination,small ubiquitin-like modifier(SUMO)ylation,acetylation,and truncation,contribute to its microtubule dissociation,misfolding,and subcellular *** causes mitochondrial damage,synaptic impairments,gliosis,and neuroinflammation,eventually leading to neurodegeneration and cognitive *** review summarizes the recent findings on the underlying mechanisms of tau protein in the onset and progression of Alzheimer’s disease and discusses tau-targeted treatment of Alzheimer’s disease.

关键词： acetylation Alzheimer’s disease cognitive deficits gliosis mitochondria damage neuroinflammation phosphorylation synaptic impairments tau tau immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of volcanism on the formation and hydrocarbon generation of organic-rich shale in the Jiyang Depression, Bohai Bay Basin, China

引用

Petroleum Science 2024年第3期21卷 1539-1551页

作者： Jia-Hong Gao Xin-ping liang Zhi-Jun Jin Quan-You liu Chang-Rong li Xiao-Wei Huang Ju-ye Shi Peng li State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Efficient Development Institute of EnergyPeking University Petroleum Exploration and Production Research Institute SINOPECBeijing100871 China School of Energy Resources China University of Geosciences Beijing100083 China

Globally,most organic-rich shales are deposited with volcanic ash *** ash,a source for many sedimentary basins,can affect the sedimentary water environment,alter the primary productivity,and preserve the organic matter(OM)through physical,chemical,and biological *** an increasing number of breakthroughs in shale oil exploration in the Bohai Bay Basin in recent years,less attention has been paid to the crucial role of volcanic impact especially its influence on the OM enrichment and hydrocarbon ***,we studied the petrology,mineralogy,and geochemical characteristics of the organic-rich shale in the upper submember of the fourth member(Es_(4)^(1))and the lower submember of the third member(Es_(3)^(3))of the Shahejie Formation,aiming to better understand the volcanic impact on organic-rich shale *** results show that total organic carbon is higher in the upper shale intervals rich in volcanic ash with enriched light rare earth elements and moderate Eu *** indicates that volcanism promoted OM formation before or after the *** positive correlation between Eu/Eu*and Post-Archean Australian Shale indicates hydrothermal activity before the volcanic *** plane graph of the hydrocarbon-generating intensity(S1+S2)suggests that the heat released by volcanism promoted hydrocarbon ***,the nutrients carried by volcanic ash promoted biological blooms during Es_(4)^(1 )and Es_(3)^(3) deposition,yielding a high primary *** blooms consume large amounts of oxygen and form anoxic environments conducive to the burial and preservation of ***,this study helps to further understand the organic-inorganic interactions caused by typical geological events and provides a guide for the next step of shale oil exploration and development in other lacustrine basins in China.

关键词： Volcanic ash Hydrocarbon generation Organic-rich shale Shahejie Formation Jiyang Depression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：