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A clinicopathological analysis in unsuspected gallbladder carcinoma: A report of 23 cases

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World Journal of Gastroenterology 2007年第12期13卷 1857-1861页

作者： li-ning xu Sheng-Quan Zou Department of Hepatobiliary Surgery of PLA General Hospital Beijing 100853 China Department of General Surgery of Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM： To study the clinicopathological characteristics of unsuspected gallbladder carcinoma （UGC）. METHODS： We retrospectively studied 23 cases of UGC in Tongji Hospital, and compared their clinicopathological characteristics with 33 cases of preoperatively diagnosed gallbladder carcinoma （PDGC）. RESULTS： The proportion of UGC coexisting with cholecystolithiasis was significantly higher than that of PDGC （x^2 = 13.53, P 〈 0.01）. The infection rate of hepatitis B virus was 21.74% （5/23） in UGC and 30.30% （10/33） in PDGC. Nine （39.13%） of 23 patients with UGC and 8/33 （24.24） PDGC had contact with schistosome pestilent water. The rate of multiple pregnancies was 56.52% （13/23） in the patients with UGC and 42.42% （14/33） in PDGC. The primary location of the UGC was mostly in the neck and body of the gallbladder, and that of the PDGC was often in the body and bottom. The incidence of Nevin stage I and 11 UGC was significantly higher than that of PDGC （x^2 = 4.44, P 〈 0.05 and 2 = 4.96, P 〈 0.05） while that of Nevin stage V UGC was significantly lower than that of PDGC （x^2 = 7.59, P 〈 0.01）. According to the grading of carcinoma, the incidence of well-differentiated UGC was significantly higher than that of PDGC （2 = 4.16, P 〈 0.05）, and that of poorlydifferentiated UGC was significantly lower than that of PDGC （x^2 = 4.48, P 〈 0.05）.CONCLUSION： There are different characteristics between UGC and PDGC, such as in primary location, malignant degree and incidence of coexistence with cholecystolithiasis. Cholecystolithiasis, hepatitis B, schistosome and multiple pregnancies were high risk factors for gallbladder carcinoma.

关键词： Gallbladder neoplasms Clinical pathology Diagnostic techniques and procedures Diagnostic errors Surgery

Effect of welding process on the microstructure and properties of dissimilar weld joints between low alloy steel and duplex stainless steel

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International Journal of Minerals,Metallurgy and Materials 2012年第6期19卷 518-524页

作者： Jing Wang Min-xu Lu Lei Zhang Wei Chang li-ning xu li-hua Hu Institute for Advanced Materials and Technology University of Science and Technology Beijing Beijing 100083 China Research Institute of China National Offshore Oil Corporation Beijing 100027 China

To obtain high-quality dissimilar weld joints, the processes of metal inert gas （MIG） welding and tungsten inert gas （TIG） welding for duplex stainless steel （DSS） and low alloy steel were compared in this paper. The microstructure and corrosion morphology of dissimilar weld joints were observed by scanning electron microscopy （SEM）; the chemical compositions in different zones were detected by en- ergy-dispersive spectroscopy （EDS）; the mechanical properties were measured by microhardness test, tensile test, and impact test; the corro- sion behavior was evaluated by polarization curves. Obvious concentration gradients of Ni and Cr exist between the fusion boundary and the type II boundary, where the hardness is much higher. The impact toughness of weld metal by MIG welding is higher than that by TIG weld- ing. The corrosion current density of TIG weld metal is higher than that of MIG weld metal in a 3.5wt% NaC1 solution. Galvanic corrosion happens between low alloy steel and weld metal, revealing the weakness of low alloy steel in industrial service. The quality of joints pro- duced by MIG welding is better than that by TIG welding in mechanical performance and corrosion resistance. MIG welding with the filler metal ER2009 is the suitable welding process for dissimilar metals jointing between UNS $31803 duplex stainless steel and low alloy steel in practical application.

关键词： dissimilar metals welds stainless steel alloy steel microstructure mechanical properties corrosion

Establishment of an Assessment System for the Prediction of Severe Post-operative Complications after Hepatectomy Based on Preoperative Parameters

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Current Medical Science 2022年第5期42卷 1088-1093页

作者： li-ning xu Ying-ying xu Gui-ping li Bo YANG Department of General Surgery The Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing100853China Department of Internal Medicine Henan Cancer HospitalZhengzhou450003China Department of Radiology Hubei Province Integrated Hospital of Chinese and Western MedicineWuhan430015China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective At present,there is no appropriate system to evaluate the severe complications of liver surgery through the preoperative *** study aimed to design and verify a risk assessment system for the prediction of severe post-operative complications after a hepatectomy based on the preoperative *** A retrospective analysis was performed on 1732 patients who had undergone liver *** severity of the complications was graded by Accordion Severity Grading of post-operative *** variables were screened by multivariate analysis,and graded scores were assigned to the selected variables.A logistic regression equation was used to form the liver operation risk formula(LORF)for the prediction of severe post-operative *** LORF was verified by the receiver operating characteristic(ROC)*** The multivariate correlation analysis revealed the independent influencing factors of the severe post-operative complications of liver surgery were Child-Pugh grade(OR=4.127;Pliver segments to be removed(OR=2.209;P=0.006),organ invasion(OR=4.538;P=0.024),and pathological type(OR=4.023;P=0.002).The binomial logistic regression model was established to obtain the calculation formula(LORF)of the severe complication *** area under the ROC curve(AUC)of the LORF was *** cut-off value of the expected probability of severe complications was 0.3225(32.25%).Furthermore,in the validation data set,the corresponding AUC of the LORF was *** As a novel and simplified assessment system,the LORF could effectively predict the severe post-operative complications of liver surgery through the preoperative factors,and therefore it could be used to evaluate the risk of severe liver surgical complications before surgery.

关键词： liver surgery complication prediction

Effect of Postoperativeω-3 Fatty Acid Immunonutritional Therapy on NK Cell Gene Methylation in Elderly Patients with Gastric Cancer

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Current Medical Science 2022年第2期42卷 373-378页

作者： li-ning xu Ying-ying xu Gui-ping li Bo YANG Department of General Surgery The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing100853China Department of Internal Medicine Henan Cancer HospitalZhengzhou450003China Department of Radiology Hubei Province Integrated Hospital of Chinese and Western MedicineWuhan430015China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective This study aims to investigate the effect ofω-3 fatty acid immunonutritional therapy on natural killer(NK)cell gene methylation and function in elderly patients with gastric *** A total of 70 cases of elderly patients with gastric cancer were randomized into theω-3 fatty acid group and placebo group,according to the type of nutritional support *** methylation status of the tumor necrosis factor(TNF)-αgene promoter in peripheral NK cells was detected by methylation specific polymerase chain reaction,and the TNF-αlevel in peripheral NK cells was detected by enzyme-linked immunosorbent *** After 14 days of immunonutritional therapy withω-3 fatty acid or placebo,patients in theω-3 group had significantly higher average NK cell activity(0.27 vs.0.24,P=0.013)and lower percentages of TNF-αgene promoter methylation(25.7%vs.60%,Plication ofω-3 fatty acid may improve the activity of NK cells,which is correlated to the methylation status of the TNF-αgene promoter.

关键词： perioperative gastric carcinoma natural killer cell DNA methylation immune nutrition

Electrochemical impedance spectroscopy study on the corrosion of the weld zone of 3Cr steel welded joints in CO_2 environments

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International Journal of Minerals,Metallurgy and Materials 2015年第5期22卷 500-508页

作者： li-ning xu Jin-yang Zhu Min-xu Lu Lei Zhang Wei Chang Corrosion and Protection Center Key Laboratory for Environmental Fracture (MOE) Institute for Advanced Materials and Technology University of Science and Technology Beijing CNOOC Research Institute

The welded joints of 3Cr pipeline steel were fabricated with commercial welding wire using the gas tungsten arc welding （GTAW） technique. Potentiodynamic polarization curves, linear polarization resistance （LPR）, electrochemical impedance spectroscopy （EIS）, scan- ning electron microscopy （SEM）, and energy-dispersive spectrometry （EDS） were used to investigate the corrosion resistance and the growth of a corrosion film on the weld zone （WZ）. The changes in electrochemical characteristics of the film were obtained through fitting of the EIS data. The results showed that the average corrosion rate of the WZ in CO2 environments first increased, then fluctuated, and finally de- creased gradually. The formation of the film on the WZ was divided into three stages： dynamic adsorption, incomplete-coverage layer forma- tion, and integral layer formation.

关键词： petroleum pipelines steel corrosion welded joints carbon dioxide electrochemical impedance spectroscopy

Effect of histone deacetylase inhibitor on proliferation of biliary tract cancer cell lines

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World Journal of Gastroenterology 2008年第16期14卷 2578-2581页

作者： li-ning xu Xin Wang Sheng-Quan Zou Institute of Hepatobiliary Surgery of PLA GeneralHospital Beijing 100853 China Department of General Surgery of Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM: To explore the effect of histone deacetylase inhibitor, trichostatin A (TSA) on the growth of biliary tract cancer cell lines (gallbladder carcinoma cell line and cholangiocarcinoma cell line) in vivo and in vitro, and to investigate the perspective of histone deacetylase inhibitor in its clinical application. METHODS: The survival rates of gallbladder carcinoma cell line (Mz-ChA-l cell line) and cholangiocarcinoma cell lines (QBC939, KMBC and OZ cell lines) treated with various doses of TSA were detected by methylthiazoy tetrazolium (MTT) assay. A nude mouse model of transplanted gallbladder carcinoma (Mz-ChA-l cell line) was successfully established, and changes in the growth of transplanted tumor after treated with TSA were measured. RESULTS: TSA could inhibit the proliferation of gallbladder carcinoma cell line (Mz-ChA-l cell line) and cholangiocarcinoma cell lines (QBC939, KMBC and OZ cell lines) in a dose-dependent manner. After the nude mouse model of transplanted gallbladder carcinoma (Mz- ChA-l cell line) was successfully established, the growth of cancer was inhibited in the model after treated with TSA. CONCLUSION: TSA can inhibit the growth of cholangiocarcinoma and gallbladder carcinoma cell lines in vitro and in vivo.

关键词： Biliary tract cancer Gallbladder carcinoma Cholangiocarcinoma Proliferation Trichostatin A

Individualized risk estimation for postoperative pulmonary complications after hepatectomy based on perioperative variables

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World Journal of Gastrointestinal Surgery 2022年第7期14卷 685-695页

作者： li-ning xu Ying-Ying xu Gui-Ping li Bo Yang Department of General Surgery The Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Internal Medicine Henan Cancer HospitalZhengzhou 450003Henan ProvinceChina Department of Radiology Hubei Province Integrated Hospital of Chinese and Western MedicineWuhan 430015Hubei ProvinceChina Department of Radiology Affiliated Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND At present,there is no perfect system to evaluate pulmonary complications of liver surgery using perioperative *** To design and verify a risk assessment system for predicting postoperative pulmonary complications(PPCs)after hepatectomy based on perioperative *** A retrospective analysis was performed on 1633 patients who underwent liver *** variables were screened using univariate and multivariate analyses,and graded scores were assigned to the selected *** regression was used to develop the liver operation pulmonary complication scoring system(LOPCSS)for the prediction of *** LOPCSS was verified using the receiver operating characteristic *** According to the multivariate correlation analysis,the independent factors which influenced PPCs of liver surgery were age[≥65 years old/liver segments to be removed(≥3/≤2,OR=1.683,P=0.002),operation duration(≥180 min/lications was *** incidence of complications in the group with≤4 points was significantly lower than that in the group with≥6 points(2.95%vs 33.40%,Plidation dataset,the corresponding AUC of LOPCSS was *** As a novel and simplified assessment system,the LOPCSS can effectively predict PPCs of liver surgery through perioperative variables.

关键词： liver surgery Complication Pulmonary Prediction

Heredity Analysis and Gene Mapping of Bruchid Resistance of a MungbeanCultivar V2709

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Agricultural Sciences in China 2008年第6期7卷 672-677页

作者： SUN Lei CHENG xu-zhen WANG Su-hua WANG li-xia liU Chang-you MEI li xu ning Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China

Bruchid is a serious insect pest of mungbean [Vigna radiata （L.） Wilczek] and can inflict serious loss. A resistant variety from India, V2709, was crossed with a susceptible variety, Zhonglti 1, from the World Vegetable Center, Asian Vegetable Research and Development Center （AVRDC）. Segregation of the F2, BC1F1, and F3 populations showed that bruchid resistance of V2709 is controlled by a single dominant locus. To find molecular marker linked with the resistant locus, 63 randomly amplified polymorphic DNA markers and 113 sets of SSR/STS primers were used in a bulked segregant analysis. Two of the markers, OPC-06 and STSbr2, were found to be linked with the locus （named as Br2）. Further analysis suggested that the genetic distances between these two markers and Br2 were 11.0 and 5.8 cM, respectively.

关键词： mungbean V2709 bruchid resistance heredity analysis STS RAPD

Hepatic injury in rats with obstructive jaundice: roles of the protein kinase C signal pathway and cytoprotection of fructose

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Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 577-581页

作者： Jian-Ming Wang Hui Wang li-ning xu Sheng-Quan Zou Department of General Surgery Tongji HospitalTongji Medical College Huazhong University of Science and Technology Wuhan 430030 China. wangjm18@***

BACKGROUND: Fructose is cytoprotective during bile salt-induced apoptosis of hepatocytes by regulating protein kinase C (PKC). This study was undertaken to explore the regulating mechanism of hepatic injury in rats with obstructive jaundice, and to detect the PKC signal pathway. METHODS: Rat hepatocytes were isolated by in situ colla-genase perfusion and primary culture, and pretreated with various concentrations of PKC agonist phorbol myristate acetale (PMA) and inhibitor chelerythrine for 20 minutes. After pretreatment, 50 μmol/L glycochenodeoxycholate (GCDC) was added for additional 24 hours. Subsequently, the cells were detected by FCM and TUNEL. After adding with different concentrations of fructose and 100 μmol GCDC , the hepatocytes were evaluated by FCM and TUNEL. Experimental obstructive jaundice was induced with fructose and without fructose via double ligation of the bile duct for 3, 7, 14, and 21 days. Apoptotic status in the liver of all rats was detected with TUNEL, and PKC protein in the liver of obstructive jaundice ( OJ) with the immunohisto-chemistry method. RESULTS: PMA increased GCDC-induced apoptosis and chelerythrine decreased GCDC-induced apoptosis in a concentration-dependent manner. Adding with different concentration of fructose and 100 μmol GCDC, the decreased apoptotic rate was related to the concentration of fructose. The apoptotic rate of the liver was related to times of OJ. PKC and apoptosis index (AI) were the highest after a 14-day ligation of the bile duct without use of fructose. AI and PKC were decreasing from a 14-day ligation of the bile duct with fructose. CONCLUSIONS: PKC takes part in the regulation, occurrence , and progression of hepatic injury in OJ. Fructose is cytoprotective during bile salt-induced apoptosis of hepato-cytes by regulating PKC.

关键词： cholestasis hepatic injury protein kinase C fructose