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Research 2024年第2期6卷 319-327页

作者： lihong Hong Haiyao Yang liqiang liu mingzhou li Yuanyuan liu Baoqin Chen Huakang Yu Wenbo Ju Zhi-Yuan li School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

An optical spectrometer is a basic spectral instrument that probes microscopic physical and chemical properties of macroscopic objects but generally suffers from difficulty in broadband time-resolved *** this work,we report the creation of ultrabroadband white-light laser with a 3-dB bandwidth covering 385 to 1,080 nm,pulse energy of 1.07 mJ,and pulse duration of several hundred femtoseconds by passing 3-mJ pulse energy,50-fs pulse duration Ti:Sapphire pulse laser through a cascaded fused silica plate and chirped periodically poled lithium niobate *** utilize this unprecedented superflat,ultrabroadband,and intense femtosecond laser light source to build a single-shot(i.e.,single-pulse)subpicosecond pulse laser ultraviolet-visible-near-infrared spectrometer and successfully measure various atomic and molecular absorption *** single-shot ultrafast spectrometer may open up a frontier to monitor simultaneously the ultrafast dynamics of multiple physical and chemical processes in various microscopic systems.

关键词： Pulse utilize frontier

Composite structure Al_(2)O_(3)/Al_(2)O_(3)-YAG:Ce/YAG ceramics with high color spatial uniformity for white laser lighting

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Journal of Advanced Ceramics 2024年第2期13卷 189-197页

作者： Pengfei Sang Le Zhang Jian Kang mingzhou li Shiwei Chen Peng Yang Bingheng Sun Yang li Wieslaw Strek Hao Chen Jiangsu Key Laboratory of Advanced Laser Materials and Devices School of Physics and Electronics EngineeringJiangsu Normal UniversityXuzhou 221116China Jiangsu Xiyi Advanced Materials Research Institute of Industrial Technology Xuzhou 221400China Xuzhou EAGLED Technology Co. Ltd.Xuzhou 221116China Xuzhou Kangna Advanced Materials Technology Co. Ltd.Xuzhou 221116China Xuzhou Fuchang Electronic Technology Co. Ltd.Xuzhou 221116China Shanghai Institute of Optics Fine Mechanics Chinese Academy of SciencesShanghai 201800China School of Material Science and Engineering Shanghai Institute of TechnologyShanghai 201418China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China Institute of Low Temperature and Structure Research Polish Academy of SciencesWroclaw 50-422Poland

Composite ceramic phosphor(CCP)is a candidate light-conversion material to obtain the high-quality laser lighting *** based on the transmissive configuration model could not simultaneously meet the requirements of angular color uniformity and high thermal *** this study,a novel composite structure ceramic was designed,including Al_(2)O_(3)-YAG:Ce/YAG layered ceramic with a size of 1 mm×1 mm for lighting,and Al_(2)O_(3) ceramic(φ=16.0 mm)was used as the wrapping material due to its outstanding thermal *** prepared ceramics exhibited excellent thermal performance and no yellow ring *** this design,we achieved the match of the intensity distribution of the blue and yellow lights,resulting in a high angular color uniformity of 0.9 with a view angle of±80°.All ceramics showed no luminous saturation phenomenon,even the laser power density was increased up to 47.51 W/mm^(2).A high-brightness white-light source with a luminous flux of 618 lm,a luminous efficiency of 126 lm/W,a CCT of 6615 K,and a CRI of 69.9 was obtained in the transmissive *** particular,the surface temperature of the ceramic was as low as 74.1℃ under a high laser radiation(47.51 W/mm^(2)).These results indicate that Al_(2)O_(3)/Al_(2)O_(3)-YAG:Ce/YAG composite structure ceramic is a promising luminescent material in the high-power laser lighting applications.

关键词： Al_(2)O_(3)/Al_(2)O_(3)-YAG:Ce/YAG angular color uniformity high thermal stability high-power laser lighting

Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1494-1511页

作者： Guangliang Gao Rui liu Silu Hu Mengnan He Jiaman Zhang Dengfeng Gao Jing li Jiwei Hu Jiwen Wang Qigui Wang mingzhou li Long Jin livestock and Poultry Multi‑Omics Key Laboratory of Ministry of Agriculture and Rural Affairs College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Chongqing Engineering Research Center of Goose Genetic Improvement Institute of Poultry ScienceChongqing Academy of Animal SciencesRongchang DistrictChongqing 402460China

Background Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy intake. As a result, goose offers an excellent model for studying obesity, metabolic disorders, and liver diseases in mammals. Although the impact of the three-dimensional arrangement of chromatin within the cell nucleus on gene expression and transcriptional regulation is widely acknowledged, the precise functions of chromatin architecture reorganization during fat deposition in goose liver tissues still need to be fully *** In this study, geese exhibited more pronounced changes in the liver index and triglyceride(TG) content following the consumption of the high-fat diet(HFD) than mice without significant signs of inflammation. Additionally, we performed comprehensive analyses on 10 goose liver tissues(5 HFD, 5 normal), including generating highresolution maps of chromatin architecture, conducting whole-genome gene expression profiling, and identifying H3K27ac peaks in the livers of geese and mice subjected to the HFD. Our results unveiled a multiscale restructuring of chromatin architecture, encompassing Compartment A/B, topologically associated domains, and interactions between promoters and enhancers. The dynamism of the three-dimensional genome architecture, prompted by the HFD, assumed a pivotal role in the transcriptional regulation of crucial genes. Furthermore, we identified genes that regulate chromatin conformation changes, contributing to the metabolic adaptation process of lipid deposition and hepatic fat changes in geese in response to excessive energy intake. Moreover, we conducted a cross-species analysis comparing geese and mice exposed to the HFD, revealing unique characteristics specific to the goose liver compared to a mouse. These chromatin conformation changes help elucidate the observed characteristics of fat

关键词： Compartment A/B Goose fatty liver Promoter-enhancer interactions Regulation of gene expression

A cell transcriptomic profile p ovides insights into adipocytes of porcine mammary gland across development

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Journal of Animal Science and Biotechnology 2024年第1期15卷 182-200页

作者： Yongliang Fan Long Jin Zhiping He Tiantian Wei Tingting Luo Jiaman Zhang Can liu Changjiu Dai Chao A Yan liang Xuan Tao Xuebin Lv Yiren Gu mingzhou li State Key Laboratory of Swine and Poultry Breeding Industry College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Key Laboratory of Qinghai‑Tibetan Plateau Animal Genetic Resource Reservation and Utilization Southwest Minzu UniversityChengdu 610041China Animal Breeding and Genetics Key Laboratory of Sichuan Province Sichuan Animal Science AcademyChengdu 610000China

Background Studying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous, and its physiological function dependents on the gene expression of multiple cell types. Most studies focused on epithelial cells, disregarding the role of neighboring *** Here, we constructed the largest transcriptomic dataset of porcine mammary gland cells thus far. The dataset captured 126,829 high-quality nuclei from physiological mammary glands across five developmental stages(d 90 of gestation, G90;d 0 after lactation, L0;d 20 after lactation, L20;2 d post natural involution, PI2;7 d post natural involution, PI7). Seven cell types were identified, including epithelial cells, adipocytes, endothelial cells, fibroblasts cells, immune cells, myoepithelial cells and precursor cells. Our data indicate that mammary glands at different developmental stages have distinct phenotypic and transcriptional signatures. During late gestation(G90), the differentiation and proliferation of adipocytes were inhibited. Meanwhile, partly epithelial cells were completely differentiated. Pseudo-time analysis showed that epithelial cells undergo three stages to achieve lactation, including cellular differentiation, hormone sensing, and metabolic activation. During lactation(L0 and L20), adipocytes area accounts for less than 0.5% of mammary glands. To maintain their own survival, the adipocyte exhibited a poorly differentiated state and a proliferative capacity. Epithelial cells initiate lactation upon hormonal stimulation. After fulfilling lactation mission, their undergo physiological death under high intensity lactation. Interestingly, the physiological dead cells seem to be actively cleared by immune cells via CCL21-ACKR4 pathway. This biological process may be an important mechanism for maintaining homeostasis of the mammary gland. During natural involution(PI2 and PI7), epithelial cell populatio

关键词： Adipocytes Cell–cell interaction Development Mammary gland snRNA-seq

基于MetCal的铜阳极炉精炼过程热力学仿真模型

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中国有色金属学报 2024年第7期34卷 2436-2451页

作者：徐少春李明周赵志慧钟立桦何发友黄金堤江西理工大学冶金工程学院赣州341000 紫金矿业集团股份有限公司龙岩361000 赤峰金通铜业有限公司赤峰024000

基于多相平衡原理、过程反应机理和MetCal软件平台,采用化学平衡常数法,建立铜阳极炉精炼过程热力学仿真模型和仿真系统。在典型生产工况条件下,模拟计算氧化期和还原期的产物组成和关键技术指标。结果表明:氧化期铜液中Cu含量的计算相... 详细信息

基于多相平衡原理、过程反应机理和MetCal软件平台,采用化学平衡常数法,建立铜阳极炉精炼过程热力学仿真模型和仿真系统。在典型生产工况条件下,模拟计算氧化期和还原期的产物组成和关键技术指标。结果表明:氧化期铜液中Cu含量的计算相对误差为0.14%,微量元素S、O的含量计算绝对误差分别为0.0057%和0.252%;还原期铜液中Cu含量相对误差为0.16%,S、O的含量计算绝对误差分别为0.0003%和0.002%,精炼渣Cu含量计算误差为4.69%,Pb、Zn、As、Sb和Bi等杂质元素在氧化期铜液与粗铜中的分配比计算结果与生产数据误差分别为2.82%、4.94%、6.24%、6.69%和0.07%。因此,所构建模型和计算系统能较好地反映铜阳极炉精炼过程的实际生产情况,具有精准预测该精炼过程和优化工艺参数的潜力,可有效指导铜阳极炉精炼过程的生产实践。

关键词：回转式阳极炉火法精炼 MetCal 热力学仿真模型

基于MetCal的铜阳极炉精炼过程热力学仿真分析

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中国有色金属学报 2024年第9期34卷 3141-3155页

基于所构建的铜阳极炉精炼过程热力学仿真模型及系统,计算了某典型阳极炉精炼生产工况,验证模型热力学分析的可行性,进而考察气料比(R_(GF))、石英熔剂率(R_(Flux))和精炼温度(t)等工艺参数对产物组成及杂质分配行为的影响。结果表明:提... 详细信息

基于所构建的铜阳极炉精炼过程热力学仿真模型及系统,计算了某典型阳极炉精炼生产工况,验证模型热力学分析的可行性,进而考察气料比(R_(GF))、石英熔剂率(R_(Flux))和精炼温度(t)等工艺参数对产物组成及杂质分配行为的影响。结果表明:提高R_(GF)、R_(Flux),可在一定程度上改变精炼渣组成,改善杂质入渣脱除效果,但因精炼渣量较小,除Co和Cr外其他杂质元素的实际入渣脱除率变化不大;提高温度对产物组分影响不大,但会降低杂质的脱除效果。综合工艺参数对阳极精炼过程的影响规律,得到的较优工艺参数为R_(GF)为22 m^(3)/t,R_(Flux)为0.16%,t为1200℃。在此条件下,铜液的Cu品位、S含量和O含量分别约为99.39%、0.0065%、0.17%。

关键词：铜阳极炉精炼 MetCal软件热力学仿真分析

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Reorganization of 3D genome architecture across wild boar and Bama pig adipose tissues

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1011-1027页

作者： Jiaman Zhang Pengliang liu Mengnan He Yujie Wang Hua Kui Long Jin Diyan li mingzhou li Institute of Animal Genetics and Breeding College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China

Background:A growing body of evidence has revealed that the mammalian genome is organized into hierarchical layers that are closely correlated with and may even be causally linked with variations in gene *** studies have characterized chromatin organization in various porcine tissues and cell types and compared them among species and during the early development of ***,how chromatin organization differs among pig breeds is poorly ***:In this study,we investigated the 3D genome organization and performed transcriptome characterization of two adipose depots(upper layer of backfat[ULB]and greater omentum[GOM])in wild boars and Bama pigs;the latter is a typical indigenous pig in *** found that over 95%of the A/B compartments and topologically associating domains(TADs)are stable between wild boars and Bama *** contrast,more than 70%of promoterenhancer interactions(PEIs)are dynamic and widespread,involving over a thousand *** in chromatin structure are associated with changes in the expression of genes that are involved in widespread biological functions such as basic cellular functions,endocrine function,energy metabolism and the immune *** 95%and 97%of the genes associated with reorganized A/B compartments and PEIs in the two pig breeds differed between GOM and ULB,***:We reported 3D genome organization in adipose depots from different pig *** a comparison of Bama pigs and wild boar,large-scale compartments and TADs were mostly conserved,while fine-scale PEIs were extensively *** chromatin architecture in these two pig breeds was reorganized in an adipose depotspecific *** results contribute to determining the regulatory mechanism of phenotypic differences between Bama pigs and wild boar.

关键词： 3D genome organization A/B compartments Adipose tissues PEI Pig breeds TAD

Effects of two different glycoprotein platelet Ⅱb/Ⅲa inhibitors and the clinical endpoints in patients with intracranial Pipeline flow diverter implant

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Journal of Interventional Medicine 2020年第4期3卷 174-179页

作者： Qiao Deng Shichao Zhang mingzhou li Guozhong Zhang Wenfeng Feng Southern Medical University Department of NeurosurgeryNanfang HospitalGuangzhou510515China

Objective:To compare the antiplatelet effect and major adverse cerebrovascular events of Pipeline for intracranial aneurysms using glycoproteinⅡb/Ⅲa antagonists(GPI)eptifibatide and ***:Retrospective analysis of relevant data of patients using GPIs combined with oral antiplatelet therapy in Nanfang Hospital of Southern Medical University from December 2017 to December *** study was approved by the ethics Committee of Nanfang Hospital of Southern Medical *** to the random use of GPIs drugs,they were assigned to the eptifibatide group and tirofiban *** data,platelet inhibition rates at baseline,24 h and 72 h after administration,short-term major adverse cerebrovascular events,and bleeding complications were compared between the two ***:A total of 47 patients were included in this study,including 24 patients in eptifibatide group and 23 patients in tirofiban *** was no significant difference in average age(53.75 vs.53.91 years)and body mass index(BMI)(24.39 vs.22.73 kg/m2)between eptifibatide group and tirofiban *** was no significant difference in coagulation factor function(R),fibrinogen function(K),fibrinolysis function(EPL),comprehensive coagulation index(Cl),arachidonic acid pathway inhibition rate(AA%)and adenosine diphosphate inhibition rate(ADP%).However,the baseline level of residual platelet function MA(ADP)in eptifibatide group was significantly higher than that in tirofiban group(50.79 vs.35.29 mm,P=0.0026).There was a statistical difference in the platelet aggregation function MA(65.38 vs.62.54 mm,p=0.0442),the rate of spontaneous hemorrhagic stroke(4.3%vs.0%)and the rate of asymptomatic minor bleeding(26.08%vs.4.1%)in the two groups(P<0.05).Conclusion:Both eptifibatide and tirofiban can effectively inhibit platelets,but the effect of etifeptide is better than that of tirofiban in preventing intracranial microhemorrhage and asymptomatic cerebral infarction.

关键词： Eptifibatide Tirofiban Cerebral hemorrhage Flow guiding device

Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data

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Science China(life Sciences) 2020年第5期63卷 750-763页

作者： Xiaomeng Tian Ran li Weiwei Fu Yan li Xihong Wang Ming li Duo Du Qianzi Tang Yudong Cai Yiming Long Yue Zhao mingzhou li Yu Jiang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Institute of Animal Genetics and Breeding College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China

Pigs were domesticated independently in the Near East and China,indicating that a single reference genome from one individual is unable to represent the full spectrum of divergent sequences in pigs ***,12 de novo pig assemblies from Eurasia were compared in this study to identify the missing sequences from the reference *** a result,72.5 Mb of nonredundant sequences(~3% of the genome)were found to be absent from the reference genome(Sscrofa11.1)and were defined as *** the pan-sequences,9.0 Mb were dominant in Chinese pigs,in contrast with their low frequency in European *** sequence dominant in Chinese pigs contained the complete genic region of the tazarotene-induced gene 3(TIG3)gene which is involved in fatty acid *** flanking sequences and Hi-C based methods,27.7% of the sequences could be anchored to the reference *** supplementation of these sequences could contribute to the accurate interpretation of the 3D chromatin structure.A web-based pan-genome database was further provided to serve as a primary resource for exploration of genetic diversity and promote pig breeding and biomedical research.

关键词： pan-genome pig reference genome 3D chromatin structure presence-absence variation

Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet.

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