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Engineering atomic Rb-N configurations to tune radical pathways for highly selective photocatalytic H2O2 synthesis coupled with biomass valorization

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者：贵天翔 Pan SU Ying liU li-ming chen Key Laboratory of Molecular Biophysics of Ministry of Education School of Life Science &TechnologyHuazhong University of Science & Technology

Purpose The electrogenic Na+/HCO3 – cotransporters NBCe1(SLC4 A4) and electroneutral NBCn1(SLC4 A7) of solute carrier 4(SLC4) family play a fundamentally important role in the regulation of acid-base balance both on the cellular and systemic levels in the *** to usage of distinct promoters and/or alternative splicing, both SLC4 A4 and SLC4 A7 can produce multiple *** major variation in NBCn1 is the optional inclusion of cassette II(123 amino acids)arising from alternative ***1-B(variant B of NBCe1) and NBCn1 contain an autoinhibitory domain(AID) in the amino-terminus(Nt).NBCe1-B and NBCn1 contains only basal activity due to inhibition by the AID, but both can be greatly stimulated by protein interaction with IRBIT(the IP3 R binding protein released with inositol 1,4,5-trisphosphate).The purpose of the present study was to gain insight into the role of cassette II in the functional regulation of *** We generated chimeras of NBCn1 and NBCe1 by replacing parts of the Nt domain of NBCe1 with those from *** constructs were heterologously expressed in Xenopus laevis oocytes for functional assay with two-voltage electrode clamp(TEV).Results Firstly, to examine whether the AID of NBCn1 is inhibitory to NBCe1, we replaced the entire Nt domain of NBCe1-B with the Nt of NBCn1-D to generate n1 DNt-e1 TMD or the Nt of NBCn1-G to generate n1 GNt-e1 *** TEV, both n1 DNt-e1 TMD and n1 GNt-e1 TMD are electrogenic and can be significantly stimulated by IRBIT, suggesting that the AID of NBCn1 is inhibitory to NBCe1 ***, the activity of n1 GNt-e1 TMD is significantly higher than that of n1 DNte1 *** to NBCn1-G, the Nt of NBCn1-D contains a unique alternative cassette II(123 amino-acids).The above data suggest that cassette II is inhibitory to NBCe1 *** then introduced cassette II of NBCn1 into the Nt of wild-type NBCe1-B right after cassette *** manipulation greatly decreases the activity of NBCe1 both wi

关键词： bicarbonate transporter electrophysiology NBCe1 NBCn1 IRBIT auto-inhibition

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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye li Shuang Pan Yihuang chen Qiong liu College of Chemistry and Materials Engineering Wenzhou University Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a green and costeffective production ***,achieving highly selective H2O2synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H2O2and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride（CNRb）.The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h-1for H2O2generation and photooxidation rate of 3.75 mM h-1for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion （SCC） efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H2O2coupled with biomass valorization.

关键词： Free radical reactions

Effects of Solution for Washing Nasopharyngeal on Local pH Value and Hacterial Infection in Patients with Nasopharyngeal Carcinoma

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现代护理 2003年第8期9卷 575-576页

作者： Tang Yuping liu Taowen chen Sen li Xiufen li ming chen Huangji 541002 Department of Oncology, Nanxishan Hospital of Guang Xi. Guilin

Objective To detect the relationship of pH value and bacterial infection on nasopha-ryngeal surface and effects of washing solution in patients with nasopharyngeal carcinoma (NPC).Methods The bacteria was observed by agar plate culture and pH value was measured by accurately pH testing paper on nasopharyngeal surface before and after washing the region by physiologic saline (the control group) and 3. 00% NaHCO2 (the observation group) in NPC patiens. Results After being washed, the pH value was elevated in patients washing with 3.00% NaHCOs solution, but was not ob-vious changed in patiens washing with physiologic saline. Compared with pre-washing, the positive rateof bacte ria culture was lower on nasopharynged in both group (3.00% NaHCO3 from 40.0% to 3.33%,Pline from 36.65% to 13.33%, P> 0.05) after washing. Conclusions The bac-terial infection is associated with pH value on nasopharyngeal, and 3.00% NaHCO3 salution might be more efficiency than physiologic saline for preventing bacterial infection on nasopharyngeal in patients na-sonharvngeal carcinoma.

关键词：冲洗液鼻咽癌鼻咽部pH值细菌感染护理放射治疗并发症

Single-pixel imaging with neutrons

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Science Bulletin 2021年第2期66卷 133-138,M0003页

作者： Yu-Hang He Yi-Yi Huang Zhi-Rong Zeng Yi-Fei li Jun-Hao Tan li-ming chen ling-An Wu ming-Fei li Bao-Gang Quan Song-lin Wang Tian-Jiao liang Institute of Physics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China IFSA Collaborative Innovation Center and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China College of Engineering Physics Shenzhen Technology UniversityShenzhen 518118China Beijing Institute of Aerospace Control Devices Beijing 100039China

Neutron imaging is an invaluable tool for noninvasive analysis in many ***,neutron facilities are expensive and inconvenient to access,while portable sources are not strong enough to form even a static image within an acceptable time frame using traditional neutron *** we demonstrate a new scheme for single-pixel neutron imaging of real objects,with spatial and spectral resolutions of 100 lm and 0.4%at 1A,*** illumination down to 1000 neutron counts per frame pattern was *** experimental setup is simple,inexpensive,and especially suitable for low intensity portable sources,which should greatly benefit applications in biology,material science,and industry.

关键词： Single-pixel neutron imaging Spectral neutron imaging High resolution neutron ghost imaging

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang liu Farid Manshaii Jinmiao chen Xinfei Wang Shaolei Wang Junyi Yin ming Yang Xuxu chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian li Xueer liu Zelin Zhang Xiaoxuan chen Weiqiang chen Kangsheng li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Significance of MD-2 and MD-2B expression in rat liver during acute cholangitis

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World Journal of Hepatology 2010年第6期2卷 233-238页

作者： Hui-Lai Miao, Zhi-Dong Qiu, Fu-Long Hao, Yong-Hui Bi, ming-Yi li, ming chen, Nian-Ping chen, Fei Zhou, Department of Hepatobiliary Surgery, the Affiliated Hospital of Guangdong Medical College, Zhanjing 524001, Guangdong Province, China Hepatobiliary Surgery, Research Institute of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China Hui-Lai Miao Zhi-Dong Qiu Ming-Yi Li Ming Chen Nian-Ping Chen Department of Hepatobiliary Surgery the Affiliated Hospital of Guangdong Medical College Zhanjing 524001 Guangdong Province China.

AIM: To investigate the expression of myeloid differentiation protein-2 (MD-2), MD-2B (a splicing isoform of MD-2 that can block Toll-like receptor 4 (TLR4)/MD-2 LPS-mediated signal transduction) and TLR4 in the liver of acute cholangitis rats. METHODS: Male Sprague-Dawley rats (SPF level) were randomly divided into four groups: (A) sham-operated group; (B) simple common bile duct ligation group; (C)acute cholangitis group; and (D) acute cholangitis anti- TLR4 intervention group (n = 25 per group). Rat liver tissue samples were used to detect TLR4, MD-2 and MD-2B mRNA expression by fluorescence quantitative PCR in parallel with pathological changes. RESULTS: In acute cholangitis, liver TLR4 and MD-2 mRNA expression levels at 6, 12, 24, 48 and 72 h were gradually up-regulated but MD-2B mRNA expression gradually down-regulated (P liver injury while MD-2B plays a negative regulatory role.

关键词： Acute cholangitis Toll-like receptor 4 Myeloid differentiation protein-2 Myeloid differentiation protein-2 splicing isoform

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高轨失稳目标单载荷相对位姿测量方法

宇航学报 2017年第10期38卷 1105-1113页

作者：李荣华李金明陈凤肖余之大连交通大学机械工程学院大连116028 上海宇航系统工程研究所上海201109

针对线阵扫描型激光雷达在探测高轨失稳目标过程中,发生时空非定常点云数据畸变,而需多载荷协同方式测量相对位姿问题,提出一种激光雷达同向差分扫描测量方法。该方法基于运动目标畸变点云信息瞬时拓扑结构不变性,首先对相邻两次扫描的... 详细信息

针对线阵扫描型激光雷达在探测高轨失稳目标过程中,发生时空非定常点云数据畸变,而需多载荷协同方式测量相对位姿问题,提出一种激光雷达同向差分扫描测量方法。该方法基于运动目标畸变点云信息瞬时拓扑结构不变性,首先对相邻两次扫描的畸变点云进行配准来获取目标运动增量、解算目标瞬时运动参数。其次,逐条恢复畸变扫描线点云所处目标真实几何位置、完成目标三维重建。然后以目标三维模型为初始位姿基准,通过设定增量次数阈值不断更新位姿基准实现误差自标定。最后通过叠加位姿增量获取目标相对位姿。该方法在缺失非合作目标先验信息的情况下,仅使用单一载荷,不仅实现了目标三维点云模型的重建,而且精确测量了空间非合作目标相对位姿。

关键词：同向差分扫描畸变恢复自标定位姿增量

Effects of dietary sodium on the expression of Na+/HCO3– cotransporters NBCn1 and NBCn2 in the small intestine and the kidney in rat

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Effects of dietary sodium on the expression of Na+/HCO3– co...