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远程学习中教学交互层次塔的哲学基础探讨

中国远程教育 2016年第9期 7-13,79页

作者：王志军陈丽陈敏韩世梅江南大学教育信息化研究中心北京师范大学远程教育研究中心华中师范大学国家数字化学习工程技术研究中心北京开放大学社会教育学院

远程学习教学交互层次塔因深入揭示了远程学习中教学交互发生的过程而受到研究者的广泛关注。本研究首先概述了哈贝马斯交往理论的核心概念与思想,包括交往行为与语言交往的三大有效性原则、交往理性与理想的话语情景、主体间性。基于此... 详细信息

远程学习教学交互层次塔因深入揭示了远程学习中教学交互发生的过程而受到研究者的广泛关注。本研究首先概述了哈贝马斯交往理论的核心概念与思想,包括交往行为与语言交往的三大有效性原则、交往理性与理想的话语情景、主体间性。基于此,结合主体在由客观、社会、主观内在三个世界组成的生活世界中的交往特点,将其与教学交互层次塔的核心思想以及三层教学交互的关系进行了系统分析,并从交往理性、主体间性两个方面分析其对远程学习教学交互带来的新认识与启示。研究发现哈贝马斯基于生活世界的交往行为以及交往理性的概念为远程学习教学交互层次塔提供了有力支持,与教学交互层次塔的核心思想具有较强的一致性,是远程学习教学交互层次塔理论的哲学基础。交往行为理论中理想的话语情境以及所倡导的主体间性可以支撑和深化我们对远程学习教学交互的认识。该研究从哲学层面上对远程学习教学交互层次塔理论进行了补充和完善,有助于建构完整的远程学习教学交互理论体系。

关键词：哈贝马斯交往行为理论远程学习教学交互层次塔哲学基础

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急性百草枯中毒70例心肌损害分析

创伤与急诊电子杂志 2016年第3期4卷 148-151页

作者：李敏陈敏福建省立医院急诊内科福州350002 福建省急救中心福州350002 福建省急诊医学研究所福州350002

目的观察急性百草枯(paraquat,PQ)中毒对心肌的损害,使该中毒患者得到更加全面的治疗。方法对PQ中毒患者70例血清心肌酶谱、肌钙蛋白I(cardiac troponin I,cTnI)、脑钠肽(brain natriuretic pcptide,BNP)的变化及心电图检查指标作回顾... 详细信息

目的观察急性百草枯(paraquat,PQ)中毒对心肌的损害,使该中毒患者得到更加全面的治疗。方法对PQ中毒患者70例血清心肌酶谱、肌钙蛋白I(cardiac troponin I,cTnI)、脑钠肽(brain natriuretic pcptide,BNP)的变化及心电图检查指标作回顾性分析。结果血清心肌酶谱及c Tn I、BNP在PQ中毒急性期变化明显,且随中毒程度加深而增高,并有显著改变;上述指标在死亡组和存活组中的比较差异亦具有统计学意义(P均<0.05)。同时PQ中毒患者可出现多样性、复合性心电图改变。结论 PQ中毒患者有较高的心肌损害发生率,中毒越重,心肌损害越明显,需要相应的治疗。

关键词：百草枯中毒心肌酶心肌损伤

点状产气单胞菌脯氨酰内肽酶在大肠杆菌中的高效表达

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生物化学与生物物理学报 2000年第2期32卷 183-186页

作者：李民徐皓陈常庆中国科学院上海生物工程研究中心!上海200233

采用PCR分段克隆法将点状产气单胞菌点状亚种 (Aeromonaspuctatasubsp .puctata)脯氨酰内肽酶 ( pro lylendopeptidase ,apPEP)的编码区基因分成 3段扩增并拼接成编码 690个氨基酸的完整基因apPEP ,将其克隆在表达载体 pBL和 pKKH上 ,... 详细信息

采用PCR分段克隆法将点状产气单胞菌点状亚种 (Aeromonaspuctatasubsp .puctata)脯氨酰内肽酶 ( pro lylendopeptidase ,apPEP)的编码区基因分成 3段扩增并拼接成编码 690个氨基酸的完整基因apPEP ,将其克隆在表达载体 pBL和 pKKH上 ,构建成温度和IPTG诱导型高效表达apPEP的重组大肠杆菌BL2 1/ pBL PEP和BL2 1/pKKH PEP。诱导后 ,重组apPEP的表达量占菌体总蛋白质的 3 0 %左右 ,活力是野生菌的 10 0倍左右 ,表达产物为可溶性的胞内蛋白 ,非还原SDS PAGE显示为单体 ,分子量为 76kD ,与基因序列预测的分子量一致。采用阴离子HPLC纯化得到了纯度大于 90 %的重组apPEP ,酶比活力为 67u/mg。N端氨基酸序列测定的结果证实了表达的正确性。

关键词：脯氨酰内肽酶大肠杆菌高效表达纯化

Discussion on Ring Problem in Faulty（n, k）-Star-Graphs

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Discussion on Ring Problem in Faulty（n, k）-Star-Graphs

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

2006年全国理论计算机科学学术年会

作者： li Jing-li ZHAO Xue-min chen Man-li (School of Information Science and Engineering, Yunnan University, Kunming 650091) (library of Yunnan University,Yunnan University,Kunming 650091)

＜正＞In this paper, we discuss the embedded ring in faulty（n,k）-star-graph. A ring of length n! /（n-k）! -f is obtained when Sn,k has at most n-2 faulty nodes and n-k≥2.

关键词： ( n k) -star-graph Ring Fault-tolerance

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Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming li Jianfeng li Guoliang chen Tao lin Penghui Zhang Kuileung Tong Ningning chen Shaoyu liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian li Xueer liu Zelin Zhang Xiaoxuan chen Weiqiang chen Kangsheng li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑life lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous li deposition and highly reversible li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous li+flux lithium metal battery

Stereoselective Synthesis of α-Aminonitril on Glucose Templates

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Stereoselective Synthesis of α-Aminonitril on Glucose Templ...

第三届全国有机化学学术会议

作者： ZHANG, Peng-Fei GU, Yi-Xin GUO, Jun-li chen, min (Department of Chemistry, Hangzhou Teachers College, Zhejiang 310036)

＜正＞ Both proteinogenic and non proteinogenic α-amino acids are of particular interest as constituents of peptide factors , peptidomimetics and antibiotics for the construction of modern selective ***, α-amino acid derivatives are interesting building units for chiral-pool syntheses of enantiomerically pure natural *** efforts in modern organic synthesis are centered on the synthesis of enantiomerically pureα-amino acids. During the past three decades efficient methods of asymmetric synthesis of α-amino acids have been developed;most of them are based on electrophilic transformations of organometallic *** the concept that the chi-

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我国开设股价指数期货的必要性和现实性

郑州大学学报（哲学社会科学版） 2000年第5期33卷 37-41页

作者：李朝民陈金贤西安交通大学管理学院陕西西安710049

目前我国推出股票价格指数期货合约交易不仅是必要的 ,而且是可行的 ,上市股指期货交易的条件已经具备 ,时机已经成熟。有关管理层应尽早推出我国的股价指数期货合约的交易 ,一方面为个人和机构股市投资者提供一种新的有效的证券避险和... 详细信息

目前我国推出股票价格指数期货合约交易不仅是必要的 ,而且是可行的 ,上市股指期货交易的条件已经具备 ,时机已经成熟。有关管理层应尽早推出我国的股价指数期货合约的交易 ,一方面为个人和机构股市投资者提供一种新的有效的证券避险和投资手段 ,分散股市投资风险 ,有利于股市的健康发展 ;另一方面 ,进一步丰富我国金融衍生投资工具 ,促进期货和证券市场的发展 ,提高我国的国际金融地位。同时 ,由于竞争性期货交易机制的价格发现功能 ,股指期货可进一步加强股票指数作为宏观经济晴雨表的预警作用。

关键词：股价指数系统性风险期货合约中国股价指数期货股票市场上市股票指数期货交易股票现货市场