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New conversion of Friendlnder reaction of 3-amino-1H-benzo[f]chromene-2-carbonitriles with cyclohexanone

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Chinese Chemical Letters 2008年第1期19卷 15-18页

作者： Jia Rong li li Jun zhang Xi Quan Yang Qing li Dong Wang Chun Xia Wang Da Xin Shi Qi zhang School of Chemical Engineering and Environment Beijing Institute of Technology Beijing 100081 China

Two different skeletons of heterocyclic compounds, quinoline and quinazolinone analogs could be obtained by a novel one-pot synthesis from substituted 3-amino- 1H-benzo[f]chromene-2-carbonitrile derivatives and cyclohexanone in DMF in the catalyst of anhydrous Zinc chloride under reflux. A plausible mechanism was proposed. 2007 Jia Rong li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Friedlander cyclocondensation Quinoline and quinazolinone analogs New conversion

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen li Leilei liang Baoshan zhang Yi Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun Wang Qing Shi Guofan zhang Yuxuan Zhu Binbin li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

DDoS Attack Autonomous Detection Model Based on Multi-Strategy Integrate Zebra Optimization Algorithm

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Computers, Materials & Continua 2025年第1期82卷 645-674页

作者： Chunhui li Xiaoying Wang Qingjie zhang Jiaye liang Aijing zhang School of Information Engineering Institute of Disaster PreventionLangfang065201China Langfang Key Laboratory of Network Emergency Protection and Network Security Langfang065201China

Previous studies have shown that deep learning is very effective in detecting known ***,when facing unknown attacks,models such as Deep Neural Networks(DNN)combined with Long Short-Term Memory(LSTM),Convolutional Neural Networks(CNN)combined with LSTM,and so on are built by simple stacking,which has the problems of feature loss,low efficiency,and low ***,this paper proposes an autonomous detectionmodel for Distributed Denial of Service attacks,Multi-Scale Convolutional Neural Network-Bidirectional Gated Recurrent Units-Single Headed Attention(MSCNN-BiGRU-SHA),which is based on a Multistrategy Integrated Zebra Optimization Algorithm(MI-ZOA).The model undergoes training and testing with the CICDDoS2019 dataset,and its performance is evaluated on a new GINKS2023 *** hyperparameters for Conv_filter and GRU_unit are optimized using the Multi-strategy Integrated Zebra Optimization Algorithm(MIZOA).The experimental results show that the test accuracy of the MSCNN-BiGRU-SHA model based on the MIZOA proposed in this paper is as high as 0.9971 in the CICDDoS 2019 *** evaluation accuracy of the new dataset GINKS2023 created in this paper is *** to the MSCNN-BiGRU-SHA model based on the Zebra Optimization Algorithm(ZOA),the detection accuracy on the GINKS2023 dataset has improved by 5.81%,precisionhas increasedby 1.35%,the recallhas improvedby 9%,and theF1scorehas increasedby 5.55%.Compared to the MSCNN-BiGRU-SHA models developed using Grid Search,Random Search,and Bayesian Optimization,the MSCNN-BiGRU-SHA model optimized with the MI-ZOA exhibits better performance in terms of accuracy,precision,recall,and F1 score.

关键词： Distributed denial of service attack intrusion detection deep learning zebra optimization algorithm multi-strategy integrated zebra optimization algorithm

Bulging Performance and Quality Control of Aluminum Alloy Tailor-welded Overlapping Sheets Based on Interface Friction

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 258-264页

作者： GAO Tiejun GAO Bowen li Weijie zhang Jiabin College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China Shenyang Aerospace Xinguang Group Co.L td. Shenyang 110043China

In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded sheets by covering the tailor-welded sheets with better plastic properties overlapping *** the same time,the interface friction effect between the overlapping and tailor-welded sheets was utilized to control the stress magnitude and further improve the formability and quality of the tailor-welded *** this work,the bulging process of the tailor-welded overlapping sheets was taken as the research *** alloy tailor-welded overlapping sheets bulging specimens were studied by a combination of finite element analysis and experimental *** results show that the appropriate use of interface friction between tailor-welded and overlapping sheets can improve the formability of tailor-welded sheets and control the flow of weld seam to improve the forming *** increasing the interface friction coefficient on the side of tailor-welded sheets with higher strength and decreasing that on the side of tailor-welded sheets with lower strength,the deformation of the tailor-welded sheets are more uniform,the offset of the weld seam is minimal,the limit bulging height is maximal,and the forming quality is optimal.

关键词： tailor-welded sheets overlapping sheet bulging interface friction weld seam stress

The Four Intersection-and-Difference Model for line-line Topological Relations

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Geo-Spatial Information Science 2007年第4期10卷 293-298页

作者： DENG Min li Zhilin li Guangqiang zhang Xuesong Department of Surveying and Geo-informatics Central South University Yuelu Mountain Changsha 410083. China

The description of line-line topological relations is still an unsolved issue although much effort has been done. The problem is involved in many practical applications such as spatial query, spatial analysis and cartographic generalization. To develop a sound and effective approach to describe line-line relations, it is first necessary to define the topology of an individual line, i.e., local topology. The concept of connective degree is used for the identification of topological differences in the geometric structure of a line. The general topological definition of a line is given, i.e., endpoints set and interior point set. This definition can be applied to the embedded spaces of different dimensions, whether co-dimension is equal to or larger than zero. On this basis, a generic model called the 4 intersection-and-difference is set up for the description of basic line-line topological relations, upon which a conceptual neighborhood graph is built with consideration of topological distance, it is concluded that the proposed model can represent the property of topological changes, and basic relations between line segments in IR^1 and IR^2.

关键词： topological relations line object topological distance conceptual neighborhood co-dimension

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面向软件产品线中特征选择的多目标优化算法

软件学报 2017年第10期28卷 2548-2563页

作者：连小利张莉北京航空航天大学计算机学院北京100191

软件产品线中,产品定制的核心是选择合适的特征集.由于多个非功能需求间往往相互制约甚至发生冲突,特征选择的本质是多目标优化过程.优化过程的搜索空间被特征间错综复杂的依赖和约束关系以及明确的功能需求大大限制.另外,有些非功能需... 详细信息

软件产品线中,产品定制的核心是选择合适的特征集.由于多个非功能需求间往往相互制约甚至发生冲突,特征选择的本质是多目标优化过程.优化过程的搜索空间被特征间错综复杂的依赖和约束关系以及明确的功能需求大大限制.另外,有些非功能需求有明确的数值约束,而有些则仅要求尽可能地得到优化.多样的非功能需求约束类型也给优化选择过程带来极大的挑战.提出一种含修正算子的多目标优化算法MOOFs.首先,设计特征间依赖和约束关系描述语言DL-DCF来统一规范特征选择过程中必须遵守的规则,所有的非功能需求都转化为优化目标,相关的数值约束则作为优化过程中特征选择方案的过滤器.另外,设计了修正算子用于保证选择出的特征配置方案必满足产品线的特征规则约束.通过与4种常用的多目标优化算法在4个不同规模的特征模型上的运行结果进行对比,表明该方法能够更快地产生满足约束的优化解,且优化解具备更好的收敛性与多样性.

关键词：软件产品线特征选择多目标优化算法非功能需求功能需求

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei zhang Chunxiao Wei Panpan Zhao Yongchun Wang Mingxi li li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli zhang Tian li Jie Miao Zhina zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei zhang Haiting li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1