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Chinese Journal of Structural Chemistry 2005年第12期24卷 1462-1467页

作者： li Feng li tao-Hai CAO Rong State Key Laboratory of Structural Chemistr3 Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fujian Fuzhou 350002 China

Two coordination polymers have been synthesized from cpg/4,4＇-bipy/metal ions reaction system, [Zn（cpg）（4,4＇-bipy）0.5（H2O）]·H2O 1 and [Cd（cpg）（4,4＇-bipy）0.5（H2O）2]·H2O 2. X- ray analyses show that different coordination geometries of zinc and cadmium ions lead to similar ladder structures （tetra-for zinc ion and hexa- for cadmium ion）, in which all the flexible cpg molecules exist as single conformations of anti-form.

关键词： hydrothermal synthesis flexible ligand prediction

One-pot Three-component Mannich Reaction Catalyzed by 2-Hydroxylpyridine

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Chemical Research in Chinese Universities 2013年第4期29卷 710-713页

作者： JIN li-li LEI Yun-tao College of Sciences China Pharmaceutical University Nanjing 210009 P. R. China

An effcient synthetic protocol for the β-amino carbonyl compounds was developed via one-pot three- component Mannich reaction of aromatic aldehydes, aromatic amines and cyclohexanone catalyzed by 2-hydroxylpy- ridine under mild reaction conditions, β-Amino carbonyl compounds were obtained in moderate to good yields and rea- sonable diastereoselectivities. The effects of different solvents, catalyst amounts and the scope of different substrates on the Mannich reactions were investigated. The plausible reaction mechanism was also discussed.

关键词： 2-Hydroxylpyridine Catalyze Mannich reaction fl-Amino carbonyl compound

A new aryltetrahydronaphthalene lignan from Epimedium brevicornum

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Chinese Chemical Letters 2011年第1期22卷 85-87页

作者： Hai Zhou li Guo Jun Luo Hong Mei li Xiao Lei li Rong tao li The college of life Science and Technology Kunming University of Science and Technology Kunming 650224 China

A new aryltetrahydronaphthalene lignan, （＋）-cycloolivil formaldehyde condensate （1）, was isolated from the whole plants of Epimedium brevicornum （Berberidaceae）. Its structure was elucidated on the basis of MS,... 详细信息

关键词： Epimedium brevicornum lignan Cycloolivil formaldehyde condensate

Design of Near-optimal Earth Escape Orbits for Solar Sail Spacecraft

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Journal of Harbin Institute of Technology(New Series) 2013年第1期20卷 12-16页

作者： Xiao-Ning Shi li-tao li Nai-Gang Cui Dept. Astronautical Engineering Harbin Institute of Technology

With the increase of the interest in solar sailing, it is required to provide a basis for future detailed planetary escape mission analysis by drawing together prior work, clarifying and explaining previously anomalies. In this paper, a technique for escaping the Earth by using a solar sail is developed and numerically simulated. The spacecraft is initially in a geosynchronous transfer orbit (GTO). Blended solar sail analytical control law, explicitly independent of time, are then presented, which provide near-optimal escape trajectories and maintain a safe minimum altitude and which are suitable as a potential autonomous onboard controller. This control law is investigated from a range of initial conditions and is shown to maintain the optimality previously demonstrated by the use of a single-energy gain control law but without the risk of planetary collision. Finally, it is shown that the blending solar sail analytical control law is suitable for solar sail on-board autonomously control system.

关键词： near-optimal solar sail escape trajectory analytical method blending control law

Multiple organ dysfunction and rhabdomyolysis associated with moonwort poisoning: Report of four cases

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World Journal of Clinical Cases 2020年第2期8卷 479-486页

作者： Fang li An-Bao Chen Yong-Chun Duan Rui liao Yu-Wei Xu li-li tao Department of Emergency Medicine The Second Affiliated Hospital of Kunming Medical University

BACKGROUND Moonwort is a widely used Chinese herbal medicine. It has various pharmacological effects, such as relieving cough and preventing asthma. To date,multiple organ dysfunction and rhabdomyolysis caused by moonwort poisoning have not been *** SUMMARY Here we report four cases of moonwort poisoning that presented with multiple organ dysfunction and rhabdomyolysis accompanied by vomiting, fatigue, and muscle aches. One patient was an adult male, two were adult females, and one was a boy, with an age range of 7–64 years. The adults were treated with hemoperfusion and symptomatic therapies, while the child was treated with plasma exchange and symptomatic therapies. All four patients *** Blood purification combined with symptomatic treatment may be an effective method for managing multiple organ dysfunction and rhabdomyolysis caused by acute moonwort poisoning.

关键词： Moonwort poisoning Multiple organ dysfunction Rhabdomyolysis Hemoperfusion Plasma exchange Case report

Schisanlactone G,a new 3,4-seco-lanostane triterpenoid from Schisandra sphenanthera

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Chinese Chemical Letters 2009年第5期20卷 601-603页

作者： Rong Ren Guo Jun Luo Hong Mei li Zhao Yuan Wu Hai Zhou li Rong tao li The College of life Science and Technology Kunming University of Science and Technology Kunming 650224 PR China

A new 3,4-seco-lanostane triterpenoid, schisanlactone G （1）, was isolated from the fruits of Schisandra sphenanthera. Its structure was established on the basis of extensive spectroscopic analysis.

关键词： Schisandra sphenanthera Triterpenoid Schisanlactone G

Azacitidine maintenance therapy for blastic plasmacytoid dendritic cell neoplasm allograft: A case report

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World Journal of Clinical Cases 2024年第1期12卷 136-141页

作者： li-li tao Hui-Ting Wen Zi-Yi Wang Juan Cheng li Zhao Department of Hematology The First Clinical Medical CollegeLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Hematology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare,highly invasive malignant *** is no universally accepted standard of care because of its rarity and the dearth of prospective *** is still challenging for some patients to achieve persistent clinical remission or cure,despite the success of allogeneic hematopoietic stem cell transplantation(allo-HSCT),indicating that there is still a significant recurrence *** report a case of prevention of BPDCN allograft recurrence by azacitidine maintenance therapy and review the relevant *** SUMMARY We report a 41-year-old man with BPDCN who was admitted to hospital due to skin sclerosis for>5 mo’*** was diagnosed by combined clinical assessment and laboratory *** diagnosis,the patients underwent induction consolidation chemotherapy to achieve the first complete remission,followed by bridging ***-transplantation,azacitidine(75 mg/m2 for 7 d)was administered as maintenance therapy,with repeat administration every 4–6 wk and appropriate extension of the chemotherapy *** 10 cycles,the patient has been disease free for 26 mo after *** assessments of bone marrow morphology,minimal residual disease,full donor chimerism,Epstein–Barr virus,and cytomegalovirus all yielded normal results with no abnormalities *** Azacitidine may be a safe and effective maintenance treatment for BPDCN following transplantation because there were no overt adverse events during the course of treatment.

关键词： Blastic plasmacytoid dendritic cell neoplasm Azacitidine Allogeneic hematopoietic stem cell transplantation Maintenance therapy Case report

Dexamethasone enhances invasiveness ofAspergillusfumigatus conidia and fibronectin expression in A549 cells

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Chinese Medical Journal 2013年第17期126卷 3289-3294页

作者： li tao li Jing-chao QI Qian li Yu Department of Respiratory Medicine Qilu Hospital of Shandong University Jinan Shandong 250012 China

Background The efficacies of current treatments for invasive aspergillus （IA） are unsatisfactory and new therapeutic targets or regimens to treat IA are urgently needed. Previous studies have indicated that the ability of conidia to invade host cells is critical in IA development and fibronectin has a hand in the conidia adherence process. In the clinical setting, many patients who receive glucocorticoid for extended periods are susceptible to Aspergillus fumigatus （A. fumigatus） infection, for this reason we investigated the effect of glucocorticoid on conidia invasiveness by comparing the invasiveness of A. fumigatus conidia in the type II human alveolar cell line （A549） cultured with different concentrations of dexamethasone. We also explored the relationships between dexamethasone and fibronectin expression. Methods Following culture with anti-fibronectin antibodies and/or dexamethasone, type II human alveolar A549 cells were infected with conidia of A. fumigatus. After 4 hours, the extracellular free conidia were washed away and the remaining immobilized conidia were released using Triton-X 100 and quantified by counting the colony-forming units. The invasiveness of conidia was measured by calculating the invasion rate （%）. The transcription of the fibronectin gene in cells cultured with different concentrations of dexamethasone for 24 hours was tested by fluorogenic quantitative RT-PCR while the expression of fibronectinin cells cultured for 48 hours was tested by Western blotting and immunocytochemistry. Results A significant reduction in the invasiveness of conidia was seen in the cells cultured with anti-fibronectin antibody （（14.42±1.68）% vs. （19.17±2.53）%, P 〈0.05）, but no significant difference was observed in cells cultured with a combination of anti-fibronectin antibody and dexamethasone （6.37×10^-5 mol/L）. There was no correlation between the dexamethasone concentration and the invasiveness of conidia after dexamethasone pretreatment of cells for 4 ho

关键词： Aspergillus fumigatus conidia invasiveness dexamethasone fibronectin

IONIC CONDUCTIVITY AND CATALYTIC PERFORMANCE OF A2BO4/La2O3 CATALYSTS FOR OXIDATIVE COUPliNG OF METHANE

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Journal of Energy Chemistry 1993年第3期 203-211页

作者： BI Ying-li XIA Xin-Rui li li-tao ZHEN Kai-Ji Department of Chemistry, Jilin University Changchun, Jilin 130023

A series of La2O3cartalysts modified by A2BO4compounds with supe-rionic conductivity were prepared. It was observed that the addition of A2BO4compounds to La2O3enhances C2yields, and the C2yields over the modified cat-alysts are intimately related with their conductivities. The effects of A2BO4compounds on the conductivity and catalytic performance were discussed. Onlywhen ion A has high conductivity, can the catalyst show good catalytic perfor-mance. A mechanism for interpreting the significant effects of alkali metals wasproposed.

关键词： IONIC CONDUCTIVITY AND CATALYTIC PERFORMANCE OF A2BO4/La2O3 CATALYSTS FOR OXIDATIVE COUPliNG OF METHANE BO La

Impact of Antiretroviral Therapy on the Spread of Human Immunodeficiency Virus in Chaoyang District, Beijing, China： Using the Asian Epidemic Model

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Chinese Medical Journal 2017年第1期130卷 32-38页

作者： li-li tao Min liu Shu-Ming li Jue liu Shu-lin Jiang li-Juan Wang Feng-Ji Luo Ning Wang Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China Department of STD and AIDS Prevention and Control Beijing Chaoyang District Centre for Disease Control and Prevention Beijing 100021 China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

Background： Successful antiretroviral therapy （ART） has been demonstrated to be effective in reducing the infectivity of human immunodeficiency virus （HIV）. We conducted a study to predict the potential effect of ART on the spread of HIV in Chaoyang District, Beijing, China, using the Asian Epidemic Model （AEM）. Methods： The AEM baseline workbook was used to determine the current infection status and to project the future spread of HIV under current conditions. We changed the input on the ART coverage from 2014 to 2025 and also modified the treatment eligibility in the AEM intervention workbook, in order to allow for analysis of the projected downstream impact of ART. Results： By gradually increasing the ART coverage rate from 29.7% （rate of 2013） to 40.0%, 50.0%, 60.0%, 70.0%, 80.0%, and 90.0% （at CD4＋ ≤350 cells/μl）, and by changing the dates of coverage from 2014 to 2020, the number of new infections showed a cumulative decline of 0.60%, 1.59%, 2.94%, 5.33%, 9.32%, and 14.98%, respectively. After 2020, the projected rates of infection rebounded slightly, so with the exception of the years with very high coverage （90.0%）, new infections continued to decrease. When we changed the initial threshold of therapy to CD4＋ cell counts ≤500 cells/μl, new infections decreased 6.00%, 11.64%, 15.92%, 21.11%, 26.92%, 33.05%, and 38.75%, respectively, under varying ART coverages. Conclusion： Our study demonstrates that the early initiation of ART for people living with HIV/acquired immune deficiency syndrome （AIDS） has a positive effect in slowing the spread of HIV.

关键词： Antiretroviral Therapy Asian Epidemic Model Human Immunodeficiency Virus Impact Transmission