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Fracture spacing behavior in layered rocks subjected to different driving forces： a numerical study based on fracture infilling process

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Frontiers of Earth Science 2014年第4期8卷 472-489页

作者： lianchong li Shaohua li Chun'an tang School of Civil Engineering Dalian University of Technology Dalian 116024 China

Natural layered rocks subjected to layerparallel extension typically develop an array of opening- mode fractures with a remarkably regular spacing. This spacing often scales with layer thickness, and it decreases as extension increases until fracture saturation is reached. To increase the understanding of how these opening-mode fractures form in layered rocks, a series of 2D numerical simulations are performed to investigate the infilling process of fractures subjected to different driving forces. Numerical results illustrate that any one of the following could be considered as a driving force behind the propagation of infilling fractures： thermal effect, internal fluid pressure, direct extension loading, or pure compressive loading. Fracture spacing initially decreases with loading process, and at a certain ratio of fracture spacing to layer thickness, no new fractures nucleate （saturated）. Both an increase in the opening of the infilled fractures and interface delamination are observed as mechanisms that accommodate additional strain. Interface debonding stops the transition of stress from the neighboring layers to the embedded central layer, which may preclude further infilling of new fractures. Whatever the driving force is, a large overburden stress and a large elastic contrast between the stiff and soft layers （referred to as a central or fractured layer and the top and bottom layers） are key factors favoring the development of tensile stress around the infilled fractures in the models. Fracture spacing is expected to decrease with increasing overburden stress. Numerical results highlight the fracturing process developed in heterogeneous and layered sedimentary rocks which provides supplementary information on the stress distribution and failure-induced stress redistribution., It also shows, in detail, the propagation of the fracture zone and the interaction of the fractures, which are impossible to observe in field and are difficult to consider with static st

关键词： opening-mode fractures fracture spacing,driving force numerical simulation heterogeneity

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SNMS: an intelligent transportation system network architecture based on WSN and P2P network

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 65-70页

作者： li li liU Yuan-an tang Bi-hua Wireless Center Beijing University of posts and TelecommunicationsBeijing 100876 China

With the development of city road networks, the question of how to obtain information about the roads is becoming more and more important. In this article, sensor network with mobile station （SNMS）, a novel two-tiered intelligent transportation system （ITS） network architecture based on wireless sensor network （WSN） and peer-to-peer （P2P） network, is proposed to provide significant traffic information about the road and thereby, assist travelers to take optimum decisions when they are driving. A detailed explanation with regard to the strategy of each level as well as the design of two main components in the network, sensor unit （SU） and mobile station （MS）, is presented. Finally, a representative scenario is described to display the operation of the system.

关键词： SNMS WSN P2E SU MS

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Validation And Reliability of Distress Thermometer in Chinese Cancer Patients

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Chinese Journal of Cancer Research 2011年第1期23卷 54-58页

作者： li-li tang Ye-ning Zhang Ying Pang Hai-wei Zhang li-li Song Key laboratory of Corcinogenesis and Translational Research (Ministry of Education) Department of Psycho-OntologyPeking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective：To examine the validation and reliability of the distress thermometer（DT） recommended by National Comprehensive Cancer Network（NCCN） in Chinese cancer ***：A total of 574 Chinese cancer patients from Beijing Cancer Hospital completed the detection of DT,the Hospital Anxiety and Depression Scale（HADS） and Symptom Checklist 90（SCL-90）,Receiver Operating Characteristic（ROC） curve and Area Under the Curve（AUC） were used to analyze the validation relative to HADS and *** patients with DT≥4 and whose distress caused by emotional problems were interviewed with the MiNi International Neuro-psychiatric Interview（MINI）（Chinese Version 5.0）.This version was used to analyze cancer patients＇ psychological and Psychiatric symptoms during the cancer process;*** 106 cancer patients in rehabilitation stage and stable condition were asked to fill in DT two times,at the base time and after 7-10 ***：Data of ROC indicates that a DT cutoff score of 4 yielded AUC of 0.80 with a optimal sensitivity（0.80） and specificity（0.70） relative to HADS,and AUC of 0.83 with the greatest sensitivity（0.87） and specificity（0.72） against *** DT also has acceptable test-retest reliability（r=0.800,P=0.000）;According to the interview results,the most common psychiatric problems cancer patients have adjustment disorder,depression,and ***：The data suggest that DT has acceptable overall accuracy and reliability as a screening tool for testing distress severity and specific problems causing distress in Chinese cancer *** is worth being used in oncology clinic,the rapid screening and interview could help caregivers to identify psychological and psychiatric problems of cancer patients and provide useful information for further treatment.

关键词： Validation Reliability Cancer patients Distress thermometer

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Ultrastructural changes in the optic nerve and capillary vessels during early stages of optic nerve injury

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Neural Regeneration Research 2008年第9期3卷 995-999页

作者： Xuehong Ju Xiuyun li Xiaoshuang li Hongtao tang Hongguo liu Department of Anatomy Weifang Medical College Weifang 261042 Shandong Province China

BACKGROUND： Capillaries are the only blood supply for optic nerves, which makes the system more vulnerable to impaired blood circulation. OBJECTIVE： To observe the ultrastructural changes in the optic nerves and capillaries in rabbits following intracanalicular segment injury to the optic nerve. DESIGN, TIME AND SETTING： Comparative, observational, pathological morphology was performed at the Department of Anatomy, Weifang Medical College from September to November 2007. MATERIALS： Models of intracanalicular segment injury to the optic nerve were induced in the right eye of thirty healthy, adult rabbits by a free-falling metal cylinder. The H-7500 transmission electron microscope was provided by Hitachi, Japan. METHODS： All rabbits were randomly assigned into experimental （n = 25） and control （n = 5） groups. Optic nerve specimens were obtained from the experimental group at 0.5, 6, 12, 48, and 96 hours, respectively, following injury. Ultrastructural changes to the optic nerves and their capillaries were observed by electron microscopy. Optic nerve injury was not established in the control group, but optic nerve specimens were collected similarly to the experimental group. MAIN OUTCOME MEASURES： Ultrastructural changes in the injured optic nerves and their capillaries. RESULTS： Thirty rabbits were included in the final analysis. In the control group, cross-sections of the optic nerves exhibited varied thicknesses with regularly arranged fibers. The axons appeared to be smooth with condensed myelin sheaths and oval mitochondria. The microtubules and microfilaments were clearly seen. The lumens of the capillaries were regular with densely arranged endothelial cells and visible mitochondria. In the experimental group, 30 minutes after injury to the optic nerves, swollen axons, sparse myelin sheath, disordered microtubules and microfilaments, swollen mitochondria, and a decreased number of pinocytosis vesicles and microfilaments in endothelial cells of the capillaries w

关键词： capillary injury optic nerve ultrastructure

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Coordinated organogel templated fabrication of silver/polypyrrole composite nanowires

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Chinese Chemical Letters 2011年第1期22卷 123-126页

作者： Bo Tian li li Ming tang Kai Chen Yu Xia Xin Jin Laboratory of Advanced Materials Department of Chemical Engineering Tsinghua University Beijing 100084 China

A new method to fabricate metal/conducting polymer composite nanowires is presented by taking silver/polypyrrole composite nanowires as an example. A silver （D-coordinated organogel as template was prepared firstly, and redox-polymerization of pyrrole took place on the gel fiber, giving product of silver/polypyrrole nanowires. The silver/polypyrrole nanowires were characterized by multiple techniques. This strategy could be carried out in one-step procedure at room temperature, and it proves the utility of coordinated organogels in template synthesis of polymer nanostructures.

关键词： Coordinated organogel Template polymerization Polypyrrole Composite nanowires

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Theoretical Studies on Structures and Properties of Endohedral Fullerenes Complexes: XH_n@C_(32)(X=F, O, N, C; n=1―4)

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Chemical Research in Chinese Universities 2008年第2期24卷 220-222页

作者： CHANG Ying-fei HONG Bo SUN li-li tang Shu-wei WANG Rong-shun Institute of Functional Material Chemistry Faculty of Chemistry Northeast Normal University Changchun 130024 P R. China

Theoretical studies on structures and properties of endohedral fullerene complexes formed by encapsulating small molecules of HF, H20, NH3, and CH4 in a C32 fullerene cage, were carried out by ab initio method. Current calculations reveal that these processes to encase them in fullerene are energetically unfavorable because of the small cavity size of C32. The red shift in the F-H stretching frequency indicates the potential existence of hydrogen bonding between the HF molecule and the carbon cage.

关键词： Endohedral fullerene C32 Ab initio Stretching frequency Hydrogen bonding

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Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells

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Acta Pharmacologica Sinica 2005年第6期26卷 673-678页

作者： li-li tang, Rui WANG, Xi-can tang~2 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

Aim: To study the effects of huperzine A (HupA) on neuritogenic activity and the expression of nerve growth factor (NGF). Methods: After being treated with 10 μmol/L HupA, neurite outgrowth of PC 12 cells was observed and counted under phase-contrast microscopy. Mitogenic activity was assayed by [~3H]thymidine incorporation. Cell cytotoxicity was evaluated by lactate dehydrogenase (LDH) release. AChE activity, mRNA and protein expression were measured by the Ellman’s method, RT-PCR, and Western blot, respectively. NGF mRNA and protein levels were determined by RT-PCR and EliSA assays. Results: Treatment of PC 12 cells with 10 渭mol/L HupA for 48 h markedly increased the number of neurite-bearing cells, but caused no significant alteration in cell viability or other signs of cytotoxicity. In addition to inhibiting AChE activity, 10 渭mol/L HupA also increased the mRNA and protein levels of this enzyme. In addition, following 2 h exposure of the astrocytes to 10 渭mol/L HupA, there was a significant up-regula-tion of mRNA for NGF and P75 low-affinity NGF receptor. The protein level of NGF was also increased after 24 h treatment with HupA. Conclusion: Our findings demonstrate for the first time that HupA has a direct or indirect neurotrophic activity, which might be beneficial in treatment of neurodegenerative disorders such as Alzheimer disease.

关键词： huperzine A nerve growth factor neurite outgrowth: acetylcholinesterase inhibitors

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An infertile man with gynecomastia caused by a novel mutation of the androgen receptor gene

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Asian Journal of Andrology 2015年第3期17卷 509-510页

作者： Hui-Ying Xu Cheng-Di li li-li tang ling-ling Wang Xia YU Xue-Mei Gu Xiang-Yang lin Bi-Cheng Chen Clinical Laboratory Diagnostic Centre The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China Department of Urology The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China Department of Pathology The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China Department of Surgery Wenzhou Key Laboratory of Surgery The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China

Dear Editor, We present here a rare case that an infertile man had gynecomastia for 8 years, which might be caused by a novel mutation （c. 728 T 〉 G） found in the transactivation domain （TAD） of androgen recept... 详细信息

关键词： @@

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Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo li Fu tang Jingkai Zhang Yuetong Kang Hean Zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

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Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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