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Effect of high cholesterol diet on spatial learning and memory in a rat model of Alzheimer’s disease

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Neural Regeneration Research 2008年第5期3卷 478-481页

作者： Chuanqin Fang Huadong Zhou Jingcheng li Jing li meng Zhang Yanjiang Wang ChangyueGao Juan Deng Department of Neurology Institute of Field Surgery Daping Hospital Third Mifitary Medical University of Chinese PLA Chongqing 400042China

BACKGROUND： Recently study indicates a potentially important link between cholesterol, Aβ deposit, and clinicopathological manifestation of Alzheimer＇s disease （AD）. OBJECTIVE： To study the effect of high cholesterol diet on cognitive function and neuronal loss of hippocampal dentate gyrus in AD model rats. DESIGN, TIME AND SETTING： A randomized controlled animal study, which was performed in the Laboratory of Stem Cells, Department of Pathology, Third Military Medical University of Chinese PLA from February 2006 to March 2007. MATERIALS： Twenty healthy, male, Wistar rats, aged 3-4 months and weighing （300 ± 20） g, were selected for this study. A β 1- 40 was provided by Sigma Company, USA. Standard diet and high cholesterol diet mixed with cholesterol （5%）, sodium hypocholic acid （1%）, lard （10%）, and ordinary rat food （84%） were provided by Experimental Animal Center, Institute of Field Surgery, Daping Hospital, Third Military Medical University of Chinese PLA. METHODS： Rats were fed on high cholesterol diet or standard diet for eight successive weeks. Then, rats were randomly divided into cholesterol diet ＋A β, high cholesterol diet ＋ phosphate buffered saline（PBS）, standard diet ＋ A β, and standard diet ＋ PBS group, with five rats in each group. AD rat models were established by local injection of A β 1-40 solution （10 μ L） into the hippocampal dentate gyrus. Rats in the control group were injected with the same volume of PBS. After injection, rat were fed for two weeks MAIN OUTCOME MEASURES： Neuronal cells in the hippocampal dentate gyrus were detected by Nissl staining; spatial navigation and spatial probe were detected by Morris water maze to reflect learning and memory. RESULTS： Twenty rats were included in the final analysis, without any loss. （1） Neuronal numbers： neuronal loss in the high cholesterol diet ＋ A β and standard diet ＋ A β groups was significantly higher than in the PBS groups （P 〈 0.01）. In particular, loss of pyramidal cells in the high chole

关键词： cholesterol diet Alzheimer's disease cognitive function

Electrochemical detection of human ferritin based on gold nanorod reporter probe and cotton thread immunoassay device

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Chinese Chemical Letters 2017年第2期28卷 226-230页

作者： Ting-Ting Song Wei Wang li-li meng Yan liu Xiao-Bo Jia Xun Mao Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry & Materials Science Northwest University Xi'an 710127 China Center of Analysis Guangdong Medical College Dongguan 523808 China

In this study,a natural cotton thread immunoassay device combined with gold nanorod（GNR） reporter probe is developed for the rapid,sensitive and quantitative electrochemical determination of human ferritin,a lung cancer related *** ferritin as an analyte and a pair of monoclonal antibodies are used to demonstrate the proof-of-concept on the cotton thread immunoassay *** enhancement of the sensitivity is achieved by using gold nanorod as an electroactive report probe compared with a traditional gold nanoparticle（GNP） report *** device was capable of measuring 1.58 ng/mL ferritin in 30 min by anodic stripping voltammetry（ASV） testing,which meet the requirement for clinical diagnosis.

关键词： Cotton thread immunoassay device Gold nanorod reporter probe Point-of-care diagnosis Protein detection Electrochemical immunoassay

Nondestructive determination of paper properties of Populus × euramericana with near infrared spectroscopy

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Forestry Studies in China 2013年第3期15卷 246-252页

作者： Yan YANG Shu-Yuan HUO Chun-li YAO li-li meng College of Material Science and Technology Beijing Forestry University

Five Populus x euramericana wood samples representing three different sites were selected and nearinfrared （NIR） spectra were obtained. For these sections, basis weight, brightness and three mechanical properties （tensile index, tearing index and bursting index） were determined by standard analytical methods. Calibrations were developed for each paper property using the NIR spectra, data on paper properties, using partial least squares （PLS） regression. The results show that the coefficients of correlation of calibration and validation for basis weight were 0.8824 and 0.8299, respectively; the standard error of calibration （SEC） and prediction （SEP） were 1.150 and 1.170, respectively. In testing for brightness, the correlation coefficient of calibration was 0.9621 and for validation 0.9612, while the SEC and SEP were 0.997 and 1.300, respectively; paper brightness and NIR spectroscopy were highly correlated. NIR spectroscopy can be used to predict tensile, tearing and bursting indices of paper samples rapidly. We found that the paper properties fitted by NIR and GB methods were highly correlated. The coefficients of correlation of calibration and validation for basis weight exceeded 0.8000, while the SEC and SEP were very small. These results reveal that the five paper properties of Populus x euramericana and those predicted by the NIR model were highly correlated. We conclude that the NIR models can be used for the prediction of paper properties.

关键词： near infrared spectroscopy Populus x euramericana paper properties

Composition and bioactivity of secretion from Stauronematus compressicornis (Fabricius)

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Forestry Studies in China 2009年第2期11卷 122-126页

作者： ZHAO Xiao-dan meng Qing-ling YU li-zheng li meng-lou Forestry Entomology Laboratory of Academic Forestry Northwest A＆F University Yangling 712100 P. R. China

We analyzed the composition and studied the bioactivity of secretion from the poplar sawfly, Stauronematus compressicornis （Fabricius）. A leaf-sandwich method was applied to test the bioactivity of the secretion. Coomassie brilliant blue, gas chromatography （GC） and other methods were used to analyze and carry out protein assays, amino acid analyses, fatty acid and cholesterol detection of the secretion. Results show that the secretion had a significant antifeeding effect on 4th instar larvae of the armyworm （Pseudaletia separata Walker）. Dissolved in 0.27 mol.L^-1 HCl, 0.1 mol.L^-1 NaOH and 0.05 mol.L^-1 Na2HPO4 separately, the secretions had antifeeding rates ranging from 22.7% to 49.6%. Meanwhile, the weights of the secretion-treated insects were significantly lower than those of the control. Biochemical detection showed that the proteins contained in the secretion were composed of 16 amino acids. The secretion also contained small amounts of cholesterol and fatty acids, which included lauric acid, myristic acid, myristoleic acid, seventeen carbonic acids and oleic acid.

关键词： Stauronematus compressicornis (Fabricius) secretion composition bioactivity antifeeding rate

LONG-TERM OBSERVATION FOR OSSEOINTEGRATION OF CALCIUM PHOSPHATE SOL-GEL COATING ON Ti-6Al-4V IMPLANTS

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Chinese Medical Sciences Journal 2007年第3期22卷 183-186页

作者： Cheng Yang Yuan-ying li li-e meng Jing-xin Chen Yi Huang Stomatology Center Union Hospital Tongji Medical College Huazhong University of Science ＆ Technology Wuhan 430022

Objective To observe the long-term impact of calcium phosphate （CaP） sol-gel coating on bone growth around porous-surfaced implant. Methods The porous-surfaced Ti-6Al-4V implants were prepared with the addition of a thin film of CaP sol-gel coating, and implanted into the tibiae of 8 rabbits, each with two implants. Implanted sites were allowed to heal for 2, 8, 12, and 24 weeks, after which specimens were obtained for scanning electron microscope analysis using the freezefracture technique. Results The sol-gel coated implants recovered by freeze-fracture technique showed extensive bone growth from the endosteum along the implant surface. The bone was in direct contact with the CaP layer. The cement line-like layer was clearly demonslxated to be an intervening electron dense afibrillar layer between the CaP coat and the overlying newly deposited bone. The stability and osseointegration of the porous-surfaced implants seemed not to be affected by the osteoclastic resorption of CaP layer occurred during 24 weeks of healing. Conclusion Based on the findings in the long-term observation, the addition of a thin layer of CaP promotes an extensive osseointegrated interface between the porous-surfaced Ti-6Al-4V implants and the newly deposited bone.

关键词： calcium phosphate sol-gel implant osteoconduction scanning electron microscopy

“Treat and repair”therapy for giant patent ductus arteriosus complicated with pulmonary embolism

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Journal of Geriatric Cardiology 2023年第12期20卷 890-894页

作者： Jian-Ming WANG li-li meng Jia-Wang XIAO Zhong-Chao WANG Jing-Song GENG Qi-Guang WANG Department of Congenital Heart Disease General Hospital of Northern Theater CommandShenyangChina

Patent ductus arteriosus(PDA)is one of the most common congenital heart defects,accounting for 5%-10%of congenital heart diseases.[1]Its combination with pulmonary embolism(PE)is extremely rare,and there are few relevant *** giant PDA complicated with PE is prone to pulmonary hypertension(PH),which will significantly increase the right heart load,right ventricle hypertrophy,and result in clinical escape diagnosis or misdiagnosis.

关键词： ductus diagnosis congenital

Flow stress equation for multipass hot-rolling of aluminum alloys

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Journal of Central South University of Technology 2001年第1期8卷 13-17页

作者： ZHANG Hui,PENG Da shu,YANG li bin,meng li ping (Department of Materials Science and Engineering, Central South University, Changsha 410083, China) Department of Materials Science and Engineering Central South University Changsha China

A series of simple axisymmetric compression tests were carried out on the computer servo controlled Gleeble 1 500 machine when strain rates ranged between 0.05 25 s -1 and deformation temperature 300 500 ℃. The results show that flow stress is related to the Zener Hollonom parameter Z and strain, as well as the static recrystallization fraction between passes during multipass hot deformation of 5182 aluminum alloy. Hence, a modified exponential flow stress equation was presented by considering the values of ln A and β as functions of strain, and by using the uniform softening method and incorporating the static recrystallization fraction between passes to consider the effects of residual strain during multipass hot rolling of 5182 aluminum alloy. The validity of the equation was examined by a typical non isothermal multipass deformation test.

关键词： aluminum alloy multipass hot rolling flow stress equation

Regulation of leptin in involution of mammary gland

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Journal of Northeast Agricultural University(English Edition) 2007年第4期14卷 345-348页

作者： li meng li Qingzhan Key Laboratory of Dairy Science of Ministry of Education Northeast Agricultural University Harbin 150030 China

Leptin, a protein hormone produced and secreted predominantly by white adipose tissue, has a critical role in the regulation and coordination of energy metabolism. Leptin is produced in the mammary gland by the fat tissue or by the mammary epithelium. In vitro study has shown that leptin triggers apoptosis in mammary epithelial cells. Mammary gland involution is characterized by extensive apoptosis of the epithelial cells. At the onset of involution, STAT3 is specifically *** studies show that leptin act as a paracrine and autocrin factor to influence mammary epithelial cell proliferation and differentiation. This paper reviewed the function of leptin to the involution of mammary gland.

关键词： involution leptin mammary gland

鲁迅精神观照下的少数民族文化传承和发展研究

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贵州民族研究 2016年第3期37卷 100-103页

作者：李莉萌山东大学(威海) 山东威海264209

社会转型发展中少数民族文化的传承发展必须要有先进的文化精神来引领,鲁迅精神是我国文化精神的一面旗帜,鲁迅的文化自觉、独立自由、民族情怀及文化创新、社会批判等精神,对于民族文化传承发展中的困惑和纠结等问题都有突出的引领和... 详细信息

社会转型发展中少数民族文化的传承发展必须要有先进的文化精神来引领,鲁迅精神是我国文化精神的一面旗帜,鲁迅的文化自觉、独立自由、民族情怀及文化创新、社会批判等精神,对于民族文化传承发展中的困惑和纠结等问题都有突出的引领和指导意义,只有秉承以上鲁迅精神,才能促使民族文化更好地传承,并推进民族文化的繁荣发展。

关键词：鲁迅精神少数民族文化传承