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Human immunodeficiency virus-associated dementia complex with positive 14-3-3 protein in cerebrospinal fluid:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2065-2073页

作者： Yun-Sen He Xiao-Hong Qin Min Feng Qin-Jiang Huang Meng-Jun Zhang li-li guo Ming-Bin Bao Ye Tao Hong-Yuan Dai Bo Wu Department of Neurosurgery Sichuan Lansheng Brain Hospital&Shanghai Lansheng Brain Hospital Investment Co.Ltd.Chengdu 610036Sichuan ProvinceChina Department of Psychiatry Sichuan Provincial Center for Mental HealthChengdu 610072Sichuan ProvinceChina Department of Geriatrics Municipal People’s Hospital in LuzhouLuzhou 646000Sichuan ProvinceChina Department of Neurosurgery Wenjiang District People’s Hospital of ChengduChengdu 611100Sichuan ProvinceChina Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China ChengduChengdu 610072Sichuan ProvinceChina Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-associated dementia(HAD)is a subcortical form of dementia characterized by memory deficits and psychomotor ***,HAD often presents with symptoms similar to those of Creutzfeldt-Jakob disease(CJD),particularly in patients with acquired immune deficiency syndrome(AIDS).CASE SUMMARY We report the case of a 54-year-old male who exhibited cognitive dysfunction and secondary behavioral changes following HIV infection and suspected prion *** patient was diagnosed with HIV during hospitalization and his cerebrospinal fluid tested positive for 14-3-3 *** electroencephalogram showed a borderline-abnormal periodic triphasic wave ***-enhanced magnetic resonance imaging revealed moderate encephalatrophy and ***,symptomatic treatment and administration of amantadine were pursued for presumed CJD,but the patient’s condition continued to *** contrast,the patient’s condition improved following anti-HIV *** individual is also the only patient with this prognosis to have survived over 4 ***,the diagnosis was revised to *** In the diagnostic process of rapidly progressive dementia,it is crucial to rule out as many potential causes as possible and to consider an autopsy to diminish diagnostic *** 14-3-3 protein should not be regarded as the definitive marker for *** laboratory screening for infectious diseases is essential to enhance diagnostic precision,especially in AIDS patients with potential ***,a trial of diagnostic treatment may be considered when additional testing is not feasible.

关键词： HIV-associated dementia Cognitive dysfunction Creutzfeld-Jakob disease Rapidly progressive dementia Case report

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世界高等教育中心转移机制分析

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清华大学教育研究 2024年第1期45卷 39-49页

作者：李立国中国人民大学教育学院北京100872

16世纪以来,全球先后形成了意大利、英国、法国、德国、美国5个科学和人才中心。世界科学中心、高等教育中心是周期性转移的。转移的时机、机制与关键组织变革是高等教育中心转移的核心要素。从转移的时机看,科学发展、技术变革与工业... 详细信息

16世纪以来,全球先后形成了意大利、英国、法国、德国、美国5个科学和人才中心。世界科学中心、高等教育中心是周期性转移的。转移的时机、机制与关键组织变革是高等教育中心转移的核心要素。从转移的时机看,科学发展、技术变革与工业化为高等教育中心转移提供了历史条件。世界高等教育中心转移的机制是高等教育机构的新设置或者创新性改造,高等教育机构依技术变革与工业化做出相应创新,学术组织化程度的提高是实现高等教育中心转移的关键组织变革。高等教育需要及时有效回应外部环境的挑战与机遇,及时有效实施组织变革与制度创新,才能抓住机会窗口,成为世界高等教育中心。

关键词：世界高等教育中心科学中心技术革命工业化高等教育机构学术组织化

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优化资源布局与高等教育强国建设

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大学教育科学 2024年第1期 14-20页

作者：李立国李建龙中国人民大学教育学院北京100872 中国人民大学教育部教育发展与公共政策研究中心北京100872 中国人民公安大学教务处北京100038 北京理工大学北京100038

面向建设高等教育强国的目标,在资源布局与优化方面,我国要扩大高等教育资源总量供给,促进优质高等教育资源扩容,提高高等教育资源投入效益。在教育经费投入难以大规模增长、学龄人口可能逐年下降,且高等教育已经实现普及化的背景下,资... 详细信息

面向建设高等教育强国的目标,在资源布局与优化方面,我国要扩大高等教育资源总量供给,促进优质高等教育资源扩容,提高高等教育资源投入效益。在教育经费投入难以大规模增长、学龄人口可能逐年下降,且高等教育已经实现普及化的背景下,资源布局优化的重点应该放在如何促进高等教育结构优化与质量提高,适应、促进和引领经济社会发展上。具体来说,为了实现高等教育强国建设目标,我国当前应着力优化高等教育人才培养结构,提升研究生人才培养能力;扩大优质高等学校数量和布局,积极扩大“双一流”高校人才培养规模;加快高等教育集聚发展,适应建设世界重要人才中心和创新高地的新要求;加快学科专业优化调整,适应经济发展与产业结构转型升级需求。

关键词：资源布局优化高等教育强国 “双一流”高校学科专业优化高等教育集聚发展

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Targeted metabolomics study of fatty-acid metabolism in lean metabolic-associated fatty liver disease patients

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World Journal of Gastroenterology 2024年第27期30卷 3290-3303页

作者： Pei-Qi Sun Yi-Fu Yuan Qin Cao Xiao-Yan Chen Yuan-Ye Jiang Wen-Min Dong li-li guo Department of Gastroenterology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China Department of Pharmacy Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Central Laboratory Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China

BACKGROUND The annual incidence of metabolic-associated fatty liver disease(MAFLD)in China has been increasing and is often overlooked owing to its insidious *** 50%of the patients have a normal weight or are not *** are said to have lean-type MAFLD,and few studies of such patients are *** MAFLD is associated with abnormal lipid metabolism,lipid-targeted metabolomics was used in this study to provide experimental evidence for early diagnosis and *** and analyze metabolic ***-Q-Orbitrap/MS content determination was used to determine serum palmitic acid(PA),oleic acid(OA),linoleic acid(LA),and arachidonic acid(AA)levels in lean-type MAFLD *** Urea nitrogen and uric acid levels were higher in lean-type MAFLD patients than in healthy individuals(Plinesterase levels were higher in lean-type MAFLD patients than in healthy indi-viduals(Plipoprotein and apolipoprotein A-1 were lower in lean-type MAFLD patients than in healthy individuals(Plism of fatty acids were found with P*** levels of PA,OA,LA,and AA were significantly increased compared with healthy *** The metabolic profiles of lean-type MAFLD patients and healthy participants differed significantly,yielding 65 identified ***,OA,LA,and AA exhibited the most significant changes,offering valuable clinical guidance for prevention and treatment of lean-type MAFLD.

关键词： Lean-type metabolic-associated fatty liver disease Targeted serum metabolomics Fatty acids Principal component analysis Orthogonal partial least squares-discriminant analysis©The Author(s)2024.Published by Baishideng Publishing Group Inc.All rights reserved.

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城市群高等教育资源配置优化与世界重要人才中心和创新高地建设

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高等教育研究 2024年第2期45卷 1-12页

作者：李立国田浩然中国人民大学教育学院北京100872

城市群是建设人才中心和创新高地的载体。以珠三角、长三角、京津冀、长江中游和成渝城市群为对象研究发现,我国高等教育资源配置跟不上城市群及区域经济、区域创新的发展要求,跟不上城市群内部经济及创新的调整步调;优质高等教育资源... 详细信息

城市群是建设人才中心和创新高地的载体。以珠三角、长三角、京津冀、长江中游和成渝城市群为对象研究发现,我国高等教育资源配置跟不上城市群及区域经济、区域创新的发展要求,跟不上城市群内部经济及创新的调整步调;优质高等教育资源发展跟不上城市群高等教育规模扩张;资源调配机制改革跟不上释放市场和地方活力的要求。为此,需构建以区域协同发展为主的资源配置模式,构建与经济社会及创新发展相适应的高等教育资源配置格局,注重集聚发展、优势发展及城市群内部资源配置协调。

关键词：城市群高等教育人才中心创新高地

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督脉扶阳灸联合温针灸治疗阳虚寒凝证膝骨性关节炎的临床研究

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川北医学院学报 2024年第3期39卷 337-340页

作者：吴杰李立国张莹莹马子荣阜阳市中医医院骨伤科二安徽阜阳236000 阜阳市中医医院针推二科安徽阜阳236000 阜阳市中医医院推拿科安徽阜阳236000

目的:探讨督脉扶阳灸联合温针灸治疗膝骨性关节炎(KOA)的疗效及对血清C反应蛋白(CRP)、红细胞沉降率(ESR)水平的影响。方法:选取72例KOA患者为研究对象,按照针灸治疗方式不同分为对照组和观察组,每组各36例。对照组患者予以温针灸治疗;... 详细信息

目的:探讨督脉扶阳灸联合温针灸治疗膝骨性关节炎(KOA)的疗效及对血清C反应蛋白(CRP)、红细胞沉降率(ESR)水平的影响。方法:选取72例KOA患者为研究对象,按照针灸治疗方式不同分为对照组和观察组,每组各36例。对照组患者予以温针灸治疗;观察组患者予以督脉扶阳灸联合温针灸治疗,疗程均为14 d。比较两组患者临床疗效、中医证候积分(TCMSS)、关节功能(WOMAC评分)、关节腔内积液厚度、滑膜厚度、血清CRP及ESR水平。结果:观察组治疗总有效率高于对照组(94.44%vs.77.78%,P<0.05)。治疗后,观察组患者TCMSS、WOMAC评分、膝关节关节腔内积液厚度、滑膜厚度、血清CRP及ESR水平均低于对照组(P<0.05)。结论:在温针灸基础上增加督脉扶阳灸治疗KOA,可提高临床疗效,缓解疼痛、僵硬症状,提高膝关节功能,减少关节腔内积液,改善滑膜炎性病变,降低血清CRP、ESR水平。

关键词：膝骨性关节炎督脉扶阳灸温针灸 C反应蛋白红细胞沉降率

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light People:*** Mazur speaks about ultrafast optics and education

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light(Science & Applications) 2024年第3期13卷 402-406页

作者： Chenzi guo Yang li Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina State Key Laboratory of Precision Measurement Technology and Instrument Department of Precision InstrumentTsinghua UniversityBeijingChina

*** Mazur is a great influencer over and beyond the optics *** a physicist,he is a pioneer of ultrafast optics and was one of the inventors of colliding-pulse mode-locked *** an educator,he not only gave talks to thousands,but also revolutionized teaching with his globally renowned methodology“Peer Instruction”.As a leader and entrepreneur,he co-founded several companies and was President of Optica(formerly the Optical Society)and currently is the Chair of the Optica ***,light:Science&Applications talked with *** Mazur about his opinions on research,education and *** full interview video can be found in the Supplementary File.

关键词： optics education companies

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A unified stochastic damage model for concrete based on multi-scale energy dissipation analysis

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Science China(Technological Sciences) 2024年第3期67卷 863-877页

作者： guo ChengGong li Jie College of Civil Engineering Tongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Shanghai 200092China

This work proposes a unified damage model for concrete within the framework of stochastic damage mechanics. Based on the micro-meso stochastic fracture model(MMSF), the nonlinear energy dissipation process of the microspring from nanoscale to microscale is investigated. In nanoscale, the rate process theory is adopted to describe the crack growth rate;therefore, the corresponding energy dissipation caused by a representative crack propagation can be obtained. The scale gap from nanoscale to microscale is bridged by a crack hierarchy model. Thus, the total energy dissipated by all cracks from the nanoscale to the microscale is gained. It is found that the fracture strain of the microspring can be derived from the above multi-scale energy dissipation analysis. When energy dissipation is regarded as some microdamage to the microspring, the constitutive law of the microspring is no longer linearly elastic, as previously assumed. By changing the expression of the damage evolution law from fracture strain to energy dissipation threshold, the new damage evolution model is derived. The proposed model can not only replicate the original static model but also extend to cases of rate dependence. By deriving the fracture strain under different strain rates, the rate sensitivity of concrete materials can be reflected. The model parameters can be conveniently obtained by identifying them with experimental data. Finally, several numerical examples are presented to verify the proposed model.

关键词： concrete damage model stochastic damage rate dependent energy dissipation

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Stable graphene oxide-based lyotropic liquid crystals for interfacial lubrication

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Friction 2024年第5期12卷 954-967页

作者： Yumei guo Hanglin li Jiusheng li Xiangqiong ZENG Laboratory for Advanced Lubricating Materials Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai201210China University of Chinese Academy of Sciences Beijing100049China

Lyotropic liquid crystals have lubricating properties due to their ordered assembly and fluidity,whose mesogens are often characterized by amphiphilic *** the attention that graphene oxide(GO)has been studied as a novel amphiphilic lyotropic mesogen this decade,and GO applied as a lubrication additive has been demonstrated in both oil and water-based systems,little research reveals the interfacial lubrication of GO liquid crystals *** work reports that GO aqueous dispersion can form lyotropic liquid crystals above a specific critical concentration of 5.00 mg/mL,providing a form of stable water-based lubricant,which can keep stable for several months and can reduce friction by 37.3%and wear by 25.24%.The liquid crystal phase was verified by polarizing microscope and synchrotron radiation small-angle X-ray scattering,and its rheological properties and viscoelasticity were studied by interfacial *** formation of lyotropic liquid crystals can enhance the stability of GO aqueous dispersions at high density,simultaneously ensuring friction decrease and anti-wear *** is attributed to the stable nematic network by the ordered GO *** ordered assembly structure bears vertical shear force,therefore,reducing the *** is also assumed that the wide lateral size of graphene oxide promotes the nematic phase thus smoothes the graphene oxide film composed spontaneously under the coincidence of lamellar liquid crystal and 2D layered *** this work,the interlayer lubrication of GO was optimized,and the problem of GO dispersion sedimentation was solved by *** range of interfacial lubrication of GO aqueous dispersion has been expanded and the synergistic effect is conducive to the environmentally friendly lubricants.

关键词： lyotropic liquid crystal graphene oxide aqueous lubrication tribological behavior

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Predicting torsional capacity of reinforced concrete members by data-driven machine learning models

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 444-460页

作者： Shenggang CHEN Congcong CHEN Shengyuan li Junying guo Quanquan guo Chaolai li School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 211116China Jiangsu Key Laboratory Environmental Impact and Structural Safety in Engineering China University of Mining and TechnologyXuzhou 211116China China Nuclear Power Design Co.Ltd. Shenzhen 518031China School of transportation and science engineering Beihang UniversityBeijing 100191China China Construction First Group Corporation limited Beijing 100161China

Due to the complicated three-dimensional behaviors and testing limitations of reinforced concrete(RC)members in torsion,torsional mechanism exploration and torsional performance prediction have always been *** the present paper,several machine learning models were applied to predict the torsional capacity of RC *** results of a total of 287 torsional specimens were collected through an overall literature *** of extreme gradient boosting machine(XGBM),random forest regression,back propagation artificial neural network and support vector machine,were trained and tested by 10-fold cross-validation *** performances of proposed machine learning models were evaluated and compared,both with each other and with the calculated results of existing design codes,i.e.,GB 50010,ACI 318-19,and Eurocode *** results demonstrated that better predictive performance was achieved by machine learning models,whereas GB 50010 slightly overestimated the torsional capacity,and ACI 318-19 and Eurocode 2 underestimated it,especially in the case of ACI *** XGBM model gave the most favorable predictions with R^(2)=0.999,RMSE=1.386,MAE=0.86,andλ=***,strength of concrete was the most sensitive input parameters affecting the reliability of the predictive model,followed by transverse-to-longitudinal reinforcement ratio and total reinforcement ratio.

关键词： RC members torsional capacity machine learning models design codes

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