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Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22

World Journal of Gastroenterology 2017年第11期23卷 2002-2011页

作者： Ya-Hui Ni li-juan huo Ting-Ting li Department of Gastroenterology First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

AIM To explore the effect of interleukin(IL)-22 on in vitro model of alcoholic liver fibrosis hepatic stellate cells(HSCs), and whether this is related to regulation of *** HSC-T6 cells were incubated with 25, 50, 100, 200 and 400 μmol/L acetaldehyde. After 24 and 48 h, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was used to detect proliferation of HSCs to choose the best concentration and action time. We used the optimal concentration of acetaldehyde(200 μmol/L) to stimulate HSCs for 24 h, and treated the cells with a final concentration of 10, 20 or 50 ng/m L IL-22. The cell proliferation rate was detected by MTT assay. The cell cycle was analyzed by flow cytometry. The expression of nuclear factor-related factor(Nrf)2 and α-smooth muscle antigen was detected by western blotting and immunocytochemistry. The levels of malondialdehyde(MDA) and glutathione(GSH) were measured by spectrophotometry. RESULTS In the MTT assay, when HSCs were incubated with acetaldehyde, activity and proliferation were higher than in the control group, and were most obvious after 48 h treatment with 200 μmol/L acetaldehyde. The number of cells in G0/G1 phases was decreased and the number in S phase was increased in comparison with the control group. When treated with different concentrations of IL-22, HSC-T6 cell activity and proliferation rate were markedly decreased in a dosedependent manner, and cell cycle progression was arrested from G1 to S phase. Western blotting and immunocytochemistry demonstrated that expression of Nrf2 total protein was not significantly affected. Expression of Nrf2 nuclear protein was low in thecontrol group, increased slightly in the model group(or acetaldehyde-stimulated group), and increased more obviously in the IL-22 intervention groups. The levels of MDA and GSH in the model group were significantly enhanced in comparison with those in the control group. In cells treated with IL-22, the MDA level was attenuat

关键词： Interleukin-22 Alcoholic liver fibrosis Hepatic stellate cells Nrf2 Oxidative stress

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Review on the abiotic degradation of biodegradable plastic poly(butylene adipate-terephthalate):Mechanisms and main factors of the degradation

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Chinese Chemical Letters 2025年第1期36卷 158-164页

作者： Haibo Ye Qianyu li juan li Didi li Zhimin Ao Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health Guangzhou Key Laboratory Environmental Catalysis and Pollution ControlInstitute of Environmental Health and Pollution ControlGuangzhou 510006China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of EducationSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China School of Environment Beijing Normal UniversityBeijing 100875China

Poly(butylene adipate-terephthalate)(PBAT),as one of the most common and promising biodegradable plastics,has been widely used in agriculture,packaging,and other industries due to its strong biodegradability *** is well known that PBAT suffers a series of natural weathering,mechanical wear,hydrolysis,photochemical transformation,and other abiotic degradation processes before being ***,it is particularly important to understand the role of abiotic degradation in the life cycle of *** the abiotic degradation of PBAT has not been systematically summarized,this review aims to summarize the mechanisms and main factors of the three major abiotic degradation pathways(hydrolysis,photochemical transformation,and thermochemical degradation)of *** was found that all of them preferentially destroy the chemical bonds with higher energy(especially C-O and C=O)of PBAT,which eventually leads to the shortening of the polymer chain and then leads to reduction in molecular *** main factors affecting these abiotic degradations are closely related to the energy or PBAT *** findings provide important theoretical and practical guidance for identifying effective methods for PBAT waste management and proposing advanced schemes to regulate the degradation rate of PBAT.

关键词： Biodegradable plastics PBAT Abiotic degradation Degradation mechanism

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Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao liURui ZHENG liang DENG Jiahui ZHANG Wenzheng huo Jinlu HUANG li Shanghai Marine Diesel Engine Research Institute Shanghai 201108China National Key Laboratory of Marine Engine Science and Technology Shanghai 201108China Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm)and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC)with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT)imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： dual-orifice nozzle nozzle structure atomization spray flame asymmetry

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Sequence-activated chemiluminescence probes:programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang juan li Wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science&TechnologyShanghai 200237China

Sequence-activated chemiluminescence(CL)technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial *** fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest,thus enabling high-contrast signals under complex physiological *** sequential activation could be triggered by enzymes,reactive oxygen species(ROS),biothiols or changes in the *** unique sequence-activated CL probes bestow several advantages,including minimal background,deep-tissue penetration,and the ability of non-invasive or minimally invasive *** sequence-activated CL techniques represent a significant advancement in molecular imaging and *** this mini-review,we focus on the latest developments in sequential CL probes,addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide

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Removal of arsenic from water by silver nanoparticles and Fe-Ce mixed oxide supported on polymeric anion exchanger

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Journal of Environmental Sciences 2025年第5期151卷 540-549页

作者： li li Su-juan Yu Rong-gang Zheng Qing-cun li Rui liu Jing-fu liu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China University of Chinese Academy of Sciences Beijing 100049China Department of Ecology and Resources Engineering He Tao CollegeInner Mongolia 015000China

By encapsulating nanoscale particles of goethite(α-FeO(OH)),hydrous ceric oxide(CeO_(2)·H_(2)O,HCO)and silver nanoparticles(AgNPs)in the pores of polystyrene anion exchanger D201,a novel nanocomposite FeO(OH)-HCO-Ag-D201 was prepared for the effective removal of arsenic from *** isotherm study shows that FeO(OH)-HCO-Ag-D201 has excellent adsorption performance for As(III)and As(V),with an increased adsorption capacity of As(III)to 40.12 mg/g compared to that of 22.03 mg/g by the composite adsorbent without AgNPs(FeO(OH)-HCO-D201).The adsorption kinetics data showed that the sorption rate of FeO(OH)-HCO-Ag-D201 for As(III)is less than that for As(V),and the adsorption of As(III)and As(V)were consistent with the pseudo-second-order model and the pseudofirst-order model,*** or basic conditions are favored for the adsorption of As(III/V)by FeO(OH)-*** with nitrate/chloride/bicarbonate,sulfate/silicate/phosphate showed more remarkable inhibition of arsenic removal by FeO(OH)-HCO-Ag-D201,whereas natural organic matter showed no interference to the arsenic *** As(V)adsorption involved different interactions such as electrostatic attraction and surface complexation,while the adsorption of As(III)involved the part oxidization of As(III)to As(V)and the simultaneous adsorption of As(III)and As(V).In addition to the Ce(IV)in CeO_(2)·H_(2)O acted as an oxidant,the synergistic effect ofα-FeO(OH)and AgNPs also contributed to the oxidization of As(III)to As(V).Moreover,the reusable property suggested that this FeO(OH)-HCO-Ag-D201 nanocomposite has great potential for arsenic-contaminated water purification.

关键词： FeO(OH)-HCO-Ag-D201 Arsenic removal Synergistic effect Oxidation Electrostatic attraction Surface complexation

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The association of isocarbophos and isofenphos with different types of glucose metabolism:The role of inflammatory cells

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Journal of Environmental Sciences 2025年第1期147卷 322-331页

作者： Jintian Geng Dandan Wei Lulu Wang Qingqing Xu juan Wang Jiayu Shi Cuicui Ma Mengzhen Zhao Wenqian huo Tao Jing Chongjian Wang Zhenxing Mao Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Occupational and Environmental Health Sciences College of Public HealthZhengzhou UniversityZhengzhou 450001China School of Public Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation *** were 2701 participants in the case-control study,including 896 patients with T2DM,900 patients with IFG,905 subjects with *** isocarbophos and isofenphos concentrationsweremeasured using gas chromatography and triple quadrupole tandem mass *** linear models were used to calculate the relationships between plasma isofenphos and isocarbophos levels with inflammatory factor levels and *** cell was used as mediators to estimate the mediating effects on the above *** and isofenphos were positively related with T2DM after adjusting for other *** odds ratio(95%confidence interval)(OR(95%CI))for T2DM was 1.041(1.015,1.068)and for IFG was 1.066(1.009,1.127)per unit rise in *** prevalence of T2DM increased by 6.4%for every 1 unit more of ln-isofenphos(OR(95%CI):1.064(1.041,1.087)).Additionally,a 100%rise in ln-isocarbophos was linked to 3.3%higher ln-HOMA2IR and a 0.029 mmol/L higher glycosylated hemoglobin(HbA1c)(95%CI:0.007,0.051).While a 100%rise in ln-isofenphos was linked to increase in ln-HOMA2 and ln-HOMA2IR of 5.8%and 3.4%,***,white blood cell(WBC)and neutrophilic(NE)were found to be mediators in the relationship between isocarbophos and T2DM,and the corresponding proportions were 17.12%and 17.67%,*** and isocarbophos are associated with IFG and T2DM in the rural Chinese population,WBC and NE have a significant role in this relationship.

关键词： Isocarbophos Isofenphos Type 2 diabetes mellitus Inflammatory cells Mediation effect

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缬沙坦对肝硬化患者门静脉压力及肝纤维化指标的影响

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世界华人消化杂志 2009年第11期17卷 1139-1142页

作者：霍丽娟刘莹张锁娟山西医科大学第一医院消化科山西省太原市030001

目的:观察缬沙坦对肝硬化患者血流动力学指标及CGRP、HA、CG、PAI-1的影响.方法:肝硬化患者随机分为对照组和治疗组各18例,对照组给予常规治疗,治疗组在此基础上加用缬沙坦80mg/dpo,疗程1mo.治疗前后应用彩色多普勒超声仪检测门、脾静... 详细信息

目的:观察缬沙坦对肝硬化患者血流动力学指标及CGRP、HA、CG、PAI-1的影响.方法:肝硬化患者随机分为对照组和治疗组各18例,对照组给予常规治疗,治疗组在此基础上加用缬沙坦80mg/dpo,疗程1mo.治疗前后应用彩色多普勒超声仪检测门、脾静脉的内径与流速,同时采用放免法检测血CGRP、HA、CG的水平,酶联免疫法测定血PAI-1的水平.结果:缬沙坦可使门、脾静脉的内径减小,流速增快.缬沙坦亦可降低患者CGRP、HA、CG、PAI-1的水平(73.15±14.59ng/Lvs75.79±15.06ng/L,422.34±183.94μg/Lvs498.39±197.53μg/L,12.50±8.92mg/Lvs24.23±13.05mg/L,28.09±10.80μg/Lvs32.56±11.18μg/L,均P<0.05).结论:缬沙坦能够在一定程度上降低门静脉压力,同时具有一定的抗肝纤维化作用.

关键词：缬沙坦肝硬化血流动力学降钙素基因相关肽肝纤维化

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Enhancing performance of fullerene-based organic electrochemical transistors via side-chain engineering

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Nano Research 2025年第2期18卷 905-912页

作者： Wenxin Fang Zijie li Chengdong Wang Xiaowei Zhao Junyu li Gang Ye Fengwei huo li Qiu Yanxi Zhang Wei Huang Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Yunnan Key Laboratory of Electromagnetic Materials and Devices National Center for International Research on Photoelectric and Energy MaterialsSchool of Materials and EnergyYunnan UniversityKunming 650091China Sinopec Shanghai Research Institute of Petrochemical Technology Shanghai 201028China Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan 430062China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(NanjingTech)Nanjing 211800China Frontiers Science Center for Flexible Electronics MIIT Key Laboratory of Flexible Electronics(KLoFE)Northwestern Polytechnical UniversityXi'an 710072China

The performance of organic electrochemical transistors(OECTs)relies on the interaction between organic semiconductors and ***,hydrophilic ethylene glycol(EG)side chains are incorporated into organic semiconductors to improve the channel’s capacity to absorb ***,the EG substituted organic semiconductors tend to swell when immersed in aqueous electrolytes and exhibit microstructural changes induced by dopant *** our research,we introduce an alkyl spacer to create distance between the fullerene and EG *** approach is designed to reduce the negative effects of swelling and balance the ion and electron *** conducted an analysis of OECTs using four fullerene derivatives:no alkyl spacer,butyl,hexyl,and octyl *** OECTs based on fullerene derivatives with butyl and hexyl spacers exhibit enhanced transconductance(g_(m)=11.8 and 19.4 mS)compared to the ones without alkyl *** has also been observed that the butyl and hexyl spacers lead to a more than tenfold increase in volumetric *** increasing the alkyl spacer(octyl group)leads to no transistor *** study uncovers the relationship between alkyl spacers and the performance of OECTs based on fullerene *** will serve as a guideline for designing n-type small molecules for ***,we showcased the potential of utilizing OECTs based on these fullerene derivatives in cation sensing,which is promising for developing sweat sensors.

关键词： organic electrochemical transistors fullerene derivatives ethylene glycol side chains ion and electron conduction

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甘草酸二铵对溃疡性结肠炎大鼠的治疗作用

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世界华人消化杂志 2009年第4期17卷 399-404页

作者：霍丽娟郭海荣山西医科大学第一临床医学院消化内科山西省太原市030001

目的:观察甘草酸二铵(DG)对溃疡性结肠炎(UC)大鼠的治疗作用并探讨其可能的作用机制.方法:50只♂清洁级健康Wistar大鼠分为正常对照组,模型对照组,5-氨基水杨酸(5-ASA)组,DG组,5-ASA+DG组,每组10只.用2,4-二硝基氯苯+乙酸联合建模法制... 详细信息

目的:观察甘草酸二铵(DG)对溃疡性结肠炎(UC)大鼠的治疗作用并探讨其可能的作用机制.方法:50只♂清洁级健康Wistar大鼠分为正常对照组,模型对照组,5-氨基水杨酸(5-ASA)组,DG组,5-ASA+DG组,每组10只.用2,4-二硝基氯苯+乙酸联合建模法制备UC大鼠模型.观察疾病活动指数(DAI)、结肠黏膜组织学变化、髓过氧化物酶(MPO)及超氧化物歧化酶(SOD)活性,免疫组织化学法检测核因子-κB(NF-κB)及诱生型一氧化氮合酶(iNOS)表达.结果:与模型对照组相比,DG组和5-ASA组大鼠的DAI(3.30±1.34,3.20±1.14vs7.80±1.62,均P<0.01)、组织学损伤评分(1.88±0.34,1.84±0.21vs3.09±0.22,均P<0.01)、MPO活性(0.46±0.07,0.47±0.04vs0.61±0.04,均P<0.01)和结肠黏膜NF-κB(0.373±0.031,0.368±0.028vs0.517±0.028,均P<0.01)、iNOS(0.350±0.015,0.365±0.025vs0.487±0.021,均P<0.01)表达显著降低,SOD活性(19.83±3.36,20.27±2.44vs13.09±3.24均P<0.01)显著增高;DG联合5-ASA治疗组以上指标改善更明显(均P<0.01),且与正常对照组相比各指标间差异无统计学意义.DG组和5-ASA组相比上述各指标间差异也无统计学意义.结论:DG可有效治疗UC,其作用机制可能与抑制NF-κB活化、清除氧自由基、抗氧化损伤等有关.与5-ASA联用其治疗效果优于两者单独用药.

关键词：甘草酸二铵溃疡性结肠炎髓过氧化物酶超氧化物歧化酶核因子-κB 诱生型一氧化氮合酶

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Decellularized amniotic membrane promotes the anti-inflammatory response of macrophages via PI3K/AKT/HIF-1α pathway

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Chinese Chemical Letters 2025年第1期36卷 403-407页

作者： Xiongbo Song Jinwen Xiao juan Wu li Sun Long Chen Department of Orthopedics Guizhou Provincial People’s HospitalGuiyang 550000China The Lab of Tissue Engineering and Translational Medicine College of MedicineGuizhou UniversityGuiyang 550000China Wuhan Kangchuang Biotechnology Wuhan 430074China

Macrophages undergo dynamic transitions between M1 and M2 states,exerting profound influences on both inflammatory and regenerative *** biocompatible and wound-healing properties of decellularized amniotic membrane(d AM)make it a subject of exploration for its potential impact on the anti-inflammatory response of *** findings unequivocally demonstrate that d AM promotes anti-inflammatory M2 polarization of macrophage,with its cytokine-rich content posited as a potential *** application of RNA sequencing unveils differential gene expression,implicating the hypoxia inducible factor-1α(HIF-1α)signaling pathway in this intricate *** investigation further demonstrates that d AM facilitates anti-inflammatory M2 polarization of macrophage through the upregulation of epidermal growth factor(EGF),which,in turn,activates the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway and stabilizes HIF-1α.This cascade results in a noteworthy augmentation of anti-inflammatory gene *** study significantly contributes to advancing our comprehension of d AM's immunomodulatory role in tissue repair,thereby suggesting promising therapeutic potential.

关键词： Macrophage Decellularized amniotic membrane Anti-inflammatory response Hypoxia inducible factor-1α Epidermal growth factor

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