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Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 592-598页

作者： li-jiang tang Jian-jun jiang Xiao-feng CHEN Jian-an WANG Xian-fang liN Yu-xi DU Cong-feng FANG Zhao-xia PU Department of Cardiology Taizhou Hospital Wenzhou Medical College Taizhou 317000 China Department of Cardiology Hangzhou 310009 China Cardiovascular Key Lab of Zhejiang Province the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Echocardiography Taizhou Hospital Wenzhou Medical College Taizhou 317000 China

Objective:Uric acid(UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome(MS).This study aims to investigate the relation between UA levels and aortic root ***:A total of 348 hypertensive patients [age(67.5±9.8) years] with or without MS were included in the *** aortic root diameters at the aortic annulus,the sinuses of Valsalva,the sinotubular junction,and the proximal part of the ascending aorta were measured using a two-dimensional(2D) *** UA levels were also measured for all ***:A high UA level is independently associated with aortic root diameters at the sinuses of Valsalva(P=0.001) and the proximal ascending aorta(P<0.0001) in the hypertensive patients without *** contrast,aortic root diameters were not significantly related to UA levels in the hypertensive patients with ***,increased UA levels were associated with an increased risk for aortic root dilatation in the patients without MS(sex-adjusted hazard ratio 1.75,95% confidence intervals(CI) 1.27-2.41),but not in those with ***:This study demonstrated an independent relationship between the aortic root dimensions and increased levels of serum UA in the hypertensive patients without *** understanding of the mechanisms underlying these associations may allow a clearer interpretation of the potential value of specific urate-lowering treatment on cardiovascular disease.

关键词： Aortic root Uric acid Hypertension Metabolic syndrome

Preparation and Properties of High Hardness and Oxidation Resisting Coating Using Electric Arc Spray

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材料热处理学报 2004年第05B期25卷 984-987页

作者： liZhuo-xin CUIli WANGjiang-ping tangChun-tian BeijingUniversityofTechnology Beijing100022

A coating with high hardness, wear and oxidation resistance was prepared by electric arc spray. The hardness, bonding strength, abrasive wear and values of porosity and oxidation resistance of the coating were investigated. The microstructures and function of Cr3C2 of the coating were analyzed. The results showed surface Rockness Hardness HR30 reached 72.5 and average bond strength reached 49.1Mpa. Also porosity value was less than 2%. In addition, it was found from the comparison between the coating and 45CT coating that, oxidation resistance of the coating was less than that of 45CT, but the abrasive wear of the coating was obvious better than that of 45CT.

关键词：硬度磨损性能高温氧化电弧喷镀

Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第5期19卷 333-341页

作者： Hui ZHOU Yan CHEN Shu-wei HUANG Peng-fei HU li-jiang tang Department of Cardiology Zhejiang Hospital Department of Cardiology the Second Affiliated Hospital of Zhejiang Chinese Medical University

Objective： To investigate the effect of tea polyphenols on cardiac function in rats with diabetic cardiomyo- pathy, and the mechanism by which tea polyphenols regulate autophagy in diabetic cardiomyopathy. Methods： Sixty Sprague-Dawley （SD） rats were randomly divided into six groups： a normal control group （NC）, an obesity group （OB）, a diabetic cardiomyopathy group （DCM）, a tea polyphenol group （TP）, an obesity tea polyphenol treatment group （OB-TP）, and a diabetic cardiomyopathy tea polyphenol treatment group （DCM-TP）. After successful modeling, serum glucose, cholesterol, and triglyceride levels were determined; cardiac structure and function were inspected by ul- trasonic cardiography; myocardial pathology was examined by staining with hematoxylin-eosin; transmission electron microscopy was used to observe the morphology and quantity of autophagosomes; and expression levels of autophagy-related proteins LC3-11, SQSTM1/p62, and Beclin-1 were determined by Western blotting. Results： Com- pared to the NC group, the OB group had normal blood glucose and a high level of blood lipids; both blood glucose and lipids were increased in the DCM group; ultrasonic cardiograms showed that the fraction shortening was reduced in the DCM group. However, these were improved significantly in the DCM-TP group. Hematoxylin-eosin staining showed disordered cardiomyocytes and hypertrophy in the DCM group; however, no differences were found among the remaining groups. Transmission electron microscopy revealed that the numbers of autophagosomes in the DCM and OB-TP groups were obviously increased compared to the NC and OB groups; the number of autophagosomes in the DCM-TP group was reduced. Western blotting showed that the expression of LC3-11/I and Beclin-1 increased obviously whereas the expression of SQSTM1/p62 was decreased in the DCM and OB-TP groups （P〈0.05）. Conclusions： Tea polyphenols had an effect on diabetic cardiomyopathy in rat cardiac function and may alter the levels of a

关键词： Tea polyphenol Autophagy Diabetic cardiomyopathy Obesity lipid metabolism disorder

Wafer-Scale Vertical 1D GaN Nanorods/2D MoS₂/PEDOT:PSS for Piezophototronic Effect-Enhanced Self-Powered Flexible Photodetectors

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： tang, Xin jiang, Hongsheng lin, Zhengliang Wang, Xuan Wang, Wenliang li, Guoqiang South China Univ Technol State Key Lab Luminescent Mat & Devices Guangzhou 510640 Peoples R China South China Univ Technol Sch Mat Sci & Engn Dept Elect Mat Guangzhou 510640 Peoples R China

Vertical 1D GaN nanorod arrays/2D MoS2/PEDOT:PSS heterostructures in wafer scale have been fabricated for flexible photodetection ***-powered flexible photodetector at compressive strain reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W-1 and response times of 40/45 mu s, which are superior to the state-of-the-art flexible *** work not only provides a valuable strategy for the design and construction of tunable van der Waals heterostructures, but also opens a new opportunity for flexible sensors. van der Waals (vdW) heterostructures constructed by low-dimensional (0D, 1D, and 2D) materials are emerging as one of the most appealing systems in next-generation flexible photodetection. Currently, hand-stacked vdW-type photodetectors are not compatible with large-area-array fabrication and show unimpressive performance in self-powered mode. Herein, vertical 1D GaN nanorods arrays (NRAs)/2D MoS2/PEDOT:PSS in wafer scale have been proposed for self-powered flexible photodetectors arrays firstly. The as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W-1 and a high detectivity of 1.2 x 1011 Jones, as well as a fast response speed of 54/71 mu s, thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II heterojunction. Notably, the strain-tunable photodetection performances of device have been demonstrated. Impressively, the device at - 0.78% strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W-1, a detectivity of 2.6 x 1011 Jones, and response times of 40/45 mu s, which are superior to the state-of-the-art self-powered flexible photodetectors. This work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection, which performs well in flexible sensors.

关键词： Vertical nanorod arrays van der Waals heterostructure Piezophototronic effect Self-powered photodetection Flexible sensors

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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视觉、功能、文化:现代包装设计的情感价值

装饰 2018年第2期 42-45页

作者：李江唐也栋北京师范大学艺术与传媒学院

现代包装设计从实用为主的功能主义向着满足人们精神和心理的需求方面转变,从单纯地保护商品、展示商品信息的功能层面上升到促进商品销售、建立品牌美誉的高度,并从视觉表现、功能深化和"溢价"价值等方向实现这种转变。

关键词：包装设计情感性设计心理设计趣味

Establisment of a novel pig model of pancreatoduodenal allotransplantation

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 192-196页

作者： Jian-Shui li, Yong tang, jiang-Tao Wei and Zhao-Da Zhang Chengdu, China Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041 , China and Department of Anesthesia, Chengdu Railway Central Hospital, Chengdu 610081, China Department of General Surgery West China HospitalSichuan UniversityChengdu 610041 China.

BACKGROUND: Pancreas transplantation is a valid thera- py for patients with type 1 diabetes mellitus (IDDM). This study was undertaken to establish a stable pig model of whole pancreatoduodenal allotransplantation of physiologi- cally coincidence for pancreas transplantation. METHODS: The IDDM pig model was made by resection of the pancreas from the recipient. The portal vein of the donor was end-to-side anastomosed to the anterior mesen- teric vein (equal to the superior mesenteric vein) or the portal vein of the recipient. The far end of the celiac axis was anastomosed to each other. With end-to-side fashion, the duodenum of the donor was anastomosed to the jeju- num of the recipient. RESULTS: In 16 transplantations, results were satisfactory. The anatomical results and immune function including the function of the pancreas were similar to those of human be- ing. CONCLUSION: Of the pancreas of the pig, this study of pancreatic transplantation shows that the novel pig whole pancreatoduodenal allotransplantation model is ideal.

关键词： pancreatoduodenal transplantation model diabetes pig