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Cavernous hemangioma of the ileum in a young man:A case report and review of literature

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World Journal of Clinical Cases 2022年第28期10卷 10146-10154页

作者： li Yao li-Wei li Bing Yu Xiao-Dan Meng Shi-Quan liu li-hua xie Rong-Fen Wei Jie liang hua-Qiang Ruan Jun Zou Jie-An huang Department of Gastroenterology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530005Guangxi Zhuang Autonomous RegionChina

BACKGROUND Small intestinal cavernous hemangioma is a rare disease,especially in the *** is difficult to accurately diagnose due to its hidden location and nonspecific clinical ***,we reported a case of ileal cavernous hemangioma with chronic hemorrhage in a 20-year-old man and review the literature to gain a better understanding of this *** SUMMARY The patient complained of intermittent melena and hematochezia for > 3 *** lowest hemoglobin level revealed by laboratory testing was 3.4 g/d L(normal range:12-16 g/dL).However,the gastroscopy,colonoscopy and peroral doubleballoon enteroscopy(DBE) showed no signs of *** transanal DBE detected a lesion at about 340 cm proximal to the ileocecal ***,we performed an exploratory laparoscopy and the lesion was *** the operation,the patient had no ***,the pathological examination identified the neoplasm as an ileal cavernous hemangioma,thereby resulting in gastrointestinal *** This report might improve the diagnosis and treatment of ileal cavernous hemangioma.

关键词： Cavernous hemangioma Ileum Gastrointestinal hemorrhage Anemia Double-balloon enteroscopy Contrast-enhanced computed tomography Case report

Construction of an efficient genomic editing system with CRISPR/Cas9 in the vector mosquito Aedes albopictus

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Insect Science 2019年第6期26卷 1045-1054页

作者： Tong liu Wen-Qiang Yang Yu-Gu xie Pei-Wen liu li-hua xie Feng lin Chen-Ying li Jin-Bao Gu Kun Wu Gui-Yun Yan Xiao-Guang Chen Department of Pathogen Biology Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public Health Southern Medical University Guangzhou China

Aedes (Stegomyia) albopictus, also known as the Asian tiger mosquito, is a mosquito which originated in Asia. In recent years, it has become increasingly rampant throughout the world. This mosquito can transmit several arboviruses, including dengue, Zika and chikungunya viruses, and is considered a public health threat. Despite the urgent need of genome engineering to analyze specific gene functions, progress in genetical manipulation of Ae. albopictus has been slow due to a lack of efficient methods and genetic markers. In the present study, we established targeted disruptions in two genes, kynurenine hydroxylase (kh) and dopachrome conversion enzyme (yellow), to analyze the feasibility of generating visible phenotypes with genome editing by the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR-associated protein 9 (Cas9) system in Ae. albopictus. Following Cas9 single guide RNA ribonucleoprotein injection into the posterior end of pre-blastoderm embryos, 30%-50% of fertile survivors produced alleles that failed to complement existing kh and yellow mutations. Complete eye and body pigmentation defects were readily observed in GI pupae and adults, indicating successful generation of highly heritable mutations. We conclude that the CRISPR/Cas9-mediated gene editing system can be used mAe. albopictus and that it can be adopted as an efficient tool for genome-scale analysis and biological study.

关键词： Aedes albopictus CRISPR/Cas9 dopachrome conversion enzyme (yellow) gene editing kynurenine hydroxylase (kh)

Hydrocolloid dressing in preventing nasal trauma secondary to nasal continuous positive airway pressure in preterm infants

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World Journal of Emergency Medicine 2014年第3期5卷 218-222页

作者： li-hua xie Hunan Children’s Hospital

BACKGROUND:Continuous positive airway pressure(CPAP) with nasal devices(nCPAP) is widely used in the respiratory management of newborns. The present study aimed to compare the incidence of nasal trauma secondary to nasal continuous positive airway pressure(nCPAP) protected with or without hydrocolloid dressing in preterm ***:This prospective controlled study was performed in the neonatal intensive care unit(NICU) of the Children’s Hospital of Hunan Province from March 1,2010 to June 31,2010. A total of 65 infants,46 males and 19 females,were recruited in this study. Their average gestational age was 32.6 weeks(range 28–37 weeks). The infants were randomly divided into clinical trial group(group A,n=33) and control group(group B,n=32). Paraff in oil was smeared around the nostrils before inserting prongs in group B; the infants in group A were covered on the infant’s nostrils surface with hydrocolloid dressing(hydrocolloid dressing,1.8 mm thick,90029 T,3M Company,Minnesota,USA) with a size of 2–3 cm cutting two holes adapted to the nose and nostrils. The nostrils of those infants were inspected daily during nCPAP support until they were weaned off ***:Nine infants(2 in group A and 7 in group B) developed nasal injury during nCPAP support. The Chi-square test revealed that there was a statistically signifi cant difference(P=0.01) in the incidence of nasal injury between groups A and ***:The study demonstrated that hydrocolloid dressing signifi cantly decreased the incidence and the severity of nasal injury.

关键词： Continuous positive airway pressure Nasal injury Hydrocolloid dressing Preterm infants Nasal prongs

Development and validation of a model integrating clinical and coronary lesion-based functional assessment for longterm risk prediction in PCI patients

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Journal of Geriatric Cardiology 2024年第1期21卷 44-63页

作者： Shao-Yu WU Rui ZHANG Sheng YUAN Zhong-Xing CAI Chang-Dong GUAN Tong-Qiang ZOU li-hua xie Ke-Fei DOU State Key Laboratory of Cardiovascular Disease BeijingChina Cardiometabolic Medicine Center Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To establish a scoring system combining the ACEF score and the quantitative blood flow ratio(QFR) to improve the long-term risk prediction of patients undergoing percutaneous coronary intervention(PCI).METHODS In this population-based cohort study, a total of 46 features, including patient clinical and coronary lesion characteristics, were assessed for analysis through machine learning models. The ACEF-QFR scoring system was developed using 1263consecutive cases of CAD patients after PCI in PANDA Ⅲ trial database. The newly developed score was then validated on the other remaining 542 patients in the *** In both the Random Forest Model and the Deep Surv Model, age, renal function(creatinine), cardiac function(LVEF)and post-PCI coronary physiological index(QFR) were identified and confirmed to be significant predictive factors for 2-year adverse cardiac events. The ACEF-QFR score was constructed based on the developmental dataset and computed as age(years)/EF(%) + 1(if creatinine ≥ 2.0 mg/d L) + 1(if post-PCI QFR ≤ 0.92). The performance of the ACEF-QFR scoring system was preliminarily evaluated in the developmental dataset, and then further explored in the validation dataset. The ACEF-QFR score showed superior discrimination(C-statistic = 0.651;95% CI: 0.611-0.691, P libration(Hosmer–Lemeshow χ^(2)= 7.070;P = 0.529) for predicting 2-year patient-oriented composite endpoint(POCE). The good prognostic value of the ACEF-QFR score was further validated by multivariable Cox regression and Kaplan–Meier analysis(adjusted HR = 1.89;95% CI: 1.18–3.04;log-rank P linical and coronary lesion-based functional variables(ACEF-QFR)was developed, and its ability for prognostic prediction in patients with PCI was further validated to be signi

关键词： patients coronary prediction

Angiography-derived radial wall strain predicts coronary lesion progression in non-culprit intermediate stenosis

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Journal of Geriatric Cardiology 2022年第12期19卷 937-948页

作者： Zhi-Qing WANG Bo XU Chun-Ming li Chang-Dong GUAN Yue CHANG li-hua xie Su ZHANG Jia-Yue huaNG Patrick W Serruys William Wijns liang-Long CHEN Sheng-Xian TU Department of Cardiology Fujian Heart Medical CenterFujian Institute of Coronary Heart DiseaseFujian Medical University Union HospitalFujianChina Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Cardiology National Clinical Research Center for Cardiovascular DiseasesFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina The Lambe Institute for Translational Medicine and Curam University of GalwayGalwayIreland

BACKGROUND Intermediate coronary lesions(ICLs)are highly prevalent but ported mixed *** strain has been associated with plaque vulnerability,yet its role in predicting lesion progression is largely *** purpose of this study was to determine the predictive value of angiography-derived radial wall strain(RWS)for progression of untreated non-culprit *** Post-hoc analysis was conducted in a study cohort including 603 consecutive patients with 808 ICLs identified at index procedure with angiographic follow-up of up to two *** analysis was performed on selected angiographic frames with minimal foreshortening and vessel *** progression was defined as≥20%increase in percent diameter *** Lesion progression occurred in 49 ICLs(6.1%)with a median follow-up period of 16.8 *** RWS(RWSmax),frequently located at the proximal and throat plaque regions,distinguished progressive ICLs from silent *** largest area under the curve value of 0.75(95%CI:0.67–0.82,P12.6%.According to this threshold,178 ICLs were classified as having a high strain *** to a high strain amplitude with RWS_(max)>12.6%was independently associated with an increased risk of lesion progression(adjusted HR=6.82,95%CI:3.67–12.66,P<0.001).CONCLUSIONS Assessment of RWS from coronary angiography is feasible and provides independent prognostic value in patients with untreated ICLs.

关键词： coronary stenosis strain

The prognostic value of collateral circulation in coronary chronic total occlusion underwent percutaneous coronary intervention

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Journal of Geriatric Cardiology 2024年第2期21卷 232-241页

作者： Xiao-Ying HU Wei-Xian YANG Chang-Dong GUAN li-hua xie Ke-Fei DOU Yong-Jian WU Jin-Qing YUAN Jie QIAN Yue-Jin YANG Shu-Bin QIAO Lei SONG Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center for Cardiovascular Diseases BeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND The prognostic value of coronary collateral circulation(CC)in patients undergoing chronic total occlusion(CTO)percutaneous coronary intervention(PCI)is *** purpose of the study was to assess the prognostic value of current two CC grading systems and their association with long-term outcomes in patients with CTO underwent *** We consecutively enrolled patients with single-vessel CTO underwent PCI between January 2010 and *** patients were categorized into well-developed or poor-developed collaterals group according to angiographic Werner's CC(grade 2 *** 0–1)or Rentrop(grade 3 *** 0–2)grading *** primary endpoint was 5-year cardiac *** Of 2452 enrolled patients,the overall technical success rate was 74.1%.Well-developed collaterals were present in686 patients(28.0%)defined by Werner's CC grade 2,and in 1145 patients(46.7%)by Rentrop grade *** to Werner's CC grading system,patients with well-developed collaterals had a lower rate of 5-year cardiac death compared with those with poordeveloped collaterals(1.6%vs.3.3%,P=0.02),those with suboptimal recanalization was associated with higher rate of 5-year cardiac death compared with optimal recanalization(4.7%vs.0.8%,P=0.01)and failure patients(4.7%vs.1.6%,P=0.12).However,the similar effect was not shown in Rentrop grading *** In patients with the single-vessel CTO underwent PCI,well-developed collaterals by Werner's CC definition were associated with lower rate of 5-year cardiac ***'s CC grading system had a greater prognostic value than Rentrop grading system in patients with CTO underwent PCI.

关键词： coronary collateral occlusion

In vivo anti-tumor effect of hybrid vaccine of dendritic cells and esophageal carcinoma cells on esophageal carcinoma cell line 109 in mice with severe combined immune deficiency

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World Journal of Gastroenterology 2008年第8期14卷 1167-1174页

作者： Guang-hua Guo Su-Zuan Chen Jing Yu Juan Zhang li-li Luo li-hua xie Zhong-Jing Su Hong-Mei Dong Hong Xu li-Biao Wu Department of Gastroenterology The First Affiliatecl Hospital of Shantou University Medical College Shantou 515041Guangdong Province China

AIM： To develop a fusion vaccine of esophageal carcinoma cells and dendritic cells （DC） and observe its protective and therapeutic effect against esophageal carcinoma cell line 109 （EC109）. METHODS： The fusion vaccine was produced by fusing traditional polyethyleneglycol （PEG）, inducing cytokine, sorting CD34＋ magnetic microbead marker and magnetic cell system （MACS）. The liver, spleen and lung were pathologically tested after injection of the fusion vaccine. To study the therapeutic and protective effect of the fusion vaccine against tumor EC109, mice were divided immune group and therapeutic group. The immune group was divided into P, E, D and ED subgroups, immunized by phosphate buffered solution （PBS）, inactivated EC109, DC and the fusion vaccine respectively, and attacked by EC109 cells. The tumor size, weight, latent period and mouse survival period were recorded and statistically analyzed. The therapeutic group was divided into four subgroups： P, inactivated EC109, D and ED subgroups, which were attacked by EC109 and then treated with PBS, inactivated EC109, DC, and EC109-DC respectively. Pathology and flow cytometry were also used to study the therapeutic effect of the fusion vaccine against EC109 cells.RESULTS： Flow cytometry showed that the expression of folate receptor （FR）, EC109 （C）, Des （D） in human nasopharyngeal carcinoma cell line （HNE1）（B） was 78.21%, 89.50%, and 0.18%, respectively. The fusion cells （C） were highly expressed. No tumor was found in the spleen, lung and liver after injection of the fusion vaccine. Human IgG was tested in peripheral blood lymphocytes （PBL）. In the immune group, the latent period was longer in EC109-DC subgroup than in other subgroups, while the tumor size and weight were also smaller than those in ED subgroup. In the therapeutic group, the tumor size and weight were smaller in ED subgroup than in P, inactivated EC109 and DC subgroups. CONCLUSION： Fusion cells are highly expressed not only in FR but also in CD8

关键词： Dendritic cells Esophageal carcinoma cells Cell fusion Immune protection Immunotherapy

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基于认证测试的通用安全协议设计方法

上海交通大学学报 2006年第3期40卷 524-527页

作者：李谢华李建华杨树堂上海交通大学电子工程系上海200030

以认证测试方法为基础,提出了一种通用的安全协议形式化设计方法,使用该方法对Needham-Schroeder(NS)公钥协议进行了重新设计.最后通过认证测试方法证明了重新设计的NS协议能够满足安全协议的保密性、身份认证和数据认证的要求,并且有... 详细信息

以认证测试方法为基础,提出了一种通用的安全协议形式化设计方法,使用该方法对Needham-Schroeder(NS)公钥协议进行了重新设计.最后通过认证测试方法证明了重新设计的NS协议能够满足安全协议的保密性、身份认证和数据认证的要求,并且有效避免了原NS协议存在的中间人攻击问题.

关键词：安全协议认证测试 Needham-Schroeder公钥协议

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基于消息类型检测的认证测试分析方法

上海交通大学学报 2007年第1期41卷 85-89,99页

作者：李谢华杨树堂李建华诸鸿文上海交通大学电子工程系上海200240

将消息类型的概念和检测方法引入认证测试的分析过程,提出基于消息类型检测的认证测试分析方法,从而完善了认证测试在对称密钥协议验证中的应用,使其具有发现消息重放攻击和类型攻击的能力.对Neuman-Stubblebine协议和Kao-Chow协议的分... 详细信息

将消息类型的概念和检测方法引入认证测试的分析过程,提出基于消息类型检测的认证测试分析方法,从而完善了认证测试在对称密钥协议验证中的应用,使其具有发现消息重放攻击和类型攻击的能力.对Neuman-Stubblebine协议和Kao-Chow协议的分析结果表明,基于消息类型检测的认证测试方法能够发现对Neuman-Stubblebine协议的类型攻击,并且为Kao-Chow协议提供更为准确的证明.

关键词：认证测试消息类型 Neuman—Stubblebine协议 Kao—Chow认证协议