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Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1

Current Medical Science 2024年第1期44卷 223-231页

作者： hong-li zhang Na li lin DONG hong-xia MA Mo-chi YANG Department of Ophthalmology General Hospital of Ningxia Medical UniversityYinchuan 750004China

Objective Retinoblastoma(RB)is a prevalent type of eye cancer in *** homeobox 1(Prox1)is a homeobox transcriptional repressor and downstream target of the proneural gene that is relevant in lymphatic,hepatocyte,pancreatic,heart,lens,retinal,and cancer *** goal of this study was to investigate the role of Prox1 in RB cell proliferation and drug resistance,as well as to explore the underlying Notch1 *** Human RB cell lines(SO-RB50 and Y79)and a primary human retinal microvascular endothelial cell line(ACBRI-181)were used in this *** expression of Prox1 and Notch1 mRNA and protein in RB cells was detected using quantitative real time-polymerase chain reaction(RT-qPCR)and Western *** proliferation was assessed after Prox1 overexpression using the Cell Counting Kit-8 and the MTS ***-resistant cell lines(SO-RB50/vincristine)were generated and treated with Prox1 to investigate the role of Prox1 in drug *** employed pcDNA-Notch1 to overexpress Notch1 to confirm the role of Notch1 in the protective function of ***,a xenograft model was constructed to assess the effect of Prox1 on RB in *** Prox1 was significantly downregulated in RB *** of Prox1 effectively decreased RB cell growth while increasing the sensitivity of drug-resistant cells to ***1 was involved in Prox1’s regulatory ***1 was identified as a target gene of Prox1,which was found to be upregulated in RB cells and repressed by increased Prox1 *** pcDNA-Notch1 was transfected,the effect of Prox1 overexpression on RB was ***,by downregulating Notch1,Prox1 overexpression slowed tumor development and increased vincristine sensitivity in *** These data show that Prox1 decreased RB cell proliferation and drug resistance by targeting Notch1,implying that Prox1 could be a potential therapeutic target for RB.

关键词： Proxl Notch1 retinoblastoma cells proliferation drug resistance

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“场域理论”视角下职业院校专业课教师“德技并修”行动逻辑探究

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教育探索 2024年第4期 75-82页

作者：李鸿章江苏省滨海中等专业学校江苏东盐城224500

职业院校实行“德技并修”的关键就是专业课教师。通过分析职业教育场域中存在多样的资本介入引发多元冲突、“惯习”造成技能教师角色定位的失败、多种“场域”的入侵造成师生价值迷失等三重困境,提出以厘清资本逻辑为落脚点、重构专... 详细信息

职业院校实行“德技并修”的关键就是专业课教师。通过分析职业教育场域中存在多样的资本介入引发多元冲突、“惯习”造成技能教师角色定位的失败、多种“场域”的入侵造成师生价值迷失等三重困境,提出以厘清资本逻辑为落脚点、重构专业课教师“惯习”为着眼点、增强场域中以人为本的核心为出发点的三条行动逻辑。从而实现技术传授与价值引领的完美统一,从而培养出“德技双馨”的高素质劳动者和技能人才。

关键词：德技并修场域理论职业教育

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基于浮游藻类个体数的星云湖水质评价研究

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环境科学导刊 2024年第2期43卷 6-10页

作者：李芸仙李红章玉溪市江川区星云街道规划建设和环境保护中心云南玉溪652600 玉溪市生态环境局江川分局生态环境监测站云南玉溪622600

近年来国内淡水湖泊浮游藻类监测一般以细胞数为计数单位,但现有的基于藻类数据的湖泊水质评价仅适用于藻类个体数。为此,本研究选择云南省玉溪市星云湖,开展基于藻类个体数监测的湖泊水质评价,检验其与基于化学指标的水质评价结果的一... 详细信息

近年来国内淡水湖泊浮游藻类监测一般以细胞数为计数单位,但现有的基于藻类数据的湖泊水质评价仅适用于藻类个体数。为此,本研究选择云南省玉溪市星云湖,开展基于藻类个体数监测的湖泊水质评价,检验其与基于化学指标的水质评价结果的一致性,比较理化指标监测与藻类个体数监测的优势和劣势,探讨今后开展藻类个体数监测工作的必要性。认为基于藻类个体数的水质评价方法可反映水生态环境的综合状况,有其独特价值,并且监测工作投入比理化指标监测少,但存在对技术人员的素质要求高、培训周期长、难以质控等缺点。

关键词：浮游藻类个体数多样性指数水质评价

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New Exact Solutions for Konopelchenko-Dubrovsky Equation Using an Extended Riccati Equation Rational Expansion Method

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Communications in Theoretical Physics 2006年第5期45卷 I0003-I0003,770-776页

作者： SONG li-Na zhang hong-Qing Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

Taking the Konopelchenko-Dubrovsky system as a simple example, some familles of rational formal hyperbolic function solutions, rational formal triangular periodic solutions, and rational solutions are constructed by using the extended Riccati equation rational expansion method presented by us. The method can also be applied to solve more nonlinear partial differential equation or equations.

关键词： Konopelchenko-Dubrovsky equation extended Riccati equation rational expansion method nonlinear partial differential equation or equations

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Extended sine-Gordon Equation Method and Its Application to Maccari＇s System

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Communications in Theoretical Physics 2005年第5X期44卷 783-788页

作者： SONG li-Na zhang hong-Qing Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

An extended sine-Gordon equation method is proposed to construct exact travelling wave solutions to Maccari's equation based upon a generalized sine-Gordon equation. It is shown that more new travelling wave solutions can be found by this new method, which include bell-shaped soliton solutions, kink-shaped soliton solutions, periodic wave solution, and new travelling waves.

关键词： Maccari's system exact travelling wave solution extended sine-Gordon equation method

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Extended Jacobi Elliptic Function Rational Expansion Method and Its Application to （2＋1）-Dimensional Stochastic Dispersive Long Wave System

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Communications in Theoretical Physics 2007年第6期47卷 969-974页

作者： SONG li-Na zhang hong-Qing Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

In this work, by means of a generalized method and symbolic computation, we extend the Jacobi elliptic function rational expansion method to uniformly construct a series of stochastic wave solutions for stochastic evolution equations. To illustrate the effectiveness of our method, we take the （2＋ 1）-dimensional stochastic dispersive long wave system as an example. We not only have obtained some known solutions, but also have constructed some new rational formal stochastic Jacobi elliptic function solutions.

关键词： stochastic evolution equations (2+ 1)-dimensional stochastic dispersive long wave system rational formal stochastic Jacobi elliptic function solutions

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Blimp-1 protein and Hans classification on prognosis of diffuse large B-cell lymphoma and their interrelation

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Chinese Journal of Cancer 2010年第9期29卷 781-786页

作者： Yan Song Zhi Cao ling li hong-Tu zhang Xun zhang Department of Pathology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing100021 P. R. China

Background and Objective:Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma (NHL), is heterogeneous on molecular and clinical levels, therefore, its prognosis is difficult to *** study aimed to evaluate the value of Blimp-1 protein and Hans classification in predicting the prognosis of DLBCL and their ***:The clinical records of 136 patients with DLBCL were *** patients were followed up for 5-80 months (median, 39 months).Immunohistochemical staining for CD10, MUM1, Bcl-6, and Blimp-1 were performed on paraffin-embedded tumor tissues from the 136 *** correlations of Blimp-1 protein and Hans classification in prognosis of DLBCL and their interrelation were ***:Blimp-1 was detected in 38 (30.0%) patients, and was associated with a significantly shorter overall survival (OS) (P=0.030).Using the Hans classification based upon the expression of CD10, Bcl-6, and MUM1, 54 patients had germinal center B-cell (GCB) phenotype and 82 had non-GCB *** 5-year OS rate was 75% in the GCB group and 52% in the non-GCB group (P=0.020).The positive rate of Blimp-1 was 22.2% in the GCB group and 31.7% in the non-GCB group (P=0.329).The Cox regression multivariate analysis showed that international prognosis index (IPI) and Hans classification had independent prognostic significance, whereas Blimp-1 was not an independent prognostic ***:The patients with GCB subtype of DLBCL had better prognosis than the non-GCB *** level of Blimp-1 expression in the patients with DLBCL implies a shorter survival, but it is not associated with Hans classification.

关键词： B细胞淋巴瘤分类价值弥漫性预后飞艇蛋白发电机断路器免疫组织化学染色

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Quark Transport Properties in the Region of Coexistence of Both Hadronic and QGP Phases

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Communications in Theoretical Physics 2001年第7期36卷 47-52页

作者： CHEN Xiang-Jun li hong WANG Gang zhang Wei-Ning HUO Lei Department of Physics Harbin Institute of Technology Harbin 150001 China Department of Physics Harbin Institute of Technology Harbin 150001 China Department of Physics Harbin Institute of Technology Harbin 150001 China Department of Physics Harbin Institute of Technology Harbin 150001 China Department of Physics Harbin Institute of Technology Harbin 150001 China

The physical picture of coexistence of both hadronic and QGP phases is given by Friedberg and T.D. Lee's nontopology soliton model. The transport properties of quark in color space and spin space in a system of two-ph... 详细信息

关键词： hadron, quark-gluon plasma, soliton, transport property

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Video caching and scheduling with edge cooperation

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Digital Communications and Networks 2024年第2期10卷 450-460页

作者： Zhidu li Fuxiang li Tong Tang hong zhang Jin Yang School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China Advanced Network and Intelligent Connection Technology Key Laboratory of Chongqing Education Commission of China Chongqing400065China Key Laboratory of Ubiquitous Sensing and Networking in Chongqing Chongqing400065China

In this paper,we explore a distributed collaborative caching and computing model to support the distribution of adaptive bit rate video *** aim is to reduce the average initial buffer delay and improve the quality of user *** the difference between global and local video popularities and the time-varying characteristics of video popularity,a two-stage caching scheme is proposed to push popular videos closer to users and minimize the average initial buffer *** on both long-term content popularity and short-term content popularity,the proposed caching solution is decouple into the proactive cache stage and the cache update *** the proactive cache stage,we develop a proactive cache placement algorithm that can be executed in an off-peak *** the cache update stage,we propose a reactive cache update algorithm to update the existing cache policy to minimize the buffer *** results verify that the proposed caching algorithms can reduce the initial buffer delay efficiently.

关键词： Video service Distributed and collaborative caching Long-term popularity Short-term popularity

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Effect of oxide inclusions on MnS precipitates and tensile mechanical property of high-strength low-alloy steel

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Journal of Iron and Steel Research International 2024年第5期31卷 1210-1220页

作者： Xiao-yong Gao hong Wei li-feng zhang School of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina School of Materials Science and Engineering Yanshan UniversityQinhuangdao066004HebeiChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing100144China

The key role of oxide inclusions on the microstructure and mechanical property of a high-strength low-alloy steel was *** field emission scanning electron microscope equipped with energy-dispersive spectrometry was used to characterize MnS *** inclusions play an important role in the shape control of MnS *** oxides fovored to decrease the size and the aspect ratio of MnS *** less oxide inclusions in the steel,approximately over 16.7%MnS precipitates were with aspect ratio a>5 and pure MnS precipitates accounted for 75.9%in ***,with more oxide inclusions in the steel,only 7.4%MnS precipitates were with a>5 and pure MnS precipitates accounted for 60.1%in *** of MnS by oxide inclusions improved the strength and inhibited the *** oxide inclusions in the steel increased the yield strength and tensile strength of the steel in both longitudinal and transverse directions,and lowered the anisotropy of the mechanical property.

关键词： High-strength low-alloy steel MnS Oxide inclusion Mechanical property Anisotropy

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