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Effect of Zr addition on microstructures and mechanical properties of Ni-46Ti-4Al alloy

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Rare Metals 2011年第5期30卷 522-526页

作者： li Yan YU Kaiyuan song Xiaoyun ZHANG fei School of Materials Science and Engineering Beihang University Beijing 100191 China Key Laboratory of Aerospace Materials and Performance （Ministry of Education of China） Beihang University Beijing 100191 China

The microstructures and mechanical properties of Ni-（46-x）Ti-4Al-xZr （x = 0-8, at.%） alloys have been investigated by scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, and mechanical tests. The results show that the Ni-Ti-Al-Zr alloys are composed of TiNi and （Ti, Al） 2 Ni with Zr as a solid solution element in both phases, and the third phase, （Zr, Ti, Al） 2 Ni, appears in Ni-40Ti-4Al-6Zr and Ni-38Ti-4Al-8Zr alloys. The compressive yield strength at room temperature increases with the increase of Zr content due to the solid-solution strengthening of Zr and precipitation strengthening of （Ti, Al, Zr） 2 Ni phase. However, the Ni-42Ti-4Al-4Zr alloy exhibits the maximum compressive yield strength at 873 and 973 K because of the softening of （Zr, Ti, Al） 2 Ni phase in the alloys with more Zr addition. The tensile stress-strain tests and the SEM fracture surface observations show that the brittle to ductile transition temperature of Ni-42Ti-4Al-4Zr alloy is between 873 and 923 K.

关键词： intermetallics zirconium microstructure mechanical properties

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大熊猫胃内纤毛虫检测初报

动物学报 2005年第3期51卷 526-529页

作者：费立松杨光友张志和汤纯香刘选珍王强李明喜张安居成都动物园成都610081 四川农业大学动物科技学院四川雅安625014 成都大熊猫繁育研究基地成都610081 中国保护大熊猫研究中心四川卧龙623006

Twenty three captive giant pandas, fecal specimens and stomach juice from five captive giant pandas(Ailuropoda melanoleuca)were tested for ciliate in 2004. Of them, ciliates of Epdinium *** Entodinium *** found in the stomach of five giant panda. Density of ciliates in each stomach of giant pandas were 4.21×10 4 ind./ml, 6.98×10 4 ind./ml, 3.05×10 4 ind./ml, 4.46×10 4 ind./ml and 4.38×10 4 ind./ml respectively. But all the fecal specimens were negative.

关键词：纤毛虫大熊猫初报检测 and the 胃 for in all

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： song-Meng Wang Hao Nian Yan-Fang Wang li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong liping Huang Xiaoping Wang Wei Jiang liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Correlation between surface charge and hydration on mineral surfaces in aqueous solutions: A critical review

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International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 857-871页

作者： Hong-liang li Wen-nan Xu fei-fei Jia Jian-bo li Shao-xian song Yuri Nahmad College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G2V4Canada School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China Instituto de Fiscia Universidad Autonoma de San Luis PotosiAv.Sierra LeonaSan Luis Potosi 78000Mexico

Surface charges and hydration are predominant properties of colloidal particles that govern colloidal stability in aqueous *** properties usually coexist and interact with each *** correlation between the surface charge and hydration of minerals is summarized on the basis of innovative experimental,theoretical,and molecular dynamics simulation *** factors affecting the adsorption behavior of ions and water molecules,such as ion concentration,ion hydration radius and valence,and surface properties,are *** example,the hydration and adsorption states completely differ between monovalent and divalent *** ions of the same valence,the effect of surface charge on the hydration force follows the Hofmeister adsorption *** concentration exerts a significant effect on the hydration force at high ion ***,the ion correlations in high-concentration electrolyte systems become long *** interfacial water structure largely depends on surface *** hydration layer between different surfaces shows large qualitative differences.

关键词： surface hydration surface charged ion mineral water molecule

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei song Yu-Ze li Wen-li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

lipase-activated glycopeptide nano-assemblies as an antibiotic nano-adjuvant to inhibit Pseudomonas aeruginosa biofilm and enhance antibacterial activity

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Science China Chemistry 2022年第12期65卷 2538-2547页

作者： Yifei song Jingkai Zhang Yue fei Zhangjian Huang Xiaoxuan liu li-li li CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing100190China College of life Science and Technology Beijing University of Chemical TechnologyBeijing100029China State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Drug DiscoveryCenter of Advanced Pharmaceutics and BiomaterialsChina Pharmaceutical UniversityNanjing210009China

Bacterial infections,especially those caused by biofilms,pose a serious threat to public *** this work,we propose a glycopeptide-based antibiotic nano-adjuvant(GalAc-2) that can synergistically enhance the antibacterial activity of antibiotics through its biofilm inhibition *** glycopeptide nanoparticles can be specifically activated by bacterial infection overexpressed lipase and sequentially enlarged by glycosyl exposure on the *** stability and bonding affinity of the nanoparticles were enhanced through the increase in β-sheet *** bacterial growth inhibition rate of the mixture of levofloxacin(LEV) and GalAc-2 at 0.54 μg/m L was over sevenfold higher than that of LEV alone because of the electrostatic and multivalence Lec A interactions that inhibited biofilm formation on the bacterial ***,the mixture of the antibiotic with GalAc-2 significantly inhibited the abscess exposed to skin infection and significantly reduced the infiltration of immune *** believe that GalAc-2 can be further used to enhance broad-spectrum antibiotic sensitization and prolong the lifetime of antibiotics.

关键词： glycopeptide self-assembly antibiotic nano-adjuvant bacteria biofilm

The antibacterial activity of Berberis heteropoda Schrenk and its effect on irritable bowel syndrome in rats

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Chinese Journal of Natural Medicines 2020年第5期18卷 356-368页

作者： li li ZHU Hui-Min YAN Qi li song-Ya li fei College of Pharmacy Xinjiang Medical UniversityUrumqi 830011China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

The dried roots of Berberis heteropoda Schrenk have traditionally been used to treat acute gastroenteritis and dysentery. The aim of this study was to confirm the antibacterial activity of an extract of Berberis heteropoda Schrenk root in vitro and its therapeutic effects on rats with diarrhea-predominant irritable bowel syndrome(D-IBS) in vivo, as well as to identify the related signaling pathways. A water extract of Berberis heteropoda Schrenk root(BHS) inhibited the growth of S. aureus, E. coli, P. aeruginosa and S. faecalis. BHS potentially damaged the structure of the bacterial cell membrane and decreased the activity of some membranous enzymes, eventually killing the S. aureus, E. coli, P. aeruginosa and S. faecalis bacteria. Oral administration of BHS(low, middle and high dose group, L, M and H) significantly alleviated the abdominal pain, diarrhea, and depression-like symptoms of D-IBS rats, and the efficacy index ranged from 30% to 60%, indicating that the BHS treatment was effective. BHS(L, M and H) alleviated the abnormal pathological changes in the brain, as evidenced by HE staining. The expression of CHAT, 5-HT, C-FOS and CGRP was reduced by the BHS treatment(L, M and H). Our findings provide novel insights into the use of the natural product BHS to inhibit pathogenic bacteria by destroying the bacterial structure, indicating that BHS possesses certain biological activities. Furthermore, BHS has the potential to alleviate diarrhea, abdominal pain and depression-like behaviors in D-IBS rats by regulating the brain-gut peptide levels.

关键词： Diarrhea-type irritable bowel syndrome Antibacterial activity Antidiarrhea Anti-abdominal pain Antidepressant effects Berberis heteropoda Schrenk roots

Patterned Solutions of a Homogenous Diffusive Predator-Prey System of Holling Type-Ⅲ

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Acta Mathematicae Applicatae Sinica 2016年第4期32卷 1073-1086页

作者： A-ying WAN Zhi-qiang song li-fei ZHENG School of Mathematics and Statistics Hulunbeir College Hailar 021008 China School of Mining Technology Hulunbeir College Hailar 021008 China Department of Applied Mathematics Northwest A and F University Yangling 712100 China

In this paper, a diffusive predator-prey system of Holling type functional III is considered. For one hand, we considered the possibility of the occurrence of Turing patterns of the system. Our results show that there is no Turing patterns found in the system. On the other hand, we performed detailed Hopf bifurcation analysis to the systems, and showed that the system have multiple oscillatory patterns. Moreover, we also derived the conditions to determine the Hopf bifurcation direction and the stability of the bifurcating periodic solutions. Computer simulations are included to support our theoretical analysis.

关键词： diffusive predator-prey system Hholling type functional response Hopf bifurcation turing insta-bility.

Global trends and hotspots of type 2 diabetes in children and adolescents:A bibliometric study and visualization analysis

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World Journal of Diabetes 2025年第1期16卷 140-168页

作者： Fang-Shuo Zhang Hai-Jing li Xue Yu Yi-Ping song Yan-Feng Ren Xuan-Zhu Qian Jia-li liu Wen-Xun li Yi-Ran Huang Kuo Gao School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus(T2DM)among children and adolescents *** to rapid disease progression,severe long-term cardiorenal complications,a lack of effective treatment strategies,and substantial socioeconomic burdens,it has become an urgent public health issue that requires management and *** T2DM differs from adult *** a significant increase in our understanding of youth-onset T2DM over the past two decades,the related review and evidence-based content remain *** To visualize the hotspots and trends in pediatric and adolescent T2DM research and to forecast their future research *** This study utilized the terms“children”,“adolescents”,and“type 2 diabetes”,retrieving relevant articles published between 1983 and 2023 from three citation databases within the Web of Science Core Collection(SCI,SSCI,ESCI).Utilizing CiteSpace and VoSviewer software,we analyze and visually represent the annual output of literature,countries involved,and participating *** allows us to predict trends in this research *** analysis encompasses co-cited authors,journal overlays,citation overlays,time-zone views,keyword analysis,and reference analysis,*** A total of 9210 articles were included,and the annual publication volume in this field showed a steady growth *** United States had the highest number of publications and the highest *** United States also had the most research institutions and the strongest research *** global hot journals were primarily diabetes professional journals but also included journals related to nutrition,endocrinology,and *** analysis showed that research related to endothelial dysfunction,exposure risk,cardiac metabolic risk,changes in gut microbiota,the impact on comorbidities and outcomes,etc.,were emerging *** have maintained their popularity in this field,sugges

关键词： Child Adolescent Type 2 diabetes mellitus Bibliometrics Knowledge mapping Visualization CiteSpace VOSviewer