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Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan Zheng Hongqiang li Wei Chen Yu-fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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基于文献计量学和内容分析的我国隐性教育研究热点与趋势分析

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华北理工大学学报（社会科学版） 2022年第1期22卷 84-91页

作者：杨洁李鹤飞华北理工大学管理学院河北唐山063210 华北理工大学期刊社河北唐山063210

以“中国知网(CNKI)”作为文献数据来源,采用文献计量法,从文献年代分布、期刊作者、研究机构、研究热点等角度,对国内隐性教育研究的相关文献进行分析。结果表明,我国隐性教育研究处于二次快速发展期,研究成果分布集中,未形成稳定的核... 详细信息

以“中国知网(CNKI)”作为文献数据来源,采用文献计量法,从文献年代分布、期刊作者、研究机构、研究热点等角度,对国内隐性教育研究的相关文献进行分析。结果表明,我国隐性教育研究处于二次快速发展期,研究成果分布集中,未形成稳定的核心作者群,其研究热点与国家政策密切联系。研究趋势表现为研究对象丰富化,研究主体多元化,研究主题时代性。

关键词：隐性教育文献计量研究热点与趋势

Design and characterization study of dual D-shaped no-core fiber based SPR sensor for refractive index and temperature measurement

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Optoelectronics Letters 2025年

作者： liu Yinggang li Rui li fei Xu Xinyi Zhou Rui Shaanxi Engineering Research Center of Oil and Gas Resource Optical Fiber Detection & Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas wells， Xi'an Shiyou University

To address the issue of temperature cross-sensitivity in refractive index （RI） measurement， a fiber-optic Surface Plasmon Resonance （SPR） sensor based on dual D-shaped no-core fiber （NCF） is proposed and designed. The sensor mainly consists of D-shaped NCF， Ag/Fe2O3composite film， and polydimethylsiloxane （PDMS）， where the silver and Fe2O3are successively coated on both D-shaped surfaces of NCF to generate SPR and enhance the oxidation resistance. The layer of PDMS coated on one D-shaped surface acts as a tunable ambient medium sensing the temperature variation and affecting the transmission spectrum of the sensor. Since the surface plasmon waves are excited in the two D-shaped surfaces with different films， the two RI and temperature-dependent spectral resonance peaks with different wavelengths will be produced. Research results demonstrate that the two peaks’ wavelengths have different responses to the variations of ambient RI and temperature. In the refractive index range of 1.36-1.376 and temperature range of 10-100 °C， the RI and temperature sensitivities reach to 5000 nm/RIU and -0.546 nm/°C， respectively. With the sensitivity coefficient matrix， simultaneous measurement of refractive index and temperature can be realized， and the corresponding accuracy is superior to 0.4×10-5RIU and 0.037°C.

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我国成人学习者终身学习需求分析

华北理工大学学报（社会科学版） 2018年第3期18卷 99-107页

作者：李鹤飞李宏坤华北理工大学党委/校长办公室河北唐山063210 华北理工大学冀唐学院河北唐山063210

学习型社会是当今主流社会形态,终身学习思想是国际社会的主流思想,学习文化在我国正逐步形成。文章对成人学习者的学习需求进行问卷调查,通过数据分析和统计检验,结合瑞典、韩国等经验,形成研究结论,提出了整合终身学习资源、促进资源... 详细信息

学习型社会是当今主流社会形态,终身学习思想是国际社会的主流思想,学习文化在我国正逐步形成。文章对成人学习者的学习需求进行问卷调查,通过数据分析和统计检验,结合瑞典、韩国等经验,形成研究结论,提出了整合终身学习资源、促进资源细分;促进终身学习项目化、人本化、可操作化;设置终身学习专职从业人员;促进终身教育立法,构建立体化服务体系等发展建议。

关键词：成人学习者终身学习需求

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao li Yu Deng Hongbin Wu Xiaojian Xu fei Niu Xinlong Dong Bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

我国高校教师队伍建设政策研究——基于2012-2022年发布的36份政策文本的分析

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华北理工大学学报（社会科学版） 2023年第1期23卷 108-116页

作者：孙炜烨李鹤飞华北理工大学管理学院河北唐山063210 华北理工大学期刊社河北唐山063210

对2012-2022年中央层面发布的高校教师队伍建设相关政策文本从发文时间、发文主体以及政策种类等方面进行政策文献量化分析,运用***6软件对政策文本内容进行高频词提取并排位以及生成语义网络图谱。经过研究发现,政策文本关注热点集中... 详细信息

对2012-2022年中央层面发布的高校教师队伍建设相关政策文本从发文时间、发文主体以及政策种类等方面进行政策文献量化分析,运用***6软件对政策文本内容进行高频词提取并排位以及生成语义网络图谱。经过研究发现,政策文本关注热点集中于加强高校师德师风建设、推动高校教师队伍管理改革、完善优化教师激励机制以及提升教师教学科研各方面能力素质等方面。另外,从主体看,青年教师、思想政治课教师、辅导员以及新入职教师是政策关注的焦点,根据对政策文本的内容分析得到研究结论。最后,基于对36份政策文本的分析从各级教育主管部门、相关政策协同部门、各级各类高校以及高校教师四个主体角度给出相关启示。

关键词：高校教师队伍政策文本政策研究量化分析

基于CNKI文献计量学的我国“教育焦虑”的分析研究

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华北理工大学学报（社会科学版） 2022年第6期22卷 71-78页

作者：张渊君李鹤飞华北理工大学心理与精神卫生学院河北唐山063210 华北理工大学期刊社河北唐山063210

基于中国知网CNKI数据库,运用SATI、Ucinet和Netdraw软件,从文献年代分布与年度发文数量、发文期刊、发文机构、发文作者、研究热点和理论基础六个角度对“教育焦虑”领域发文进行分析。研究发现,“教育焦虑”领域的研究正处于发展期,... 详细信息

基于中国知网CNKI数据库,运用SATI、Ucinet和Netdraw软件,从文献年代分布与年度发文数量、发文期刊、发文机构、发文作者、研究热点和理论基础六个角度对“教育焦虑”领域发文进行分析。研究发现,“教育焦虑”领域的研究正处于发展期,发文总量不多,发文机构较分散,研究成果并不集中。主要研究阵地集中在师范类高校,核心作者群还未形成,研究热点包括家庭教育、基础教育、校外培训机构、“双减”政策等,研究空间较大。

关键词： “教育焦虑” 文献计量研究热点

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美国联邦政府高等教育财政资助政策历史评述

职业技术教育 2014年第31期35卷 74-77页

作者：刘旭东甘少杰李鹤飞河北联合大学河北唐山063009 渤海大学辽宁锦州121013

财政资助是现代国家中央政府调控高等教育的主要手段。经过历史的发展与完善,财政资助已经成为美国联邦政府参与高等教育的主要方式。基于公共政策选择理论和教育成本分担理论,联邦政府不断为高等教育提供强大的财政支持,并以此调控高... 详细信息

财政资助是现代国家中央政府调控高等教育的主要手段。经过历史的发展与完善,财政资助已经成为美国联邦政府参与高等教育的主要方式。基于公共政策选择理论和教育成本分担理论,联邦政府不断为高等教育提供强大的财政支持,并以此调控高等教育的发展方向,使其成为美国政府实现国家发展目标的利益诉求工具。二者之间的这种互动关系,反映了美国联邦政府参与高等教育的理论基础与现实需要。

关键词：联邦政府高等教育财政资助政策美国

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang he Chang-Qing liu li-fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS